JPWO2019191501A5 - - Google Patents

Info

Publication number

JPWO2019191501A5

JPWO2019191501A5 JP2020551874A JP2020551874A JPWO2019191501A5 JP WO2019191501 A5 JPWO2019191501 A5 JP WO2019191501A5 JP 2020551874 A JP2020551874 A JP 2020551874A JP 2020551874 A JP2020551874 A JP 2020551874A JP WO2019191501 A5 JPWO2019191501 A5 JP WO2019191501A5

Authority

JP

Japan

Prior art keywords

cells

population

teff

hdaci

lymphocytes

Prior art date

2022-04-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000004027 cell Anatomy 0.000 claims 44
• 238000000034 method Methods 0.000 claims 24
• 210000004698 lymphocyte Anatomy 0.000 claims 18
• 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 14
• 239000003276 histone deacetylase inhibitor Substances 0.000 claims 14
• 102100030704 Interleukin-21 Human genes 0.000 claims 9
• 108010074108 interleukin-21 Proteins 0.000 claims 9
• 239000000203 mixture Substances 0.000 claims 6
• 230000000977 initiatory effect Effects 0.000 claims 5
• 210000001744 T-lymphocyte Anatomy 0.000 claims 3
• NCNRHFGMJRPRSK-MDZDMXLPSA-N belinostat Chemical compound ONC(=O)\C=C\C1=CC=CC(S(=O)(=O)NC=2C=CC=CC=2)=C1 NCNRHFGMJRPRSK-MDZDMXLPSA-N 0.000 claims 3
• INVTYAOGFAGBOE-UHFFFAOYSA-N entinostat Chemical compound NC1=CC=CC=C1NC(=O)C(C=C1)=CC=C1CNC(=O)OCC1=CC=CN=C1 INVTYAOGFAGBOE-UHFFFAOYSA-N 0.000 claims 3
• 102100036301 C-C chemokine receptor type 7 Human genes 0.000 claims 2
• 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 claims 2
• 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 2
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 2
• 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 2
• 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 2
• 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 2
• 102100033467 L-selectin Human genes 0.000 claims 2
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 2
• NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 2
• 229960003094 belinostat Drugs 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 2
• 238000009169 immunotherapy Methods 0.000 claims 2
• 210000004985 myeloid-derived suppressor cell Anatomy 0.000 claims 2
• 229960005184 panobinostat Drugs 0.000 claims 2
• FWZRWHZDXBDTFK-ZHACJKMWSA-N panobinostat Chemical compound CC1=NC2=CC=C[CH]C2=C1CCNCC1=CC=C(\C=C\C(=O)NO)C=C1 FWZRWHZDXBDTFK-ZHACJKMWSA-N 0.000 claims 2
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
• 230000008672 reprogramming Effects 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 2
• WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 2
• LLOKIGWPNVSDGJ-AFBVCZJXSA-N (3s,6s,9s,12r)-3,6-dibenzyl-9-[6-[(2s)-oxiran-2-yl]-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone Chemical compound C([C@H]1C(=O)N2CCC[C@@H]2C(=O)N[C@H](C(N[C@@H](CC=2C=CC=CC=2)C(=O)N1)=O)CCCCCC(=O)[C@H]1OC1)C1=CC=CC=C1 LLOKIGWPNVSDGJ-AFBVCZJXSA-N 0.000 claims 1
• BWDQBBCUWLSASG-MDZDMXLPSA-N (e)-n-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1h-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide Chemical compound C=1NC2=CC=CC=C2C=1CCN(CCO)CC1=CC=C(\C=C\C(=O)NO)C=C1 BWDQBBCUWLSASG-MDZDMXLPSA-N 0.000 claims 1
• OBKXEAXTFZPCHS-UHFFFAOYSA-N 4-phenylbutyric acid Chemical compound OC(=O)CCCC1=CC=CC=C1 OBKXEAXTFZPCHS-UHFFFAOYSA-N 0.000 claims 1
• 102000008203 CTLA-4 Antigen Human genes 0.000 claims 1
• 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
• 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
• 102000001398 Granzyme Human genes 0.000 claims 1
• 108060005986 Granzyme Proteins 0.000 claims 1
• 108010002350 Interleukin-2 Proteins 0.000 claims 1
• HRNLUBSXIHFDHP-UHFFFAOYSA-N N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]benzamide Chemical compound NC1=CC=CC=C1NC(=O)C(C=C1)=CC=C1CNC1=NC=CC(C=2C=NC=CC=2)=N1 HRNLUBSXIHFDHP-UHFFFAOYSA-N 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 102000004503 Perforin Human genes 0.000 claims 1
• 108010056995 Perforin Proteins 0.000 claims 1
• LLOKIGWPNVSDGJ-UHFFFAOYSA-N Trapoxin B Natural products C1OC1C(=O)CCCCCC(C(NC(CC=1C=CC=CC=1)C(=O)N1)=O)NC(=O)C2CCCN2C(=O)C1CC1=CC=CC=C1 LLOKIGWPNVSDGJ-UHFFFAOYSA-N 0.000 claims 1
• RTKIYFITIVXBLE-UHFFFAOYSA-N Trichostatin A Natural products ONC(=O)C=CC(C)=CC(C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-UHFFFAOYSA-N 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 229940077840 beleodaq Drugs 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 230000000779 depleting effect Effects 0.000 claims 1
• 210000003162 effector t lymphocyte Anatomy 0.000 claims 1
• 229950005837 entinostat Drugs 0.000 claims 1
• 210000002540 macrophage Anatomy 0.000 claims 1
• 210000003071 memory t lymphocyte Anatomy 0.000 claims 1
• 210000000822 natural killer cell Anatomy 0.000 claims 1
• 229950009215 phenylbutanoic acid Drugs 0.000 claims 1
• 238000001959 radiotherapy Methods 0.000 claims 1
• 108010060596 trapoxin B Proteins 0.000 claims 1
• RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 claims 1
• 229960000604 valproic acid Drugs 0.000 claims 1
• 229960000237 vorinostat Drugs 0.000 claims 1
• 229940061261 zolinza Drugs 0.000 claims 1