JPWO2019210109A5 - - Google Patents
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- Publication number
- JPWO2019210109A5 JPWO2019210109A5 JP2020560247A JP2020560247A JPWO2019210109A5 JP WO2019210109 A5 JPWO2019210109 A5 JP WO2019210109A5 JP 2020560247 A JP2020560247 A JP 2020560247A JP 2020560247 A JP2020560247 A JP 2020560247A JP WO2019210109 A5 JPWO2019210109 A5 JP WO2019210109A5
- Authority
- JP
- Japan
- Prior art keywords
- abcb5
- pip2
- composition
- isoform
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101150037263 PIP2 gene Proteins 0.000 claims 18
- 101100262439 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) UBA2 gene Proteins 0.000 claims 18
- 102100021501 ATP-binding cassette sub-family B member 5 Human genes 0.000 claims 15
- 101000677872 Homo sapiens ATP-binding cassette sub-family B member 5 Proteins 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 201000011510 cancer Diseases 0.000 claims 11
- 102000001708 Protein Isoforms Human genes 0.000 claims 10
- 108010029485 Protein Isoforms Proteins 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 7
- 150000003904 phospholipids Chemical class 0.000 claims 7
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 claims 6
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 6
- 239000000556 agonist Substances 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 101150010947 ABCB5 gene Proteins 0.000 claims 5
- 125000005313 fatty acid group Chemical group 0.000 claims 5
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 4
- 235000013922 glutamic acid Nutrition 0.000 claims 4
- 239000004220 glutamic acid Substances 0.000 claims 4
- 230000037361 pathway Effects 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Substances [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108091079001 CRISPR RNA Proteins 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 108091028113 Trans-activating crRNA Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 2
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims 1
- 101100297694 Arabidopsis thaliana PIP2-7 gene Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108091007960 PI3Ks Proteins 0.000 claims 1
- 101100456541 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) MEC3 gene Proteins 0.000 claims 1
- 101100483663 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) UFD1 gene Proteins 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 238000010362 genome editing Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024061950A JP2024154382A (ja) | 2018-04-25 | 2024-04-08 | Ａｂｃｂ５のリガンドおよび基質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862662670P | 2018-04-25 | 2018-04-25 | |
| US62/662,670 | 2018-04-25 | ||
| PCT/US2019/029235 WO2019210109A1 (en) | 2018-04-25 | 2019-04-25 | Abcb5 ligands and substrates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024061950A Division JP2024154382A (ja) | 2018-04-25 | 2024-04-08 | Ａｂｃｂ５のリガンドおよび基質 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021522266A JP2021522266A (ja) | 2021-08-30 |
| JP2021522266A5 JP2021522266A5 (https=) | 2022-05-09 |
| JPWO2019210109A5 true JPWO2019210109A5 (https=) | 2022-05-09 |
| JP7611701B2 JP7611701B2 (ja) | 2025-01-10 |
Family
ID=68295729
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560247A Active JP7611701B2 (ja) | 2018-04-25 | 2019-04-25 | Ａｂｃｂ５のリガンドおよび基質 |
| JP2024061950A Pending JP2024154382A (ja) | 2018-04-25 | 2024-04-08 | Ａｂｃｂ５のリガンドおよび基質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024061950A Pending JP2024154382A (ja) | 2018-04-25 | 2024-04-08 | Ａｂｃｂ５のリガンドおよび基質 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12448461B2 (https=) |
| EP (1) | EP3784249A4 (https=) |
