JPWO2020057619A5 - - Google Patents
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- Publication number
- JPWO2020057619A5 JPWO2020057619A5 JP2021540357A JP2021540357A JPWO2020057619A5 JP WO2020057619 A5 JPWO2020057619 A5 JP WO2020057619A5 JP 2021540357 A JP2021540357 A JP 2021540357A JP 2021540357 A JP2021540357 A JP 2021540357A JP WO2020057619 A5 JPWO2020057619 A5 JP WO2020057619A5
- Authority
- JP
- Japan
- Prior art keywords
- tcr
- variable domain
- chain variable
- exon
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091008153 T cell receptors Proteins 0.000 claims 65
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 65
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 101700070835 NCOR2 Proteins 0.000 claims 9
- 102100001100 TRAC Human genes 0.000 claims 9
- 101700078141 TRAC Proteins 0.000 claims 9
- 102100009727 TRBC1 Human genes 0.000 claims 9
- 101700083255 TRBC1 Proteins 0.000 claims 9
- 102100009726 TRBC2 Human genes 0.000 claims 9
- 101700003299 TRBC2 Proteins 0.000 claims 9
- 210000004027 cells Anatomy 0.000 claims 8
- 230000035772 mutation Effects 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102100014838 FCGRT Human genes 0.000 claims 3
- 101710003435 FCGRT Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 210000000349 Chromosomes Anatomy 0.000 claims 1
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 230000000295 complement Effects 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 230000001809 detectable Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811109677 | 2018-09-21 | ||
| CN201811109677.3 | 2018-09-21 | ||
| PCT/CN2019/106816 WO2020057619A1 (fr) | 2018-09-21 | 2019-09-19 | Récepteur de lymphocytes t de haute affinité reconnaissant un antigène afp |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022502078A JP2022502078A (ja) | 2022-01-11 |
| JPWO2020057619A5 true JPWO2020057619A5 (fr) | 2022-09-29 |
| JP7505785B2 JP7505785B2 (ja) | 2024-06-25 |
Family
ID=69888304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021540357A Active JP7505785B2 (ja) | 2018-09-21 | 2019-09-19 | Ａｆｐ抗原を識別する高親和性ｔ細胞受容体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220033458A1 (fr) |
| EP (1) | EP3854802A4 (fr) |
| JP (1) | JP7505785B2 (fr) |
| KR (1) | KR20210108941A (fr) |
| CN (1) | CN110938136B (fr) |
| AU (1) | AU2019344871A1 (fr) |
| CA (1) | CA3113536A1 (fr) |
| IL (1) | IL281660A (fr) |
| SG (1) | SG11202102903QA (fr) |
| WO (1) | WO2020057619A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113621070A (zh) * | 2020-05-06 | 2021-11-09 | 华夏英泰（北京）生物技术有限公司 | 一种t细胞抗原受体、其多聚体复合物及其制备方法和应用 |
| CN113667008A (zh) * | 2020-05-15 | 2021-11-19 | 香雪生命科学技术（广东）有限公司 | 一种识别afp抗原的高亲和力t细胞受体 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2645256C2 (ru) | 2013-06-26 | 2018-02-19 | Гуандун Сянсюэ Лайф Сайенсис, Лтд. | Высокостабильный т-клеточный рецептор и способ его получения и применения |
| GB201313377D0 (en) * | 2013-07-26 | 2013-09-11 | Adaptimmune Ltd | T cell receptors |
| CN104087592B (zh) * | 2014-05-13 | 2016-01-27 | 天津医科大学总医院 | Afp158-166特异性tcr基因及其转基因t细胞及体外增殖方法及用途 |
| US20180208658A1 (en) * | 2015-04-03 | 2018-07-26 | Eureka Therapeutics, Inc. | Constructs targeting afp peptide/mhc complexes and uses thereof |
| CN106459178B (zh) * | 2015-09-09 | 2018-06-12 | 广东香雪精准医疗技术有限公司 | 针对rhamm抗原短肽的高亲和力t细胞受体 |
| CN106519019B (zh) * | 2015-11-06 | 2018-07-03 | 广东香雪精准医疗技术有限公司 | 识别prame抗原的tcr |
| GB201604494D0 (en) * | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Transfected T-Cells and T-Cell receptors for use in immunotherapy against cancers |
| GB201608052D0 (en) * | 2016-05-09 | 2016-06-22 | Univ Oslo Hf | T-cell receptors which recognise frameshift mutants of TGF-beta RII |
| CN108264550B (zh) * | 2017-01-04 | 2021-04-23 | 香雪生命科学技术（广东）有限公司 | 一种识别源自于prame抗原短肽的tcr |
-
2019
- 2019-09-19 EP EP19861880.3A patent/EP3854802A4/fr active Pending
- 2019-09-19 SG SG11202102903QA patent/SG11202102903QA/en unknown
- 2019-09-19 AU AU2019344871A patent/AU2019344871A1/en active Pending
- 2019-09-19 US US17/278,504 patent/US20220033458A1/en active Pending
- 2019-09-19 KR KR1020217011808A patent/KR20210108941A/ko unknown
- 2019-09-19 JP JP2021540357A patent/JP7505785B2/ja active Active
- 2019-09-19 WO PCT/CN2019/106816 patent/WO2020057619A1/fr active Application Filing
- 2019-09-19 CA CA3113536A patent/CA3113536A1/fr active Pending
- 2019-09-19 CN CN201910888722.8A patent/CN110938136B/zh active Active
-
2021
- 2021-03-21 IL IL281660A patent/IL281660A/en unknown
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