JPWO2019236699A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2019236699A5
JPWO2019236699A5 JP2020564904A JP2020564904A JPWO2019236699A5 JP WO2019236699 A5 JPWO2019236699 A5 JP WO2019236699A5 JP 2020564904 A JP2020564904 A JP 2020564904A JP 2020564904 A JP2020564904 A JP 2020564904A JP WO2019236699 A5 JPWO2019236699 A5 JP WO2019236699A5
Authority
JP
Japan
Prior art keywords
ethylpiperazine
trifluoromethyl
ethyl
carboxamide
ethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020564904A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021528375A (ja
JP7359783B2 (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/035572 external-priority patent/WO2019236699A1/en
Publication of JP2021528375A publication Critical patent/JP2021528375A/ja
Publication of JPWO2019236699A5 publication Critical patent/JPWO2019236699A5/ja
Priority to JP2023168698A priority Critical patent/JP2024009837A/ja
Application granted granted Critical
Publication of JP7359783B2 publication Critical patent/JP7359783B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020564904A 2018-06-05 2019-06-05 メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用 Active JP7359783B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023168698A JP2024009837A (ja) 2018-06-05 2023-09-28 メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862681011P 2018-06-05 2018-06-05
US62/681,011 2018-06-05
US201862734873P 2018-09-21 2018-09-21
US62/734,873 2018-09-21
PCT/US2019/035572 WO2019236699A1 (en) 2018-06-05 2019-06-05 Melanocortin subtype-2 receptor (mc2r) antagonists and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023168698A Division JP2024009837A (ja) 2018-06-05 2023-09-28 メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用

Publications (3)

Publication Number Publication Date
JP2021528375A JP2021528375A (ja) 2021-10-21
JPWO2019236699A5 true JPWO2019236699A5 (de) 2022-06-10
JP7359783B2 JP7359783B2 (ja) 2023-10-11

Family

ID=68692821

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020564904A Active JP7359783B2 (ja) 2018-06-05 2019-06-05 メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用
JP2023168698A Pending JP2024009837A (ja) 2018-06-05 2023-09-28 メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023168698A Pending JP2024009837A (ja) 2018-06-05 2023-09-28 メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用

Country Status (15)

Country Link
US (6) US10562884B2 (de)
EP (1) EP3802500A4 (de)
JP (2) JP7359783B2 (de)
KR (1) KR20210005995A (de)
CN (1) CN112533904A (de)
AU (1) AU2019280689A1 (de)
BR (1) BR112020024577A2 (de)
CA (1) CA3101644A1 (de)
IL (1) IL279152B1 (de)
MA (1) MA52806A (de)
MX (1) MX2020013085A (de)
SG (1) SG11202012071TA (de)
TW (1) TWI816809B (de)
WO (1) WO2019236699A1 (de)
ZA (1) ZA202007343B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020024577A2 (pt) 2018-06-05 2021-03-09 Crinetics Pharmaceuticals, Inc. Antagonistas de receptor de melanocortina subtipo 2 (mc2r) e usos dos mesmo
US20230015914A1 (en) * 2019-11-07 2023-01-19 Crinetics Pharmaceuticals, Inc. Melanocortin subtype-2 receptor (mc2r) antagonists and uses thereof
CA3164117A1 (en) * 2019-12-18 2021-06-24 Crinetics Pharmaceuticals, Inc. Gem-disubstituted piperidine melanocortin subtype-2 receptor (mc2r) antagonists and uses thereof
BR112023018816A2 (pt) * 2021-03-19 2023-10-31 Crinetics Pharmaceuticals Inc Antagonista do receptor de melanocortina subtipo-2 (mc2r) para o tratamento de doença
CN115368246A (zh) * 2021-05-21 2022-11-22 上海赛岚生物科技有限公司 一类精氨酸甲基转移酶抑制剂及其用途
WO2023163945A1 (en) * 2022-02-23 2023-08-31 Crinetics Pharmaceuticals, Inc. Treatment of congenital adrenal hyperplasia and polycystic ovary syndrome
WO2023219952A1 (en) * 2022-05-10 2023-11-16 Radionetics Oncology, Inc. Melanocortin type 2 receptor (mc2r) targeted therapeutics and uses thereof
WO2024130091A1 (en) * 2022-12-16 2024-06-20 Crinetics Pharmaceuticals, Inc. Crystalline melanocortin subtype-2 receptor (mc2r) antagonist

