JPWO2020006432A5 - - Google Patents
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- Publication number
- JPWO2020006432A5 JPWO2020006432A5 JP2020570791A JP2020570791A JPWO2020006432A5 JP WO2020006432 A5 JPWO2020006432 A5 JP WO2020006432A5 JP 2020570791 A JP2020570791 A JP 2020570791A JP 2020570791 A JP2020570791 A JP 2020570791A JP WO2020006432 A5 JPWO2020006432 A5 JP WO2020006432A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heterocyclyl
- group
- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 134
- 125000000623 heterocyclic group Chemical group 0.000 claims 119
- 125000000753 cycloalkyl group Chemical group 0.000 claims 108
- 125000001072 heteroaryl group Chemical group 0.000 claims 102
- 125000003118 aryl group Chemical group 0.000 claims 101
- 125000003545 alkoxy group Chemical group 0.000 claims 82
- 125000001188 haloalkyl group Chemical group 0.000 claims 72
- 229910052736 halogen Inorganic materials 0.000 claims 63
- 150000002367 halogens Chemical class 0.000 claims 63
- 229910052739 hydrogen Inorganic materials 0.000 claims 61
- 239000001257 hydrogen Substances 0.000 claims 61
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 60
- -1 cyano, hydroxy Chemical group 0.000 claims 59
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 57
- 125000004093 cyano group Chemical group *C#N 0.000 claims 56
- 125000001424 substituent group Chemical group 0.000 claims 52
- 150000002431 hydrogen Chemical class 0.000 claims 47
- 125000003342 alkenyl group Chemical group 0.000 claims 31
- 150000001875 compounds Chemical class 0.000 claims 26
- 229940002612 prodrug Drugs 0.000 claims 19
- 239000000651 prodrug Substances 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 19
- 239000012453 solvate Substances 0.000 claims 19
- 125000000304 alkynyl group Chemical group 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 125000004450 alkenylene group Chemical group 0.000 claims 14
- 125000002947 alkylene group Chemical group 0.000 claims 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 14
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 14
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims 11
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 206010011703 Cyanosis Diseases 0.000 claims 4
- 125000004744 butyloxycarbonyl group Chemical group 0.000 claims 4
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 150000001735 carboxylic acids Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 241000711549 Hepacivirus C Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 229940044665 STING agonist Drugs 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 229910021386 carbon form Inorganic materials 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 239000012646 vaccine adjuvant Substances 0.000 claims 1
- 229940124931 vaccine adjuvant Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862691208P | 2018-06-28 | 2018-06-28 | |
| US62/691,208 | 2018-06-28 | ||
| PCT/US2019/039860 WO2020006432A1 (en) | 2018-06-28 | 2019-06-28 | Fused tricyclic heterocycle compounds and therapeutic uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021530442A JP2021530442A (ja) | 2021-11-11 |
| JP2021530442A5 JP2021530442A5 (https=) | 2022-06-22 |
| JPWO2020006432A5 true JPWO2020006432A5 (https=) | 2022-06-22 |
Family
ID=68987618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020570791A Pending JP2021530442A (ja) | 2018-06-28 | 2019-06-28 | 縮合三環系複素環化合物およびその治療上の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11535633B2 (https=) |
| EP (1) | EP3813827A4 (https=) |
| JP (1) | JP2021530442A (https=) |
| KR (1) | KR20210025016A (https=) |
| CN (1) | CN112351778B (https=) |
