JPWO2019140188A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2019140188A5 JPWO2019140188A5 JP2020538841A JP2020538841A JPWO2019140188A5 JP WO2019140188 A5 JPWO2019140188 A5 JP WO2019140188A5 JP 2020538841 A JP2020538841 A JP 2020538841A JP 2020538841 A JP2020538841 A JP 2020538841A JP WO2019140188 A5 JPWO2019140188 A5 JP WO2019140188A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- mmol
- compound
- disease
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023143506A JP2023179445A (ja) | 2018-01-11 | 2023-09-05 | 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862616253P | 2018-01-11 | 2018-01-11 | |
| US62/616,253 | 2018-01-11 | ||
| PCT/US2019/013193 WO2019140188A1 (en) | 2018-01-11 | 2019-01-11 | Inhibitors of dihydroceramide desaturase for treating disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023143506A Division JP2023179445A (ja) | 2018-01-11 | 2023-09-05 | 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021510818A JP2021510818A (ja) | 2021-04-30 |
| JPWO2019140188A5 true JPWO2019140188A5 (zh) | 2022-01-19 |
| JP7346425B2 JP7346425B2 (ja) | 2023-09-19 |
Family
ID=67219929
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538841A Active JP7346425B2 (ja) | 2018-01-11 | 2019-01-11 | 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 |
| JP2023143506A Pending JP2023179445A (ja) | 2018-01-11 | 2023-09-05 | 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023143506A Pending JP2023179445A (ja) | 2018-01-11 | 2023-09-05 | 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11597715B2 (zh) |
| EP (1) | EP3737361A4 (zh) |
| JP (2) | JP7346425B2 (zh) |
| KR (1) | KR20200119807A (zh) |
| CN (1) | CN111787916B (zh) |
| AU (1) | AU2019207887B2 (zh) |
| CA (1) | CA3087729A1 (zh) |
| WO (1) | WO2019140188A1 (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018081167A1 (en) | 2016-10-24 | 2018-05-03 | Yumanity Therapeutics | Compounds and uses thereof |
| WO2018112077A1 (en) * | 2016-12-13 | 2018-06-21 | Centaurus Therapeutics | Inhibitors of dihydroceramide desaturase for treating disease |
| EP3700934A4 (en) | 2017-10-24 | 2021-10-27 | Yumanity Therapeutics, Inc. | COMPOUNDS AND USES OF THESE COMPOUNDS |
| CA3087729A1 (en) * | 2018-01-11 | 2019-07-18 | Centaurus Therapeutics | Inhibitors of dihydroceramide desaturase for treating disease |
| US20230404972A1 (en) * | 2020-11-25 | 2023-12-21 | Lysosomal and Rare Disorders Research and Treatment Center, Inc. | Inhibition of caspase pathway as a treatment for lysosomal storage disorders |
| EP4378938A1 (en) * | 2021-07-29 | 2024-06-05 | Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. | Novel parp7 inhibitor and use thereof |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62249945A (ja) * | 1986-04-23 | 1987-10-30 | Fuji Photo Film Co Ltd | ハイドロキノン・モノエステル類の合成方法 |
| AU6179998A (en) | 1997-02-24 | 1998-09-09 | Zymogenetics Inc. | Calcitonin mimetics |
| FR2770131A1 (fr) * | 1997-10-27 | 1999-04-30 | Union Pharma Scient Appl | Nouvelle association pharmaceutique a activite analgesique |