| JP (2) | JP7611701B2 (https=) |
| KR (2) | KR102928177B1 (https=) |
| CN (1) | CN112423765A (https=) |
| AU (2) | AU2019257728A1 (https=) |
| CA (1) | CA3097875A1 (https=) |
| MX (1) | MX2020011297A (https=) |
| SG (1) | SG11202010260XA (https=) |
| WO (1) | WO2019210109A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2772535T1 (sl) | 2006-05-31 | 2022-08-31 | Children's Medical Center Corporation | ABC5 pozitivne mezenhimske matične celice kot imunomodulatorji |
| US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
| AU2014262590B2 (en) | 2013-05-10 | 2018-05-10 | Children's Medical Center Corporation | Wound healing and tissue engineering |
| CN111007240A (zh) * | 2019-12-02 | 2020-04-14 | 中国医学科学院北京协和医院 | 一种基于crispr技术的均相酶免疫检验系统及其方法和应用 |
| CN115835882A (zh) * | 2020-04-15 | 2023-03-21 | 儿童医学中心公司 | 靶向多形性胶质母细胞瘤中的abcb5 |
| CN113082210B (zh) * | 2021-03-09 | 2023-04-18 | 广州白云山医药集团股份有限公司白云山制药总厂 | 一种肿瘤化疗药物组合物 |
| CN116445573A (zh) * | 2022-08-30 | 2023-07-18 | 苏州大学 | 一种以抑制trim54泛素化降解stat2为靶点的抗病毒ade药物筛选方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3587465T2 (de) | 1984-09-10 | 1994-01-20 | Hsc Res Dev Corp | Vielfache Drogen-Resistenz in Säugetierzellinien und Isolierung der determinanten Glykoprotein-DNS. |
| US5837258A (en) | 1991-08-30 | 1998-11-17 | University Of South Florida | Induction of tissue, bone or cartilage formation using connective tissue growth factor |
| ES2329953T3 (es) | 1996-04-19 | 2009-12-02 | Osiris Therapeutics, Inc. | Regeneracion e incremento de hueso utilizando celulas madre mesenquimales. |
| US6152142A (en) | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
| AU749675B2 (en) | 1998-03-13 | 2002-07-04 | Mesoblast International Sarl | Uses for human non-autologous mesenchymal stem cells |
| US6368636B1 (en) | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| CA2266805C (en) | 1998-03-27 | 2015-04-28 | An-Go-Gen Inc. | Cell-based gene therapy in the treatment of pulmonary disorders |
| AU2999199A (en) | 1998-04-03 | 1999-10-25 | Osiris Therapeutics, Inc. | Mesenchymal stem cells as immunosuppressants |
| PT1082410E (pt) | 1998-05-29 | 2007-11-09 | Osiris Therapeutics Inc | Células estaminais mesenquimatosas humanas cd45+ e/ou fibroblastos+ |
| JP2003510071A (ja) | 1999-09-28 | 2003-03-18 | ジェンテスト・コーポレーション | Ｐ−糖タンパク質およびその使用 |
| US6673606B1 (en) | 2000-04-12 | 2004-01-06 | The Children's Hospital Of Philadelphia | Therapeutic uses for mesenchymal stromal cells |
| CA2411101C (en) | 2000-06-05 | 2018-01-16 | Brigham And Women's Hospital, Inc. | A gene encoding a multidrug resistance human p-glycoprotein homologue on chromosome 7p15-21 and uses thereof |
| US20040175366A1 (en) | 2003-03-07 | 2004-09-09 | Acell, Inc. | Scaffold for cell growth and differentiation |
| EP1702061A4 (en) | 2003-11-24 | 2007-05-02 | Univ Rockefeller | METHOD OF INSULATING A SELF-RENEWING, MULTIPOTENTIAL, SLOWLY CIRCULATING CELL |
| US20050186672A1 (en) | 2004-01-27 | 2005-08-25 | Reliance Life Sciences Pvt. Ltd. | Tissue system with undifferentiated stem cells derived from corneal limbus |
| WO2006103685A2 (en) | 2005-03-28 | 2006-10-05 | Vision Research Foundation | A method for cultivating cells derived from corneal limbal tissue and cells deived from corneal limbal tissue |
| KR101441843B1 (ko) | 2005-10-18 | 2014-09-17 | 내셔날 쥬이쉬 헬스 | 조건부 불멸화 장기 줄기 세포 및 상기 세포의 제조 및 사용 방법 |
| WO2007112097A2 (en) | 2006-03-24 | 2007-10-04 | Children's Medical Center Corporation | Novel signature self renewal gene expression programs |
| GB0610778D0 (en) | 2006-05-31 | 2006-07-12 | Het Nl Kanker I | Phosphatidylinositol phospahte and apoptosis |
| SI2772535T1 (sl) | 2006-05-31 | 2022-08-31 | Children's Medical Center Corporation | ABC5 pozitivne mezenhimske matične celice kot imunomodulatorji |
