JPWO2019175216A5 - - Google Patents
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- JPWO2019175216A5 JPWO2019175216A5 JP2020547326A JP2020547326A JPWO2019175216A5 JP WO2019175216 A5 JPWO2019175216 A5 JP WO2019175216A5 JP 2020547326 A JP2020547326 A JP 2020547326A JP 2020547326 A JP2020547326 A JP 2020547326A JP WO2019175216 A5 JPWO2019175216 A5 JP WO2019175216A5
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- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- composition
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090001123 antibodies Proteins 0.000 claims 37
- 102000004965 antibodies Human genes 0.000 claims 37
- 239000000427 antigen Substances 0.000 claims 20
- 102000038129 antigens Human genes 0.000 claims 20
- 108091007172 antigens Proteins 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 101700082799 IL2RA Proteins 0.000 claims 6
- 102100002950 ISG20 Human genes 0.000 claims 6
- 101700015336 ISG20 Proteins 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 102000000588 Interleukin-2 Human genes 0.000 claims 4
- 108010002350 Interleukin-2 Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 3
- 229940121650 immune-checkpoint protein inhibitors Drugs 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000003042 antagnostic Effects 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 210000004027 cells Anatomy 0.000 claims 2
- 230000002489 hematologic Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000035800 maturation Effects 0.000 claims 2
- 239000000546 pharmaceutic aid Substances 0.000 claims 2
- 108010047814 Antigen-Antibody Complex Proteins 0.000 claims 1
- 230000035693 Fab Effects 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 206010039509 Scab Diseases 0.000 claims 1
- 108010070144 Single-Chain Antibodies Proteins 0.000 claims 1
- 102000005632 Single-Chain Antibodies Human genes 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 238000009566 cancer vaccine Methods 0.000 claims 1
- 108091006028 chimera Proteins 0.000 claims 1
- 230000000779 depleting Effects 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 108010045030 monoclonal antibodies Proteins 0.000 claims 1
- 102000005614 monoclonal antibodies Human genes 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862642218P | 2018-03-13 | 2018-03-13 | |
| US201862642243P | 2018-03-13 | 2018-03-13 | |
| US201862642230P | 2018-03-13 | 2018-03-13 | |
| US201862642232P | 2018-03-13 | 2018-03-13 | |
| US201862642248P | 2018-03-13 | 2018-03-13 | |
| US62/642,248 | 2018-03-13 | ||
| GB1804027.9 | 2018-03-13 | ||
| GBGB1804029.5A GB201804029D0 (en) | 2018-03-13 | 2018-03-13 | Anti-CD25 antibody agents |
| EPPCT/EP2018/056312 | 2018-03-13 | ||
| US62/642,243 | 2018-03-13 | ||
| US62/642,230 | 2018-03-13 | ||
| PCT/EP2018/056312 WO2018167104A1 (en) | 2017-03-17 | 2018-03-13 | Fc-optimized anti-cd25 for tumour specific cell depletion |
| US62/642,232 | 2018-03-13 | ||
| GB1804029.5 | 2018-03-13 | ||
| GBGB1804028.7A GB201804028D0 (en) | 2018-03-13 | 2018-03-13 | Anti-CD25 antibody agents |
| GBGB1804027.9A GB201804027D0 (en) | 2018-03-13 | 2018-03-13 | Anti-CD25 antibody agents |
| US62/642,218 | 2018-03-13 | ||
| GB1804028.7 | 2018-03-13 | ||
| PCT/EP2019/056248 WO2019175216A1 (en) | 2018-03-13 | 2019-03-13 | Anti-cd25 for tumour specific cell depletion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021516973A JP2021516973A (ja) | 2021-07-15 |
| JPWO2019175216A5 true JPWO2019175216A5 (fi) | 2022-03-18 |
Family
ID=67903878
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020547326A Pending JP2021516973A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547331A Pending JP2021515565A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547399A Active JP7451415B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547332A Pending JP2021516974A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547415A Pending JP2021515568A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547363A Active JP7451414B2 (ja) | 2018-03-13 | 2019-03-13 | 抗ｃｄ２５抗体剤 |
| JP2020547333A Active JP7510348B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547371A Active JP7474701B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５抗体 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020547331A Pending JP2021515565A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547399A Active JP7451415B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547332A Pending JP2021516974A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547415A Pending JP2021515568A (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547363A Active JP7451414B2 (ja) | 2018-03-13 | 2019-03-13 | 抗ｃｄ２５抗体剤 |
| JP2020547333A Active JP7510348B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５ |
| JP2020547371A Active JP7474701B2 (ja) | 2018-03-13 | 2019-03-13 | 腫瘍特異的細胞枯渇のための抗ｃｄ２５抗体 |
Country Status (14)
| Country | Link |
