JPWO2020047099A5 - - Google Patents
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- JPWO2020047099A5 JPWO2020047099A5 JP2021510707A JP2021510707A JPWO2020047099A5 JP WO2020047099 A5 JPWO2020047099 A5 JP WO2020047099A5 JP 2021510707 A JP2021510707 A JP 2021510707A JP 2021510707 A JP2021510707 A JP 2021510707A JP WO2020047099 A5 JPWO2020047099 A5 JP WO2020047099A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- days
- notch
- exposure process
- population
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims 54
- 210000004027 cell Anatomy 0.000 claims 53
- 108010070047 Notch Receptors Proteins 0.000 claims 23
- 102000005650 Notch Receptors Human genes 0.000 claims 23
- 239000000018 receptor agonist Substances 0.000 claims 13
- 229940044601 receptor agonist Drugs 0.000 claims 13
- 210000001744 T-lymphocyte Anatomy 0.000 claims 8
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 108091008915 immune receptors Proteins 0.000 claims 6
- 102000027596 immune receptors Human genes 0.000 claims 6
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 4
- 108091008874 T cell receptors Proteins 0.000 claims 4
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 4
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 3
- 101000914947 Bungarus multicinctus Long neurotoxin homolog TA-bm16 Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 2
- 102100033467 L-selectin Human genes 0.000 claims 2
- 102000001760 Notch3 Receptor Human genes 0.000 claims 2
- 108010029756 Notch3 Receptor Proteins 0.000 claims 2
- 102000001753 Notch4 Receptor Human genes 0.000 claims 2
- 108010029741 Notch4 Receptor Proteins 0.000 claims 2
- 102000011842 Serrate-Jagged Proteins Human genes 0.000 claims 2
- 108010036039 Serrate-Jagged Proteins Proteins 0.000 claims 2
- 238000011467 adoptive cell therapy Methods 0.000 claims 2
- 108700041286 delta Proteins 0.000 claims 2
- 229940127276 delta-like ligand 3 Drugs 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 102000018361 Contactin Human genes 0.000 claims 1
- 108060003955 Contactin Proteins 0.000 claims 1
- 101150077941 DLK2 gene Proteins 0.000 claims 1
- 101000994439 Danio rerio Protein jagged-1a Proteins 0.000 claims 1
- 102100026662 Delta and Notch-like epidermal growth factor-related receptor Human genes 0.000 claims 1
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 claims 1
- 101001054266 Homo sapiens Delta and Notch-like epidermal growth factor-related receptor Proteins 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108010002352 Interleukin-1 Proteins 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
- 108090000172 Interleukin-15 Proteins 0.000 claims 1
- 102000013691 Interleukin-17 Human genes 0.000 claims 1
- 108050003558 Interleukin-17 Proteins 0.000 claims 1
- 108010065637 Interleukin-23 Proteins 0.000 claims 1
- 108010066979 Interleukin-27 Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100023181 Neurogenic locus notch homolog protein 1 Human genes 0.000 claims 1
- 108700037638 Neurogenic locus notch homolog protein 1 Proteins 0.000 claims 1
- 102100025246 Neurogenic locus notch homolog protein 2 Human genes 0.000 claims 1
- 108700037064 Neurogenic locus notch homolog protein 2 Proteins 0.000 claims 1
- 102000001759 Notch1 Receptor Human genes 0.000 claims 1
- 108010029755 Notch1 Receptor Proteins 0.000 claims 1
- 102000001756 Notch2 Receptor Human genes 0.000 claims 1
- 108010029751 Notch2 Receptor Proteins 0.000 claims 1
- 102100032702 Protein jagged-1 Human genes 0.000 claims 1
- 102100032733 Protein jagged-2 Human genes 0.000 claims 1
- 101710170213 Protein jagged-2 Proteins 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 101150102995 dlk-1 gene Proteins 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 108010074108 interleukin-21 Proteins 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000002463 transducing effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862723936P | 2018-08-28 | 2018-08-28 | |
