JPWO2019217433A5

JPWO2019217433A5 -

Info

Publication number: JPWO2019217433A5
Application number: JP2020561880A
Authority: JP
Publication date: 2022-05-16

Claims

With an ablation device containing multiple electrodes configured to generate an electric field to ablate the tissue within the subject.
A pulse waveform generator that can be coupled to the ablation device and is configured to deliver a voltage pulse to the ablation device in the form of a pulse waveform.
A first level of the hierarchy of the pulse waveform, the first level of the pulse, comprising a first set of pulses and a first time delay separating the continuous pulses of the first set of pulses. The first level, where each pulse in the set has a pulse duration,
A second set of pulses includes a second set of pulses and a second time delay that separates a contiguous first set of pulses out of the first set of pulses. A second level of the hierarchy, wherein each second time delay is at least three times as long as the first time delay.
The third level of the hierarchy separates a plurality of second sets of pulses as a third set of pulses and a contiguous second set of pulses out of the plurality of second sets of pulses. Each third time delay, including the third time delay, is at least 30 times longer than the second time delay.
A fourth set of pulses includes a third set of pulses and a fourth time delay that separates a contiguous third set of pulses out of the third set of pulses. A pulse waveform generator comprising a fourth level, wherein each fourth level has a duration of at least 10 times the third time delay, the fourth level of the hierarchy. system.

Each pulse in each first set of pulses comprises a two-phase pulse each having a voltage amplitude of at least 500 volts, and the pulse duration of each two-phase pulse is 0 . The system of claim 1, wherein the system ranges from 5 nanoseconds to 20 microseconds.

The system of claim 1, wherein the fourth set of pulses comprises at least two third sets of pulses and a third set of less than 40 pulses.

The system of claim 1, wherein each fourth time delay has a fixed period.

The system according to claim 1, wherein the period of the fourth time delay is different.

The system of claim 5, wherein the fourth time delay comprises a repeat value of at least one time delay.

The system of claim 5, wherein each fourth time delay has a period ranging from at least 10 times the time delay to less than 1000 times the third time delay.

The system of claim 1, wherein each fourth time delay period is greater than the cardiac cycle of the heart.

The pulse waveform further separates a plurality of fourth sets of pulses as a fifth set of pulses and a contiguous fourth set of pulses out of the plurality of fourth sets of pulses. 1 . system.

The pulse waveform generator is placed in the cardiac cycle of the heart so that a contiguous second set of pulses of the plurality of second sets of the pulses is delivered during the refractory period of the heart's distinct cardiac cycle. 1. system.

10. The system of claim 10, wherein each second set of pulses comprises at least two first sets of pulses, and less than 40 first sets of pulses.

10. The system of claim 10, further comprising a cardiac stimulator configured to generate a pacing signal to control the timing of the cardiac cycle of the heart.

The pulse waveform generator is further configured to deliver the voltage pulse to a plurality of electrode sets of the ablation device, and the voltage pulse delivered to the first electrode set is the voltage to the second electrode set. The system of claim 1, wherein the pulse delivery is off by a certain amount of time.