CN114209413A - Multi-stage controllable composite pulse generation control system - Google Patents
Multi-stage controllable composite pulse generation control system Download PDFInfo
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Abstract
The application discloses control system takes place for multistage controllable compound pulse, generate the unit including first pulse, output two-way high-pressure high frequency microsecond pulse burst and two-way high frequency nanosecond pulse burst respectively, two-way high-pressure high frequency microsecond pulse burst is connected with electrode group through first high voltage switch array, two-way high frequency nanosecond pulse burst is connected with electrode group through second high voltage switch array, electrode group includes N group's electrode, and first high voltage switch array or second high voltage switch array are used for the control to act on the break-make of the electrode of human body portion of waiting to melt. The multi-stage controllable composite pulse generation control system comprises two paths of mutually independent pulse output loops, and the two-way high-voltage high-frequency microsecond pulse group and the two-way high-frequency nanosecond pulse group are respectively output, so that multi-level pulse width continuous adjustment of nanosecond high-voltage pulses can be realized, and meanwhile, the electrical parameters of the microsecond high-frequency high-voltage pulses can be continuously adjusted.
Description
Technical Field
The application relates to the field of medical equipment, in particular to a multi-stage controllable composite pulse generation control system.
Background
Pulsed electric field ablation is a novel "sharp instrument" for treating pancreatic cancer. In recent years, tumor ablation technology has become one of the most promising methods for treating solid tumors in this century by virtue of the advantages of small trauma, good curative effect, quick recovery, repeatability and the like. The medicine achieves the curative effect which is comparable with that of the operation in partial tumors of liver, lung, kidney, thyroid gland and the like, and is called as a 'knife' without moving knife. However, the traditional ablation technology (radio frequency, microwave, laser, cryoablation, etc.) can damage surrounding important structures while killing tumor cells by using the cold/heat effect, so that severe complications such as pancreatic fistula, biliary fistula, hemorrhage, etc. are easily caused, and the pancreas becomes an applied 'forbidden region'. With the development of national defense high-power impulse weapon technology and the deepening of cell electrophysiology understanding, a novel impulse electric field ablation technology comes into force.
Different from the traditional ablation, the pulse electric field ablation is to apply high-voltage electric pulses to phospholipid bilayers of cell membranes in a short time to cause transmembrane potential to be formed, so that unstable potential is generated, irreversible penetrating damage is formed on the cell membranes, and nanoscale pores are generated. However, in the current pulsed electric field ablation technology, the microsecond pulse technology generally adopts the low-voltage unipolar pulse technology, and in order to achieve an ideal ablation range, the pulse width needs to be increased to improve the energy density, but the problem of serious muscle jitter is caused along with the increase of the pulse width; moreover, the unipolar pulse also has the problems of uneven pulse electric field distribution and uneven distribution of the ablation range between the anode and the cathode.
Disclosure of Invention
The utility model aims to provide a control system takes place for multistage controllable compound pulse reduces single pulse width according to the dose-effect relation to multistage compound narrow pulse crowd replaces single wide pulse, promotes the voltage level, reaches the same effect of melting with low pressure wide pulse, has solved the muscle shake problem that the wide pulse brought simultaneously again.
The application discloses control system takes place for multistage controllable compound pulse, generate the unit including first pulse, output two-way high-pressure high frequency microsecond pulse burst and two-way high frequency nanosecond pulse burst respectively, two-way high-pressure high frequency microsecond pulse burst is connected with electrode group through first high voltage switch array, two-way high frequency nanosecond pulse burst is connected with electrode group through second high voltage switch array, electrode group includes N group's electrode, and first high voltage switch array or second high voltage switch array are used for the control to act on the break-make of the electrode of human body portion of waiting to melt.
Preferably, the pulse frequency of the bidirectional high-voltage high-frequency microsecond pulse group is 1 Hz-30 KHz, and the microsecond pulse width is 1 uS-200 uS.
Preferably, the pulse frequency of the bidirectional high-frequency nanosecond pulse group is 1 Hz-100 KHz, and the nanosecond pulse width is 10 nS-900 nS.
