JPWO2020030923A5 - - Google Patents
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- Publication number
- JPWO2020030923A5 JPWO2020030923A5 JP2021531197A JP2021531197A JPWO2020030923A5 JP WO2020030923 A5 JPWO2020030923 A5 JP WO2020030923A5 JP 2021531197 A JP2021531197 A JP 2021531197A JP 2021531197 A JP2021531197 A JP 2021531197A JP WO2020030923 A5 JPWO2020030923 A5 JP WO2020030923A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- pore
- optionally
- liposome
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004169 proteins and genes Human genes 0.000 claims 26
- 108090000623 proteins and genes Proteins 0.000 claims 26
- 239000002502 liposome Substances 0.000 claims 22
- 210000004027 cells Anatomy 0.000 claims 12
- 241000193738 Bacillus anthracis Species 0.000 claims 10
- 230000000975 bioactive Effects 0.000 claims 10
- 101700080605 NUC1 Proteins 0.000 claims 6
- 101700006494 nucA Proteins 0.000 claims 6
- 101710027502 pagA Proteins 0.000 claims 6
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 4
- 101700044940 BM86 Proteins 0.000 claims 4
- 229920000272 Oligonucleotide Polymers 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000000074 antisense oligonucleotide Substances 0.000 claims 4
- 108020003112 toxins Proteins 0.000 claims 4
- 230000002238 attenuated Effects 0.000 claims 3
- 230000003834 intracellular Effects 0.000 claims 3
- 239000011148 porous material Substances 0.000 claims 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 229920000160 (ribonucleotides)n+m Polymers 0.000 claims 2
- 206010068168 Androgenetic alopecia Diseases 0.000 claims 2
- 229920000033 CRISPR Polymers 0.000 claims 2
- 108010082319 CRISPR-Associated Protein 9 Proteins 0.000 claims 2
- 102100011490 EIF2AK2 Human genes 0.000 claims 2
- 101710006371 EIF2AK2 Proteins 0.000 claims 2
- 229920002391 Guide RNA Polymers 0.000 claims 2
- 108020005004 Guide RNA Proteins 0.000 claims 2
- 108091007232 Nucleic acid- binding domain Proteins 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 238000010459 TALEN Methods 0.000 claims 2
- 231100000765 Toxin Toxicity 0.000 claims 2
- 208000001455 Zika Virus Infection Diseases 0.000 claims 2
- 201000004296 Zika fever Diseases 0.000 claims 2
- 201000002996 androgenic alopecia Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 238000010362 genome editing Methods 0.000 claims 2
- 200000000018 inflammatory disease Diseases 0.000 claims 2
- 230000001665 lethal Effects 0.000 claims 2
- 231100000518 lethal Toxicity 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 230000003000 nontoxic Effects 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 230000001105 regulatory Effects 0.000 claims 2
- 230000001225 therapeutic Effects 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 239000000304 virulence factor Substances 0.000 claims 2
- 206010000496 Acne Diseases 0.000 claims 1
- 206010000565 Acquired immunodeficiency syndrome Diseases 0.000 claims 1
- 229940065181 Bacillus anthracis Drugs 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 229940107161 Cholesterol Drugs 0.000 claims 1
- 206010011401 Crohn's disease Diseases 0.000 claims 1
- 210000000172 Cytosol Anatomy 0.000 claims 1
- 206010013801 Duchenne muscular dystrophy Diseases 0.000 claims 1
- 201000011001 Ebola hemorrhagic fever Diseases 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 210000001808 Exosomes Anatomy 0.000 claims 1
- 102100011941 FMO5 Human genes 0.000 claims 1
- 101700054986 FMO5 Proteins 0.000 claims 1
- 101700058973 GAL4 Proteins 0.000 claims 1
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 241000701806 Human papillomavirus Species 0.000 claims 1
- 102100011539 LGALS4 Human genes 0.000 claims 1
- 101710015850 LGALS4 Proteins 0.000 claims 1
- 229920002521 Macromolecule Polymers 0.000 claims 1
- 108020004999 Messenger RNA Proteins 0.000 claims 1
- 108020004388 MicroRNAs Proteins 0.000 claims 1
- 210000004940 Nucleus Anatomy 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 210000003463 Organelles Anatomy 0.000 claims 1
- BHMBVRSPMRCCGG-OUTUXVNYSA-N Prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 231100000654 Protein toxin Toxicity 0.000 claims 1
