JPWO2020053239A5 - - Google Patents

Info

Publication number

JPWO2020053239A5

JPWO2020053239A5 JP2021537505A JP2021537505A JPWO2020053239A5 JP WO2020053239 A5 JPWO2020053239 A5 JP WO2020053239A5 JP 2021537505 A JP2021537505 A JP 2021537505A JP 2021537505 A JP2021537505 A JP 2021537505A JP WO2020053239 A5 JPWO2020053239 A5 JP WO2020053239A5

Authority

JP

Japan

Prior art keywords

sequence

seq

fusion protein

antibody

mutations

Prior art date

2022-09-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 108020001507 fusion proteins Proteins 0.000 claims description 93
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 60
• 150000001413 amino acids Chemical class 0.000 claims description 56
• 230000035772 mutation Effects 0.000 claims description 39
• 229910052698 phosphorus Inorganic materials 0.000 claims description 24
• 229910052717 sulfur Inorganic materials 0.000 claims description 24
• 238000000034 method Methods 0.000 claims description 20
• 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims description 13
• 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims description 13
• 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims description 13
• 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims description 12
• 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims description 12
• 102000039446 nucleic acids Human genes 0.000 claims description 12
• 108020004707 nucleic acids Proteins 0.000 claims description 12
• 150000007523 nucleic acids Chemical class 0.000 claims description 12
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 11
• 229920001184 polypeptide Polymers 0.000 claims description 10
• 229910052700 potassium Inorganic materials 0.000 claims description 9
• 239000007787 solid Substances 0.000 claims description 3
• 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 2
• 210000004899 c-terminal region Anatomy 0.000 description 6
• 230000027455 binding Effects 0.000 description 3
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• 102000000844 Cell Surface Receptors Human genes 0.000 description 1
• 108010001857 Cell Surface Receptors Proteins 0.000 description 1
• HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 description 1
• 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 description 1
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