Preferably, the first pulse generating unit includes a main control unit, a high voltage power supply unit, and a first pulse unit; the second pulse generating unit comprises a main control unit, a high-voltage power supply unit and a second pulse unit; the main control unit is connected with the input end of the high-voltage power supply unit; the output end of the high-voltage power supply unit is electrically connected with the first pulse unit through a first switch;
the main control unit sends a control signal to the high-voltage power supply unit, and when the first switch is in a first state, the first pulse unit works and outputs a bidirectional high-voltage high-frequency microsecond pulse group; when the first switch is in a second state, the second pulse unit works and outputs a bidirectional high-frequency nanosecond pulse group.
Preferably, an adjustable resistor VR is arranged between the high-voltage power supply unit and the first switch.
Preferably, a first isolation transformer is arranged between the first pulse unit and the first high-voltage switch array, a first current sensor is further arranged at the output end of the first isolation transformer, and the first current sensor is electrically connected with the main control unit; and a second isolation transformer is arranged between the second pulse unit and the second high-voltage switch array, a second current sensor is further arranged at the output end of the second isolation transformer, and the second current sensor is electrically connected with the main control unit.
Preferably, the first pulse unit comprises a first high-voltage capacitor and a first high-voltage switch, and the first high-voltage switch is an H-bridge circuit; the first high-voltage capacitor is connected in parallel with the H-bridge circuit; the second pulse unit comprises a second high-voltage capacitor and a second high-voltage switch, and the second high-voltage switch is a SIC high-voltage switch; and the second high-voltage capacitor is connected with the SIC high-voltage switch in parallel.
Preferably, the intelligent control system further comprises a switch unit and a display unit, and the switch unit and the display unit are both connected with the main control unit.
Preferably, the pulse cardiac generator further comprises an electrocardio unit for collecting electrocardiosignals, the electrocardio unit is connected with the input end of the main control unit, and the main control unit controls the first pulse unit or the second pulse unit to output pulse signals in the electrocardio refractory period of the heart.
Has the advantages that: the multi-stage controllable composite pulse generation control system comprises two paths of mutually independent pulse output loops, a bidirectional high-voltage high-frequency microsecond pulse group and a bidirectional high-frequency nanosecond pulse group are respectively output, and the two paths of mutually independent pulse output loops are conducted and switched through a first switch. The pulse group is used for replacing a single pulse to act on an ablation target point, and the pulse group is sent in a single electrocardio refractory period through a high-frequency and bidirectional pulse mode to weaken the muscle contraction reaction. And multi-electrode switching is carried out through the first/second high-voltage switch arrays, so that high-voltage multi-path independent output is realized, and ablation pulse energy is provided for different ablation target points. The method can realize nanosecond-level high-voltage pulse multi-level pulse width continuous adjustment, simultaneously realize microsecond-level high-frequency high-voltage pulse electrical parameter continuous adjustment, and the voltage level can be adjusted in a continuous wide range of 1KV-10KV, so that the method can be used for pulse ablation therapy or for exploring and testing optimal parameters of ablation effect, and provides various parameter supports for ablation of different tumor tissues.
Drawings
FIG. 1 is an electrical diagram of a composite pulse generation control system;
FIG. 2 is a schematic diagram of windings of a first isolation transformer and a second isolation transformer;
FIG. 3 is a diagram of a SIC high-voltage switch;
FIG. 4 is a schematic diagram of a first high voltage switch array;
FIG. 5 is an example of a single-level bi-directional high frequency pulse;
FIG. 6 is an example of a pulse burst bi-directional composite pulse;
FIG. 7 is an example of a stepped-up and stepped-down multi-level composite pulse burst;
FIG. 8 is an example of a complex burst of ramp-up and ramp-down with triangular envelopes;
FIG. 9 is an example of a slow-rise composite pulse burst;
FIG. 10 is an example of a slow-falling composite pulse burst;
in the figure: 100. a display unit; 110. a main control unit; 120. a switch unit; 130. a high voltage power supply unit; 140. an adjustable resistor; 150. a first switch; 151. a first high-voltage capacitor; 160. a first high voltage switch; 164. a first isolation transformer; 180. a first current sensor; 190. a first high voltage switch array; 200. a second high-voltage capacitor; 210 a second high voltage switch; 220. a second isolation transformer; 230. a second current sensor; 240. a second high voltage switch array; 250. a second drive circuit; 300. an electrocardiogram unit.
Detailed Description
In the following description, numerous technical details are set forth in order to provide a better understanding of the present application. However, it will be understood by those skilled in the art that the technical solutions claimed in the present application may be implemented without these technical details and with various changes and modifications based on the following embodiments.