| US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| US6894063B2 (en) | 2000-09-14 | 2005-05-17 | Schering Corporation | Substituted urea neuropeptide Y Y5 Receptor antagonists |
| ES2170030B1 (es) | 2000-12-19 | 2003-11-16 | Consejo Superior Investigacion | Inhibidores de la dihidroceramida desaturasa. |
| CN1911913A (zh) | 2001-07-26 | 2007-02-14 | 先灵公司 | 取代脲类神经肽y y5受体拮抗剂 |
| CN1798735A (zh) | 2003-06-12 | 2006-07-05 | 诺沃挪第克公司 | 用作激素敏感性脂肪酶的抑制剂的1－芳基－4－(芳氧基羰基)－哌嗪衍生物 |
| EP1636187A1 (en) * | 2003-06-12 | 2006-03-22 | Novo Nordisk A/S | Substituted piperazine carbamates for use as inhibitors of hormone sensitive lipase |
| US7129235B2 (en) | 2003-07-11 | 2006-10-31 | Abbott Laboratories | Amides useful for treating pain |
| WO2005014580A1 (en) | 2003-08-08 | 2005-02-17 | Janssen Pharmaceutica, N.V. | Pyridyl piperazinyl ureas |
| US7491720B2 (en) | 2004-10-29 | 2009-02-17 | Banyu Pharmaceutical Co., Ltd. | Aminopyridine derivatives having Aurora A selective inhibitory action |
| TW200633990A (en) | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
| CA2588607A1 (en) | 2004-11-23 | 2006-06-01 | Ptc Therapeutics, Inc. | Carbazole, carboline and indole derivatives useful in the inhibition of vegf production |
| EP2937341B1 (en) | 2004-12-30 | 2017-07-05 | Janssen Pharmaceutica N.V. | 4-(benzyl)-piperazine-1-carboxylic acid phenylamide derivatives and related compounds as modulators of fatty acid amide hydrolase (faah) for the treatment of anxiety, pain and other conditions |
| US7790726B2 (en) | 2005-08-16 | 2010-09-07 | Chemocentryx, Inc. | Monocyclic and bicyclic compounds and methods of use |
| US20100048714A1 (en) | 2006-06-19 | 2010-02-25 | University Of Utah Research Foundation | Methods and Compositions Related to Inhibition of Ceramide Synthesis |
| EP2065369A4 (en) | 2006-08-23 | 2011-12-28 | Astellas Pharma Inc | UREA CONNECTION OR SALT THEREOF |
| CA2711211A1 (en) | 2008-01-03 | 2009-07-09 | Aft Pharmaceuticals Ltd. | Oral pharmaceutical suspension comprising paracetamol and ibuprofen |
| WO2010023512A1 (en) | 2008-08-28 | 2010-03-04 | Matrix Laboratories Ltd. | Novel vanilloid receptor modulators, process for their preparation and pharmaceutical compositions containing them |
| FR2939135B1 (fr) | 2008-12-02 | 2010-12-03 | Galderma Res & Dev | Nouveaux composes 4-(azacycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
| NZ594556A (en) | 2009-01-28 | 2013-11-29 | Rigel Pharmaceuticals Inc | Carboxamide compounds and methods for using the same |
| JP2010195688A (ja) * | 2009-02-23 | 2010-09-09 | Shionogi & Co Ltd | Ｎｐｙｙ５受容体拮抗作用を有するアミド及びウレア誘導体 |
| JPWO2011078369A1 (ja) | 2009-12-25 | 2013-05-09 | 持田製薬株式会社 | 新規アリールウレア誘導体 |
| CN103172635B (zh) * | 2011-12-21 | 2016-04-27 | 上海医药工业研究院 | 哌嗪或哌啶类化合物、其盐、中间体、制备方法及应用 |
| WO2015038704A1 (en) * | 2013-09-11 | 2015-03-19 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Compositions for preparing cardiomyocytes |
| EP3478678A1 (en) | 2016-06-30 | 2019-05-08 | Basilea Pharmaceutica International AG | Mitochondrial inhibitors for the treatment of proliferation disorders |
