JPWO2019126776A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2019126776A5 JPWO2019126776A5 JP2020534456A JP2020534456A JPWO2019126776A5 JP WO2019126776 A5 JPWO2019126776 A5 JP WO2019126776A5 JP 2020534456 A JP2020534456 A JP 2020534456A JP 2020534456 A JP2020534456 A JP 2020534456A JP WO2019126776 A5 JPWO2019126776 A5 JP WO2019126776A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- crystal
- compound
- viii
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024002729A JP2024050607A (ja) | 2017-12-21 | 2024-01-11 | 結晶性の置換シクロヘキシルピラゾロ［１，５－ａ］ピリミジニルカルボキサミド化合物およびその治療的使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762608652P | 2017-12-21 | 2017-12-21 | |
| US62/608,652 | 2017-12-21 | ||
| PCT/US2018/067330 WO2019126776A1 (en) | 2017-12-21 | 2018-12-21 | Crystalline substituted cyclohexyl pyrazolo[1,5-a]pyrimidinyl carboxamide compound and therapeutic uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024002729A Division JP2024050607A (ja) | 2017-12-21 | 2024-01-11 | 結晶性の置換シクロヘキシルピラゾロ［１，５－ａ］ピリミジニルカルボキサミド化合物およびその治療的使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021506920A JP2021506920A (ja) | 2021-02-22 |
| JP2021506920A5 JP2021506920A5 (https=) | 2022-09-22 |
| JPWO2019126776A5 true JPWO2019126776A5 (https=) | 2022-09-22 |
Family
ID=65139206
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020534456A Pending JP2021506920A (ja) | 2017-12-21 | 2018-12-21 | 結晶性の置換シクロヘキシルピラゾロ［１，５−ａ］ピリミジニルカルボキサミド化合物およびその治療的使用 |
| JP2024002729A Pending JP2024050607A (ja) | 2017-12-21 | 2024-01-11 | 結晶性の置換シクロヘキシルピラゾロ［１，５－ａ］ピリミジニルカルボキサミド化合物およびその治療的使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024002729A Pending JP2024050607A (ja) | 2017-12-21 | 2024-01-11 | 結晶性の置換シクロヘキシルピラゾロ［１，５－ａ］ピリミジニルカルボキサミド化合物およびその治療的使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20200339587A1 (https=) |
| EP (1) | EP3728265A1 (https=) |
| JP (2) | JP2021506920A (https=) |
| WO (1) | WO2019126776A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015342883B2 (en) | 2014-11-06 | 2020-07-02 | Bial - R&D Investments, S.A. | Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders |
| HRP20240644T1 (hr) | 2014-11-06 | 2024-08-02 | Bial-R&D Investments, S.A. | Supstituirani pirazolo(1,5-a)pirimidini i njihova uporaba u liječenju medicinskih poremećaja |
| WO2016073889A1 (en) | 2014-11-06 | 2016-05-12 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
| CA3020305A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| US11192892B2 (en) | 2016-04-06 | 2021-12-07 | Bial—R&D Investments, S.A. | Substituted pyrazolo[1,5-a]pyrimidines for the treatment of medical disorders |
| EP3440081A4 (en) | 2016-04-06 | 2019-09-18 | Lysosomal Therapeutics Inc. | PYRROLO [1,2-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER |
| SG11201809693SA (en) | 2016-05-05 | 2018-11-29 | Lysosomal Therapeutics Inc | SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| EP3452455A4 (en) | 2016-05-05 | 2019-11-13 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMDAZO [1,2-] PYRIDINES, SUBSTITUTED IMIDAZO [1,2-] PYRAZINES, RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF ILLNESSES |
| IL323027A (en) | 2023-03-01 | 2025-10-01 | Bial – R& D Invest S A | Formulation |
| EP4676488A1 (en) | 2023-03-10 | 2026-01-14 | Bial-R&D Investments, S.A. | Treatment of parkinson's disease in a patient using a glucocerebrosidase activator |
| WO2025198486A1 (en) | 2024-03-22 | 2025-09-25 | BIAL – R&D Investments, S.A. | Process for preparing a pyrazolo[1,5-a]pyrimidinyl carboxamide compound |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001051919A2 (en) * | 2000-01-07 | 2001-07-19 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
