IN2014DN06164A - - Google Patents

Download PDF

Info

Publication number
IN2014DN06164A
IN2014DN06164A IN6164DEN2014A IN2014DN06164A IN 2014DN06164 A IN2014DN06164 A IN 2014DN06164A IN 6164DEN2014 A IN6164DEN2014 A IN 6164DEN2014A IN 2014DN06164 A IN2014DN06164 A IN 2014DN06164A
Authority
IN
India
Prior art keywords
immunogens
relates
olps
aids
prevention
Prior art date
Application number
Inventor
Christian Brander
Pujadas Beatriz Mothe
Anuska Llano
Original Assignee
Esteve Labor Dr
Fundació Privada Inst De Recerca De La Sida Caixa
Institució Catalana De Recerca I Estudis Avançats
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr, Fundació Privada Inst De Recerca De La Sida Caixa, Institució Catalana De Recerca I Estudis Avançats filed Critical Esteve Labor Dr
Publication of IN2014DN06164A publication Critical patent/IN2014DN06164A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids vectors and host cells expressing these immunogens as well as vaccines including said immunogens.
IN6164DEN2014 2012-01-27 2013-01-28 IN2014DN06164A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12382031.8A EP2620446A1 (en) 2012-01-27 2012-01-27 Immunogens for HIV vaccination
PCT/EP2013/051596 WO2013110818A2 (en) 2012-01-27 2013-01-28 Immunogens for hiv vaccination

Publications (1)

Publication Number Publication Date
IN2014DN06164A true IN2014DN06164A (en) 2015-08-21

Family

ID=47603800

Family Applications (1)

Application Number Title Priority Date Filing Date
IN6164DEN2014 IN2014DN06164A (en) 2012-01-27 2013-01-28

Country Status (16)

Country Link
US (4) US9988425B2 (en)
EP (3) EP2620446A1 (en)
JP (2) JP6306514B2 (en)
KR (2) KR102108149B1 (en)
CN (2) CN110372798A (en)
AU (2) AU2013213564B2 (en)
BR (1) BR112014018396B1 (en)
CA (1) CA2862172C (en)
ES (1) ES2932407T3 (en)
IL (2) IL233771B (en)
IN (1) IN2014DN06164A (en)
MX (2) MX358711B (en)
NZ (3) NZ723229A (en)
RU (2) RU2648791C2 (en)
WO (1) WO2013110818A2 (en)
ZA (1) ZA201405204B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9090673B2 (en) * 2003-12-12 2015-07-28 City Of Hope Synthetic conjugate of CpG DNA and T-help/CTL peptide
WO2010077613A1 (en) 2008-12-09 2010-07-08 Gilead Sciences, Inc. Modulators of toll-like receptors
EP2620446A1 (en) 2012-01-27 2013-07-31 Laboratorios Del Dr. Esteve, S.A. Immunogens for HIV vaccination
HK1247128A1 (en) * 2014-03-21 2018-09-21 纽泰克温图斯公司 A non-naturally occuring porcine reproductive and respiratory syndrome virus(prrsv) and methods of using
EP4140485A1 (en) 2014-07-11 2023-03-01 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of hiv
EA201790369A1 (en) 2014-09-16 2017-10-31 Джилид Сайэнс, Инк. SOLID FORMS OF THOUGH-RECEPTOR MODULATOR
MA40783A (en) 2014-10-03 2017-08-08 Los Alamos Nat Security Llc HIV VACCINES CONTAINING ONE OR MORE POPULATION EPISENSUS ANTIGENS
AU2020279988A1 (en) 2019-05-22 2021-12-23 Aelix Therapeutics, S.L. Dosage regimens for vaccines
JP2022535337A (en) 2019-05-22 2022-08-08 ギリアード サイエンシーズ， インコーポレイテッド Combining TLR7 Modulating Compounds with HIV Vaccines
CA3145791A1 (en) 2019-07-16 2021-01-21 Gilead Sciences, Inc. Hiv vaccines and methods of making and using
AU2020384323A1 (en) * 2019-11-14 2022-06-02 Aelix Therapeutics, S.L. Dosage regimens for vaccines
WO2021228816A1 (en) 2020-05-12 2021-11-18 Janssen Vaccines & Prevention B.V. Administration of homologous adenoviral vectors
WO2022084333A1 (en) 2020-10-20 2022-04-28 Janssen Vaccines & Prevention B.V. Hiv vaccine regimens
KR20230131481A (en) 2021-01-14 2023-09-13 길리애드 사이언시즈, 인코포레이티드 HIV vaccine and methods of use thereof
WO2024084441A1 (en) 2022-10-19 2024-04-25 Aelix Therapeutics, S.L. Combination hiv vaccine
EP4417974A1 (en) 2023-02-17 2024-08-21 Fundació Privada Institut de Recerca de la SIDA-Caixa Cd33 as a biomarker of hiv control
WO2025017540A1 (en) 2023-07-20 2025-01-23 Aelix Therapeutics, S.L. Method of treatment of hiv infection with vaccine
CN118389553A (en) * 2024-03-01 2024-07-26 中国科学技术大学 Immune-enhancing RNA molecule, composition, vaccine and kit thereof

