CN112969784A - 工程化调节性t细胞 - Google Patents

工程化调节性t细胞 Download PDF

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Publication number
CN112969784A
CN112969784A CN201980067986.5A CN201980067986A CN112969784A CN 112969784 A CN112969784 A CN 112969784A CN 201980067986 A CN201980067986 A CN 201980067986A CN 112969784 A CN112969784 A CN 112969784A
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seq
car
motif
treg
engineered
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M·马丁内斯-洛德拉
A·桑切斯-富尤
G·隆巴尔迪
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Kings College London
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Kings College London
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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    • A61K40/00—Cellular immunotherapy
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07K2319/00—Fusion polypeptide
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
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CN201980067986.5A 2018-08-31 2019-08-30 工程化调节性t细胞 Pending CN112969784A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1814203.4A GB201814203D0 (en) 2018-08-31 2018-08-31 Engineered regulatory t cell
GB1814203.4 2018-08-31
PCT/GB2019/052422 WO2020044055A1 (en) 2018-08-31 2019-08-30 Engineered regulatory t cell

Publications (1)

Publication Number Publication Date
CN112969784A true CN112969784A (zh) 2021-06-15

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CN201980067986.5A Pending CN112969784A (zh) 2018-08-31 2019-08-30 工程化调节性t细胞

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US (1) US20210338726A1 (https=)
EP (1) EP3844264A1 (https=)
JP (2) JP2021536237A (https=)
KR (1) KR20210054543A (https=)
CN (1) CN112969784A (https=)
AU (1) AU2019333012A1 (https=)
CA (1) CA3110012A1 (https=)
GB (2) GB201814203D0 (https=)
IL (1) IL280942A (https=)
SG (1) SG11202101668TA (https=)
WO (1) WO2020044055A1 (https=)

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CN113811363A (zh) * 2019-03-29 2021-12-17 汉诺威医学院 用于HvG病的治疗的CAR
CN114369621A (zh) * 2021-12-07 2022-04-19 深圳市先康达生命科学有限公司 一种基因生物制剂及其制备方法和应用
CN115427440A (zh) * 2020-02-25 2022-12-02 圭尔医疗有限公司 用于工程化细胞的嵌合受体

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WO2021041806A1 (en) 2019-08-30 2021-03-04 Allogene Therapeutics, Inc. Chimeric cytokine receptors comprising tgf beta binding domains
JP2023514407A (ja) 2020-02-24 2023-04-05 アロジーン セラピューティクス，インコーポレイテッド 増強された活性を有するｂｃｍａ ｃａｒ－ｔ細胞
JP2023521519A (ja) * 2020-04-06 2023-05-24 セレディット エルエルシー キメラ抗原受容体を発現し低減した炎症性サイトカインシグナル伝達を有する遺伝子改変された免疫細胞
CN112852748B (zh) * 2020-04-16 2023-11-21 成都仕康美生物科技有限公司 靶向HLA-A的嵌合抗原受体、编码基因、CAR-Tregs细胞及其制备方法、用途
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CN111849916B (zh) * 2020-07-21 2021-08-27 广东先康达生物科技有限公司 一种免疫细胞及其制剂与应用
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TW202321286A (zh) 2021-09-21 2023-06-01 英商圭爾醫療有限公司 抗p75ntr嵌合抗原受體
GB202117298D0 (en) 2021-11-30 2022-01-12 Quell Therapeutics Ltd Signalling protein
US20250017967A1 (en) 2021-12-17 2025-01-16 Quell Therapeutics Limited Anti-thymocyte globulin for immunomodulation of a subject with regulatory t cells
CN118434761A (zh) 2021-12-22 2024-08-02 圭尔医疗有限公司 组成型细胞因子受体
US20250099584A1 (en) * 2022-02-18 2025-03-27 Institut National de la Santé et de la Recherche Médicale Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance
WO2023180690A1 (en) 2022-03-22 2023-09-28 Quell Therapeutics Limited Methods and products for culturing t cells and uses thereof
JP2025527729A (ja) * 2022-08-26 2025-08-22 ソノマ バイオセラピューティクス， インコーポレイテッド テザリングされたインターロイキン２組み換え受容体及び使用方法
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EP4403580A1 (en) 2023-01-23 2024-07-24 Medizinische Hochschule Hannover Anti-entpd3 chimeric antigen receptor
KR20250169635A (ko) 2023-01-23 2025-12-03 메디치니쉐 호흐슐레 하노버 항-entpd3 키메라 항원 수용체
IL322333A (en) 2023-02-07 2025-09-01 Quell Therapeutics Ltd Culture method for TREG cells
EP4669343A1 (en) 2023-02-24 2025-12-31 Medizinische Hochschule Hannover CHIMERIC ANTIGEN RECIPIENT
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EP4434539A1 (en) 2023-03-20 2024-09-25 Medizinische Hochschule Hannover Chimeric antigen receptor
CN121586582A (zh) 2023-03-20 2026-02-27 汉诺威医学院 嵌合抗原受体
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WO2024254450A1 (en) * 2023-06-07 2024-12-12 Cellmidi Company Limited Improved endodomains and immune cells comprising the same
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WO2026008994A1 (en) 2024-07-04 2026-01-08 Quell Therapeutics Limited Expression construct
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113811363A (zh) * 2019-03-29 2021-12-17 汉诺威医学院 用于HvG病的治疗的CAR
CN113811363B (zh) * 2019-03-29 2025-01-10 汉诺威医学院 用于HvG病的治疗的CAR
US12486327B2 (en) 2019-03-29 2025-12-02 Medizinische Hochschule Hannover CAR for use in the treatment of HvG disease
CN115427440A (zh) * 2020-02-25 2022-12-02 圭尔医疗有限公司 用于工程化细胞的嵌合受体
CN114369621A (zh) * 2021-12-07 2022-04-19 深圳市先康达生命科学有限公司 一种基因生物制剂及其制备方法和应用
CN114369621B (zh) * 2021-12-07 2023-10-31 深圳市先康达生命科学有限公司 一种基因生物制剂及其制备方法和应用

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GB2591929A (en) 2021-08-11
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