JPWO2020044055A5 - - Google Patents
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- JPWO2020044055A5 JPWO2020044055A5 JP2021510710A JP2021510710A JPWO2020044055A5 JP WO2020044055 A5 JPWO2020044055 A5 JP WO2020044055A5 JP 2021510710 A JP2021510710 A JP 2021510710A JP 2021510710 A JP2021510710 A JP 2021510710A JP WO2020044055 A5 JPWO2020044055 A5 JP WO2020044055A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- car
- motif
- endodomain
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 31
- 210000003289 regulatory T cell Anatomy 0.000 claims 17
- 239000000427 antigen Substances 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 14
- 108091007433 antigens Proteins 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 108010029477 STAT5 Transcription Factor Proteins 0.000 claims 11
- 102100024481 Signal transducer and activator of transcription 5A Human genes 0.000 claims 11
- 102100033438 Tyrosine-protein kinase JAK1 Human genes 0.000 claims 8
- 101000997835 Homo sapiens Tyrosine-protein kinase JAK1 Proteins 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 201000004624 Dermatitis Diseases 0.000 claims 5
- 210000004185 liver Anatomy 0.000 claims 5
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 4
- 101000934996 Homo sapiens Tyrosine-protein kinase JAK3 Proteins 0.000 claims 4
- 102000042838 JAK family Human genes 0.000 claims 4
- 108091082332 JAK family Proteins 0.000 claims 4
- 102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 208000024908 graft versus host disease Diseases 0.000 claims 4
- 108010093036 interleukin receptors Proteins 0.000 claims 4
- 102000002467 interleukin receptors Human genes 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 230000017423 tissue regeneration Effects 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 3
- 208000026935 allergic disease Diseases 0.000 claims 3
- 208000010668 atopic eczema Diseases 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 3
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 claims 2
- 230000000172 allergic effect Effects 0.000 claims 2
- 208000037976 chronic inflammation Diseases 0.000 claims 2
- 230000006020 chronic inflammation Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 102100036842 C-C motif chemokine 19 Human genes 0.000 claims 1
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims 1
- 102100025279 C-X-C motif chemokine 11 Human genes 0.000 claims 1
- 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 102100036008 CD48 antigen Human genes 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 102100039061 Cytokine receptor common subunit beta Human genes 0.000 claims 1
- 102100033587 DNA topoisomerase 2-alpha Human genes 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 108010075944 Erythropoietin Receptors Proteins 0.000 claims 1
- 102100036509 Erythropoietin receptor Human genes 0.000 claims 1
- 102100030421 Fatty acid-binding protein 5 Human genes 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 206010016946 Food allergy Diseases 0.000 claims 1
- 102100020948 Growth hormone receptor Human genes 0.000 claims 1
- 102100028541 Guanylate-binding protein 2 Human genes 0.000 claims 1
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 claims 1
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 1
- 101000713106 Homo sapiens C-C motif chemokine 19 Proteins 0.000 claims 1
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 claims 1
- 101000858060 Homo sapiens C-X-C motif chemokine 11 Proteins 0.000 claims 1
- 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000716130 Homo sapiens CD48 antigen Proteins 0.000 claims 1
- 101001033280 Homo sapiens Cytokine receptor common subunit beta Proteins 0.000 claims 1
