JPWO2020022494A1 - 消化管再生のためのシート状細胞培養物 - Google Patents

消化管再生のためのシート状細胞培養物 Download PDF

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JPWO2020022494A1
JPWO2020022494A1 JP2020532508A JP2020532508A JPWO2020022494A1 JP WO2020022494 A1 JPWO2020022494 A1 JP WO2020022494A1 JP 2020532508 A JP2020532508 A JP 2020532508A JP 2020532508 A JP2020532508 A JP 2020532508A JP WO2020022494 A1 JPWO2020022494 A1 JP WO2020022494A1
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sheet
cell culture
cells
present disclosure
cell
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Japanese (ja)
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JPWO2020022494A5 (https=
Inventor
安広 丸屋
安広 丸屋
亮 松本
亮 松本
慎一朗 小林
慎一朗 小林
賢悟 金高
賢悟 金高
晋 江口
晋 江口
賢 大仁田
賢 大仁田
慶一 橋口
慶一 橋口
文哉 大橋
文哉 大橋
匡記 松村
匡記 松村
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Terumo Corp
Nagasaki University NUC
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Terumo Corp
Nagasaki University NUC
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Publication of JPWO2020022494A5 publication Critical patent/JPWO2020022494A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3882—Hollow organs, e.g. bladder, esophagus, urether, uterus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3826—Muscle cells, e.g. smooth muscle cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/22—Materials or treatment for tissue regeneration for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2020532508A 2018-07-27 2019-07-26 消化管再生のためのシート状細胞培養物 Pending JPWO2020022494A1 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018140977 2018-07-27
JP2018140977 2018-07-27
PCT/JP2019/029479 WO2020022494A1 (ja) 2018-07-27 2019-07-26 消化管再生のためのシート状細胞培養物

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JPWO2020022494A1 true JPWO2020022494A1 (ja) 2021-08-02
JPWO2020022494A5 JPWO2020022494A5 (https=) 2022-02-21

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US (1) US20200390937A1 (https=)
EP (1) EP3741399A4 (https=)
JP (1) JPWO2020022494A1 (https=)
CN (1) CN111787959A (https=)
SG (1) SG11202007242UA (https=)
WO (1) WO2020022494A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7536235B2 (ja) * 2020-09-28 2024-08-20 国立大学法人信州大学 細胞移植材、その製造方法及び使用方法
CN116848231A (zh) * 2021-02-08 2023-10-03 国立大学法人长崎大学 用于覆盖胰脏的切面的片状细胞培养物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528755A (ja) * 2003-08-01 2007-10-18 株式会社カルディオ 三次元組織構造体
WO2010016469A1 (ja) * 2008-08-04 2010-02-11 片山化学工業株式会社 Ｎｅｌｌ－１による組織・臓器異所再生制御技術
JP2016052271A (ja) * 2014-09-03 2016-04-14 テルモ株式会社 シート状細胞培養物とフィブリンゲルとの積層体の製造方法
WO2017130802A1 (ja) * 2016-01-29 2017-08-03 学校法人東京女子医科大学 間葉系幹細胞を含む細胞シート組成物、及び、それを用いた管腔臓器の治癒方法

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
JPH06104061B2 (ja) 1989-02-10 1994-12-21 花王株式会社 細胞培養支持体材料
JP4755368B2 (ja) 2001-07-24 2011-08-24 株式会社セルシード 高密度細胞アレイ用基板、製造法、及びその利用方法
JP2007089442A (ja) 2005-09-28 2007-04-12 Terumo Corp 骨格筋芽細胞の分離方法
JP4569971B2 (ja) 2007-01-19 2010-10-27 Ｈｏｙａ株式会社 治療用物質の運搬投与器具
JP5219610B2 (ja) 2007-05-22 2013-06-26 Ｈｏｙａ株式会社 治療用物質の運搬投与器具
JP5378743B2 (ja) 2008-09-30 2013-12-25 テルモ株式会社 医療用細胞シートの製造方法
JP5667357B2 (ja) 2009-11-30 2015-02-12 テルモ株式会社 シート状細胞培養物の製造方法
JP2014179151A (ja) 2013-03-15 2014-09-25 Toshiba Corp 半導体記憶装置
US9950094B2 (en) * 2013-03-19 2018-04-24 Tokyo Women's Medical University Layered cell sheets containing myoblasts and method for producing same
HK1219502A1 (zh) * 2013-05-17 2017-04-07 泰尔茂株式会社 片状细胞培养物的制造方法
WO2015054383A1 (en) * 2013-10-09 2015-04-16 The University Of Arizona Muscle cell patches and uses therefor
JP6599089B2 (ja) * 2014-09-03 2019-10-30 テルモ株式会社 補強部を有するシート状細胞培養物とフィブリンゲルとの積層体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528755A (ja) * 2003-08-01 2007-10-18 株式会社カルディオ 三次元組織構造体
WO2010016469A1 (ja) * 2008-08-04 2010-02-11 片山化学工業株式会社 Ｎｅｌｌ－１による組織・臓器異所再生制御技術
JP2016052271A (ja) * 2014-09-03 2016-04-14 テルモ株式会社 シート状細胞培養物とフィブリンゲルとの積層体の製造方法
WO2017130802A1 (ja) * 2016-01-29 2017-08-03 学校法人東京女子医科大学 間葉系幹細胞を含む細胞シート組成物、及び、それを用いた管腔臓器の治癒方法

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Title
MARUYA, Y. ET AL.: "Autologous adipose-derived stem cell sheets enhance the strength of intestinal anastomosis", REGEN THER, vol. 7, JPN6019040937, 2017, pages 24 - 33, XP055680018, ISSN: 0004980157, DOI: 10.1016/j.reth.2017.06.004 *
TANAKA, S. ET AL.: "Cell sheet technology for the regeneration of gastrointestinal tissue using a novel gastric perforat", SURG TODAY, vol. 47, JPN6019040931, 2017, pages 114 - 21, ISSN: 0005080526 *
TANAKA, T. ET AL.: "Development of a novel rat model with pancreatic fistula and the prevention of this complication usi", J GASTROENTEROL, vol. 48, JPN6019040934, 2013, pages 1081 - 9, XP055680016, ISSN: 0004980156, DOI: 10.1007/s00535-012-0706-9 *
堺裕輔, 外1名: "細胞シートによる消化器の創傷治癒と機能性臓器の作製", 膜, vol. 43, JPN6019040942, March 2018 (2018-03-01), pages 34 - 9, ISSN: 0004980158 *

Also Published As

Publication number Publication date
WO2020022494A1 (ja) 2020-01-30
SG11202007242UA (en) 2020-08-28
US20200390937A1 (en) 2020-12-17
CN111787959A (zh) 2020-10-16
EP3741399A1 (en) 2020-11-25
EP3741399A4 (en) 2021-05-05

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