To make the objects, technical solutions and advantages of the present application more clear, embodiments of the present application will be described in further detail below with reference to the accompanying drawings.
A multi-stage controllable composite pulse generation control system comprises a first pulse generation unit and a second pulse generation unit which respectively output a bidirectional high-voltage high-frequency microsecond pulse group and a bidirectional high-frequency nanosecond pulse group, and various pulse forms are shown in figures 5-10. The bidirectional high-voltage high-frequency microsecond pulse group is connected with the electrode group through the first high-voltage switch array, the bidirectional high-frequency nanosecond pulse group is connected with the electrode group through the second high-voltage switch array, and the electrode group comprises N groups of electrodes. In other words, the first pulse generating unit and the second pulse generating unit share one electrode group at a time. As shown in fig. 4, the first high-voltage switch array is used for controlling the on-off of the electrodes acting on the to-be-ablated part of the human body, 1, … …, p in the figure represents p groups of electrodes, and the second high-voltage switch array has the same structure as the first high-voltage switch array.
Specifically, as shown in fig. 1, the multi-stage controllable composite pulse generation control system includes a main control unit 110, a high voltage power supply unit 130, a first pulse unit, and a second pulse unit. The main control unit 110 is connected with the input end of the high-voltage power supply unit 130, and the output end of the high-voltage power supply unit 130 is connected with the first pulse unit and the second pulse unit through the first switch 150; the main control unit 110 sends a control signal to the high-voltage power supply unit 130, when the first switch 150 is in a first state, the first pulse unit works and outputs a bidirectional high-voltage high-frequency microsecond pulse group, the pulse frequency is 1 Hz-30 KHz, and the microsecond envelope pulse width is 1 uS-200 uS; when the first switch 150 is in a second state, the second pulse unit works to output a bidirectional high-frequency nanosecond pulse group, wherein the pulse frequency is 1 Hz-100 KHz, and the nanosecond pulse width is 10 nS-900 nS. The pulse voltage range is 200V-10000V. Specifically, the main control unit 110 adopts an MCU + FPGA control mode or a DSP + FPGA mode, which is a core control center of the entire control system and is responsible for sending driving signals, controlling high-voltage pulse voltage, controlling timing sequence, processing pulse current feedback, and processing and responding various abnormal signals. The high voltage power supply unit 130 is an energy provider of the pulse power supply, the voltage amplitude level of the high voltage power supply unit is accurately adjusted through a serial port instruction of the main control unit 110, and the voltage adjustment can be realized by low analog voltage adjustment, wherein the upper limit and the lower limit of the low analog voltage adjustment range respectively correspond to the upper limit voltage and the lower limit voltage output by the high voltage power supply unit 130, the ratio is constant, and the adjustment is limited. An adjustable resistor 140 is disposed between the high voltage power supply unit 130 and the first switch 150, and the adjustable resistor 140 is a high voltage power resistant resistor, which plays a role of current limiting and protects the first high voltage capacitor 151 and the second high voltage capacitor 200 from being damaged by high impact current.
In addition, in order to make the functions of the control system more complete, the control system of the present application further includes a display unit 100, a switch unit 120, and an electrocardiograph unit 300, and the display unit 100, the switch unit 120, and the electrocardiograph unit 300 are all connected to the main control unit 110. The display unit 100 may employ a liquid crystal display, a touchable display, a resistive mode screen, a capacitive mode screen, or the like. The display unit 100 is used for displaying the setting of the parameters of the electric pulses, the patient information, the pulse transmission mode, the voltage amplitude, the pulse width, the number of pulses and the status bar of the device before the pulses are transmitted; after entering the pulse transmission mode, the display unit 100 is configured to display parameters such as a pulse transmission progress, a pulse current, and a system state; after the pulse transmission is finished, the display unit 100 is used for displaying information such as pulse transmission end information and treatment parameter storage. The switch unit 120 is in a key on array or keyboard mode or in a touch screen form, and includes an emergency stop switch and a start switch. The switch unit 120 is used to control the input of the treatment parameters and the patient information, wherein the emergency switch is used to turn off the high voltage power unit 130 in case of emergency, and stop sending the pulse, for example, when the patient life index is abnormal, the high voltage pulse needs to be turned off in time. The electrocardiograph unit 300 is responsible for collecting electrocardiograph signals of a patient and generating R wave signals, the main controller unit determines a pulse sending time interval according to the received electrocardiograph signals, specifically, the time interval refers to a time period from the detection of the rising edge of the R wave to the end of the R wave, and the time interval is a ventricular contraction period, a safety refractory period and a safety period for sending pulses.
