JPWO2020087116A5 - - Google Patents
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- Publication number
- JPWO2020087116A5 JPWO2020087116A5 JP2021525181A JP2021525181A JPWO2020087116A5 JP WO2020087116 A5 JPWO2020087116 A5 JP WO2020087116A5 JP 2021525181 A JP2021525181 A JP 2021525181A JP 2021525181 A JP2021525181 A JP 2021525181A JP WO2020087116 A5 JPWO2020087116 A5 JP WO2020087116A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- tumor
- cells
- binding domain
- tag
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims 44
- 102000038129 antigens Human genes 0.000 claims 44
- 108091007172 antigens Proteins 0.000 claims 44
- 206010028980 Neoplasm Diseases 0.000 claims 36
- 210000000612 Antigen-Presenting Cells Anatomy 0.000 claims 24
- 229920001184 polypeptide Polymers 0.000 claims 24
- 210000002865 immune cell Anatomy 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 19
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 13
- 210000004882 non-tumor cells Anatomy 0.000 claims 10
- 210000001519 tissues Anatomy 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 210000004881 tumor cells Anatomy 0.000 claims 7
- 210000004443 Dendritic Cells Anatomy 0.000 claims 6
- 210000004027 cells Anatomy 0.000 claims 6
- 102100013137 CD40 Human genes 0.000 claims 5
- 101710040446 CD40 Proteins 0.000 claims 5
- 210000001744 T-Lymphocytes Anatomy 0.000 claims 4
- 102000004965 antibodies Human genes 0.000 claims 4
- 108090001123 antibodies Proteins 0.000 claims 4
- -1 eXACT tag Proteins 0.000 claims 3
- 108010011170 Ala-Trp-Arg-His-Pro-Gln-Phe-Gly-Gly Proteins 0.000 claims 2
- 102100005826 CD19 Human genes 0.000 claims 2
- 101700087100 CD19 Proteins 0.000 claims 2
- 102100007290 CD274 Human genes 0.000 claims 2
- 101710012053 CD274 Proteins 0.000 claims 2
- 102100008186 CD83 Human genes 0.000 claims 2
- 101700013105 CD83 Proteins 0.000 claims 2
- 101710026722 CLEC9A Proteins 0.000 claims 2
- 102000007563 Galectins Human genes 0.000 claims 2
- 108010046569 Galectins Proteins 0.000 claims 2
- 102100019437 ITGAX Human genes 0.000 claims 2
- 101710006689 ITGAX Proteins 0.000 claims 2
- 210000003171 Lymphocytes, Tumor-Infiltrating Anatomy 0.000 claims 2
- 102100015262 MYC Human genes 0.000 claims 2
- 210000002540 Macrophages Anatomy 0.000 claims 2
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 2
- 102100007289 PDCD1LG2 Human genes 0.000 claims 2
- 101710011976 PDCD1LG2 Proteins 0.000 claims 2
- 210000000400 T-Lymphocytes, Cytotoxic Anatomy 0.000 claims 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 210000003289 regulatory T cell Anatomy 0.000 claims 2
- 210000000481 Breast Anatomy 0.000 claims 1
- 210000001072 Colon Anatomy 0.000 claims 1
- 210000000822 Killer Cells, Natural Anatomy 0.000 claims 1
- 210000004072 Lung Anatomy 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000000735 allogeneic Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002147 killing Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2018904117 | 2018-10-30 | ||
| AU2018904117A AU2018904117A0 (en) | 2018-10-30 | Polypeptides and uses thereof | |
| AU2019903255 | 2019-09-04 | ||
| AU2019903255A AU2019903255A0 (en) | 2019-09-04 | Polypeptides and uses thereof | |
| PCT/AU2019/051189 WO2020087116A1 (en) | 2018-10-30 | 2019-10-29 | Bispecific polypeptides for engagement of car expressing immune cells with antigen presenting cells and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022528024A JP2022528024A (ja) | 2022-06-08 |
| JPWO2020087116A5 true JPWO2020087116A5 (ru) | 2022-11-10 |
Family
ID=70461795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021525181A Pending JP2022528024A (ja) | 2018-10-30 | 2019-10-29 | Ｃａｒを発現する免疫細胞に抗原提示細胞を係合させるための二重特異性ポリペプチド及びそれらの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11866504B2 (ru) |
| EP (1) | EP3877417A4 (ru) |
| JP (1) | JP2022528024A (ru) |
| KR (1) | KR20210108361A (ru) |
| CN (1) | CN113195535A (ru) |
| AU (2) | AU2019370618C1 (ru) |
| CA (1) | CA3117079A1 (ru) |
| SG (1) | SG11202104180WA (ru) |
| WO (1) | WO2020087116A1 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022012681A1 (en) * | 2020-07-16 | 2022-01-20 | Nanjing Legend Biotech Co., Ltd. | Multispecific chimeric antigen receptors and uses thereof |
| WO2024059899A1 (en) * | 2022-09-20 | 2024-03-28 | Currus Biologics Pty Ltd | Bispecific polypeptides and uses thereof |
| WO2024059901A1 (en) * | 2022-09-20 | 2024-03-28 | Currus Biologics Pty Ltd | A method of rescuing exhausted immune cells |
| WO2024059900A1 (en) * | 2022-09-20 | 2024-03-28 | Currus Biologics Pty Ltd | Anti-flag antibodies |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2990416B1 (en) * | 2014-08-29 | 2018-06-20 | GEMoaB Monoclonals GmbH | Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders |
| CN104829730A (zh) * | 2015-04-14 | 2015-08-12 | 苏静 | 一种能联合免疫细胞增强肿瘤杀伤能力的双特异性抗体及其制备方法和应用 |
| US10591465B2 (en) * | 2015-05-12 | 2020-03-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for labeling, detection and isolation of Foxp3+ regulatory T cells, isolated population of Foxp3+ regulatory T cells thus obtained and uses thereof |
| WO2017167350A1 (en) * | 2016-03-30 | 2017-10-05 | Horst Lindhofer | Multispecific antibodies for use in the treatment of a neoplasm of the urinary tract |
| KR20180135460A (ko) | 2016-04-15 | 2018-12-20 | 자임워크스 인코포레이티드 | 면역치료제를 표적으로 하는 다중-특이적 항원-결합 작제물 |
| WO2020028444A1 (en) * | 2018-07-30 | 2020-02-06 | University Of Southern California | Improving the efficacy and safety of adoptive cellular therapies |
-
2019
- 2019-10-29 EP EP19879319.2A patent/EP3877417A4/en active Pending
- 2019-10-29 KR KR1020217016400A patent/KR20210108361A/ko unknown
- 2019-10-29 WO PCT/AU2019/051189 patent/WO2020087116A1/en unknown
- 2019-10-29 CA CA3117079A patent/CA3117079A1/en active Pending
- 2019-10-29 JP JP2021525181A patent/JP2022528024A/ja active Pending
- 2019-10-29 SG SG11202104180WA patent/SG11202104180WA/en unknown
- 2019-10-29 US US17/289,997 patent/US11866504B2/en active Active
- 2019-10-29 CN CN201980075175.XA patent/CN113195535A/zh active Pending
- 2019-10-29 AU AU2019370618A patent/AU2019370618C1/en active Active
-
2022
- 2022-11-04 AU AU2022263573A patent/AU2022263573A1/en active Pending
-
2023
- 2023-11-13 US US18/507,157 patent/US20240150482A1/en active Pending
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