JPWO2020038352A5 - - Google Patents
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- JPWO2020038352A5 JPWO2020038352A5 JP2021509893A JP2021509893A JPWO2020038352A5 JP WO2020038352 A5 JPWO2020038352 A5 JP WO2020038352A5 JP 2021509893 A JP2021509893 A JP 2021509893A JP 2021509893 A JP2021509893 A JP 2021509893A JP WO2020038352 A5 JPWO2020038352 A5 JP WO2020038352A5
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- Prior art keywords
- nucleic acid
- steroid
- administered
- pharmaceutical composition
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023205807A JP7690713B2 (ja) | 2018-08-20 | 2023-12-06 | レーベル遺伝性視神経症を治療するための組成物及び方法 |
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810948193.1A CN110846392A (zh) | 2018-08-20 | 2018-08-20 | 一种重组腺相关病毒或含其的试剂盒及其应用 |
| CN201810948193.1 | 2018-08-20 | ||
| CNPCT/CN2018/103937 | 2018-09-04 | ||
| PCT/CN2018/103937 WO2020000641A1 (zh) | 2018-06-29 | 2018-09-04 | 编码人nadh脱氢酶亚单位蛋白的核酸及其应用 |
| CN201811221305.X | 2018-10-19 | ||
| CN201811221305.XA CN111073899B (zh) | 2018-10-19 | 2018-10-19 | 一种编码人nadh脱氢酶亚单位4蛋白的核酸及其应用 |
| CN201811230856.2A CN111068071A (zh) | 2018-10-22 | 2018-10-22 | 基因治疗Leber遗传学视神经病变 |
| CN201811230856.2 | 2018-10-22 | ||
| CNPCT/CN2018/113799 | 2018-11-02 | ||
| PCT/CN2018/113799 WO2020082417A1 (zh) | 2018-10-22 | 2018-11-02 | 基因治疗Leber遗传性视神经病变 |
| PCT/CN2018/118662 WO2020077756A1 (zh) | 2018-10-19 | 2018-11-30 | Nd4蛋白的编码序列及其应用 |
| CNPCT/CN2018/118662 | 2018-11-30 | ||
| PCT/CN2019/070461 WO2020037938A1 (zh) | 2018-08-20 | 2019-01-04 | 一种重组腺相关病毒或含其的试剂盒及其应用 |
| CNPCT/CN2019/070461 | 2019-01-04 | ||
| PCT/CN2019/101538 WO2020038352A1 (en) | 2018-08-20 | 2019-08-20 | Compositions and methods for treating leber's hereditary optic neuropathy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023205807A Division JP7690713B2 (ja) | 2018-08-20 | 2023-12-06 | レーベル遺伝性視神経症を治療するための組成物及び方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021534201A JP2021534201A (ja) | 2021-12-09 |
| JP2021534201A5 JP2021534201A5 (https=) | 2022-08-29 |
| JPWO2020038352A5 true JPWO2020038352A5 (https=) | 2022-08-29 |
| JP7403852B2 JP7403852B2 (ja) | 2023-12-25 |
Family
ID=74668040
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021509893A Active JP7403852B2 (ja) | 2018-08-20 | 2019-08-20 | レーベル遺伝性視神経症を治療するための組成物及び方法 |
| JP2023205807A Active JP7690713B2 (ja) | 2018-08-20 | 2023-12-06 | レーベル遺伝性視神経症を治療するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023205807A Active JP7690713B2 (ja) | 2018-08-20 | 2023-12-06 | レーベル遺伝性視神経症を治療するための組成物及び方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11352645B2 (https=) |
| EP (1) | EP3840785A4 (https=) |
| JP (2) | JP7403852B2 (https=) |
| KR (1) | KR20210068014A (https=) |
| CN (1) | CN112584874A (https=) |
| AU (1) | AU2019323434A1 (https=) |
| CA (1) | CA3109432A1 (https=) |
| SG (1) | SG11202101032VA (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240014102A (ko) | 2018-06-29 | 2024-01-31 | 우한 뉴로프스 바이오테크놀로지 리미티드 컴퍼니 | 레버 유전성 시신경병증의 치료를 위한 조성물 및 방법 |
| CA3109432A1 (en) | 2018-08-20 | 2020-02-27 | Wuhan Neurophth Biotechnology Limited Company | Compositions and methods for treating leber's hereditary optic neuropathy |
| US20210100856A1 (en) * | 2019-09-11 | 2021-04-08 | Adverum Biotechnologies, Inc. | Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept |
| CN113025633B (zh) * | 2019-12-09 | 2024-08-27 | 武汉纽福斯生物科技有限公司 | 编码人nadh脱氢酶亚单位1蛋白的核酸及其应用 |