The first pulse unit and the second pulse unit are two relatively independent pulse units, and are switched on and off through the first switch 150. When the first switch 150 is in the normally closed mode, the system selects the first pulse unit, enters the microsecond pulse mode, has the voltage level range of 1-10KV, and adopts a four-way switch module (SW 1-SW 4) to realize a bidirectional pulse circuit. When the first switch 150 is switched to a normally open mode, the system selects the second pulse unit, is in a nanosecond pulse mode, has the voltage level range of 1-5KV, adopts a high-voltage SIC switch array to realize a pulse circuit, and sends a plurality of narrow pulses in a single electrocardio refractory period, thereby realizing high frequency and reducing muscle contraction reaction. The multi-stage controllable composite pulse generation control system realizes continuous adjustment of voltage level, pulse width and frequency, and provides multiple parameter support for ablation of different tumor tissues.
Specifically, the first pulse unit includes a first high-voltage capacitor 151, a first high-voltage switch 160, a first isolation transformer 164 and a first high-voltage switch array 190, an input end of the first high-voltage switch 160 is connected with the first switch 150, two paths of pulse signals are output to an input end of the first isolation transformer 164, and an output end of the first isolation transformer 164 is connected with the first high-voltage switch array 190; the first high voltage capacitor 151 is disposed in parallel with the first high voltage switch 160. The output end of the first isolation transformer 164 is further provided with a first current sensor 180, and the first current sensor 180 is electrically connected with the main control unit 110. The first high voltage switch array 190 includes multiple independent output electrodes, which act on the affected part. In addition, the high voltage power supply unit 130 provides a driving signal to the first high voltage switch 160 through the first driving circuit.
The first high-voltage capacitor 151 is a high-voltage energy storage capacitor, provides instantaneous high energy for high-voltage output pulses, has high voltage withstanding level and high discharging speed, and is a high-voltage thin-film capacitor. The first isolation transformer 164 is a high-power pulse transformer, as shown in fig. 2, and is configured to implement isolation and transformation of high-power ultrashort pulses, and the magnetic core is made of a material with high saturation magnetic induction intensity, high magnetic permeability, low coercive force and low loss, and may be an iron-based ultrafine crystal iron core or an iron-based ultrafine crystal strip. The winding of the first isolation transformer 164 adopts a high-voltage wire with high voltage resistance not less than 30KV, and the primary winding and the secondary winding adopt a process of crossing, overlapping and mutually winding a plurality of windings, so that the magnetic leakage is reduced, the coupling rate of magnetic inductance is increased, and the efficiency of energy transfer is improved. The first high voltage switch 160 is an H-bridge circuit including 4 switching tubes SW1-SW4, wherein SW1-SW4 may be implemented by high voltage IGBTs. The H-bridge circuit realizes voltage inversion, and converts the input direct-current high voltage into bidirectional high-frequency pulse voltage, namely high-frequency positive and negative pulses, wherein the high-frequency positive and negative pulses can make the electric field intensity in an ablation region more uniform, and charge accumulation can be released in time. The multi-stage controllable high-frequency pulse group bipolar alternate stimulation effectively reduces direct current charge accumulation and single pulse energy, and solves the muscle shaking phenomenon.
The first driving circuit provides isolated driving signals for the four switch modules SW1-SW4 of the H-bridge circuit, and enough dead zones are designed for driving the upper and lower tubes of the half bridge to ensure safe conduction and disconnection, so that the upper and lower tubes are prevented from being conducted simultaneously. The implementation process of the bidirectional high-voltage high-frequency microsecond pulse group comprises the following steps: when SW1 and SW4 are turned on simultaneously, a positive pulse is sent to the first isolation transformer 164 input; when SW2 and SW3 are on, a negative going pulse is sent to the first isolation transformer 164 input. Due to the larger parasitic parameters of the first high voltage switch 160 and the influence of the inductance of the input winding of the first isolation transformer 164, the turn-off delay of the first high voltage switch 160 during the pulse commutation is larger. In order to prevent the switch from being damaged by the simultaneous conduction of the upper and lower pair of transistors SW1 and SW2 or the simultaneous conduction of SW3 and SW4 during commutation, a delay time sufficient for commutation needs to be designed. The first current sensor 180 adopts a non-contact mutual inductance mode, meets the requirements of high precision and high speed of microsecond narrow-pulse current detection, and the detection precision of steep rising edges and falling edges reaches subnanosecond level. The first high voltage switch array 190 includes a plurality of output electrodes, each electrode being controlled by a relay. The first high-voltage switch array 190 is used for realizing multi-electrode switching, realizing high-voltage multi-path independent output and providing ablation pulse energy for different ablation target points.
