JPWO2019107440A5 - - Google Patents
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- Publication number
- JPWO2019107440A5 JPWO2019107440A5 JP2019557285A JP2019557285A JPWO2019107440A5 JP WO2019107440 A5 JPWO2019107440 A5 JP WO2019107440A5 JP 2019557285 A JP2019557285 A JP 2019557285A JP 2019557285 A JP2019557285 A JP 2019557285A JP WO2019107440 A5 JPWO2019107440 A5 JP WO2019107440A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- drug
- differentiation
- epidermal
- promotes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 230000004069 differentiation Effects 0.000 claims 3
- 210000001339 epidermal cell Anatomy 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 210000004748 cultured cell Anatomy 0.000 claims 2
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- OXJGJKIURHREKH-UHFFFAOYSA-O CC(=C)C(=O)OCCP(=O)=C(O)C[N+](C)(C)C Chemical group CC(=C)C(=O)OCCP(=O)=C(O)C[N+](C)(C)C OXJGJKIURHREKH-UHFFFAOYSA-O 0.000 claims 1
- 101150060473 DHCR7 gene Proteins 0.000 claims 1
- 244000046095 Psophocarpus tetragonolobus Species 0.000 claims 1
- 235000010580 Psophocarpus tetragonolobus Nutrition 0.000 claims 1
- 244000081822 Uncaria gambir Species 0.000 claims 1
- 229940069765 bean extract Drugs 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 210000005175 epidermal keratinocyte Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 229960000342 retinol acetate Drugs 0.000 claims 1
- 235000019173 retinyl acetate Nutrition 0.000 claims 1
- 239000011770 retinyl acetate Substances 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Claims (4)
- ２－メタクリロイルオキシエチルホスホリルコリン基を有するコポリマー、アセンヤク抽出物、酢酸レチノール、及びシカクマメ抽出物からなる群から選択される少なくとも１種類の成分を含むコレステロール合成促進剤。
- 請求項１に記載のコレステロール合成促進剤を含む、表皮細胞の分化を促進するための組成物。
- 表皮細胞の分化を促進する薬剤をスクリーニングする方法であって、候補薬剤を培養細胞に作用させた場合に、該細胞のＤＨＣＲ７遺伝子の発現を亢進させる薬剤を表皮細胞の分化を促進する薬剤として選定することを特徴とする方法。
- 前記培養細胞がヒト表皮角化細胞である、請求項３に記載の方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017230166 | 2017-11-30 | ||
| JP2017230166 | 2017-11-30 | ||
| PCT/JP2018/043851 WO2019107440A1 (ja) | 2017-11-30 | 2018-11-28 | コレステロール合成促進剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2019107440A1 JPWO2019107440A1 (ja) | 2021-01-14 |
| JPWO2019107440A5 true JPWO2019107440A5 (ja) | 2022-01-31 |
| JP7471085B2 JP7471085B2 (ja) | 2024-04-19 |
Family
ID=66665228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019557285A Active JP7471085B2 (ja) | 2017-11-30 | 2018-11-28 | コレステロール合成促進剤 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP7471085B2 (ja) |
| TW (1) | TW201924673A (ja) |
| WO (1) | WO2019107440A1 (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110628737B (zh) * | 2019-10-14 | 2022-06-07 | 南京农业大学 | 一个调控黄瓜矮化性状相关基因及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003292432A (ja) * | 2002-04-04 | 2003-10-15 | Noevir Co Ltd | 皮膚外用剤 |
| JP2004107243A (ja) * | 2002-09-17 | 2004-04-08 | Fancl Corp | シワ及び／又はたるみ改善用キット |
| JP2005068073A (ja) | 2003-08-25 | 2005-03-17 | Takashi Fukazawa | 目元用化粧料 |
| JP4332458B2 (ja) | 2004-03-30 | 2009-09-16 | 日油株式会社 | 皮膚化粧料 |
| JP5311704B2 (ja) | 2004-11-25 | 2013-10-09 | 日油株式会社 | 皮膚化粧料 |
| FR2922763B1 (fr) | 2007-10-31 | 2012-12-07 | Oreal | Composition cosmetique contenant un agent tenseur et un polymere acrylique. |
| JP2010143893A (ja) * | 2008-12-22 | 2010-07-01 | Nikko Chemical Co Ltd | セリンプロテアーゼＨｔｒＡ１及び／又はＨｔｒＡ２の活性阻害剤 |
| JP6071123B2 (ja) | 2012-02-10 | 2017-02-01 | 株式会社 資生堂 | 水中油型乳化皮膚化粧料 |
| KR101664025B1 (ko) * | 2014-06-30 | 2016-10-10 | (재) 경북천연염색산업연구원 | 천연 식물 추출물을 함유하는 화장료 조성물 |
-
2018
- 2018-11-28 WO PCT/JP2018/043851 patent/WO2019107440A1/ja active Application Filing
- 2018-11-28 JP JP2019557285A patent/JP7471085B2/ja active Active
- 2018-11-30 TW TW107142926A patent/TW201924673A/zh unknown
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