JPWO2019136168A5 - - Google Patents
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- Publication number
- JPWO2019136168A5 JPWO2019136168A5 JP2020537006A JP2020537006A JPWO2019136168A5 JP WO2019136168 A5 JPWO2019136168 A5 JP WO2019136168A5 JP 2020537006 A JP2020537006 A JP 2020537006A JP 2020537006 A JP2020537006 A JP 2020537006A JP WO2019136168 A5 JPWO2019136168 A5 JP WO2019136168A5
- Authority
- JP
- Japan
- Prior art keywords
- glucose
- newborn
- pharmaceutical composition
- clc
- oral pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 11
- 239000008103 glucose Substances 0.000 claims description 11
- 108010015776 Glucose oxidase Proteins 0.000 claims description 8
- 239000004366 Glucose oxidase Substances 0.000 claims description 8
- 229940116332 glucose oxidase Drugs 0.000 claims description 8
- 235000019420 glucose oxidase Nutrition 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 5
- 229940050410 gluconate Drugs 0.000 claims description 5
- 239000008203 oral pharmaceutical composition Substances 0.000 claims 9
- 239000000825 pharmaceutical preparation Substances 0.000 claims 7
- 101100274575 Caenorhabditis elegans clh-3 gene Proteins 0.000 claims 6
- 208000032065 Convulsion neonatal Diseases 0.000 claims 5
- 108091006146 Channels Proteins 0.000 claims 4
- 230000002920 convulsive effect Effects 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000000153 supplemental effect Effects 0.000 claims 3
- 229940125400 channel inhibitor Drugs 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 4
- 206010010904 Convulsion Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/860,966 US10213491B2 (en) | 2015-05-19 | 2018-01-03 | Glucose oxidase compositions as a neonate anticonvulsant |
| US15/860,966 | 2018-01-03 | ||
| PCT/US2019/012208 WO2019136168A1 (en) | 2018-01-03 | 2019-01-03 | Glucose oxidase compositions as a neonate anticonvulsant |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021509671A JP2021509671A (ja) | 2021-04-01 |
| JPWO2019136168A5 true JPWO2019136168A5 (https=) | 2022-01-14 |
| JP2021509671A5 JP2021509671A5 (https=) | 2022-01-14 |
| JP7381469B2 JP7381469B2 (ja) | 2023-11-15 |
Family
ID=67143949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020537006A Active JP7381469B2 (ja) | 2018-01-03 | 2019-01-03 | 新生児抗痙攣薬としてのグルコースオキシダーゼ組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11666640B2 (https=) |
| EP (1) | EP3735262A4 (https=) |
| JP (1) | JP7381469B2 (https=) |
| CN (1) | CN112105378B (https=) |
| WO (1) | WO2019136168A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111440771A (zh) * | 2020-03-17 | 2020-07-24 | 中山大学附属第三医院 | 一种含有clcn2纯合突变的白质脑病患者特异诱导多能干细胞系 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364634A (en) | 1991-11-08 | 1994-11-15 | Southwest Research Institute | Controlled-release PH sensitive capsule and adhesive system and method |
| US6020317A (en) | 1993-02-19 | 2000-02-01 | Nippon Shinyaku Co. Ltd. | Glycerol derivative, device and pharmaceutical composition |
| AU7166200A (en) * | 1995-12-27 | 2001-03-08 | Genencor International, Inc. | Process for the preparation of gluconic acid and gluconic acid produced thereby |
| US5994316A (en) | 1996-02-21 | 1999-11-30 | The Immune Response Corporation | Method of preparing polynucleotide-carrier complexes for delivery to cells |
| EP0914096B1 (en) | 1996-05-17 | 2003-08-13 | Elan Drug Delivery Limited | Microparticles and their use in wound therapy |
| US20100029613A1 (en) | 2004-11-15 | 2010-02-04 | University Of Rochester | Treatment and prevention of epilepsy |
| GB0619786D0 (en) * | 2006-10-06 | 2006-11-15 | Inst Of Technology Sligo | An antimicrobial and immunostimulatory system |
| CN101626779B (zh) * | 2007-02-28 | 2012-09-05 | 森永乳业株式会社 | 口腔内用杀菌剂和含有该杀菌剂的食品添加剂 |
| DK2276505T3 (da) | 2008-03-20 | 2013-11-25 | Krister Tano | Næsespray eller næsedråber til behandling af forkølelse |
| WO2012050895A1 (en) | 2010-09-28 | 2012-04-19 | Lisa Geng | Methods for treating neurological disorders using nutrient compositions |
| WO2014165566A1 (en) | 2013-04-03 | 2014-10-09 | Emory University | Hydrophilic particle compositions, processes of production, and uses in dietary management and digestive disorders |
| US20160067190A1 (en) | 2013-04-30 | 2016-03-10 | The Children's Medical Center Corporation | Injectable nano-network gels for diabetes treatment |
| WO2015134490A1 (en) | 2014-03-03 | 2015-09-11 | The Penn State Research Foundation | Self-powered enzyme micropumps |
| CN104450806B (zh) * | 2014-11-27 | 2018-01-16 | 江南大学 | 一种酶法制备葡萄糖酸钠的方法 |
| US10213491B2 (en) | 2015-05-19 | 2019-02-26 | The Penn State Research Foundation | Glucose oxidase compositions as a neonate anticonvulsant |
| US9861597B2 (en) | 2015-05-19 | 2018-01-09 | Penn State Research Foundation | Gluconate-based compositions as a neonate anticonvulsant |
| CN106978451B (zh) * | 2017-03-29 | 2020-04-28 | 华南理工大学 | 一种固定化葡萄糖氧化酶制备葡萄糖酸钠的方法 |
| CN106929500A (zh) * | 2017-04-27 | 2017-07-07 | 南京工业大学 | 葡萄糖氧化酶/过氧化氢酶的交联酶聚体的制备方法及其应用 |
-
2019
- 2019-01-03 EP EP19736175.1A patent/EP3735262A4/en not_active Withdrawn
- 2019-01-03 JP JP2020537006A patent/JP7381469B2/ja active Active
- 2019-01-03 CN CN201980014276.6A patent/CN112105378B/zh active Active
- 2019-01-03 US US16/957,087 patent/US11666640B2/en active Active
- 2019-01-03 WO PCT/US2019/012208 patent/WO2019136168A1/en not_active Ceased
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