Specifically, the second pulse unit includes a second high voltage capacitor 200, a second high voltage switch 210, a second isolation transformer 220, and a second high voltage switch array 240. The input end of the second high-voltage switch 210 is connected to the second switch, and outputs a path of pulse signal to the input end of the second isolation transformer 220, and the output end of the second isolation transformer 220 is connected to the second high-voltage switch array 240. The second high voltage switch 210 is a SIC high voltage switch, and the second high voltage capacitor 200 is arranged in parallel with the SIC high voltage switch. The output end of the second isolation transformer 220 is further provided with a second current sensor 230, and the second current sensor 230 is electrically connected with the main control unit 110. The second high voltage switch array 240 includes multiple independent output electrodes. The second high voltage capacitor 200, the second isolation transformer 220, and the second high voltage switch array 240 function similarly to the first high voltage capacitor 151, the first isolation transformer 164, and the first high voltage switch array 190. The high-voltage power supply unit 130 provides an isolation driving signal for the SIC high-voltage switch through the second driving circuit 250
As shown in fig. 3, the second high voltage switch 210 employs SIC tubes with high speed, low rising edge and low falling edge, and since the conventional SIC tube generally has a voltage withstanding grade of 1700V, a plurality of SIC tubes are connected in series to meet the set voltage withstanding requirement. In the SIC tube multistage series circuit, when in operation, several tubes connected in series are ideally switched on and off simultaneously, so that the voltage resistance of a single tube is uniform, but due to the difference of tube parameters, even if the same driving signal is simultaneously given, the several tubes connected in series are not synchronously switched on, and as a result, the tubes delayed to be switched on are subjected to voltage exceeding the self voltage resistance level, and the tubes can be damaged. In order to avoid the problem that a plurality of SIC tubes are unevenly distributed and easily cause the withstand voltage exceeding standard of a single tube to damage, the DRC voltage-sharing technology is adopted, a transient protection diode D, a resistor R and a capacitor C can clamp voltage in a safe range in the moment of overvoltage to protect the corresponding SIC tubes, and when the SIC tubes are conducted, a DRC circuit is in an out-of-work state and does not influence the performance of the SIC tubes. Meanwhile, a high-speed optical coupler and synchronous isolation driving are adopted, and the problem that the floating driving and the driving signals are asynchronous is solved.
Controlling the system working process:
after the control system is started, the main control unit 110 first detects whether the power supply system, the display unit, the emergency stop switch state and the like of the system are normal through a self-checking program, the self-checking is qualified, and after the pulse output port is connected with a load, treatment is prepared. The user inputs treatment parameters, patient information, etc. through the touch function of the switch unit 120 or the display unit 100. When the microsecond pulse is selected, the first switch 150 is not actuated in a normally closed state. When the pulse transmission is started, the main control unit 110 transmits a voltage command (how much voltage is output) to the high-voltage power supply unit 130 and controls the pulse width and frequency, and simultaneously transmits a driving signal to the first driving circuit, so that the SW1 and the SW4 of the H-bridge circuit are conducted, the SW2 and the SW3 are conducted after the dead zone is delayed, and the H-bridge circuit alternately transmits a positive pulse and a negative pulse; meanwhile, the main control unit 110 collects the current signal of the first current sensor 180 and processes and displays the current signal on the display unit 100, and if the current value exceeds the maximum limit value or is smaller than the minimum value, the high-voltage power supply unit 130 and the first driving circuit are immediately turned off, and system state warning information is displayed on the display unit 100: over-current or under-current. When the output voltage of the dc high voltage power supply unit 130 is lower than 20% of the set high voltage, the output is stopped, and the status bar indicates that the high voltage power supply unit 130 is under-voltage. If the system displays that all is normal, the pulse transmission is normally performed, and the information of the treatment parameters, the progress of the pulse transmission, the pulse current, the system state, etc. is displayed on the display unit 100. Similarly, when the system parameters are set, the nanosecond pulse mode is selected, the first switch 150 acts after the treatment is started, the second high-voltage capacitor 200 is connected, and the pulse commutation is realized through the second driving circuit 250 and the second high-voltage switch 210.