- 101700002422 STAT3 Proteins 0.000 claims 1
- 235000003534 Saccharomyces carlsbergensis Nutrition 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 229940081969 Saccharomyces cerevisiae Drugs 0.000 claims 1
- 108020004459 Small Interfering RNA Proteins 0.000 claims 1
- 108020004688 Small Nuclear RNA Proteins 0.000 claims 1
- 208000002320 Spinal Muscular Atrophy Diseases 0.000 claims 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 1
- 210000003934 Vacuoles Anatomy 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 1
- 230000002730 additional Effects 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007172 antigens Proteins 0.000 claims 1
- 102000038129 antigens Human genes 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 210000003850 cellular structures Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 238000005516 engineering process Methods 0.000 claims 1
- 230000002068 genetic Effects 0.000 claims 1
- 230000000968 intestinal Effects 0.000 claims 1
- 150000002605 large molecules Chemical class 0.000 claims 1
- 230000001404 mediated Effects 0.000 claims 1
- 229920002106 messenger RNA Polymers 0.000 claims 1
- 229920001239 microRNA Polymers 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 230000008506 pathogenesis Effects 0.000 claims 1
- 238000005067 remediation Methods 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 229920001255 small nuclear ribonucleic acid Polymers 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
- 230000017613 viral reproduction Effects 0.000 claims 1
- 230000001018 virulence Effects 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1812992.4A GB201812992D0 (en) | 2018-08-09 | 2018-08-09 | Liposomes |
| GB1812992.4 | 2018-08-09 | ||
| PCT/GB2019/052239 WO2020030923A1 (fr) | 2018-08-09 | 2019-08-09 | Procédé de préparation de liposomes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021533825A JP2021533825A (ja) | 2021-12-09 |
| JPWO2020030923A5 true JPWO2020030923A5 (fr) | 2022-08-12 |
Family
ID=63667012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021531197A Pending JP2021533825A (ja) | 2018-08-09 | 2019-08-09 | リポソームの調製方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20210338584A1 (fr) |
| EP (1) | EP3833330A1 (fr) |
| JP (1) | JP2021533825A (fr) |
| CN (1) | CN113286578A (fr) |
| AU (1) | AU2019317788B2 (fr) |
| CA (1) | CA3108864A1 (fr) |
| GB (1) | GB201812992D0 (fr) |
| IL (1) | IL280703A (fr) |
| WO (1) | WO2020030923A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11931458B2 (en) | 2021-01-11 | 2024-03-19 | Babak Ghalili | Exosome systems, products and methods |
| CN114259573B (zh) * | 2022-01-06 | 2023-06-20 | 中国人民解放军军事科学院军事医学研究院 | 一种含有胆碱酯酶重活化剂的脑靶向脂质体及其制备方法和用途 |
| WO2023195976A1 (fr) * | 2022-04-05 | 2023-10-12 | Babak Ghalili | Systèmes, produits et procédés faisant intervenir des exosomes |
| CN115990270B (zh) * | 2022-07-14 | 2023-08-11 | 郑州大学 | 一种抑制肿瘤干性的纳米载体及其制备方法和应用 |
| CN118272405A (zh) * | 2024-02-28 | 2024-07-02 | 浙江大学杭州国际科创中心 | 一种高效分泌纳米抗体药物的基因工程菌及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012096926A2 (fr) * | 2011-01-10 | 2012-07-19 | President And Fellows Of Harvard College | Procédé pour administrer des agents dans des cellules à l'aide de toxines bactériennes |
| GB201311057D0 (en) * | 2013-06-21 | 2013-08-07 | Univ Greenwich | Antisense oligonucleotide compositions |
| WO2016187717A1 (fr) * | 2015-05-26 | 2016-12-01 | Exerkine Corporation | Exosomes utiles pour l'édition génomique |
-
2018
- 2018-08-09 GB GBGB1812992.4A patent/GB201812992D0/en not_active Ceased
-
2019
- 2019-08-09 US US17/266,904 patent/US20210338584A1/en active Pending
- 2019-08-09 CN CN201980063528.4A patent/CN113286578A/zh active Pending
- 2019-08-09 EP EP19755418.1A patent/EP3833330A1/fr active Pending
- 2019-08-09 WO PCT/GB2019/052239 patent/WO2020030923A1/fr unknown
- 2019-08-09 CA CA3108864A patent/CA3108864A1/fr active Pending
- 2019-08-09 AU AU2019317788A patent/AU2019317788B2/en active Active
- 2019-08-09 JP JP2021531197A patent/JP2021533825A/ja active Pending
-
2021
- 2021-02-07 IL IL280703A patent/IL280703A/en unknown
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