| CA3228344A1 (en) * | 2021-08-06 | 2023-02-09 | Wuhan Neurophth Biotechnology Limited Company | Composition and method for treating leber's hereditary optic neuropathy caused by nd4 mutation |
| CN116789772A (zh) * | 2022-03-18 | 2023-09-22 | 北京安龙生物医药有限公司 | Aav5扩容衣壳突变体及其扩容检测方法 |
| WO2024144330A1 (ko) * | 2022-12-29 | 2024-07-04 | 주식회사 엣진 | 레베르 유전성 시신경병증의 미토콘드리아 염기 변이 교정 시스템 |
| CN118320132A (zh) * | 2024-04-26 | 2024-07-12 | 首都医科大学附属北京友谊医院 | 重组腺相关病毒rAAV2/Rec2作为胰腺靶向性载体的应用 |
Family Cites Families (43)
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| US3625214A (en) | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
| US4906474A (en) | 1983-03-22 | 1990-03-06 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
| US4789734A (en) | 1985-08-06 | 1988-12-06 | La Jolla Cancer Research Foundation | Vitronectin specific cell receptor derived from mammalian mesenchymal tissue |
| EP0545913B1 (en) | 1986-08-18 | 1999-02-24 | Emisphere Technologies, Inc. | Delivery systems for pharmacological agents |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US5811128A (en) | 1986-10-24 | 1998-09-22 | Southern Research Institute | Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| EP0678034B1 (en) | 1993-01-11 | 1999-05-26 | Dana Farber Cancer Institute | Inducing cytotoxic t lymphocyte responses |
| AU2668897A (en) | 1996-04-19 | 1997-11-12 | Genetic Therapy, Inc. | Gene therapy involving concurrent and repeated administration of adenoviruses and immunosuppressive agents |
| US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| US20020132978A1 (en) * | 2000-03-21 | 2002-09-19 | Hans-Peter Gerber | VEGF-modulated genes and methods employing them |
| CA2442670A1 (en) * | 2001-04-13 | 2002-10-24 | The Trustees Of The University Of Pennsylvania | Method of treating or retarding the development of blindness |
| EP1751275B1 (en) | 2004-06-01 | 2017-08-16 | Avigen, Inc. | Compositions and methods to prevent aav vector aggregation |
| US20130022979A1 (en) * | 2005-04-18 | 2013-01-24 | Genesis Genomics Inc. | 3.4kb MITOCHONDRIAL DNA DELETION FOR USE IN THE DETECTION OF CANCER |
| ES2541771T3 (es) | 2005-05-03 | 2015-07-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Expresión de una proteína mitocondrial mediante un enfoque alotópico mejorado |
| CA2667705A1 (en) | 2006-10-23 | 2008-05-29 | University Of Florida Research Foundation, Inc. | Suppression of mitochondrial oxidative stress |
| EP2121914B1 (en) * | 2007-02-16 | 2014-08-20 | John Guy | Mitochondrial nucleic acid delivery systems |
| EP2565649B1 (en) * | 2007-06-20 | 2015-04-15 | Galapagos N.V. | Molecular targets and compounds, and methods to identify the same, useful in the treatment of bone and joint degenerative diseases |
| ES2563984T3 (es) * | 2008-10-22 | 2016-03-17 | Quark Pharmaceuticals, Inc. | Métodos para el tratamiento de trastornos oculares |
| DK2529020T3 (en) | 2010-01-28 | 2018-08-06 | Childrens Hospital Philadelphia | SCALABLE PREPARATION PLATF FOR CLEANING VIRAL VECTORS AND CLEANED VIRAL VECTORS FOR USE IN GENTHERAPY |
| CN102517304B (zh) | 2011-12-16 | 2013-08-28 | 中国农业科学院生物技术研究所 | 重组葡萄糖氧化酶的优化基因及其表达载体和应用 |
| US20160289674A1 (en) * | 2012-04-02 | 2016-10-06 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of membrane proteins |
| CN102634527B (zh) | 2012-04-11 | 2013-11-06 | 华中科技大学同济医学院附属同济医院 | 重组人nadh脱氢酶亚单位4基因及其表达载体构建方法 |
| TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| US10493141B2 (en) | 2014-09-17 | 2019-12-03 | The University Of Iowa Research Foundation | Viral RNA segments as immunomodulatory agents and vaccine components |
| CN104450747B (zh) * | 2014-09-23 | 2018-02-09 | 武汉纽福斯生物科技有限公司 | 用于治疗Leber遗传性视神经病变的重组腺相关病毒‑NADH脱氢酶亚单位4基因全长以及药剂 |
| EP3322297B1 (en) | 2015-07-13 | 2024-12-04 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
| CA2973885A1 (en) * | 2016-07-21 | 2018-01-21 | Stealth Biotherapeutics Corp | Therapeutic compositions including mitochondrial-targeted creatine compounds and uses thereof to treat and prevent mitochondrial diseases and conditions |
| WO2018102672A1 (en) * | 2016-12-04 | 2018-06-07 | Alavi Khorassani Moghadam Marcel Victor | Methods for treating diseases related to mitochondrial stress |
| US20180207293A1 (en) * | 2017-01-25 | 2018-07-26 | 2C Tech Corp. | Nanoparticles for sustained ophthalmic drug delivery and methods of use |
| EP3441069B1 (en) * | 2017-08-11 | 2023-04-05 | Unity Biotechnology, Inc. | Treatment of diabetic retinopathy using pharmaceutical agents that eliminate senescent cells |
| US20210163898A1 (en) * | 2018-04-16 | 2021-06-03 | The Children's Hospital Of Philadelphia | Mitochondrial rna import for treating mitochondrial disease |
| CN112384625A (zh) * | 2018-06-11 | 2021-02-19 | 珍视生物股份公司 | 重组aav载体及其使用方法 |
| CN111068071A (zh) | 2018-10-22 | 2020-04-28 | 武汉纽福斯生物科技有限公司 | 基因治疗Leber遗传学视神经病变 |
| WO2020010491A1 (zh) | 2018-07-09 | 2020-01-16 | 武汉纽福斯生物科技有限公司 | 编码人nadh脱氢酶亚单位4蛋白的核酸及其应用 |
| CN110846392A (zh) | 2018-08-20 | 2020-02-28 | 武汉纽福斯生物科技有限公司 | 一种重组腺相关病毒或含其的试剂盒及其应用 |
| KR20240014102A (ko) | 2018-06-29 | 2024-01-31 | 우한 뉴로프스 바이오테크놀로지 리미티드 컴퍼니 | 레버 유전성 시신경병증의 치료를 위한 조성물 및 방법 |
| WO2020001657A1 (en) | 2018-06-29 | 2020-01-02 | Wuhan Neurophth Biological Technology Limited Company | Compositions and methods for treating leber's hereditary optic neuropathy |
| WO2020000641A1 (zh) | 2018-06-29 | 2020-01-02 | 武汉纽福斯生物科技有限公司 | 编码人nadh脱氢酶亚单位蛋白的核酸及其应用 |
| CN111073899B (zh) | 2018-10-19 | 2021-01-01 | 武汉纽福斯生物科技有限公司 | 一种编码人nadh脱氢酶亚单位4蛋白的核酸及其应用 |
| CA3109432A1 (en) | 2018-08-20 | 2020-02-27 | Wuhan Neurophth Biotechnology Limited Company | Compositions and methods for treating leber's hereditary optic neuropathy |
| WO2020038352A1 (en) | 2018-08-20 | 2020-02-27 | Wuhan Neurophth Biological Technology Limited Company | Compositions and methods for treating leber's hereditary optic neuropathy |
| CN113025633B (zh) | 2019-12-09 | 2024-08-27 | 武汉纽福斯生物科技有限公司 | 编码人nadh脱氢酶亚单位1蛋白的核酸及其应用 |
-
2019
- 2019-08-20 CA CA3109432A patent/CA3109432A1/en active Pending
- 2019-08-20 AU AU2019323434A patent/AU2019323434A1/en not_active Abandoned
- 2019-08-20 KR KR1020217007727A patent/KR20210068014A/ko not_active Ceased
- 2019-08-20 EP EP19853225.1A patent/EP3840785A4/en not_active Withdrawn
- 2019-08-20 CN CN201980054770.5A patent/CN112584874A/zh active Pending
- 2019-08-20 SG SG11202101032VA patent/SG11202101032VA/en unknown
- 2019-08-20 JP JP2021509893A patent/JP7403852B2/ja active Active
-
2021
- 2021-02-22 US US17/181,849 patent/US11352645B2/en active Active
-
2022
- 2022-04-22 US US17/726,833 patent/US20220259619A1/en not_active Abandoned
-
2023
- 2023-12-06 JP JP2023205807A patent/JP7690713B2/ja active Active
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