It is noted that, in the application, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, the use of the verb "comprise a" to define an element does not exclude the presence of another, same element in a process, method, article, or apparatus that comprises the element.
Further, it should be understood that various changes or modifications can be made to the present application by those skilled in the art after reading the contents of the present application, and these equivalents also fall within the scope of the claims of the present application.
Claims (9)
1. The multi-stage controllable composite pulse generation control system is characterized by comprising a first pulse generation unit and a second pulse generation unit, wherein the first pulse generation unit and the second pulse generation unit respectively output a bidirectional high-voltage high-frequency microsecond pulse group and a bidirectional high-frequency nanosecond pulse group; the bidirectional high-voltage high-frequency microsecond pulse group is connected with the electrode group through a first high-voltage switch array, and the bidirectional high-frequency nanosecond pulse group is connected with the electrode group through a second high-voltage switch array; the electrode group comprises N groups of electrodes; the first high-voltage switch array or the second high-voltage switch array is used for controlling the on-off of the electrode acting on the to-be-ablated part of the human body.
2. The multi-stage controllable composite pulse generation control system according to claim 1, wherein the bidirectional high-voltage high-frequency microsecond pulse group has a pulse frequency of 1 Hz-30 KHz and a microsecond pulse width of 1 uS-200 uS.
3. The multi-stage controllable composite pulse generation control system according to claim 1, wherein the bidirectional high-frequency nanosecond pulse train has a pulse frequency of 1 Hz-100 KHz and a nanosecond pulse width of 10 nS-900 nS.
4. A multi-stage controllable composite pulse generating control system according to claim 1, 2 or 3, wherein the first pulse generating unit comprises a main control unit, a high voltage power supply unit, and a first pulse unit; the second pulse generating unit comprises a main control unit, a high-voltage power supply unit and a second pulse unit;
the main control unit is connected with the input end of the high-voltage power supply unit;
the output end of the high-voltage power supply unit is electrically connected with the first pulse unit through a first switch;
the main control unit sends a control signal to the high-voltage power supply unit, and when the first switch is in a first state, the first pulse unit works and outputs a bidirectional high-voltage high-frequency microsecond pulse group; when the first switch is in a second state, the second pulse unit works and outputs a bidirectional high-frequency nanosecond pulse group.
5. The multiple-stage controllable composite pulse generation control system according to claim 4, wherein an adjustable resistor VR is arranged between the high-voltage power supply unit and the first switch.
6. The multi-stage controllable composite pulse generating control system according to claim 4,
a first isolation transformer is arranged between the first pulse unit and the first high-voltage switch array, a first current sensor is further arranged at the output end of the first isolation transformer, and the first current sensor is electrically connected with the main control unit;
and a second isolation transformer is arranged between the second pulse unit and the second high-voltage switch array, a second current sensor is further arranged at the output end of the second isolation transformer, and the second current sensor is electrically connected with the main control unit.
7. The multi-stage controllable composite pulse generating control system according to claim 4,
the first pulse unit comprises a first high-voltage capacitor and a first high-voltage switch, and the first high-voltage switch is an H-bridge circuit; the first high-voltage capacitor is connected in parallel with the H-bridge circuit;
the second pulse unit comprises a second high-voltage capacitor and a second high-voltage switch, and the second high-voltage switch is a SIC high-voltage switch; and the second high-voltage capacitor is connected with the SIC high-voltage switch in parallel.
8. The multi-stage controllable composite pulse generation control system according to claim 4, further comprising a switch unit and a display unit, both of which are connected to the main control unit.
9. The multi-stage controllable composite pulse generating control system according to claim 4,
the electrocardio-signal acquisition device is characterized by further comprising an electrocardio unit for acquiring electrocardiosignals, wherein the electrocardio unit is connected with the input end of the main control unit, and the main control unit controls the first pulse unit or the second pulse unit to output pulse signals in the electrocardio refractory period of the heart.
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