JPWO2019193119A5 - - Google Patents
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- Publication number
- JPWO2019193119A5 JPWO2019193119A5 JP2020554181A JP2020554181A JPWO2019193119A5 JP WO2019193119 A5 JPWO2019193119 A5 JP WO2019193119A5 JP 2020554181 A JP2020554181 A JP 2020554181A JP 2020554181 A JP2020554181 A JP 2020554181A JP WO2019193119 A5 JPWO2019193119 A5 JP WO2019193119A5
- Authority
- JP
- Japan
- Prior art keywords
- aav
- sequence
- recombinant
- aav9
- aavrh74
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18305399.0 | 2018-04-05 | ||
| EP18305399 | 2018-04-05 | ||
| PCT/EP2019/058560 WO2019193119A1 (fr) | 2018-04-05 | 2019-04-04 | Sérotype du virus adéno-associé recombinant hybride entre aav9 et aavrh74 possédant un tropisme hépatique réduit |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021520203A JP2021520203A (ja) | 2021-08-19 |
| JPWO2019193119A5 true JPWO2019193119A5 (fr) | 2022-04-25 |
| JP7374119B2 JP7374119B2 (ja) | 2023-11-06 |
Family
ID=62063468
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020554181A Active JP7374119B2 (ja) | 2018-04-05 | 2019-04-04 | 減少した肝臓向性を有するＡＡＶ９とＡＡＶｒｈ７４とのハイブリッド組換えアデノ随伴ウイルス血清型 |
| JP2021558887A Withdrawn JP2022526405A (ja) | 2018-04-05 | 2019-10-04 | 肝向性の低減及び筋形質導入の増大を有するＡＡＶ９とＡＡＶｒｈ７４とのペプチド改変ハイブリッド組換えアデノ随伴ウイルス血清型 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021558887A Withdrawn JP2022526405A (ja) | 2018-04-05 | 2019-10-04 | 肝向性の低減及び筋形質導入の増大を有するＡＡＶ９とＡＡＶｒｈ７４とのペプチド改変ハイブリッド組換えアデノ随伴ウイルス血清型 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US12037362B2 (fr) |
| EP (2) | EP3775173A1 (fr) |
| JP (2) | JP7374119B2 (fr) |
| KR (2) | KR20210015770A (fr) |
| CN (1) | CN113795574A (fr) |
| AU (2) | AU2019249890A1 (fr) |
| BR (2) | BR112020020223A2 (fr) |
| CA (2) | CA3093347A1 (fr) |
| IL (2) | IL277740A (fr) |
| MA (1) | MA51353B1 (fr) |
| TN (1) | TN2020000187A1 (fr) |
| WO (2) | WO2019193119A1 (fr) |
| ZA (1) | ZA202005422B (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112040988A (zh) * | 2018-04-27 | 2020-12-04 | 海德堡大学 | 修饰的aav衣壳多肽用于治疗肌肉疾病 |
| WO2021053124A1 (fr) | 2019-09-19 | 2021-03-25 | Genethon | Système d'expression de thérapie génique atténuant la toxicité cardiaque de fkrp |
| EP4073087A4 (fr) * | 2019-11-08 | 2023-11-29 | The Board Of Regents Of The University Of Texas System | Vecteur viral adéno-associé recombiné pour la délivrance de gènes |
| TW202129002A (zh) * | 2019-12-09 | 2021-08-01 | 英商Ｕｃｌ商業有限責任公司 | 用於myh7關聯之心肌病之基因療法組合物及治療 |
| US20230032826A1 (en) | 2019-12-18 | 2023-02-02 | Genethon | Production of recombinant viral vectors from plant hairy roots |
| WO2021229255A1 (fr) | 2020-05-14 | 2021-11-18 | Genethon | Outils et procédé de prévention d'une neutralisation des virus vaa par des anticorps |
| EP3913060A1 (fr) | 2020-05-22 | 2021-11-24 | Genethon | Vecteurs codant la glucose-6-phosphatase (g6pase-a) pour la thérapie génique |
| EP4162049A1 (fr) | 2020-06-09 | 2023-04-12 | Genethon | Inhibiteurs de cilp-1 destinés à être utilisés dans le traitement de cardiomyopathies dilatées |