| TW (1) | TW202019408A (https=) |
| WO (1) | WO2020006432A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2929415T3 (es) | 2018-05-25 | 2022-11-29 | Incyte Corp | Compuestos heterocíclicos tricíclicos como activadores de STING |
| US11008344B2 (en) | 2018-07-31 | 2021-05-18 | Incyte Corporation | Tricyclic heteroaryl compounds as STING activators |
| US10875872B2 (en) | 2018-07-31 | 2020-12-29 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| JP7584802B2 (ja) * | 2018-08-24 | 2024-11-18 | アドライ・ノーティ・バイオファーマ・カンパニー・リミテッド | 高活性ｓｔｉｎｇタンパク質アゴニスト |
| CN111655682B (zh) * | 2018-08-29 | 2024-05-31 | 杭州阿诺生物医药科技有限公司 | 一种高活性sting蛋白激动剂化合物 |
| US11596692B1 (en) | 2018-11-21 | 2023-03-07 | Incyte Corporation | PD-L1/STING conjugates and methods of use |
| WO2020124059A1 (en) * | 2018-12-14 | 2020-06-18 | Eternity Bioscience Inc. | Tricyclic compounds as sting agonists, and preparation methods and medicinal uses thereof |
| US12129267B2 (en) | 2019-01-07 | 2024-10-29 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| CA3149482A1 (en) | 2019-08-02 | 2021-02-11 | Mersana Therapeutics, Inc. | Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer |
| WO2021202984A1 (en) | 2020-04-02 | 2021-10-07 | Mersana Therapeutics, Inc. | Antibody drug conjugates comprising sting agonists |
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
| CN115554303B (zh) * | 2021-09-18 | 2024-07-09 | 上海科技大学 | 一种三环类化合物、其制备方法及其应用 |
| CN119110800A (zh) * | 2022-02-21 | 2024-12-10 | 健道生物医药有限公司 | 干扰素基因刺激因子（sting）调节剂及其组合物和方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2731708B1 (fr) * | 1995-03-13 | 1997-04-30 | Synthelabo | Derives de piperidine, leur procede de preparation et leur application en therapeutique |
| FR2747678B1 (fr) * | 1996-04-22 | 1998-05-22 | Synthelabo | Composes derives d'imidazobenzoxazine, leurs procedes de preparation et leurs utilisations en therapeutique |
| CA2332239A1 (en) * | 1998-05-15 | 1999-11-25 | Guilford Pharmaceuticals Inc. | Fused tricyclic compounds which inhibit parp activity |
| ECSP003637A (es) * | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
| CA2324090A1 (en) | 1999-10-25 | 2001-04-25 | Leviton Manufacturing Co., Inc. | Electrical wiring device with multiple types of wire terminations |
| KR20080035576A (ko) * | 2005-08-05 | 2008-04-23 | 아스트라제네카 아베 | 트리사이클릭 벤즈이미다졸 및 대사체 글루타메이트 수용체조절제로서 이들의 용도 |
| EP2324044A4 (en) | 2008-08-04 | 2012-04-25 | Univ Miami | STING (STIMULATOR OF INTERFERON GENES) AS A REGULATOR OF BORROWING IMMUNE REACTIONS |
| CA2825028A1 (en) * | 2011-02-09 | 2012-08-16 | F. Hoffman-La Roche Ag | Heterocyclic compounds as pi3 kinase inhibitors |
| JP2015516989A (ja) | 2012-04-30 | 2015-06-18 | バーバー, グレン, エヌ.BARBER, Glen, N. | 免疫反応の変調 |
| US9527864B2 (en) * | 2014-09-15 | 2016-12-27 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| HRP20220936T1 (hr) | 2016-04-07 | 2022-10-28 | Glaxosmithkline Intellectual Property Development Limited | Heterociklički amidi korisni kao modulatori proteina |
| JP2019510802A (ja) * | 2016-04-07 | 2019-04-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | タンパク質調節物質として有用な複素環アミド |
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2019
- 2019-06-28 JP JP2020570791A patent/JP2021530442A/ja active Pending
- 2019-06-28 TW TW108123007A patent/TW202019408A/zh unknown
- 2019-06-28 EP EP19825637.2A patent/EP3813827A4/en not_active Withdrawn
- 2019-06-28 CN CN201980043105.6A patent/CN112351778B/zh active Active
- 2019-06-28 US US17/255,712 patent/US11535633B2/en active Active
- 2019-06-28 KR KR1020207037227A patent/KR20210025016A/ko not_active Ceased
- 2019-06-28 WO PCT/US2019/039860 patent/WO2020006432A1/en not_active Ceased