- 101000866286 Homo sapiens Excitatory amino acid transporter 1 Proteins 0.000 claims 1
- 101001062855 Homo sapiens Fatty acid-binding protein 5 Proteins 0.000 claims 1
- 101001058858 Homo sapiens Guanylate-binding protein 2 Proteins 0.000 claims 1
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 claims 1
- 101001081176 Homo sapiens Hyaluronan mediated motility receptor Proteins 0.000 claims 1
- 101000990912 Homo sapiens Matrilysin Proteins 0.000 claims 1
- 101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 claims 1
- 101001097889 Homo sapiens Platelet-activating factor acetylhydrolase Proteins 0.000 claims 1
- 101000904724 Homo sapiens Transmembrane glycoprotein NMB Proteins 0.000 claims 1
- 101000662056 Homo sapiens Ubiquitin D Proteins 0.000 claims 1
- 102100027735 Hyaluronan mediated motility receptor Human genes 0.000 claims 1
- -1 IL-17Rβ Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102100026244 Interleukin-9 receptor Human genes 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 102100030417 Matrilysin Human genes 0.000 claims 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 1
- 102100037518 Platelet-activating factor acetylhydrolase Human genes 0.000 claims 1
- 108010002519 Prolactin Receptors Proteins 0.000 claims 1
- 102100029000 Prolactin receptor Human genes 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 108091006611 SLC10A1 Proteins 0.000 claims 1
- 102000012977 SLC1A3 Human genes 0.000 claims 1
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 1
- 102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 claims 1
- 102100021988 Sodium/bile acid cotransporter Human genes 0.000 claims 1
- 108010068542 Somatotropin Receptors Proteins 0.000 claims 1
- 108010070774 Thrombopoietin Receptors Proteins 0.000 claims 1
- 102100034196 Thrombopoietin receptor Human genes 0.000 claims 1
- 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 claims 1
- 108010046308 Type II DNA Topoisomerases Proteins 0.000 claims 1
- 101710112793 Tyrosine-protein kinase JAK1 Proteins 0.000 claims 1
- 102100037932 Ubiquitin D Human genes 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 238000002650 immunosuppressive therapy Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 108040006862 interleukin-9 receptor activity proteins Proteins 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 230000002463 transducing effect Effects 0.000 claims 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024111754A JP2024138456A (ja) | 2018-08-31 | 2024-07-11 | 改変された制御性ｔ細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1814203.4A GB201814203D0 (en) | 2018-08-31 | 2018-08-31 | Engineered regulatory t cell |
| GB1814203.4 | 2018-08-31 | ||
| PCT/GB2019/052422 WO2020044055A1 (en) | 2018-08-31 | 2019-08-30 | Engineered regulatory t cell |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024111754A Division JP2024138456A (ja) | 2018-08-31 | 2024-07-11 | 改変された制御性ｔ細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021536237A JP2021536237A (ja) | 2021-12-27 |
| JPWO2020044055A5 true JPWO2020044055A5 (https=) | 2022-09-05 |
| JP2021536237A5 JP2021536237A5 (https=) | 2022-09-05 |
Family
ID=63920789
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021510710A Pending JP2021536237A (ja) | 2018-08-31 | 2019-08-30 | 改変された制御性ｔ細胞 |
| JP2024111754A Pending JP2024138456A (ja) | 2018-08-31 | 2024-07-11 | 改変された制御性ｔ細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024111754A Pending JP2024138456A (ja) | 2018-08-31 | 2024-07-11 | 改変された制御性ｔ細胞 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20210338726A1 (https=) |
| EP (1) | EP3844264A1 (https=) |
| JP (2) | JP2021536237A (https=) |
| KR (1) | KR20210054543A (https=) |
| CN (1) | CN112969784A (https=) |
| AU (1) | AU2019333012A1 (https=) |