| WO2008013492A1 (en) | 2006-07-28 | 2008-01-31 | Chundsell Medicals Ab | Embryonic stem cell markers for cancer diagnosis and prognosis |
| WO2008064244A2 (en) | 2006-11-20 | 2008-05-29 | The Trustees Of Columbia University In The City Of New York | Phosphoinositide modulation for the treatment of neurodegenerative diseases |
| EP2155248B1 (en) | 2007-04-12 | 2015-06-10 | The Brigham and Women's Hospital, Inc. | Targeting abcb5 for cancer therapy |
| US9011840B2 (en) | 2008-03-14 | 2015-04-21 | The Board Of Trustees Of The University Of Illinois | Activated mesenchymal stem cells for wound healing and impaired tissue regeneration |
| EP3978928A1 (en) | 2008-11-14 | 2022-04-06 | The Brigham and Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
| US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
| WO2010065711A1 (en) * | 2008-12-04 | 2010-06-10 | Adimab, Inc. | An abcb5 epitope and antibodies thereto for the treatment of cancer |
| KR101138091B1 (ko) | 2011-08-31 | 2012-04-24 | 세원셀론텍(주) | 중간엽 줄기세포 기본 배양 배지 조성방법, 중간엽 줄기세포 기본 배양 배지 및 이를 이용하여 배양분화된 세포치료제 |
| WO2014130518A1 (en) | 2013-02-19 | 2014-08-28 | Children's Medical Center Corporation | Abcb5(+) stem cells for treating ocular disease |
| AU2014262590B2 (en) | 2013-05-10 | 2018-05-10 | Children's Medical Center Corporation | Wound healing and tissue engineering |
| WO2016179576A1 (en) * | 2015-05-07 | 2016-11-10 | Bioxcel Corporation | Novel immunomodulatory therapeutic strategies targeting tumors in cancer |
| WO2016184793A1 (en) * | 2015-05-15 | 2016-11-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating a patient with vegfr inhibitor-resistant metastatic renal cell carcinoma |
| ES2905558T3 (es) | 2015-11-13 | 2022-04-11 | Avellino Lab Usa Inc | Procedimientos para el tratamiento de las distrofias corneales |
| WO2018185584A1 (en) | 2017-04-05 | 2018-10-11 | Pluristem Ltd. | Methods and compositions for treating acute lung injury and respiratory distress syndrome |
| US20220184136A1 (en) | 2019-03-28 | 2022-06-16 | Children's Medical Center Corporation | Highly functional manufactured abcb5+ mesenchymal stem cells |
| AU2020368845A1 (en) | 2019-10-18 | 2022-05-12 | Amniotics Ab | Processes and apparatuses for obtaining amniotic mesenchymal stem cells from amniotic fluid and cells derived thereof |
| EP4125960A4 (en) | 2020-03-30 | 2024-04-03 | Children's Medical Center Corporation | USING STEM CELLS TO TREAT EXCESSIVE INFLAMMATION |
| CN115835882A (zh) | 2020-04-15 | 2023-03-21 | 儿童医学中心公司 | 靶向多形性胶质母细胞瘤中的abcb5 |
| AU2021262864A1 (en) | 2020-04-30 | 2022-11-17 | Children's Medical Center Corporation | Antibodies specific to ABCB5 and uses thereof |
-
2019
- 2019-04-25 MX MX2020011297A patent/MX2020011297A/es unknown
- 2019-04-25 CA CA3097875A patent/CA3097875A1/en active Pending
- 2019-04-25 AU AU2019257728A patent/AU2019257728A1/en not_active Abandoned
- 2019-04-25 SG SG11202010260XA patent/SG11202010260XA/en unknown
- 2019-04-25 KR KR1020207033473A patent/KR102928177B1/ko active Active
- 2019-04-25 EP EP19793673.5A patent/EP3784249A4/en active Pending
- 2019-04-25 CN CN201980027801.8A patent/CN112423765A/zh active Pending
- 2019-04-25 US US17/050,424 patent/US12448461B2/en active Active
- 2019-04-25 KR KR1020267004454A patent/KR20260025888A/ko active Pending
- 2019-04-25 WO PCT/US2019/029235 patent/WO2019210109A1/en not_active Ceased
- 2019-04-25 JP JP2020560247A patent/JP7611701B2/ja active Active
-
2024
- 2024-04-08 JP JP2024061950A patent/JP2024154382A/ja active Pending
-
2025
- 2025-03-13 AU AU2025201810A patent/AU2025201810A1/en active Pending
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