CN113366021A - 糖基化Apo J特异性抗体及其用途 - Google Patents

糖基化Apo J特异性抗体及其用途 Download PDF

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Publication number
CN113366021A
CN113366021A CN201980069358.0A CN201980069358A CN113366021A CN 113366021 A CN113366021 A CN 113366021A CN 201980069358 A CN201980069358 A CN 201980069358A CN 113366021 A CN113366021 A CN 113366021A
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CN
China
Prior art keywords
amino acid
acid sequence
seq
sequence shown
antibody
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Pending
Application number
CN201980069358.0A
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English (en)
Chinese (zh)
Inventor
利娜·巴迪蒙马埃斯特罗
胡迪特·库韦多拉福尔斯
特雷莎·帕德罗卡普马尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grecadier Diagnostics Ltd
Consejo Superior de Investigaciones Cientificas CSIC
Fundacio Institut de Recerca de lHospital de La Santa Creu i Sant Pau
Original Assignee
Grecadier Diagnostics Ltd
Consejo Superior de Investigaciones Cientificas CSIC
Fundacio Institut de Recerca de lHospital de La Santa Creu i Sant Pau
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Application filed by Grecadier Diagnostics Ltd, Consejo Superior de Investigaciones Cientificas CSIC, Fundacio Institut de Recerca de lHospital de La Santa Creu i Sant Pau filed Critical Grecadier Diagnostics Ltd
Publication of CN113366021A publication Critical patent/CN113366021A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/775—Apolipopeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/38—Post-translational modifications [PTMs] in chemical analysis of biological material addition of carbohydrates, e.g. glycosylation, glycation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201980069358.0A 2018-10-23 2019-10-23 糖基化Apo J特异性抗体及其用途 Pending CN113366021A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18382752.6 2018-10-23
EP18382752 2018-10-23
PCT/EP2019/078855 WO2020083979A1 (en) 2018-10-23 2019-10-23 Antibodies specific for glycosylated apoj and uses thereof

Publications (1)

Publication Number Publication Date
CN113366021A true CN113366021A (zh) 2021-09-07

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ID=64426823

Family Applications (1)

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CN201980069358.0A Pending CN113366021A (zh) 2018-10-23 2019-10-23 糖基化Apo J特异性抗体及其用途

Country Status (13)

Country Link
US (1) US20210388108A1 (https=)
EP (1) EP3870614A1 (https=)
JP (1) JP2022506108A (https=)
KR (1) KR20210081397A (https=)
CN (1) CN113366021A (https=)
AU (1) AU2019365391A1 (https=)
BR (1) BR112021006516A2 (https=)
CA (1) CA3115887A1 (https=)
IL (1) IL282384A (https=)
MA (1) MA53980A (https=)
MX (1) MX2021004684A (https=)
SG (1) SG11202103124WA (https=)
WO (1) WO2020083979A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025201235A1 (zh) * 2024-03-25 2025-10-02 中国科学院分子细胞科学卓越创新中心 Clusterin 阳性心脏类器官及其应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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WO2005080434A1 (en) * 2004-02-25 2005-09-01 Universita' Degli Studi Di Roma ''tor Vergata'' Anti-clusterin oligoclonal antibodies for diagnosis and prediction of the aggressiveness of tumours, diagnostic method and related kits
WO2011098645A1 (es) * 2010-02-09 2011-08-18 Consejo Superior De Investigaciones Científicas (Csic) Uso de las isoformas de apo j como biomarcadores de lesión tisular
WO2017140256A1 (en) * 2016-02-19 2017-08-24 Huiru Wang Antibodies against n-acetylglucosamine and n-acetyl-galactosamine
WO2017178521A1 (en) * 2016-04-12 2017-10-19 Institut Català De Ciències Cardiovasculars (Iccc) Methods and kits for the diagnosis and risk stratification of patients with ischemia

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Publication number Priority date Publication date Assignee Title
WO2025201235A1 (zh) * 2024-03-25 2025-10-02 中国科学院分子细胞科学卓越创新中心 Clusterin 阳性心脏类器官及其应用

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US20210388108A1 (en) 2021-12-16
MA53980A (fr) 2022-01-26
CA3115887A1 (en) 2020-04-30
AU2019365391A1 (en) 2021-04-29
SG11202103124WA (en) 2021-04-29
BR112021006516A2 (pt) 2021-07-13
JP2022506108A (ja) 2022-01-17
WO2020083979A1 (en) 2020-04-30
MX2021004684A (es) 2021-06-04
EP3870614A1 (en) 2021-09-01
KR20210081397A (ko) 2021-07-01
IL282384A (en) 2021-06-30

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