| CA (1) | CA3110012A1 (https=) |
| GB (2) | GB201814203D0 (https=) |
| IL (1) | IL280942A (https=) |
| SG (1) | SG11202101668TA (https=) |
| WO (1) | WO2020044055A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3714944A1 (en) * | 2019-03-29 | 2020-09-30 | Medizinische Hochschule Hannover | Car for use in the treatment of hvg disease |
| WO2019169290A1 (en) | 2018-03-02 | 2019-09-06 | Allogene Therapeutics, Inc. | Inducible chimeric cytokine receptors |
| AU2019254824B2 (en) | 2018-04-18 | 2025-04-24 | Ucl Business Ltd | Method for enhancing the suppressive properties of Treg cells |
| BR112021017365A2 (pt) | 2019-03-01 | 2022-02-01 | Allogene Therapeutics Inc | Receptores de citocina quiméricos constitutivamente ativos |
| EP3931208A1 (en) | 2019-03-01 | 2022-01-05 | Allogene Therapeutics, Inc. | Chimeric cytokine receptors bearing a pd-1 ectodomain |
| WO2021041806A1 (en) | 2019-08-30 | 2021-03-04 | Allogene Therapeutics, Inc. | Chimeric cytokine receptors comprising tgf beta binding domains |
| JP2023514407A (ja) | 2020-02-24 | 2023-04-05 | アロジーン セラピューティクス，インコーポレイテッド | 増強された活性を有するｂｃｍａ ｃａｒ－ｔ細胞 |
| CN115427440A (zh) * | 2020-02-25 | 2022-12-02 | 圭尔医疗有限公司 | 用于工程化细胞的嵌合受体 |
| JP2023521519A (ja) * | 2020-04-06 | 2023-05-24 | セレディット エルエルシー | キメラ抗原受容体を発現し低減した炎症性サイトカインシグナル伝達を有する遺伝子改変された免疫細胞 |
| CN112852748B (zh) * | 2020-04-16 | 2023-11-21 | 成都仕康美生物科技有限公司 | 靶向HLA-A的嵌合抗原受体、编码基因、CAR-Tregs细胞及其制备方法、用途 |
| GB202007842D0 (en) | 2020-05-26 | 2020-07-08 | Quell Therapeutics Ltd | Polypeptide useful in adoptive cell therapy |
| CN115768870A (zh) * | 2020-06-01 | 2023-03-07 | 促进军事医学的亨利·M·杰克逊基金会公司 | 诱导型调节性t细胞，其生产方法及其用途 |
| AU2021289144A1 (en) | 2020-06-11 | 2022-12-15 | King's College London | TREM2 chimeric receptor |
| CN111849916B (zh) * | 2020-07-21 | 2021-08-27 | 广东先康达生物科技有限公司 | 一种免疫细胞及其制剂与应用 |
| GB202013477D0 (en) | 2020-08-27 | 2020-10-14 | Quell Therapeutics Ltd | Nucleic acid constructs for expressing polypeptides in cells |
| GB202017678D0 (en) | 2020-11-09 | 2020-12-23 | Quell Therapeutics Ltd | Method for cryopreserving engineered tregs |
| EP4240376B1 (en) | 2020-11-09 | 2026-03-25 | Quell Therapeutics Limited | Method for cryopreserving engineered tregs |
| US20240052015A1 (en) | 2020-12-23 | 2024-02-15 | Quell Therapeutics Limited | Inducible signalling protein |
| JP2024524865A (ja) * | 2021-06-08 | 2024-07-09 | ザ メソディスト ホスピタル | 制御性Ｔ細胞（Ｔｒｅｇ）集団を製造するための方法、Ｔｒｅｇ組成物、及び治療のための方法 |
| GB202108366D0 (en) | 2021-06-11 | 2021-07-28 | Quell Therapeutics Ltd | Multichain chimeric antigen receptor |
| GB202108364D0 (en) | 2021-06-11 | 2021-07-28 | Quell Therapeutics Ltd | Chimeric receptor |
| WO2023047100A1 (en) | 2021-09-21 | 2023-03-30 | Quell Therapeutics Ltd | Anti-trem2 chimeric antigen receptor |
| TW202321286A (zh) | 2021-09-21 | 2023-06-01 | 英商圭爾醫療有限公司 | 抗p75ntr嵌合抗原受體 |
| GB202117298D0 (en) | 2021-11-30 | 2022-01-12 | Quell Therapeutics Ltd | Signalling protein |
| WO2023102712A1 (zh) * | 2021-12-07 | 2023-06-15 | 深圳市先康达生命科学有限公司 | 一种基因生物制剂及其制备方法和应用 |
| US20250017967A1 (en) | 2021-12-17 | 2025-01-16 | Quell Therapeutics Limited | Anti-thymocyte globulin for immunomodulation of a subject with regulatory t cells |
| CN118434761A (zh) | 2021-12-22 | 2024-08-02 | 圭尔医疗有限公司 | 组成型细胞因子受体 |
| US20250099584A1 (en) * | 2022-02-18 | 2025-03-27 | Institut National de la Santé et de la Recherche Médicale | Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance |
| WO2023180690A1 (en) | 2022-03-22 | 2023-09-28 | Quell Therapeutics Limited | Methods and products for culturing t cells and uses thereof |
| JP2025527729A (ja) * | 2022-08-26 | 2025-08-22 | ソノマ バイオセラピューティクス， インコーポレイテッド | テザリングされたインターロイキン２組み換え受容体及び使用方法 |
| GB202217541D0 (en) | 2022-11-24 | 2023-01-11 | Quell Therapeutics Ltd | Recombinant receptor |