| US62/723,936 | 2018-08-28 | ||
| PCT/US2019/048574 WO2020047099A1 (en) | 2018-08-28 | 2019-08-28 | Methods and compositions for adoptive t cell therapy incorporating induced notch signaling |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021534785A JP2021534785A (ja) | 2021-12-16 |
| JPWO2020047099A5 true JPWO2020047099A5 (https=) | 2022-06-03 |
| JP2021534785A5 JP2021534785A5 (https=) | 2022-06-03 |
Family
ID=67982131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021510707A Pending JP2021534785A (ja) | 2018-08-28 | 2019-08-28 | 誘導ノッチシグナル伝達を用いた養子ｔ細胞療法の方法及び組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20210292711A1 (https=) |
| EP (1) | EP3844266A1 (https=) |
| JP (1) | JP2021534785A (https=) |
| CN (1) | CN112930393A (https=) |
| AU (1) | AU2019329984A1 (https=) |
| BR (1) | BR112021003830A2 (https=) |
| CA (1) | CA3110089A1 (https=) |
| SG (1) | SG11202101455TA (https=) |
| WO (1) | WO2020047099A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220241335A1 (en) * | 2019-07-11 | 2022-08-04 | H. Lee Moffitt Cancer Center And Research Inst5Itute, Inc. | Engineering notch ligands to enhance the anti-tumor activity of adoptively transferred t cells |
| US12365871B2 (en) | 2020-04-28 | 2025-07-22 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| WO2022165367A1 (en) * | 2021-01-29 | 2022-08-04 | Fred Hutchinson Cancer Research Center | Methods and compositions for enhancing cd4+ phenotype for adoptive t cell therapy |
| CN113832102B (zh) * | 2021-09-27 | 2024-03-12 | 苏州东岭生物技术有限公司 | Cd3/cd28/dll4磁珠及其制备方法和应用 |
| CN116716349B (zh) * | 2023-08-01 | 2023-10-31 | 江苏集萃药康生物科技股份有限公司 | 一种dll4人源化小鼠模型的构建方法及其应用 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA136551A (en) | 1911-08-03 | 1911-10-31 | Hedwig Heeron | Rolling mill |
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| US5420032A (en) | 1991-12-23 | 1995-05-30 | Universitge Laval | Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence |
| US5792632A (en) | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| WO1997034634A1 (en) | 1996-03-20 | 1997-09-25 | Sloan-Kettering Institute For Cancer Research | Single chain fv constructs of anti-ganglioside gd2 antibodies |
| CZ295997B6 (cs) * | 1996-11-07 | 2005-12-14 | Lorantis Limited | Farmaceutický prostředek s obsahem ligandu Notch a způsob tvorby T-buněk |
| JP2002524081A (ja) | 1998-09-04 | 2002-08-06 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | 前立腺−特異的膜抗原に特異的な融合受容体およびその使用 |
| US20020131960A1 (en) | 2000-06-02 | 2002-09-19 | Michel Sadelain | Artificial antigen presenting cells and methods of use thereof |
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US6689744B2 (en) | 2000-09-22 | 2004-02-10 | Genentech, Inc. | Notch receptor agonists and uses |
| US20030119771A1 (en) | 2001-08-22 | 2003-06-26 | Rompaey Luc Van | Modulators of bone homeostasis identified in a high-throughput screen |
| JP2003093048A (ja) * | 2001-09-26 | 2003-04-02 | Asahi Kasei Corp | 新規細胞製剤製造用培養媒体 |
| US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
| US20060078552A1 (en) | 2002-03-15 | 2006-04-13 | Sylvain Arnould | Hybrid and single chain meganucleases and use thereof |
| JP2006506322A (ja) * | 2002-04-05 | 2006-02-23 | ロランティス リミテッド | 内科療法 |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| WO2004032969A1 (en) * | 2002-10-09 | 2004-04-22 | Lorantis Limited | Modulation of immune function |
| JP2006517533A (ja) * | 2003-01-23 | 2006-07-27 | ロランティス リミテッド | Ｎｏｔｃｈシグナル伝達経路のアクチベーターを用いる自己免疫疾患の治療 |
| US20060153826A1 (en) | 2003-01-28 | 2006-07-13 | Sylvain Arnould | Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof |
| US20080112934A1 (en) * | 2004-11-24 | 2008-05-15 | Rafick-Pierre Sekaly | Methods To Identify, Prepare, And Use Naive T Cell Recent Thymic Emigrants |
| WO2007027226A2 (en) * | 2005-04-28 | 2007-03-08 | Board Of Regents, The University Of Texas System | Systems and methods for the production of differentiated cells |
