JPWO2020090045A1 - 抗グラム陰性菌化合物 - Google Patents
抗グラム陰性菌化合物 Download PDFInfo
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- JPWO2020090045A1 JPWO2020090045A1 JP2020554676A JP2020554676A JPWO2020090045A1 JP WO2020090045 A1 JPWO2020090045 A1 JP WO2020090045A1 JP 2020554676 A JP2020554676 A JP 2020554676A JP 2020554676 A JP2020554676 A JP 2020554676A JP WO2020090045 A1 JPWO2020090045 A1 JP WO2020090045A1
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- bacillus subtilis
- negative
- compound according
- negative bacterial
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Abstract
【化1】
Description
ヨモギの葉においては、一日のうち、日の出時間を挟む前後1時間、合計2時間の間に、乳酸菌の数が最大化するとされている。また、この時間帯以外においては、乳酸菌が減少し、光合成菌が増加するとされている。したがって、この2時間の間に、ヨモギの葉の先端から約20cmの部分を採取した。採取した6.3kgのヨモギの葉を、すぐさま、中にビニールの袋を敷いた第1の漬物樽に入れ、ヨモギの葉に、3.2kgの糖蜜と0.6kgの粗塩を振りかけた後、ビニール袋の口を閉じて密封した。ビニール袋の上から、重石を載せ、ヨモギの葉を漬け込んだ。
ラクトバチリMRS培地(:プロテオースペプトン1%、牛肉エキス1%、酵母エキス0.5%、ブドウ糖2%、Tween 80 0.1%、クエン酸アンモニウム0.5%、硫酸マグネシウム0.01%、硫酸マンガン0.005%、リン酸二カリウム0.2%、ディフコ社製)にヨモギ発酵液を滴下し、ヨモギ発酵液に含まれる細菌を培地中で培養し、必要に応じて数回の継代培養を行った。その後、培養された細菌を、ラクトバチリMRS寒天培地(上記のMRS培地に寒天3%を添加した培地)に塗抹培養し、生じたコロニーから細菌を採取した。
Bacillus subtilis MT2株を、ラクトバチリMRS培地中、35℃以上37℃以下で好気的に3日間、振とう培養した。その後、菌体を含む培地を、10000rpmで、20分間、25℃で遠心分離した。さらに、遠心分離された培地を、目開き0.45μmの滅菌フィルターでろ過して菌体を除去し、培養上澄液を得た。
グラム陽性菌として枯草菌(Bacillus subtilis, NBRC 3134)、グラム陰性菌として腸炎ビブリオ(Vibrio parahaemolyticus, 12711T)を用意した。実施例3で調製した活性バクテリオシンを含む、pHが7.8の10mLの液に、上記の菌のいずれかを107個/mLの濃度で含む0.1mLの菌液を接種し、25℃で24時間後の菌の生菌数を測定した。また、コントロールとして、濃度が0.067mol/L、pH7.2の10mLのリン酸緩衝液に0.1mLの腸炎ビブリオ(Vibrio parahaemolyticus, 12711T)の菌液を接種し、25℃で24時間後の菌の生菌数を測定した。その結果、図7に示すように、活性バクテリオシンは、枯草菌及び腸炎ビブリオの両方を同程度減少させた。
Claims (29)
- 枯草菌(Bacillus subtilis)から産生される、請求項1に記載の抗グラム陰性菌化合物。
- Bacillus subtilis MT2株(受託番号:NITE BP-02767)から産生される、請求項1に記載の抗グラム陰性菌化合物。
- 前記グラム陰性菌が、ビブリオ属細菌である、請求項1から3のいずれか1項に記載の抗グラム陰性菌化合物。
- 前記グラム陰性菌が、腸炎ビブリオである、請求項1から3のいずれか1項に記載の抗グラム陰性菌化合物。
- 真菌に対しさらに抗菌作用を有する、請求項1から5のいずれか1項に記載の抗グラム陰性菌化合物。
- 前記真菌が、トリコフィトン属菌である、請求項6に記載の抗グラム陰性菌化合物。
- 前記真菌が、白癬菌である、請求項6に記載の抗グラム陰性菌化合物。
- 前記真菌が、毛瘡菌又は趾間菌である、請求項6に記載の抗グラム陰性菌化合物。
- グラム陽性菌に対しさらに抗菌作用を有する、請求項1から9のいずれか1項に記載の抗グラム陰性菌化合物。
- グラム陰性菌に対する抗菌作用を補助する処置と併用されない、請求項1から10のいずれか1項に記載の抗グラム陰性菌化合物。
- 前記処置が、保存料の添加である、請求項11に記載の抗グラム陰性菌化合物。
- 前記保存料が、キレート剤である、請求項12に記載の抗グラム陰性菌化合物。
- 請求項1から13のいずれか1項に記載の抗グラム陰性菌化合物を含む抗グラム陰性菌薬。
- 請求項1から13のいずれか1項に記載の抗グラム陰性菌化合物を含む飲料又は食料。
- 請求項16に記載の枯草菌を含む抗グラム陰性菌薬。
- 請求項16に記載の枯草菌を含む飲料又は食料。
- Bacillus subtilis MT2株(受託番号:NITE BP-02767)。
- Bacillus subtilis MT2株(受託番号:NITE BP-02767)を含む抗グラム陰性菌薬。
- Bacillus subtilis MT2株(受託番号:NITE BP-02767)を含む飲料又は食料。