| WO2024133472A1 (en) | 2022-12-22 | 2024-06-27 | Quell Therapeutics Limited | Constitutive cytokine receptors |
| EP4403580A1 (en) | 2023-01-23 | 2024-07-24 | Medizinische Hochschule Hannover | Anti-entpd3 chimeric antigen receptor |
| KR20250169635A (ko) | 2023-01-23 | 2025-12-03 | 메디치니쉐 호흐슐레 하노버 | 항-entpd3 키메라 항원 수용체 |
| IL322333A (en) | 2023-02-07 | 2025-09-01 | Quell Therapeutics Ltd | Culture method for TREG cells |
| EP4669343A1 (en) | 2023-02-24 | 2025-12-31 | Medizinische Hochschule Hannover | CHIMERIC ANTIGEN RECIPIENT |
| EP4420676A1 (en) | 2023-02-24 | 2024-08-28 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| EP4680728A1 (en) | 2023-03-17 | 2026-01-21 | Quell Therapeutics Limited | Treg therapy |
| EP4434539A1 (en) | 2023-03-20 | 2024-09-25 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| CN121586582A (zh) | 2023-03-20 | 2026-02-27 | 汉诺威医学院 | 嵌合抗原受体 |
| WO2024194642A1 (en) | 2023-03-22 | 2024-09-26 | Quell Therapeutics Limited | Engineered t regulatory cell |
| WO2024254450A1 (en) * | 2023-06-07 | 2024-12-12 | Cellmidi Company Limited | Improved endodomains and immune cells comprising the same |
| EP4731648A1 (en) | 2023-06-21 | 2026-04-29 | Quell Therapeutics Limited | Constitutive cytokine receptors |
| WO2026008994A1 (en) | 2024-07-04 | 2026-01-08 | Quell Therapeutics Limited | Expression construct |
| GB202411558D0 (en) | 2024-08-06 | 2024-09-18 | Quell Therapeutics Ltd | Culture method |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| GB0009760D0 (en) | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
| WO2014153114A1 (en) * | 2013-03-14 | 2014-09-25 | Fred Hutchinson Cancer Research Center | Compositions and methods to modify cells for therapeutic objectives |
| ES2857998T3 (es) * | 2015-02-12 | 2021-09-29 | Univ Health Network | Receptores de antígenos quiméricos |
| GB201518816D0 (en) * | 2015-10-23 | 2015-12-09 | Autolus Ltd | Receptor |
| US20180320133A1 (en) * | 2015-11-05 | 2018-11-08 | City Of Hope | Methods for preparing cells for adoptive t cell therapy |
| WO2017100428A1 (en) * | 2015-12-09 | 2017-06-15 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of using same |
| WO2017172981A2 (en) * | 2016-03-29 | 2017-10-05 | University Of Southern California | Chimeric antigen receptors targeting cancer |
| CN109415698A (zh) * | 2016-06-16 | 2019-03-01 | 斯隆－凯特林纪念癌症中心 | 工程化Treg细胞 |
| CA3034691A1 (en) * | 2016-08-30 | 2018-03-08 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use for treating viral and other infections |
| EP3580212A4 (en) * | 2017-02-08 | 2021-03-17 | Dana Farber Cancer Institute, Inc. | REGULATION OF CHEMERIC ANTIGEN RECEPTORS |
| JP7618192B2 (ja) * | 2017-03-28 | 2025-01-21 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 移植された組織を拒絶反応から保護するための方法 |
-
2018
- 2018-08-31 GB GBGB1814203.4A patent/GB201814203D0/en not_active Ceased
-
2019
- 2019-08-30 WO PCT/GB2019/052422 patent/WO2020044055A1/en not_active Ceased
- 2019-08-30 JP JP2021510710A patent/JP2021536237A/ja active Pending
- 2019-08-30 AU AU2019333012A patent/AU2019333012A1/en not_active Abandoned
- 2019-08-30 KR KR1020217009384A patent/KR20210054543A/ko active Pending
- 2019-08-30 SG SG11202101668TA patent/SG11202101668TA/en unknown
- 2019-08-30 GB GB2104653.7A patent/GB2591929B/en active Active
- 2019-08-30 US US17/272,126 patent/US20210338726A1/en active Pending
- 2019-08-30 CA CA3110012A patent/CA3110012A1/en active Pending
- 2019-08-30 CN CN201980067986.5A patent/CN112969784A/zh active Pending
- 2019-08-30 EP EP19763058.5A patent/EP3844264A1/en active Pending
-
2021
- 2021-02-17 IL IL280942A patent/IL280942A/en unknown
-
2024
- 2024-07-11 JP JP2024111754A patent/JP2024138456A/ja active Pending
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