CA2864237A1 - Methods and apparatuses harvesting, modifying and reimplantation of dermal micro -organs - Google Patents

Methods and apparatuses harvesting, modifying and reimplantation of dermal micro -organs Download PDF

Info

Publication number
CA2864237A1
CA2864237A1 CA2864237A CA2864237A CA2864237A1 CA 2864237 A1 CA2864237 A1 CA 2864237A1 CA 2864237 A CA2864237 A CA 2864237A CA 2864237 A CA2864237 A CA 2864237A CA 2864237 A1 CA2864237 A1 CA 2864237A1
Authority
CA
Canada
Prior art keywords
dmo
apparatuses
harvesting
dermal
invention provide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2864237A
Other languages
French (fr)
Inventor
Alex Okun
Yaron Fuerst
David Shalhevet
Elisha Amir
Mordechay Bukhman
Stephen F. Bellomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medgenics Medical Israel Ltd
Original Assignee
Medgenics Medical Israel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/369,329 external-priority patent/US9107896B2/en
Application filed by Medgenics Medical Israel Ltd filed Critical Medgenics Medical Israel Ltd
Priority claimed from PCT/IL2012/050482 external-priority patent/WO2013118109A1/en
Publication of CA2864237A1 publication Critical patent/CA2864237A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/322—Skin grafting apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/0023—Surgical instruments, devices or methods, e.g. tourniquets disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00969—Surgical instruments, devices or methods, e.g. tourniquets used for transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320052—Guides for cutting instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320064—Surgical cutting instruments with tissue or sample retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/322—Skin grafting apparatus
    • A61B2017/3225—Skin grafting apparatus with processing of harvested tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medical Informatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Surgical Instruments (AREA)

Abstract

Embodiments of the present invention provide methods and apparatuses for harvesting Dermal Micro-organs (DMOs). Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro- architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus (5000, 6000) for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool (3014,6016) able to separate the DMO from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.
CA2864237A 2012-02-09 2012-11-28 Methods and apparatuses harvesting, modifying and reimplantation of dermal micro -organs Abandoned CA2864237A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/369,329 US9107896B2 (en) 2001-11-05 2012-02-09 Dermal micro-organs, methods and apparatuses for producing and using the same
US13/369,329 2012-02-09
PCT/IL2012/050482 WO2013118109A1 (en) 2003-05-01 2012-11-28 Methods and apparatuses harvesting, modifying and reimplantation of dermal micro -organs

Publications (1)

Publication Number Publication Date
CA2864237A1 true CA2864237A1 (en) 2013-08-15

Family

ID=47603901

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2864237A Abandoned CA2864237A1 (en) 2012-02-09 2012-11-28 Methods and apparatuses harvesting, modifying and reimplantation of dermal micro -organs

Country Status (8)

Country Link
EP (1) EP2811924A1 (en)
JP (1) JP2015507962A (en)
KR (1) KR20150000878A (en)
CN (1) CN104114111A (en)
AU (1) AU2012369064A1 (en)
CA (1) CA2864237A1 (en)
HK (1) HK1204899A1 (en)
MX (1) MX2014009507A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109394274B (en) * 2018-12-07 2024-01-26 中国人民解放军陆军军医大学第一附属医院 Small subcutaneous cyst detector
JP7324453B2 (en) * 2019-05-14 2023-08-10 学校法人 関西大学 Puncture aids and puncture devices

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS563044A (en) * 1979-06-25 1981-01-13 Olympus Optical Co Living body inspecting needle
US5211644A (en) * 1991-09-20 1993-05-18 Pmt Corporation Process and apparatus for a dermal graft
US5324300A (en) * 1991-10-25 1994-06-28 Elias Elias G Device for the controlled excision of tissue from a living body
DK176341B1 (en) * 1996-09-06 2007-08-27 Cook William Europ Aggregate for transluminal insertion of a tubular stent and an endovascular graft device
JP2001231783A (en) * 2000-02-23 2001-08-28 Asahi Optical Co Ltd Tissue collector for endoscope
AU2002347577A1 (en) * 2001-11-05 2003-05-19 Medgenics, Inc. System for processing tissue
US8088568B2 (en) * 2001-11-05 2012-01-03 Medgentics, Inc. Dermal micro-organs, methods and apparatuses for producing and using the same
US7468242B2 (en) * 2001-11-05 2008-12-23 Medgenics, Inc. Dermal micro organs, methods and apparatuses for producing and using the same
CN102816738B (en) * 2003-05-01 2015-03-25 迈德詹尼克斯公司 Dermal micro-organs, methods and apparatuses for producing and using the same
CN102958460B (en) * 2010-05-07 2016-06-15 通用医疗公司 Device for tissue transplantation and duplication

Also Published As

Publication number Publication date
AU2012369064A1 (en) 2014-09-18
KR20150000878A (en) 2015-01-05
AU2012369064A2 (en) 2014-10-02
AU2012369064A8 (en) 2014-10-09
HK1204899A1 (en) 2015-12-11
MX2014009507A (en) 2014-09-22
CN104114111A (en) 2014-10-22
EP2811924A1 (en) 2014-12-17
JP2015507962A (en) 2015-03-16

Similar Documents

Publication Publication Date Title
WO2013118109A8 (en) Methods and apparatuses harvesting, modifying and reimplantation of dermal micro -organs
WO2012019103A8 (en) System and apparatus for cell treatment
EP4296278A3 (en) Non-human animals having a humanized cluster of differentiation 47 gene
WO2016135559A3 (en) Materials and methods for treatment of human genetic diseases including hemoglobinopathies
CA2853731C (en) Humanized il-6 and il-6 receptor
SG10201811116UA (en) Non-human animals having a humanized programmed cell death 1 gene
WO2012019168A3 (en) Engineered nucleic acids and methods of use thereof
IN2014DN07853A (en)
WO2012140519A3 (en) Methods and systems for harvesting cells
EP4269430A3 (en) Non-human animals having a humanized signal-regulatory protein gene
CA2906970C (en) Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases
MX2013005356A (en) Use of fluopyram for controlling nematodes in crops and for increasing yield.
WO2013153553A3 (en) Compositions for controlling varroa mites in bees
EP3099334A4 (en) An improved fetal hemoglobin for genetic correction of sickle cell disease
WO2012003377A3 (en) Methods of preparing chorion tissue and products derived therefrom
SA517380883B1 (en) An Improved Expression Cassette for Packaging and Expression of Variant Factor Viii for The Treatment of Hemostasis Disorders
BR112017001978A2 (en) grain treated with a composition, method for reducing damage, method for reducing powders
WO2012094560A3 (en) Promoters, expression cassettes, vectors, kits, and methods for the treatment of achromatopsia and other diseases
MX2013000958A (en) Manufacture of inter -alpha - inhibitor proteins (iaip) from plasma.
IN2014DN06164A (en)
FR2975582B1 (en) OSTEOSYNTHESIS IMPLANT
WO2010148334A3 (en) Generation of induced pluripotent stem cells from cord blood
WO2013144727A3 (en) A scaffold material graft for wound care and/or other tissue healing applications
AU2018253575A1 (en) Natural killer cells from placenta
EA201390077A1 (en) GLUCOSOLINOLAT PROTECTOR PROTEIN AND ITS APPLICATIONS

Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20171128