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787901A (en) 1971-09-11 1972-12-18 Freistaat Bayern Represente Pa ANTIVARIOLIC VACCINE
US7815916B1 (en) 1984-08-22 2010-10-19 The United States Of America As Represented By The Secretary Of Health And Human Services Cloning and expression of HTLV-III DNA
US5554372A (en) 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
US6294322B1 (en) 1988-01-26 2001-09-25 The United States Of America As Represented By The Department Of Health And Human Services Multideterminant peptides that elicit helper T-lymphocyte cytotoxic T-lymphocyte and neutralizing antibody responses against HIV-1
US5976541A (en) 1988-01-26 1999-11-02 The United States Of America As Represented By The Department Of Health And Human Services Potent peptide for stimulation of cytotoxic T lymphocytes specific for the HIV-1 envelope
US5081226A (en) 1986-12-30 1992-01-14 The United States Of America As Represented By The Department Of Health And Human Services Synthetic peptides sharing sequence homology with the HIV envelope protein
US5128319A (en) 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
US6210873B1 (en) 1987-08-28 2001-04-03 Board Of Regents, The University Of Texas System Methods and compositions for the priming of specific cytotoxic T-lymphocyte response
GB8918200D0 (en) 1989-08-09 1989-09-20 Medical Res Council The peptide fragments of hiv
US6174666B1 (en) 1992-03-27 2001-01-16 The United States Of America As Represented By The Department Of Health And Human Services Method of eliminating inhibitory/instability regions from mRNA
US7319000B1 (en) 1992-09-16 2008-01-15 Board Of Regents, The University Of Texas System Compositions and methods for eliciting immune or anti-infective responses
RU2201421C2 (en) 1993-06-09 2003-03-27 Коннот Лабораториз Лимитед Synthetic hiv peptide (variants), immunogenic composition for induction of immune response against hiv peptides, diagnostic set for assay of hiv-specific antibodies
US6472374B1 (en) 1994-12-24 2002-10-29 Cambridge University Technical Services Limited Endometrial function
UA68327C2 (en) 1995-07-04 2004-08-16 Gsf Forschungszentrum Fur Unwe A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals
US6096313A (en) 1996-02-09 2000-08-01 Ludwig Institute For Cancer Research Compositions containing immunogenic molecules and granulocyte-macrophage colony stimulating factor, as an adjuvant
US6093400A (en) 1996-08-09 2000-07-25 Cel Sci Corporation Modified HGP-30 peptides, conjugates, compositions and methods of use
EP0969864A1 (en) 1996-08-09 2000-01-12 Viral Technologies, Inc. Hiv p-17 peptide fragment, compositions containing and methods for producing and using same
US6031647A (en) 1996-10-23 2000-02-29 Nortel Networks Corporation Stable power control for optical transmission systems
US5972339A (en) 1997-11-13 1999-10-26 The General Hospital Corporation Method of eliciting anti-HIV-1 helper T cell responses
US20040106136A1 (en) 1999-01-25 2004-06-03 Musc Foundation For Research Development Method for testing drug susceptibility of HIV