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004521117A (ja) * 2001-01-23 2004-07-15 イーライ・リリー・アンド・カンパニー メラノコルチン受容体アゴニストとしての置換ピペリジン／ピペラジン
US6977264B2 (en) 2001-07-25 2005-12-20 Amgen Inc. Substituted piperidines and methods of use
US7115607B2 (en) 2001-07-25 2006-10-03 Amgen Inc. Substituted piperazinyl amides and methods of use
EP1465867A1 (de) * 2001-10-09 2004-10-13 Neurocrine Biosciences, Inc. Liganden von melandocortinrezeptoren und damit in zusammenhang stehende zusammensetzungen und verfahren
WO2003068738A1 (en) 2002-02-11 2003-08-21 Neurocrine Biosciences, Inc. Pyrrole derivatives as ligands of melanocortin receptors
AU2003230367A1 (en) * 2002-05-10 2003-11-11 Neurocrine Biosciences, Inc. Substituted piperazine as melanocortin receptors ligands
WO2004081643A1 (en) * 2002-12-20 2004-09-23 Kaiser Aerospace & Electronics Corp. Lenslet array with polarization conversion
PT1656361E (pt) 2003-08-11 2008-03-05 Hoffmann La Roche Piperazina com um grupo fenilo substituído do tipo or e a sua utilização como inibidor de tgli1
ES2294529T3 (es) 2003-09-09 2008-04-01 F. Hoffmann-La Roche Ag Derivados de 1-(2-amino-benzoil)-piperacina como inhibidores de absorcion de glicina para el tratamiento de psicosis.
US20050124625A1 (en) 2003-10-21 2005-06-09 Salvati Mark E. Piperazine derivatives and their use as modulators of nuclear hormone receptor function
US20050119252A1 (en) 2003-10-22 2005-06-02 Neurocrine Biosciences, Inc. Ligands of melanocortin receptors and compositions and methods related thereto
US20050192286A1 (en) * 2003-10-22 2005-09-01 Neurocrine Biosciences, Inc. Ligands of melanocortin receptors and compositions and methods related thereto
RU2303597C1 (ru) * 2006-05-12 2007-07-27 Иващенко Андрей Александрович Фармацевтическая композиция, способы ее получения и применения
EP3199156A1 (de) 2016-02-01 2017-08-02 Heinrich-Heine-Universität Düsseldorf Verwendung von glycin-transporter-1-antagonisten als zentralnervöse analgetika
BR112020024577A2 (pt) 2018-06-05 2021-03-09 Crinetics Pharmaceuticals, Inc. Antagonistas de receptor de melanocortina subtipo 2 (mc2r) e usos dos mesmo

Similar Documents

Publication Publication Date Title
Tuchin Coherent-domain optical methods: Biomedical diagnostics, environment and material science
US10766877B2 (en) Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof
EP2426125B1 (de) 1,4-disubstituierte 3-Cyanpyridon-Derivate und ihre Verwendung als positive allosterische Modulatoren von mGluR2-Rezeptoren
RU2641291C2 (ru) Частично насыщенное азотсодержащее гетероциклическое соединение
AU2006311797A1 (en) Aminopyrimidines useful as kinase inhibitors
NZ541885A (en) Gyrase inhibitors and uses thereof
AU2014214846A1 (en) ERK inhibitors and uses thereof
AU2020407664A1 (en) Fluoroalkyl-oxadiazoles and uses thereof
AU2004322641A1 (en) Gyrase inhibitors and uses thereof
EA032577B1 (ru) Гетероарильные соединения, пригодные в качестве ингибиторов sumo-активирующего фермента
JPWO2019236699A5 (de)
US7368575B2 (en) 6-alkylamino-2,2′-disubstituted-7,8-disubstituted-2H-1-benzopyran derivatives as 5-lipoxygenase inhibitor
US5919824A (en) Aminophenol derivatives
EA045243B1 (ru) Антагонисты рецептора меланокортина 2 подтипа (mc2r) и пути их применения
JP2001342134A (ja) １−メチルカルバペネム誘導体を含有する抗菌剤
JP2000229969A (ja) １−メチルカルバペネム誘導体
AU2013201630A1 (en) Aminopyrimidines useful as kinase inhibitors