| EP2594562B1 (en) | 2007-05-31 | 2016-07-20 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| CA2731685A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| EP3078373A1 (en) | 2008-10-03 | 2016-10-12 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitor |
| WO2010091164A1 (en) | 2009-02-06 | 2010-08-12 | Exelixis, Inc. | Inhibitors of glucosylceramide synthase |
| WO2011133915A1 (en) | 2010-04-23 | 2011-10-27 | Isis Pharmaceuticals, Inc. | Modulation of glucosylceramide synthase (gcs) expression |
| AU2012231275A1 (en) | 2011-03-18 | 2013-10-17 | Genzyme Corporation | Glucosylceramide synthase inhibitors |
| WO2013059119A1 (en) | 2011-10-17 | 2013-04-25 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| TWI649317B (zh) | 2013-03-15 | 2019-02-01 | 健臻公司 | 製備葡糖基神經醯胺合成酶抑制劑之方法 |
| PT3079695T (pt) | 2013-12-11 | 2021-05-04 | Genzyme Corp | Inibidores de glicosilceramida-sintase |
| WO2015173169A1 (en) | 2014-05-12 | 2015-11-19 | Fondazione Istituto Italiano Di Tecnologia | Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments |
| WO2015173168A1 (en) | 2014-05-12 | 2015-11-19 | Fondazione Istituto Italiano Di Tecnologia | Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments |
| HRP20240644T1 (hr) * | 2014-11-06 | 2024-08-02 | Bial-R&D Investments, S.A. | Supstituirani pirazolo(1,5-a)pirimidini i njihova uporaba u liječenju medicinskih poremećaja |
-
2018
- 2018-12-21 JP JP2020534456A patent/JP2021506920A/ja active Pending
- 2018-12-21 WO PCT/US2018/067330 patent/WO2019126776A1/en not_active Ceased
- 2018-12-21 EP EP18837065.4A patent/EP3728265A1/en active Pending
- 2018-12-21 US US16/955,589 patent/US20200339587A1/en not_active Abandoned
-
2024
- 2024-01-11 JP JP2024002729A patent/JP2024050607A/ja active Pending
- 2024-12-12 US US18/979,274 patent/US20250340558A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021506920A5 (https=) | ||
| JPWO2019126776A5 (https=) | ||
| TWI632131B (zh) | 用於製備前列腺素醯胺之新穎方法 | |
| US20040180933A1 (en) | Process for preparing 1,2-diamino compounds | |
| EP2238152B1 (en) | Processes for preparation of dutasteride | |
| JP7685292B2 (ja) | エドキサバンの鍵中間体及びその合成方法 | |
| JP4262920B2 (ja) | 置換シクロペンタン誘導体の調製方法及びその新規結晶構造 | |
| CN107922352A (zh) | 制备蛋白质脱乙酰酶抑制剂的方法 | |
| EP3412666A1 (en) | Process and intermediates for the preparation of bcl-2 inhibitors including venetoclax through reductive amination | |
| JP2023523219A (ja) | モノアシルグリセロールリパーゼ阻害剤の合成 | |
| JP2013531004A (ja) | トロンビン特異的インヒビターの調製のための中間体及び方法 | |
| WO2019167085A1 (en) | Process for the preparation of (s)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino propanamide methanesulfonate | |
| CN105384654A (zh) | 一种羟烷基酰胺的结晶纯化方法 | |
| KR101437038B1 (ko) | (+) 및 (-)-1-(3,4-디클로로페닐)-3-아자비시클로［3.1.0］헥산의 합성 방법 | |
| WO2014081024A1 (ja) | ５－置換－２－フェニルアミノ－ベンズアミド類の製造方法 | |
| JPH02295967A (ja) | フェノキシエチルアミン誘導体の製造方法 | |
| EP2448916B1 (en) | Production of trans-4-aminocyclopent-2-ene-1-carboxylic acid derivatives | |
| EP1535900B1 (en) | Process for the preparation of nateglinide, preferably in b-form | |
| CN116034101A (zh) | 制备阿帕鲁胺的改进方法 | |
| US6479672B1 (en) | Diastereoselective preparation of Michael adducts | |
| US4078085A (en) | 3-Aminomethyl-4-homoisotwistane and its salt and process for producing same | |
| CN119954778A (zh) | 一种来那卡帕韦钠及其系列中间体化合物的合成方法 | |
| CN101506146B (zh) | 3-氨基-5-氟-4-二烷氧基戊酸酯的制备方法 | |
| EP4452924B1 (en) | Process to prepare vilanterol trifenatate | |
| KR101123281B1 (ko) | 치환된 벤즈아미드 유도체 및 그의 약제학상 허용되는 염의제조방법 |