JPWO2020026212A5 - - Google Patents
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- Publication number
- JPWO2020026212A5 JPWO2020026212A5 JP2021529544A JP2021529544A JPWO2020026212A5 JP WO2020026212 A5 JPWO2020026212 A5 JP WO2020026212A5 JP 2021529544 A JP2021529544 A JP 2021529544A JP 2021529544 A JP2021529544 A JP 2021529544A JP WO2020026212 A5 JPWO2020026212 A5 JP WO2020026212A5
- Authority
- JP
- Japan
- Prior art keywords
- whole blood
- blood sample
- fgf
- growth factor
- tubular scaffold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004369 Blood Anatomy 0.000 claims 14
- 239000008280 blood Substances 0.000 claims 14
- 239000000725 suspension Substances 0.000 claims 10
- 239000003146 anticoagulant agent Substances 0.000 claims 6
- 102000018233 Fibroblast growth factor family Human genes 0.000 claims 4
- 108050007372 Fibroblast growth factor family Proteins 0.000 claims 4
- 229920002307 Dextran Polymers 0.000 claims 3
- 229960002897 Heparin Drugs 0.000 claims 3
- ZFGMDIBRIDKWMY-PASTXAENSA-N Heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims 3
- 108050003490 Insulin-like growth factor Proteins 0.000 claims 3
- 102000014429 Insulin-like growth factor Human genes 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Vitamin C Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 3
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 3
- 229960005070 ascorbic acid Drugs 0.000 claims 3
- 235000010323 ascorbic acid Nutrition 0.000 claims 3
- 239000011668 ascorbic acid Substances 0.000 claims 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 3
- 239000003102 growth factor Substances 0.000 claims 3
- 229920000669 heparin Polymers 0.000 claims 3
- 101700052211 BDNF Proteins 0.000 claims 2
- 102100015985 BDNF Human genes 0.000 claims 2
- 210000004204 Blood Vessels Anatomy 0.000 claims 2
- 102100008428 CCL2 Human genes 0.000 claims 2
- 102100006400 CSF2 Human genes 0.000 claims 2
- 108010055292 Chemokine CCL2 Proteins 0.000 claims 2
- 108010055166 Chemokine CCL5 Proteins 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 2
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 2
- 108010063738 Interleukins Proteins 0.000 claims 2
- 102000015696 Interleukins Human genes 0.000 claims 2
- 102100012750 MDK Human genes 0.000 claims 2
- 108010092801 Midkine Proteins 0.000 claims 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 2
- 102000009618 Transforming Growth Factors Human genes 0.000 claims 2
- 108010009583 Transforming Growth Factors Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 108010001801 Tumor Necrosis Factor-alpha Proteins 0.000 claims 2
- 230000002429 anti-coagulation Effects 0.000 claims 2
- 230000002785 anti-thrombosis Effects 0.000 claims 2
- 102000005162 pleiotrophin Human genes 0.000 claims 2
- 108010056011 pleiotrophin Proteins 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- DPFYBZWSVVKNPZ-AQWIXGDGSA-N (3S,4S,6R)-2-[[(2R,4R,5R)-3,5-dihydroxy-4-methoxy-6-(methoxymethyl)oxan-2-yl]methoxymethyl]-6-ethyloxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)C(O)[C@@H](CC)OC1COC[C@@H]1C(O)[C@H](OC)[C@H](O)C(COC)O1 DPFYBZWSVVKNPZ-AQWIXGDGSA-N 0.000 claims 1
- 210000001772 Blood Platelets Anatomy 0.000 claims 1
- 102100016449 CCL5 Human genes 0.000 claims 1
- 102000001327 Chemokine CCL5 Human genes 0.000 claims 1