- 抗グラム陰性菌薬の製造における請求項1から13のいずれか1項に記載の抗グラム陰性菌バクテリオシンの使用。
- 抗グラム陰性菌薬の製造における請求項16に記載の枯草菌の使用。
- 抗グラム陰性菌薬の製造におけるBacillus subtilis MT2株(受託番号:NITE BP-02767)の使用。
- 請求項1から13のいずれか1項に記載の抗グラム陰性菌化合物を患者に投与することを含む、腸炎の治療方法。
- 請求項16に記載の枯草菌を患者に投与することを含む、腸炎の治療方法。
- Bacillus subtilis MT2株(受託番号:NITE BP-02767)を患者に投与することを含む、腸炎の治療方法。
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08506010A (ja) * | 1992-11-25 | 1996-07-02 | ユニバーシティー オブ メリーランド カレッジ パーク | 安定性と活性を高めたサブチリンの変異形 |
JP2001136959A (ja) * | 1999-11-17 | 2001-05-22 | Hiroyuki Sumi | 枯草菌菌体および/またはその産生物を含む培養物、これに由来する水溶性ビタミンk誘導体、これらを含む医薬、食品および飼料ならびにこれらの製造方法 |
JP2007518394A (ja) * | 2003-08-14 | 2007-07-12 | ザ バイオ バランス コーポレイション | 細菌菌株、該細菌菌株を含む組成物、およびそのプロバイオティクス使用 |
JP2013147469A (ja) * | 2012-01-20 | 2013-08-01 | Calpis Co Ltd | 腸内酪酸産生菌増加剤 |
JP2015509945A (ja) * | 2012-02-27 | 2015-04-02 | オラジェニクス, インコーポレイテッド | ランチビオティクスmu1140および改善された薬理学的特性および構造的特徴を有する他のランチビオティクスの変異体 |
Family Cites Families (3)
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JP4977011B2 (ja) * | 2005-03-22 | 2012-07-18 | 株式会社九州メディカル | バチルス・ズブチリスを用いた甲殻類カビ病および魚介類カビ病の予防方法 |
EP2792686A1 (en) * | 2013-04-17 | 2014-10-22 | Heinrich-Heine-Universität Düsseldorf | Methods for the expression of peptides and proteins |
JP6376751B2 (ja) * | 2013-12-11 | 2018-08-22 | アサヒカルピスウェルネス株式会社 | 循環型農業サイクルへのバチルス属細菌の使用 |
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08506010A (ja) * | 1992-11-25 | 1996-07-02 | ユニバーシティー オブ メリーランド カレッジ パーク | 安定性と活性を高めたサブチリンの変異形 |
JP2001136959A (ja) * | 1999-11-17 | 2001-05-22 | Hiroyuki Sumi | 枯草菌菌体および/またはその産生物を含む培養物、これに由来する水溶性ビタミンk誘導体、これらを含む医薬、食品および飼料ならびにこれらの製造方法 |
JP2007518394A (ja) * | 2003-08-14 | 2007-07-12 | ザ バイオ バランス コーポレイション | 細菌菌株、該細菌菌株を含む組成物、およびそのプロバイオティクス使用 |
JP2013147469A (ja) * | 2012-01-20 | 2013-08-01 | Calpis Co Ltd | 腸内酪酸産生菌増加剤 |
JP2015509945A (ja) * | 2012-02-27 | 2015-04-02 | オラジェニクス, インコーポレイテッド | ランチビオティクスmu1140および改善された薬理学的特性および構造的特徴を有する他のランチビオティクスの変異体 |
Non-Patent Citations (5)
Title |
---|
EXPERIMENTAL BIOLOGY AND MEDICINE, vol. 60, no. 1, JPN6019000179, 1945, pages 60 - 64, ISSN: 0004764877 * |
LANTIBIOTIC (A0A285JLI1_9BACI) [ONLINE], JPN6019000178, 23 May 2018 (2018-05-23), ISSN: 0005036353 * |
LANTIBIOTIC (A0A290WPH5_BACLI) [ONLINE], JPN6022017631, 23 May 2018 (2018-05-23), ISSN: 0005036351 * |
LANTIBIOTIC (A0A2X1V906_PAEPO) [ONLINE], JPN6022017629, 10 October 2018 (2018-10-10), ISSN: 0005036352 * |
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 19, JPN6019000181, 1988, pages 9508 - 9514, ISSN: 0004764878 * |
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