JPWO2020041574A5 - - Google Patents
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- Publication number
- JPWO2020041574A5 JPWO2020041574A5 JP2021509210A JP2021509210A JPWO2020041574A5 JP WO2020041574 A5 JPWO2020041574 A5 JP WO2020041574A5 JP 2021509210 A JP2021509210 A JP 2021509210A JP 2021509210 A JP2021509210 A JP 2021509210A JP WO2020041574 A5 JPWO2020041574 A5 JP WO2020041574A5
- Authority
- JP
- Japan
- Prior art keywords
- gaboxadol
- pharmaceutically acceptable
- acceptable salt
- patient
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ZXRVKCBLGJOCEE-UHFFFAOYSA-N Gaboxadol Chemical compound C1NCCC2=C1ONC2=O ZXRVKCBLGJOCEE-UHFFFAOYSA-N 0.000 claims description 63
- 229950004346 gaboxadol Drugs 0.000 claims description 63
- 150000003839 salts Chemical class 0.000 claims description 63
- 238000001727 in vivo Methods 0.000 claims description 21
- 208000024891 symptom Diseases 0.000 claims description 19
- 206010012735 Diarrhoea Diseases 0.000 claims description 8
- 206010028813 Nausea Diseases 0.000 claims description 8
- 230000008693 nausea Effects 0.000 claims description 8
- 208000015943 Coeliac disease Diseases 0.000 claims description 7
- 206010000060 Abdominal distension Diseases 0.000 claims description 6
- 208000011231 Crohn disease Diseases 0.000 claims description 6
- 208000007101 Muscle Cramp Diseases 0.000 claims description 6
- 208000006673 asthma Diseases 0.000 claims description 6
- 208000016261 weight loss Diseases 0.000 claims description 6
- 230000004580 weight loss Effects 0.000 claims description 6
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 5
- 208000008275 microscopic colitis Diseases 0.000 claims description 5
- 208000004998 Abdominal Pain Diseases 0.000 claims description 4
- 206010010774 Constipation Diseases 0.000 claims description 4
- 206010037660 Pyrexia Diseases 0.000 claims description 4
- 208000007502 anemia Diseases 0.000 claims description 4
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 3
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 3
- 208000024330 bloating Diseases 0.000 claims description 3
- 206010000087 Abdominal pain upper Diseases 0.000 claims description 2
- 208000006820 Arthralgia Diseases 0.000 claims description 2
- 206010008469 Chest discomfort Diseases 0.000 claims description 2
- 206010011224 Cough Diseases 0.000 claims description 2
- 206010012205 Delayed puberty Diseases 0.000 claims description 2
- 208000000059 Dyspnea Diseases 0.000 claims description 2
- 206010013975 Dyspnoeas Diseases 0.000 claims description 2
- 208000010201 Exanthema Diseases 0.000 claims description 2
- 208000034347 Faecal incontinence Diseases 0.000 claims description 2
- 206010025476 Malabsorption Diseases 0.000 claims description 2
- 208000004155 Malabsorption Syndromes Diseases 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 claims description 2
- 208000037656 Respiratory Sounds Diseases 0.000 claims description 2
- 206010047924 Wheezing Diseases 0.000 claims description 2
- 208000022531 anorexia Diseases 0.000 claims description 2
- 208000019902 chronic diarrheal disease Diseases 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 206010061428 decreased appetite Diseases 0.000 claims description 2
- 201000005884 exanthem Diseases 0.000 claims description 2
- 206010025482 malaise Diseases 0.000 claims description 2
- 235000015097 nutrients Nutrition 0.000 claims description 2
- 206010037844 rash Diseases 0.000 claims description 2
- 230000000306 recurrent effect Effects 0.000 claims description 2
- 208000026773 severe abdominal cramp Diseases 0.000 claims description 2
- 208000013220 shortness of breath Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 27
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 6
- 208000010643 digestive system disease Diseases 0.000 claims 6
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 4
- 208000027503 bloody stool Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 208000035861 hematochezia Diseases 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 72
- 206010009887 colitis Diseases 0.000 description 2
- 206010053759 Growth retardation Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010016165 failure to thrive Diseases 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 231100000001 growth retardation Toxicity 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862721013P | 2018-08-22 | 2018-08-22 | |
| US62/721,013 | 2018-08-22 | ||
| PCT/US2019/047673 WO2020041574A1 (en) | 2018-08-22 | 2019-08-22 | Use of gaboxadol in the treatment of gastrointestinal tract disorders and asthma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021535106A JP2021535106A (ja) | 2021-12-16 |
| JPWO2020041574A5 true JPWO2020041574A5 (https=) | 2022-08-24 |
| JP2021535106A5 JP2021535106A5 (https=) | 2022-08-24 |
Family
ID=69591079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021509210A Withdrawn JP2021535106A (ja) | 2018-08-22 | 2019-08-22 | 消化管障害および喘息の処置におけるガボキサドールの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20210177805A1 (https=) |
| EP (1) | EP3823619A4 (https=) |
| JP (1) | JP2021535106A (https=) |
| KR (1) | KR20210049855A (https=) |
| CN (1) | CN112888437A (https=) |
| AU (1) | AU2019326539A1 (https=) |
| CA (1) | CA3110218A1 (https=) |
| IL (1) | IL280859A (https=) |
| MX (1) | MX2021002113A (https=) |
| WO (1) | WO2020041574A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230107927A1 (en) | 2020-02-28 | 2023-04-06 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
| KR20220157426A (ko) * | 2020-03-25 | 2022-11-29 | 세이지 테라퓨틱스, 인크. | 호흡기 병태의 치료를 위한 작용제의 용도 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0974351A3 (en) * | 1998-04-24 | 2000-12-13 | Jouveinal | Medicament for preventing and treating gastrointestinal damage |
| AU4307800A (en) * | 1999-04-30 | 2000-11-17 | Merab Lomia | New indication for use of antiepileptic agents and medicines |
| WO2006102093A1 (en) * | 2005-03-18 | 2006-09-28 | Transform Pharmaceuticals, Inc. | Gaboxadol forms, compositions thereof, and related methods |
| US20070203216A1 (en) * | 2006-02-14 | 2007-08-30 | Bjarke Ebert | Method of treating inflammatory diseases |
| IL256912B2 (en) * | 2015-07-17 | 2024-01-01 | Ovid Therapeutics Inc | Methods of treating developmental disorders with gaboxadol |
-
2019
- 2019-08-22 CN CN201980069028.1A patent/CN112888437A/zh active Pending
- 2019-08-22 WO PCT/US2019/047673 patent/WO2020041574A1/en not_active Ceased
- 2019-08-22 MX MX2021002113A patent/MX2021002113A/es unknown
- 2019-08-22 JP JP2021509210A patent/JP2021535106A/ja not_active Withdrawn
- 2019-08-22 KR KR1020217008438A patent/KR20210049855A/ko not_active Withdrawn
- 2019-08-22 AU AU2019326539A patent/AU2019326539A1/en not_active Abandoned
- 2019-08-22 US US17/270,377 patent/US20210177805A1/en not_active Abandoned
- 2019-08-22 CA CA3110218A patent/CA3110218A1/en active Pending
- 2019-08-22 EP EP19852671.7A patent/EP3823619A4/en not_active Withdrawn
-
2021
- 2021-02-14 IL IL280859A patent/IL280859A/en unknown
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