|---|---|
| US (11) | US10745485B2 (fi) |
| EP (8) | EP3765505B1 (fi) |
| JP (8) | JP2021516973A (fi) |
| KR (3) | KR20200131286A (fi) |
| CN (8) | CN112041345A (fi) |
| AU (3) | AU2019233581A1 (fi) |
| BR (3) | BR112020016499A2 (fi) |
| CA (3) | CA3088659A1 (fi) |
| CR (3) | CR20200466A (fi) |
| MA (1) | MA51993A (fi) |
| PE (3) | PE20210289A1 (fi) |
| SG (3) | SG11202008699WA (fi) |
| TW (3) | TW201938588A (fi) |
| WO (8) | WO2019175224A1 (fi) |
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| CN112041345A (zh) | 2018-03-13 | 2020-12-04 | 塔斯克疗法有限公司 | 用于肿瘤特异性细胞清除的抗-cd25 |
| CN114630838A (zh) * | 2019-05-20 | 2022-06-14 | 法国国家健康和医学研究院 | 新的抗cd25抗体 |
| TW202138388A (zh) | 2019-12-30 | 2021-10-16 | 美商西根公司 | 以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法 |
| TW202144429A (zh) | 2020-05-14 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗ｃｄ２５抗體、其抗原結合片段及其醫藥用途 |
| AU2021378308A1 (en) * | 2020-11-13 | 2023-06-15 | Ibio, Inc. | Cd25 antibodies |
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| US20240002521A1 (en) * | 2020-11-20 | 2024-01-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-cd25 antibodies |
| JP2024508207A (ja) | 2020-12-02 | 2024-02-26 | ブイアイビー ブイゼットダブリュ | がんに対する組み合わせ治療におけるｌｔｂｒアゴニスト |
| EP4288100A1 (en) | 2021-02-02 | 2023-12-13 | Rakuten Medical, Inc. | Methods for local and systemic treatment of cancers, tumors and tumor cells |
| EP4302092A1 (en) | 2021-03-01 | 2024-01-10 | F. Hoffmann-La Roche AG | Novel biomarkers and uses thereof |
| CN115724971A (zh) | 2021-08-09 | 2023-03-03 | 南京诺艾新生物技术有限公司 | 重组抗人cd25抗体及其应用 |
| WO2023031403A1 (en) | 2021-09-02 | 2023-03-09 | F. Hoffmann-La Roche Ag | Antibodies for the treatment of aml |
| CA3230426A1 (en) * | 2021-09-03 | 2023-03-09 | Novarock Biotherapeutics, Ltd. | Bispecific binding proteins that bind cd137 and a tumor associated antigen |
| WO2023208990A1 (en) | 2022-04-26 | 2023-11-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer comprising a fas axis antagonist and a t-reg cell depleting agent antagonist, |
| CN115197321B (zh) * | 2022-06-02 | 2023-08-18 | 四川大学 | 靶向cd25的抗体及其用途 |
| CN115181182B (zh) * | 2022-06-13 | 2024-03-29 | 南京融捷康生物科技有限公司 | 一种人源化的抗cd25的单域抗体及其应用 |
| CN115181181B (zh) * | 2022-06-13 | 2024-03-29 | 南京融捷康生物科技有限公司 | 一种抗cd25的单域抗体及其应用 |
| WO2024006965A1 (en) * | 2022-06-30 | 2024-01-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cd25-specific antibodies and uses thereof |
| WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| WO2024088987A1 (en) | 2022-10-26 | 2024-05-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer |
| CN118240080A (zh) * | 2022-12-22 | 2024-06-25 | 深圳市福元生物科技有限公司 | 一种cd25单域抗体、人源化抗体、及制备方法 |
| CN116004636B (zh) * | 2023-01-10 | 2024-03-12 | 广西师范大学 | 一种不结合红细胞的差异化cd47核酸适体及其应用 |
| WO2024165454A1 (en) | 2023-02-06 | 2024-08-15 | F. Hoffmann-La Roche Ag | Combination therapy and uses thereof |
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2019
- 2019-03-13 CN CN201980019235.6A patent/CN112041345A/zh active Pending
- 2019-03-13 EP EP19709957.5A patent/EP3765505B1/en active Active
- 2019-03-13 CN CN201980019248.3A patent/CN112020514B/zh active Active
- 2019-03-13 US US16/352,717 patent/US10745485B2/en active Active
- 2019-03-13 US US16/979,931 patent/US11851494B2/en active Active
- 2019-03-13 AU AU2019233581A patent/AU2019233581A1/en active Pending
- 2019-03-13 CN CN201980019234.1A patent/CN112074536A/zh active Pending
- 2019-03-13 US US16/979,929 patent/US11802161B2/en active Active
- 2019-03-13 PE PE2020001320A patent/PE20210289A1/es unknown
- 2019-03-13 MA MA051993A patent/MA51993A/fr unknown
- 2019-03-13 KR KR1020207029205A patent/KR20200131286A/ko unknown
- 2019-03-13 WO PCT/EP2019/056258 patent/WO2019175224A1/en unknown
- 2019-03-13 AU AU2019233575A patent/AU2019233575A1/en not_active Abandoned
- 2019-03-13 CN CN201980019247.9A patent/CN112020513B/zh active Active
- 2019-03-13 CN CN201980019257.2A patent/CN112218891B/zh active Active
- 2019-03-13 CR CR20200466A patent/CR20200466A/es unknown
- 2019-03-13 JP JP2020547326A patent/JP2021516973A/ja active Pending
- 2019-03-13 TW TW108108451A patent/TW201938588A/zh unknown
- 2019-03-13 KR KR1020207029229A patent/KR20200131862A/ko unknown
- 2019-03-13 US US16/979,933 patent/US11919960B2/en active Active
- 2019-03-13 US US16/979,935 patent/US11697688B2/en active Active
- 2019-03-13 EP EP19709956.7A patent/EP3765504B1/en active Active
- 2019-03-13 TW TW108108467A patent/TW202003034A/zh unknown
- 2019-03-13 JP JP2020547331A patent/JP2021515565A/ja active Pending
- 2019-03-13 BR BR112020016499-2A patent/BR112020016499A2/pt not_active Application Discontinuation
- 2019-03-13 SG SG11202008699WA patent/SG11202008699WA/en unknown
- 2019-03-13 JP JP2020547399A patent/JP7451415B2/ja active Active
- 2019-03-13 SG SG11202008784RA patent/SG11202008784RA/en unknown
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