- 108010008978 Chemokine CXCL10 Proteins 0.000 claims 1
- 102000006579 Chemokine CXCL10 Human genes 0.000 claims 1
- 229940119744 Dextran 40 Drugs 0.000 claims 1
- 102100008645 FGF3 Human genes 0.000 claims 1
- 102100007406 FGF4 Human genes 0.000 claims 1
- 101700036125 FGF4 Proteins 0.000 claims 1
- 102100007408 FGF5 Human genes 0.000 claims 1
- 101700010264 FGF5 Proteins 0.000 claims 1
- 102100007407 FGF6 Human genes 0.000 claims 1
- 101700012851 FGF6 Proteins 0.000 claims 1
- 102100007405 FGF7 Human genes 0.000 claims 1
- 101700033323 FGF7 Proteins 0.000 claims 1
- 102100015613 FGF8 Human genes 0.000 claims 1
- 101700012405 FGF8 Proteins 0.000 claims 1
- 102100015612 FGF9 Human genes 0.000 claims 1
- 101700084870 FGF9 Proteins 0.000 claims 1
- 102000003974 Fibroblast Growth Factor 2 Human genes 0.000 claims 1
- 108090000379 Fibroblast Growth Factor 2 Proteins 0.000 claims 1
- 102000018710 Heparin-binding EGF-like growth factor Human genes 0.000 claims 1
- 101800001649 Heparin-binding EGF-like growth factor Proteins 0.000 claims 1
- 101710004181 INTS2 Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 102000004890 Interleukin-8 Human genes 0.000 claims 1
- 102100015249 VEGFA Human genes 0.000 claims 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 230000001413 cellular Effects 0.000 claims 1
- 101700023228 fgf8a Proteins 0.000 claims 1
- 230000000977 initiatory Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001737 promoting Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023000388A JP7303952B2 (ja) | 2018-08-03 | 2023-01-05 | 個別化された血管を作製する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862714200P | 2018-08-03 | 2018-08-03 | |
| US62/714,200 | 2018-08-03 | ||
| PCT/IB2019/056621 WO2020026212A2 (en) | 2018-08-03 | 2019-08-02 | Methods of preparing personalized blood vessels |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023000388A Division JP7303952B2 (ja) | 2018-08-03 | 2023-01-05 | 個別化された血管を作製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021532962A JP2021532962A (ja) | 2021-12-02 |
| JPWO2020026212A5 true JPWO2020026212A5 (de) | 2022-08-03 |
| JP7208393B2 JP7208393B2 (ja) | 2023-01-18 |
Family
ID=68104680
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021529544A Active JP7208393B2 (ja) | 2018-08-03 | 2019-08-02 | 個別化された血管を作製する方法 |
| JP2023000388A Active JP7303952B2 (ja) | 2018-08-03 | 2023-01-05 | 個別化された血管を作製する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023000388A Active JP7303952B2 (ja) | 2018-08-03 | 2023-01-05 | 個別化された血管を作製する方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US11471567B2 (de) |
| EP (2) | EP4194541B1 (de) |
| JP (2) | JP7208393B2 (de) |
| KR (1) | KR102530336B1 (de) |
| CN (1) | CN112805364A (de) |
| AU (1) | AU2019315049B2 (de) |
| BR (1) | BR112021001541B1 (de) |
| CA (1) | CA3107918A1 (de) |
| DK (1) | DK3830243T3 (de) |
| ES (1) | ES2953744T3 (de) |
| FI (1) | FI3830243T3 (de) |
| HR (1) | HRP20230834T1 (de) |
| HU (1) | HUE062715T2 (de) |
| LT (1) | LT3830243T (de) |
| MX (1) | MX2021001184A (de) |
| PL (1) | PL3830243T3 (de) |
| PT (1) | PT3830243T (de) |
| RS (1) | RS64381B1 (de) |
| SG (2) | SG11202101121YA (de) |
| SI (1) | SI3830243T1 (de) |
| WO (1) | WO2020026212A2 (de) |