| CA2891996A1 (en) | 2005-10-18 | 2007-04-26 | Duke University | Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity |
| EP2081962B1 (en) | 2006-10-19 | 2018-10-03 | Genentech, Inc. | Novel anti-notch3 antibodies and their use in the detection and diagnosis of disease |
| AR063494A1 (es) | 2006-10-19 | 2009-01-28 | Genentech Inc | Anticuerpos agonistas anti notch3 y su uso en el tratamiento de las enfermedades relacionadas con el gen notch3 |
| WO2008092445A2 (de) * | 2007-01-30 | 2008-08-07 | Deutsches Rheuma-Forschungszentrum Berlin | Verfahren zur modulation der immunantwort durch aktivierung oder inaktivierung des notch und/oder stat4 signalweges |
| CA2682527C (en) | 2007-03-30 | 2017-07-11 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes |
| DK2356270T3 (da) | 2008-11-07 | 2016-12-12 | Fabrus Llc | Kombinatoriske antistofbiblioteker og anvendelser deraf |
| WO2010059543A1 (en) | 2008-11-20 | 2010-05-27 | Merck Sharp & Dohme Corp. | Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use |
| WO2010141249A2 (en) | 2009-06-02 | 2010-12-09 | Merck Sharp & Dohme Corp. | Generation, characterization and uses thereof of anti-notch3 antibodies |
| JP6208580B2 (ja) | 2010-05-17 | 2017-10-04 | サンガモ セラピューティクス， インコーポレイテッド | 新規のｄｎａ結合タンパク質及びその使用 |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
| EP3241902B1 (en) | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| US10316289B2 (en) * | 2012-09-06 | 2019-06-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing T memory stem cell populations |
| WO2014093718A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| US10696946B2 (en) * | 2013-02-22 | 2020-06-30 | The Board Of Trustees Of The University Of Illinois | T-REG cell expansion |
| US9683039B2 (en) | 2013-03-14 | 2017-06-20 | New York University | Notch agonists for the treatment of cancer |
| EP3760719A1 (en) | 2013-11-18 | 2021-01-06 | CRISPR Therapeutics AG | Crispr-cas system materials and methods |
| KR20170007449A (ko) | 2014-05-22 | 2017-01-18 | 프레드 헛친슨 켄서 리서치 센터 | 조혈 전구체 세포의 lilrb2 및 노치 매개 증식 |
| BR112016028537A2 (pt) | 2014-06-04 | 2017-08-22 | Hutchinson Fred Cancer Res | expansão e enxerto de células-tronco utilizando agonistas de notch 1 e/ou de notch 2 |
| MX389823B (es) * | 2014-10-27 | 2025-03-20 | Fred Hutchinson Cancer Center | Composiciones y metodos para reforzar la eficacia de inmunoterapia celular adoptiva. |
| CN108431211B (zh) * | 2015-10-20 | 2026-03-24 | 富士胶片细胞动力公司 | 通过遗传编程的多谱系造血前体细胞产生 |
| SG11201803330WA (en) * | 2015-10-22 | 2018-05-30 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| MX2018005274A (es) * | 2015-10-30 | 2019-09-19 | The Regents Of The Universtiy Of California | Metodos para la generacion de celulas-t a partir de celulas madre y metodos inmunoterapeuticos que utilizan las celulas-t. |
| JP7049261B2 (ja) * | 2016-04-08 | 2022-04-06 | ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント | 幹細胞および／または前駆細胞からｔ前駆細胞を作製する方法ならびに該ｔ前駆細胞の使用 |
| US11261250B2 (en) | 2016-07-22 | 2022-03-01 | Fred Hutchinson Cancer Research Center | Bi-specific molecule for cell-specific Notch inhibition and related methods and compositions |
-
2019
- 2019-08-28 BR BR112021003830-2A patent/BR112021003830A2/pt not_active IP Right Cessation
- 2019-08-28 CA CA3110089A patent/CA3110089A1/en active Pending
- 2019-08-28 WO PCT/US2019/048574 patent/WO2020047099A1/en not_active Ceased
- 2019-08-28 SG SG11202101455TA patent/SG11202101455TA/en unknown
- 2019-08-28 CN CN201980071074.5A patent/CN112930393A/zh active Pending
- 2019-08-28 US US17/272,117 patent/US20210292711A1/en active Pending
- 2019-08-28 AU AU2019329984A patent/AU2019329984A1/en not_active Withdrawn
- 2019-08-28 JP JP2021510707A patent/JP2021534785A/ja active Pending
- 2019-08-28 EP EP19769614.9A patent/EP3844266A1/en not_active Withdrawn
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