CN112888437A - 加波沙朵在治疗胃肠道紊乱和哮喘中的用途 - Google Patents

加波沙朵在治疗胃肠道紊乱和哮喘中的用途 Download PDF

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Publication number
CN112888437A
CN112888437A CN201980069028.1A CN201980069028A CN112888437A CN 112888437 A CN112888437 A CN 112888437A CN 201980069028 A CN201980069028 A CN 201980069028A CN 112888437 A CN112888437 A CN 112888437A
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CN
China
Prior art keywords
hours
patient
gaboxadol
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980069028.1A
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English (en)
Chinese (zh)
Inventor
马修·杜林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ovid Therapeutics Inc
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Ovid Therapeutics Inc
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Filing date
Publication date
Application filed by Ovid Therapeutics Inc filed Critical Ovid Therapeutics Inc
Publication of CN112888437A publication Critical patent/CN112888437A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980069028.1A 2018-08-22 2019-08-22 加波沙朵在治疗胃肠道紊乱和哮喘中的用途 Pending CN112888437A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862721013P 2018-08-22 2018-08-22
US62/721,013 2018-08-22
PCT/US2019/047673 WO2020041574A1 (en) 2018-08-22 2019-08-22 Use of gaboxadol in the treatment of gastrointestinal tract disorders and asthma

Publications (1)

Publication Number Publication Date
CN112888437A true CN112888437A (zh) 2021-06-01

Family

ID=69591079

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980069028.1A Pending CN112888437A (zh) 2018-08-22 2019-08-22 加波沙朵在治疗胃肠道紊乱和哮喘中的用途

Country Status (10)

Country Link
US (1) US20210177805A1 (https=)
EP (1) EP3823619A4 (https=)
JP (1) JP2021535106A (https=)
KR (1) KR20210049855A (https=)
CN (1) CN112888437A (https=)
AU (1) AU2019326539A1 (https=)
CA (1) CA3110218A1 (https=)
IL (1) IL280859A (https=)
MX (1) MX2021002113A (https=)
WO (1) WO2020041574A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230107927A1 (en) 2020-02-28 2023-04-06 First Wave Bio, Inc. Methods of treating iatrogenic autoimmune colitis
KR20220157426A (ko) * 2020-03-25 2022-11-29 세이지 테라퓨틱스, 인크. 호흡기 병태의 치료를 위한 작용제의 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0974351A2 (en) * 1998-04-24 2000-01-26 Jouveinal Medicament for preventing and treating gastrointestinal damage
US20070203216A1 (en) * 2006-02-14 2007-08-30 Bjarke Ebert Method of treating inflammatory diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4307800A (en) * 1999-04-30 2000-11-17 Merab Lomia New indication for use of antiepileptic agents and medicines
WO2006102093A1 (en) * 2005-03-18 2006-09-28 Transform Pharmaceuticals, Inc. Gaboxadol forms, compositions thereof, and related methods
IL256912B2 (en) * 2015-07-17 2024-01-01 Ovid Therapeutics Inc Methods of treating developmental disorders with gaboxadol

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0974351A2 (en) * 1998-04-24 2000-01-26 Jouveinal Medicament for preventing and treating gastrointestinal damage
US20070203216A1 (en) * 2006-02-14 2007-08-30 Bjarke Ebert Method of treating inflammatory diseases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GEORGE GALLOS，ET AL.: "Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation", AM J PHYSIOL LUNG CELL MOL PHYSIOL, vol. 302, pages 248 - 256 *
MOHSEN SEIFI,ET AL.: "GABAA Receptor Subtypes Regulate Stress-Induced Colon Inflammation in Mice", GASTROENTEROLOGY, vol. 155, pages 852 - 864 *

Also Published As

Publication number Publication date
WO2020041574A1 (en) 2020-02-27
JP2021535106A (ja) 2021-12-16
AU2019326539A1 (en) 2021-03-11
KR20210049855A (ko) 2021-05-06
US20210177805A1 (en) 2021-06-17
EP3823619A1 (en) 2021-05-26
MX2021002113A (es) 2021-06-23
CA3110218A1 (en) 2020-02-27
EP3823619A4 (en) 2021-11-17
IL280859A (en) 2021-04-29

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