| ZA (1) | ZA202100888B (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113855859A (zh) * | 2021-05-28 | 2021-12-31 | 首都医科大学宣武医院 | 一种由脱细胞血管基质构建的可促进快速内皮化的小口径组织工程血管 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02274244A (ja) * | 1989-04-14 | 1990-11-08 | Yasunori Morohoshi | 人工血管およびその製造法 |
| US6376244B1 (en) | 1999-12-29 | 2002-04-23 | Children's Medical Center Corporation | Methods and compositions for organ decellularization |
| ATE390152T1 (de) * | 2000-04-28 | 2008-04-15 | Baylor College Medicine | Dezellularisierte gefässprothesen |
| WO2002035929A1 (en) | 2000-11-03 | 2002-05-10 | Vitrolife Ab | Evaluation and preservation solution |
| KR20070106696A (ko) * | 2004-12-24 | 2007-11-05 | 셀스셀 피티와이 엘티디 | 이식가능한 바이오물질 및 그 제조 방법 |
| WO2011002926A2 (en) * | 2009-07-01 | 2011-01-06 | The General Hospital Corporation | Isolated adult cells, artificial organs,rehabilitated organs, research rools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same |
| PL2782995T3 (pl) * | 2012-03-16 | 2017-05-31 | Novahep Ab | Biomodyfikowane alogeniczne naczynie krwionośne |
| RU2646506C1 (ru) | 2014-02-12 | 2018-03-05 | Торэй Индастриз, Инк. | Искусственный кровеносный сосуд |
| JP2016524954A (ja) | 2014-05-27 | 2016-08-22 | ノーバヘップ アーベー | 生物工学で作製された同種異系弁 |
| CN107106727B (zh) | 2014-10-31 | 2021-04-02 | 富士胶片株式会社 | 管状结构物、用于制造管状结构物的装置及管状结构物的制造方法 |
| KR102571649B1 (ko) * | 2014-12-19 | 2023-08-25 | 앤지오크린 바이오사이언스 인코포레이티드 | 조작된 내피 세포를 포함하는 생체적합성 임플란트 |
| CA3027505A1 (en) * | 2016-06-15 | 2017-12-21 | The General Hospital Corporation | Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions |
-
2019
- 2019-08-02 SG SG11202101121YA patent/SG11202101121YA/en unknown
- 2019-08-02 PT PT197799679T patent/PT3830243T/pt unknown
- 2019-08-02 ES ES19779967T patent/ES2953744T3/es active Active
- 2019-08-02 LT LTEPPCT/IB2019/056621T patent/LT3830243T/lt unknown
- 2019-08-02 SI SI201930612T patent/SI3830243T1/sl unknown
- 2019-08-02 EP EP23153503.0A patent/EP4194541B1/de active Active
- 2019-08-02 DK DK19779967.9T patent/DK3830243T3/da active
- 2019-08-02 MX MX2021001184A patent/MX2021001184A/es unknown
- 2019-08-02 BR BR112021001541-8A patent/BR112021001541B1/pt active IP Right Grant
- 2019-08-02 CA CA3107918A patent/CA3107918A1/en active Pending
- 2019-08-02 RS RS20230591A patent/RS64381B1/sr unknown
- 2019-08-02 US US16/529,973 patent/US11471567B2/en active Active
- 2019-08-02 JP JP2021529544A patent/JP7208393B2/ja active Active
- 2019-08-02 CN CN201980062471.6A patent/CN112805364A/zh active Pending
- 2019-08-02 HU HUE19779967A patent/HUE062715T2/hu unknown
- 2019-08-02 AU AU2019315049A patent/AU2019315049B2/en active Active
- 2019-08-02 PL PL19779967.9T patent/PL3830243T3/pl unknown
- 2019-08-02 WO PCT/IB2019/056621 patent/WO2020026212A2/en active Application Filing
- 2019-08-02 HR HRP20230834TT patent/HRP20230834T1/hr unknown
- 2019-08-02 EP EP19779967.9A patent/EP3830243B1/de active Active
- 2019-08-02 FI FIEP19779967.9T patent/FI3830243T3/fi active
- 2019-08-02 KR KR1020217005498A patent/KR102530336B1/ko active IP Right Grant
- 2019-08-02 SG SG10202112210SA patent/SG10202112210SA/en unknown
- 2019-09-20 US US16/577,421 patent/US10980916B2/en active Active
-
2021
- 2021-02-09 ZA ZA2021/00888A patent/ZA202100888B/en unknown
-
2022
- 2022-10-17 US US17/967,250 patent/US20230093436A1/en active Pending
-
2023
- 2023-01-05 JP JP2023000388A patent/JP7303952B2/ja active Active
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