| EP4161559A1 (fr) | 2020-06-09 | 2023-04-12 | Genethon | Activateur de nrf2 destiné à être utilisé dans le traitement de cardiomyopathies dilatées |
| CA3185497A1 (fr) | 2020-06-09 | 2021-12-16 | Genethon | Traitement de cardiomyopathies dilatees genetiques |
| US20230256117A1 (en) | 2020-06-19 | 2023-08-17 | Genethon | Gene therapy expression system allowing an adequate expression in the muscles and in the heart of sgcg |
| US20230242905A1 (en) | 2020-07-03 | 2023-08-03 | Genethon | Method for Engineering Novel Hybrid AAV Capsids Through Hyper Variable Regions Swapping |
| CA3184923A1 (fr) | 2020-07-10 | 2022-01-13 | William LOSTAL | Nouveau promoteur specifique des muscles |
| CN116096431A (zh) | 2020-09-10 | 2023-05-09 | 吉尼松公司 | 肽修饰的aav衣壳 |
| US20230272433A1 (en) | 2020-09-29 | 2023-08-31 | Genethon | Enhancing Utrophin Expression in Cell by Inducing Mutations Within Utrophin Regulatory Elements and Therapeutic Use Thereof |
| WO2022204476A1 (fr) | 2021-03-26 | 2022-09-29 | The Board Of Regents Of The University Of Texas System | Édition de nucléotides pour remettre en phase des transcrits de la dmd par édition de base et édition génomique prémium (« prime editing ») |
| WO2022226301A1 (fr) * | 2021-04-23 | 2022-10-27 | The University Of North Carolina At Chapel Hill | Capsides de vaa tropiques chimériques cardiaques |
| JP2024529540A (ja) | 2021-08-04 | 2024-08-06 | ジェネトン | 筋肉及びｃｎｓにおける遺伝子発現のためのハイブリッドプロモーター |
| AU2023211652A1 (en) | 2022-01-25 | 2024-08-08 | The Trustees Of The University Of Pennsylvania | Aav capsids for improved heart transduction and detargeting of liver |
| WO2023237731A1 (fr) | 2022-06-09 | 2023-12-14 | Genethon | Gde tronquée au niveau du terminal n pour le traitement de la maladie de stockage du glycogène de type iii |
| WO2023237748A1 (fr) | 2022-06-10 | 2023-12-14 | Genethon | Capside d'aav modifiée par un peptide présentant une efficacité de transduction musculaire améliorée |
| WO2024074727A1 (fr) | 2022-10-07 | 2024-04-11 | Genethon | Immunothérapie cellulaire par car-t anti-fap pour traiter des myopathies squelettiques |
| WO2024079249A1 (fr) | 2022-10-12 | 2024-04-18 | Genethon | Vecteur aav hybride améliorant l'expression d'un transgène dans le foie |
| CN116041443B (zh) * | 2022-12-30 | 2023-09-22 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| CN116693633B (zh) * | 2023-02-21 | 2023-12-22 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| CN116970041B (zh) * | 2023-07-21 | 2024-02-09 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2292780T3 (en) | 2003-09-30 | 2017-12-04 | Univ Pennsylvania | Clades and sequences of adeno-associated virus (AAV), vectors containing them, and uses thereof |
| WO2006110689A2 (fr) | 2005-04-07 | 2006-10-19 | The Trustees Of The University Of Pennsylvania | Procede d'augmentation de la fonction d'un vecteur aav |
| ES2724800T3 (es) | 2011-02-17 | 2019-09-16 | Univ Pennsylvania | Composiciones y métodos para alterar la especificidad de tejido y mejorar la transferencia génica mediada por AAV9 |
| BR112014020325A2 (pt) | 2012-02-17 | 2017-08-08 | Childrens Hospital Philadelphia | composições de vetor do aav e métodos para a transferência de gene para as células, órgãos e tecidos |
