CN112105378B - 作为新生儿抗惊厥药的葡萄糖氧化酶组合物 - Google Patents

作为新生儿抗惊厥药的葡萄糖氧化酶组合物 Download PDF

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Publication number
CN112105378B
CN112105378B CN201980014276.6A CN201980014276A CN112105378B CN 112105378 B CN112105378 B CN 112105378B CN 201980014276 A CN201980014276 A CN 201980014276A CN 112105378 B CN112105378 B CN 112105378B
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CN
China
Prior art keywords
clc
nagca
neonatal
activity
gluconate
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Active
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CN201980014276.6A
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English (en)
Chinese (zh)
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CN112105378A (zh
Inventor
陈功
吴政
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Penn State Research Foundation
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Penn State Research Foundation
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Priority claimed from US15/860,966 external-priority patent/US10213491B2/en
Application filed by Penn State Research Foundation filed Critical Penn State Research Foundation
Publication of CN112105378A publication Critical patent/CN112105378A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03004—Glucose oxidase (1.1.3.4)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201980014276.6A 2018-01-03 2019-01-03 作为新生儿抗惊厥药的葡萄糖氧化酶组合物 Active CN112105378B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/860,966 US10213491B2 (en) 2015-05-19 2018-01-03 Glucose oxidase compositions as a neonate anticonvulsant
US15/860,966 2018-01-03
PCT/US2019/012208 WO2019136168A1 (en) 2018-01-03 2019-01-03 Glucose oxidase compositions as a neonate anticonvulsant

Publications (2)

Publication Number Publication Date
CN112105378A CN112105378A (zh) 2020-12-18
CN112105378B true CN112105378B (zh) 2025-03-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980014276.6A Active CN112105378B (zh) 2018-01-03 2019-01-03 作为新生儿抗惊厥药的葡萄糖氧化酶组合物

Country Status (5)

Country Link
US (1) US11666640B2 (https=)
EP (1) EP3735262A4 (https=)
JP (1) JP7381469B2 (https=)
CN (1) CN112105378B (https=)
WO (1) WO2019136168A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111440771A (zh) * 2020-03-17 2020-07-24 中山大学附属第三医院 一种含有clcn2纯合突变的白质脑病患者特异诱导多能干细胞系

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364634A (en) 1991-11-08 1994-11-15 Southwest Research Institute Controlled-release PH sensitive capsule and adhesive system and method
US6020317A (en) 1993-02-19 2000-02-01 Nippon Shinyaku Co. Ltd. Glycerol derivative, device and pharmaceutical composition
AU7166200A (en) * 1995-12-27 2001-03-08 Genencor International, Inc. Process for the preparation of gluconic acid and gluconic acid produced thereby
US5994316A (en) 1996-02-21 1999-11-30 The Immune Response Corporation Method of preparing polynucleotide-carrier complexes for delivery to cells
EP0914096B1 (en) 1996-05-17 2003-08-13 Elan Drug Delivery Limited Microparticles and their use in wound therapy
US20100029613A1 (en) 2004-11-15 2010-02-04 University Of Rochester Treatment and prevention of epilepsy
GB0619786D0 (en) * 2006-10-06 2006-11-15 Inst Of Technology Sligo An antimicrobial and immunostimulatory system
CN101626779B (zh) * 2007-02-28 2012-09-05 森永乳业株式会社 口腔内用杀菌剂和含有该杀菌剂的食品添加剂
DK2276505T3 (da) 2008-03-20 2013-11-25 Krister Tano Næsespray eller næsedråber til behandling af forkølelse
WO2012050895A1 (en) 2010-09-28 2012-04-19 Lisa Geng Methods for treating neurological disorders using nutrient compositions
WO2014165566A1 (en) 2013-04-03 2014-10-09 Emory University Hydrophilic particle compositions, processes of production, and uses in dietary management and digestive disorders
US20160067190A1 (en) 2013-04-30 2016-03-10 The Children's Medical Center Corporation Injectable nano-network gels for diabetes treatment
WO2015134490A1 (en) 2014-03-03 2015-09-11 The Penn State Research Foundation Self-powered enzyme micropumps
CN104450806B (zh) * 2014-11-27 2018-01-16 江南大学 一种酶法制备葡萄糖酸钠的方法
US10213491B2 (en) 2015-05-19 2019-02-26 The Penn State Research Foundation Glucose oxidase compositions as a neonate anticonvulsant
US9861597B2 (en) 2015-05-19 2018-01-09 Penn State Research Foundation Gluconate-based compositions as a neonate anticonvulsant
CN106978451B (zh) * 2017-03-29 2020-04-28 华南理工大学 一种固定化葡萄糖氧化酶制备葡萄糖酸钠的方法
CN106929500A (zh) * 2017-04-27 2017-07-07 南京工业大学 葡萄糖氧化酶/过氧化氢酶的交联酶聚体的制备方法及其应用

Also Published As

Publication number Publication date
CN112105378A (zh) 2020-12-18
EP3735262A1 (en) 2020-11-11
EP3735262A4 (en) 2021-09-29
US20200345817A1 (en) 2020-11-05
US11666640B2 (en) 2023-06-06
JP7381469B2 (ja) 2023-11-15
WO2019136168A1 (en) 2019-07-11
JP2021509671A (ja) 2021-04-01

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