JP2021506920A5 - - Google Patents
Info
- Publication number
- JP2021506920A5 JP2021506920A5 JP2020534456A JP2020534456A JP2021506920A5 JP 2021506920 A5 JP2021506920 A5 JP 2021506920A5 JP 2020534456 A JP2020534456 A JP 2020534456A JP 2020534456 A JP2020534456 A JP 2020534456A JP 2021506920 A5 JP2021506920 A5 JP 2021506920A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- crystal
- viii
- compound
- solvent
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024002729A JP2024050607A (ja) | 2017-12-21 | 2024-01-11 | 結晶性の置換シクロヘキシルピラゾロ［１，５－ａ］ピリミジニルカルボキサミド化合物およびその治療的使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762608652P | 2017-12-21 | 2017-12-21 | |
| US62/608,652 | 2017-12-21 | ||
| PCT/US2018/067330 WO2019126776A1 (en) | 2017-12-21 | 2018-12-21 | Crystalline substituted cyclohexyl pyrazolo[1,5-a]pyrimidinyl carboxamide compound and therapeutic uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024002729A Division JP2024050607A (ja) | 2017-12-21 | 2024-01-11 | 結晶性の置換シクロヘキシルピラゾロ［１，５－ａ］ピリミジニルカルボキサミド化合物およびその治療的使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021506920A JP2021506920A (ja) | 2021-02-22 |
| JP2021506920A5 true JP2021506920A5 (https=) | 2022-09-22 |
| JPWO2019126776A5 JPWO2019126776A5 (https=) | 2022-09-22 |
Family
ID=65139206
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020534456A Pending JP2021506920A (ja) | 2017-12-21 | 2018-12-21 | 結晶性の置換シクロヘキシルピラゾロ［１，５−ａ］ピリミジニルカルボキサミド化合物およびその治療的使用 |
| JP2024002729A Pending JP2024050607A (ja) | 2017-12-21 | 2024-01-11 | 結晶性の置換シクロヘキシルピラゾロ［１，５－ａ］ピリミジニルカルボキサミド化合物およびその治療的使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024002729A Pending JP2024050607A (ja) | 2017-12-21 | 2024-01-11 | 結晶性の置換シクロヘキシルピラゾロ［１，５－ａ］ピリミジニルカルボキサミド化合物およびその治療的使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20200339587A1 (https=) |
| EP (1) | EP3728265A1 (https=) |
| JP (2) | JP2021506920A (https=) |
| WO (1) | WO2019126776A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015342883B2 (en) | 2014-11-06 | 2020-07-02 | Bial - R&D Investments, S.A. | Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders |
| HRP20240644T1 (hr) | 2014-11-06 | 2024-08-02 | Bial-R&D Investments, S.A. | Supstituirani pirazolo(1,5-a)pirimidini i njihova uporaba u liječenju medicinskih poremećaja |
| WO2016073889A1 (en) | 2014-11-06 | 2016-05-12 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
| CA3020305A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| US11192892B2 (en) | 2016-04-06 | 2021-12-07 | Bial—R&D Investments, S.A. | Substituted pyrazolo[1,5-a]pyrimidines for the treatment of medical disorders |
| EP3440081A4 (en) | 2016-04-06 | 2019-09-18 | Lysosomal Therapeutics Inc. | PYRROLO [1,2-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER |
| SG11201809693SA (en) | 2016-05-05 | 2018-11-29 | Lysosomal Therapeutics Inc | SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| EP3452455A4 (en) | 2016-05-05 | 2019-11-13 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMDAZO [1,2-] PYRIDINES, SUBSTITUTED IMIDAZO [1,2-] PYRAZINES, RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF ILLNESSES |
| IL323027A (en) | 2023-03-01 | 2025-10-01 | Bial – R& D Invest S A | Formulation |
| EP4676488A1 (en) | 2023-03-10 | 2026-01-14 | Bial-R&D Investments, S.A. | Treatment of parkinson's disease in a patient using a glucocerebrosidase activator |
| WO2025198486A1 (en) | 2024-03-22 | 2025-09-25 | BIAL – R&D Investments, S.A. | Process for preparing a pyrazolo[1,5-a]pyrimidinyl carboxamide compound |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001051919A2 (en) * | 2000-01-07 | 2001-07-19 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
| EP2594562B1 (en) | 2007-05-31 | 2016-07-20 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| CA2731685A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| EP3078373A1 (en) | 2008-10-03 | 2016-10-12 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitor |
| WO2010091164A1 (en) | 2009-02-06 | 2010-08-12 | Exelixis, Inc. | Inhibitors of glucosylceramide synthase |
| WO2011133915A1 (en) | 2010-04-23 | 2011-10-27 | Isis Pharmaceuticals, Inc. | Modulation of glucosylceramide synthase (gcs) expression |
| AU2012231275A1 (en) | 2011-03-18 | 2013-10-17 | Genzyme Corporation | Glucosylceramide synthase inhibitors |
| WO2013059119A1 (en) | 2011-10-17 | 2013-04-25 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| TWI649317B (zh) | 2013-03-15 | 2019-02-01 | 健臻公司 | 製備葡糖基神經醯胺合成酶抑制劑之方法 |
| PT3079695T (pt) | 2013-12-11 | 2021-05-04 | Genzyme Corp | Inibidores de glicosilceramida-sintase |
| WO2015173169A1 (en) | 2014-05-12 | 2015-11-19 | Fondazione Istituto Italiano Di Tecnologia | Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments |
| WO2015173168A1 (en) | 2014-05-12 | 2015-11-19 | Fondazione Istituto Italiano Di Tecnologia | Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments |
| HRP20240644T1 (hr) * | 2014-11-06 | 2024-08-02 | Bial-R&D Investments, S.A. | Supstituirani pirazolo(1,5-a)pirimidini i njihova uporaba u liječenju medicinskih poremećaja |
-
2018
- 2018-12-21 JP JP2020534456A patent/JP2021506920A/ja active Pending
- 2018-12-21 WO PCT/US2018/067330 patent/WO2019126776A1/en not_active Ceased
- 2018-12-21 EP EP18837065.4A patent/EP3728265A1/en active Pending
- 2018-12-21 US US16/955,589 patent/US20200339587A1/en not_active Abandoned
-
2024
- 2024-01-11 JP JP2024002729A patent/JP2024050607A/ja active Pending
- 2024-12-12 US US18/979,274 patent/US20250340558A1/en active Pending
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