JPWO2019179424A5 - - Google Patents

Info

Publication number

JPWO2019179424A5

JPWO2019179424A5 JP2020550641A JP2020550641A JPWO2019179424A5 JP WO2019179424 A5 JPWO2019179424 A5 JP WO2019179424A5 JP 2020550641 A JP2020550641 A JP 2020550641A JP 2020550641 A JP2020550641 A JP 2020550641A JP WO2019179424 A5 JPWO2019179424 A5 JP WO2019179424A5

Authority

JP

Japan

Prior art keywords

seq

antibody

glp

amino acid

acid sequence

Prior art date

2022-04-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 125000003275 alpha amino acid group Chemical group 0.000 claims description 54
• 102100039997 Gastric inhibitory polypeptide receptor Human genes 0.000 claims description 25
• 101000886866 Homo sapiens Gastric inhibitory polypeptide receptor Proteins 0.000 claims description 25
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 45
• 102000037865 fusion proteins Human genes 0.000 claims 28
• 108020001507 fusion proteins Proteins 0.000 claims 28
• 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 27
• 102400000322 Glucagon-like peptide 1 Human genes 0.000 claims 27
• 108090000765 processed proteins & peptides Proteins 0.000 claims 12
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
• 210000004899 c-terminal region Anatomy 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 108091033319 polynucleotide Proteins 0.000 claims 6
• 102000040430 polynucleotide Human genes 0.000 claims 6
• 239000002157 polynucleotide Substances 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 108091026890 Coding region Proteins 0.000 claims 3
• 208000008589 Obesity Diseases 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 235000020824 obesity Nutrition 0.000 claims 3
• 229920001184 polypeptide Polymers 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 2
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
• 101100228914 Homo sapiens GIPR gene Proteins 0.000 claims 1
• 101000886868 Homo sapiens Gastric inhibitory polypeptide Proteins 0.000 claims 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 101100228916 Mus musculus Gipr gene Proteins 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 102000050325 human granulocyte inhibitory Human genes 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 230000019491 signal transduction Effects 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 description 1