| DK2839014T3 (da) | 2012-04-18 | 2021-03-08 | Childrens Hospital Philadelphia | Sammensætning og fremgangsmåder til højeffektiv genoverførsel ved anvendelse af aav-capsid-varianter |
| US20140162319A2 (en) | 2012-05-02 | 2014-06-12 | Sangeetha Hareendran | Nucleotide sequences, methods, kit and a recombinant cell thereof |
| CN116004721A (zh) | 2013-07-12 | 2023-04-25 | 费城儿童医院 | Aav载体和用于抗aav（腺相关病毒）中和抗体的检测 |
| HUE047996T2 (hu) | 2013-07-22 | 2020-05-28 | Childrens Hospital Philadelphia | AAV variáns és készítmények, eljárások és alkalmazások sejtekbe, szervekbe és szövetekbe történõ géntranszferhez |
| WO2015191508A1 (fr) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Capsides chimériques |
| AU2015320694B2 (en) | 2014-09-24 | 2021-11-11 | City Of Hope | Adeno-associated virus vector variants for high efficiency genome editing and methods thereof |
| US10385320B2 (en) | 2015-12-02 | 2019-08-20 | The Board Of Trustees Of The Leland Stanford Junior University | Recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism |
| CA3018076A1 (fr) | 2016-03-18 | 2017-09-21 | The Children's Hospital Of Philadelphia | Agent therapeutique pour le traitement de maladies, notamment les maladies touchant le systeme nerveux central |
| SG11201811603WA (en) * | 2016-07-26 | 2019-02-27 | Biomarin Pharm Inc | Novel adeno-associated virus capsid proteins |
| CN112533644A (zh) * | 2018-04-03 | 2021-03-19 | 斯特里迪比奥公司 | 靶向眼组织的病毒载体 |
-
2019
- 2019-04-04 MA MA51353A patent/MA51353B1/fr unknown
- 2019-04-04 US US16/981,086 patent/US12037362B2/en active Active
- 2019-04-04 CA CA3093347A patent/CA3093347A1/fr active Pending
- 2019-04-04 TN TNP/2020/000187A patent/TN2020000187A1/en unknown
- 2019-04-04 WO PCT/EP2019/058560 patent/WO2019193119A1/fr active Application Filing
- 2019-04-04 EP EP19714230.0A patent/EP3775173A1/fr active Pending
- 2019-04-04 JP JP2020554181A patent/JP7374119B2/ja active Active
- 2019-04-04 KR KR1020207032024A patent/KR20210015770A/ko unknown
- 2019-04-04 BR BR112020020223-1A patent/BR112020020223A2/pt unknown
- 2019-04-04 AU AU2019249890A patent/AU2019249890A1/en active Pending
- 2019-10-04 EP EP19782603.5A patent/EP3947653A1/fr not_active Withdrawn
- 2019-10-04 CN CN201980095204.9A patent/CN113795574A/zh active Pending
- 2019-10-04 KR KR1020217031502A patent/KR20210153047A/ko not_active Application Discontinuation
- 2019-10-04 BR BR112021019821A patent/BR112021019821A2/pt not_active Application Discontinuation
- 2019-10-04 US US17/600,715 patent/US20220228167A1/en not_active Abandoned
- 2019-10-04 AU AU2019439673A patent/AU2019439673A1/en not_active Withdrawn
- 2019-10-04 WO PCT/EP2019/076958 patent/WO2020200499A1/fr unknown
- 2019-10-04 CA CA3134183A patent/CA3134183A1/fr not_active Withdrawn
- 2019-10-04 JP JP2021558887A patent/JP2022526405A/ja not_active Withdrawn
-
2020
- 2020-08-31 ZA ZA2020/05422A patent/ZA202005422B/en unknown
- 2020-10-01 IL IL277740A patent/IL277740A/en unknown
-
2021
- 2021-10-03 IL IL286926A patent/IL286926A/en unknown
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