| WO2018112077A1 (en) * | 2016-12-13 | 2018-06-21 | Centaurus Therapeutics | Inhibitors of dihydroceramide desaturase for treating disease |
| CA3087729A1 (en) * | 2018-01-11 | 2019-07-18 | Centaurus Therapeutics | Inhibitors of dihydroceramide desaturase for treating disease |
-
2019
- 2019-01-11 CA CA3087729A patent/CA3087729A1/en active Pending
- 2019-01-11 CN CN201980015846.3A patent/CN111787916B/zh active Active
- 2019-01-11 JP JP2020538841A patent/JP7346425B2/ja active Active
- 2019-01-11 KR KR1020207023098A patent/KR20200119807A/ko not_active Application Discontinuation
- 2019-01-11 EP EP19738156.9A patent/EP3737361A4/en active Pending
- 2019-01-11 AU AU2019207887A patent/AU2019207887B2/en active Active
- 2019-01-11 WO PCT/US2019/013193 patent/WO2019140188A1/en unknown
- 2019-01-11 US US16/959,807 patent/US11597715B2/en active Active
-
2023
- 2023-02-06 US US18/106,305 patent/US20230357187A1/en active Pending
- 2023-09-05 JP JP2023143506A patent/JP2023179445A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11771684B2 (en) | Inhibitors of dihydroceramide desaturase for treating disease | |
| JP7057798B2 (ja) | ｍＴＯＲＣ１阻害剤 | |
| JP7346425B2 (ja) | 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 | |
| CN105308036B (zh) | 用于激酶调节的化合物和方法及其适应症 | |
| US20190389867A1 (en) | Substituted heterocyclic inhibitors of ptpn11 | |
| JP2021502364A (ja) | 新規なスルホンアミドカルボキサミド化合物 | |
| AU2016324483B2 (en) | Methods and compositions of inhibiting DCN1-UBC12 interaction | |
| KR20170036698A (ko) | 항증식성 화합물 및 이의 사용 방법 | |
| KR20210076910A (ko) | 파르네소이드 x 수용체 효능제 및 그의 용도 | |
| BR112019011825A2 (pt) | composto, enantiômero isolado, composição farmacêutica, método para inibir a atividade do transportador de monocarboxilato mct4, ou um mutante do mesmo, em uma amostra biológica, método para inibir a atividade do transportador de monocarboxilato mct4, ou um mutante do mesmo, em relação ao transportador de monocarboxilato mct1, ou um mutante do mesmo, em um paciente, método para tratar um distúrbio mediado por transportador de monocarboxilato mct4 em um sujeito que necessite do mesmo, uso de um composto e método para obter um efeito em um paciente | |
| JP2021519308A (ja) | 転写活性化タンパク質のイミダゾピペラジン阻害剤 | |
| KR20180128937A (ko) | 질환을 치료하는데 유용한 fimh의 만노스-유래 길항제 | |
| BR112021000395A2 (pt) | Compostos imunomoduladores diméricos contra mecanismos baseados em cereblon | |
| AU2012344015A1 (en) | Novel 2H-indazoles as EP2 receptor antagonists | |
| AU2015317886A1 (en) | Pyrrolopyrimidine derivatives as NR2B NMDA receptor antagonists | |
| CA3182276A1 (en) | Inhibitors of nek7 kinase | |
| JP2019502663A (ja) | （ｒ）−１−（４−（６−（２−（４−（３，３−ジフルオロシクロブトキシ）−６−メチルピリジン−２−イル）アセトアミド）ピリダジン−３−イル）−２−フルオロブチル）−ｎ−メチル−１ｈ−１，２，３−トリアゾール−４−カルボキサミドの塩形態および多形体 | |
| JP6513075B2 (ja) | オートタキシン阻害活性を有する縮合ピラゾール誘導体 | |
| WO2021045159A1 (ja) | 併用医薬による糖尿病の治療又は予防方法 | |
| JPWO2019140188A5 (zh) | ||
| CN118201896A (zh) | PI3K-α抑制剂和其使用方法 | |
| WO2021045161A1 (ja) | 慢性腎臓病の治療又は予防方法 | |
| KR20220132538A (ko) | 디하이드로오로테이트 데하이드로게나제를 억제하는 방법 및 조성물 | |
| JP6535007B2 (ja) | 新規ピペリジンカルボキサミド化合物、その調製方法及び使用 | |
| WO2023030170A1 (zh) | 基于nampt靶蛋白的蛋白降解化合物及其应用 |