JPWO2020083979A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020083979A5 JPWO2020083979A5 JP2021523276A JP2021523276A JPWO2020083979A5 JP WO2020083979 A5 JPWO2020083979 A5 JP WO2020083979A5 JP 2021523276 A JP2021523276 A JP 2021523276A JP 2021523276 A JP2021523276 A JP 2021523276A JP WO2020083979 A5 JPWO2020083979 A5 JP WO2020083979A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- set forth
- sequence set
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 138
- 238000000034 method Methods 0.000 claims 22
- 230000000302 ischemic effect Effects 0.000 claims 19
- 102000003780 Clusterin Human genes 0.000 claims 15
- 108090000197 Clusterin Proteins 0.000 claims 15
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 208000028867 ischemia Diseases 0.000 claims 6
- 238000000338 in vitro Methods 0.000 claims 4
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 3
- 208000029078 coronary artery disease Diseases 0.000 claims 3
- 230000013595 glycosylation Effects 0.000 claims 3
- 238000006206 glycosylation reaction Methods 0.000 claims 3
- 208000031225 myocardial ischemia Diseases 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 238000004393 prognosis Methods 0.000 claims 3
- 230000000451 tissue damage Effects 0.000 claims 3
- 231100000827 tissue damage Toxicity 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 2
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 2
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical group CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 claims 2
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000002107 myocardial effect Effects 0.000 claims 2
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 2
- 208000004302 Microvascular Angina Diseases 0.000 claims 1
- 208000026018 Microvascular coronary artery disease Diseases 0.000 claims 1
- 230000004988 N-glycosylation Effects 0.000 claims 1
- 208000006117 ST-elevation myocardial infarction Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010000891 acute myocardial infarction Diseases 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000003147 glycosyl group Chemical group 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 230000001338 necrotic effect Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 238000010837 poor prognosis Methods 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 125000005629 sialic acid group Chemical group 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18382752.6 | 2018-10-23 | ||
| EP18382752 | 2018-10-23 | ||
| PCT/EP2019/078855 WO2020083979A1 (en) | 2018-10-23 | 2019-10-23 | Antibodies specific for glycosylated apoj and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022506108A JP2022506108A (ja) | 2022-01-17 |
| JP2022506108A5 JP2022506108A5 (https=) | 2022-06-14 |
| JPWO2020083979A5 true JPWO2020083979A5 (https=) | 2022-06-14 |
Family
ID=64426823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021523276A Pending JP2022506108A (ja) | 2018-10-23 | 2019-10-23 | グリコシル化ＡｐｏＪに特異的な抗体およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20210388108A1 (https=) |
| EP (1) | EP3870614A1 (https=) |
| JP (1) | JP2022506108A (https=) |
| KR (1) | KR20210081397A (https=) |
| CN (1) | CN113366021A (https=) |
| AU (1) | AU2019365391A1 (https=) |
| BR (1) | BR112021006516A2 (https=) |
| CA (1) | CA3115887A1 (https=) |
| IL (1) | IL282384A (https=) |
| MA (1) | MA53980A (https=) |
| MX (1) | MX2021004684A (https=) |
| SG (1) | SG11202103124WA (https=) |
| WO (1) | WO2020083979A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| CN120699894A (zh) * | 2024-03-25 | 2025-09-26 | 中国科学院分子细胞科学卓越创新中心 | Clusterin阳性心脏类器官及其应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| AU632065B2 (en) | 1988-09-23 | 1992-12-17 | Novartis Vaccines And Diagnostics, Inc. | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| WO1993006217A1 (en) | 1991-09-19 | 1993-04-01 | Genentech, Inc. | EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES |
| MD1367C2 (ro) | 1992-11-13 | 2000-11-30 | Idec Pharmaceuticals Corporation | Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom. |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| ITRM20040098A1 (it) * | 2004-02-25 | 2004-05-25 | Univ Roma | Anticorpi oligoclonali anticlasterina per la diagnosi di neoplasie e la predizione del loro grado di malignita', metodo diagnostico e kit relativi. |
| US10155816B2 (en) | 2005-11-28 | 2018-12-18 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
| ES2364169B1 (es) * | 2010-02-09 | 2012-07-10 | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (Titular al 50%) | Uso de las isoformas de apo j como biomarcadores de lesión tisular. |
| CA2868391A1 (en) | 2012-04-02 | 2013-10-10 | Stephane Bancel | Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same |
| WO2017139975A1 (en) * | 2016-02-19 | 2017-08-24 | Huiru Wang | Antibodies against n-acetylglucosamine and n-acetyl-galactosamine |
| EP3232200A1 (en) * | 2016-04-12 | 2017-10-18 | Institut Catalá De Ciencies Cardiovasculars (ICCC) | Methods and kits for the diagnosis and risk stratification of patients with ischemia |
-
2019
- 2019-10-23 EP EP19802086.9A patent/EP3870614A1/en active Pending
- 2019-10-23 CN CN201980069358.0A patent/CN113366021A/zh active Pending
- 2019-10-23 AU AU2019365391A patent/AU2019365391A1/en not_active Abandoned
- 2019-10-23 KR KR1020217015370A patent/KR20210081397A/ko not_active Ceased
- 2019-10-23 BR BR112021006516-4A patent/BR112021006516A2/pt unknown
- 2019-10-23 CA CA3115887A patent/CA3115887A1/en active Pending
- 2019-10-23 SG SG11202103124WA patent/SG11202103124WA/en unknown
- 2019-10-23 JP JP2021523276A patent/JP2022506108A/ja active Pending
- 2019-10-23 US US17/287,777 patent/US20210388108A1/en active Pending
- 2019-10-23 WO PCT/EP2019/078855 patent/WO2020083979A1/en not_active Ceased
- 2019-10-23 MA MA053980A patent/MA53980A/fr unknown
- 2019-10-23 MX MX2021004684A patent/MX2021004684A/es unknown
-
2021
- 2021-04-18 IL IL282384A patent/IL282384A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8026345B2 (en) | Characterization and identification of unique human adiponectin isoforms and antibodies | |
| CN102695716B (zh) | 肝病病情指标糖链标记物 | |
| JP5994121B2 (ja) | バイオマーカー | |
| CN105765385B (zh) | 预测出现主要不良心脏事件的风险的方法 | |
| RU2018139780A (ru) | Способы и наборы диагностики и стратификации риска пациентов с ишемией | |
| EP3248015B1 (en) | Compounds and methods for the detection of calprotectin | |
| CN106459926B (zh) | 杂交瘤细胞系(My-C-cC0C2-235-3H8)及其生产抗人心脏肌球蛋白结合蛋白C(C蛋白、MYBPC3、cMyBP-C或者My-C)单克隆抗体的应用 | |
| CN113892031B (zh) | 混合检测PCT和Presepsin的试剂盒、方法以及应用 | |
| CN104470942A (zh) | 生物标志物 | |
| AU2015376851A1 (en) | Glypican epitopes and uses thereof | |
| JP2011514156A (ja) | 急性冠動脈障害のためのバイオマーカー | |
| AU2016382408A1 (en) | Diagnosis of unstable angina | |
| CN106459927B (zh) | 杂交瘤细胞系(My-C-cC0C2-259-1A4)及其生产抗人心脏肌球蛋白结合蛋白C(C蛋白、MYBPC3、cMyBP-C或者My-C)单克隆抗体的应用 | |
| CN108351359A (zh) | 用于预测肝硬化患者的肝细胞癌发生风险和预后的方法 | |
| JP2022506108A5 (https=) | ||
| JP5818440B2 (ja) | バイオマーカー | |
| JPWO2020083979A5 (https=) | ||
| CN108139404B (zh) | 特异性地识别、结合活性结构的REIC/Dkk-3蛋白的抗体、以及使用该抗REIC/Dkk-3抗体的癌治疗的监测 | |
| CN113366021A (zh) | 糖基化Apo J特异性抗体及其用途 | |
| RU2021114443A (ru) | Антитела, специфические к гликозилированному apoj, и их применение | |
| KR20230104595A (ko) | 암 평가용 검정 | |
| CA2771954A1 (en) | Pneumonia biomarkers | |
| WO2025172467A1 (en) | Endotrophin assay | |
| US11267854B2 (en) | Complex-specific standardization of immunological methods for the quantification of S100A12 | |
| WO2019121925A1 (en) | Tumstatin assay |