CN1297932A (en) * 1999-11-30 2001-06-06 上海博容基因开发有限公司 Human lipoprotein precursor protein signal peptidell as one new kind of polypeptide and polynucleotides encoding this polypeptide
DE60043856D1 (en) * 1999-12-23 2010-04-01 Medical Res Council IMPROVEMENTS IN OR RELATED TO IMMUNE RESOLUTIONS AGAINST HIV
FR2803307A1 (en) * 1999-12-30 2001-07-06 Centre Nat Rech Scient SPECIFIC TH1 TYPE CD4 T LYMPHOCYTES LINES AND METHOD FOR THEIR EX VIVO INDUCTION
US20040105871A1 (en) 2000-03-02 2004-06-03 Robinson Harriet L. Compositions and methods for generating an immune response
CN1312275A (en) * 2000-03-07 2001-09-12 上海博德基因开发有限公司 Human heat shock protein 15 as one new polypeptide and polynucleotides encoding this polypeptide
AU5929101A (en) 2000-04-28 2001-11-12 Us Gov Health & Human Serv Improved immunogenicity using a combination of dna and vaccinia virus vector vaccines
DE60026199T2 (en) 2000-05-18 2006-11-23 Geneart Ag Synthetic genes for gagpol and their uses
AUPQ776100A0 (en) 2000-05-26 2000-06-15 Australian National University, The Synthetic molecules and uses therefor
JP5052732B2 (en) * 2000-08-14 2012-10-17 アメリカ合衆国 Modification of HIV Env, Gag, and Pol to enhance immunogenicity for genetic immunization
WO2002042480A2 (en) 2000-11-23 2002-05-30 Bavarian Nordic A/S Modified vaccinia ankara virus variant
CU23235A1 (en) 2001-02-28 2007-09-26 Ct Ingenieria Genetica Biotech RECOMBINANT POXVIRUS FOR CHEMICAL PROTEINS OF THE HUMAN IMMUNODEFICIENCY VIRUS AND ITS APPLICATION IN THERAPEUTICS AND AIDS PREVENTION
CN100392085C (en) 2001-09-20 2008-06-04 葛兰素集团有限公司 vaccine
AUPR842501A0 (en) 2001-10-23 2001-11-15 Epipop Pty Ltd A method for identification and development of therapeutic agents
US20050266024A1 (en) 2002-03-19 2005-12-01 Powdermed Limited Adjuvant
RU2238946C2 (en) 2002-04-22 2004-10-27 Государственный научный центр вирусологии и биотехнологии "Вектор" Artificial protein-immunogen tci comprising multiple ctl-epitopes of hiv-1 basic antigens, artificial gene tci encoding polyepitope protein-immunogen tci
KR101138067B1 (en) 2002-05-16 2012-04-24 버베리안 노딕 에이/에스 Recombinant poxvirus expressing homologous genes inserted into the poxviral genome
US7501127B2 (en) 2002-05-16 2009-03-10 Bavarian Nordic A/S Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of Modified Vaccinia virus Ankara
SI1506223T1 (en) 2002-05-16 2006-04-30 Bavarian Nordic As Fusion protein of hiv regulatory/accessory proteins
AU2003245729A1 (en) 2002-06-27 2004-01-19 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating a cytotoxic t lymphocyte immune response
EP1638993A4 (en) 2003-06-10 2007-05-09 Univ Melbourne IMMUNO-MODULATING COMPOSITIONS, USES THEREOF AND METHODS FOR PRODUCING THE SAME
CN1852734B (en) 2003-09-17 2010-12-01 杜克大学 common/ancestral immunogen
EP1678292A4 (en) 2003-09-18 2008-05-07 Univ Emory IMPROVED MVA VACCINES
CA2539864A1 (en) * 2003-09-24 2005-04-07 Oxxon Therapeutics Limited Hiv pharmaccines
GB0323840D0 (en) 2003-10-10 2003-11-12 Ist Superiore Sanita Vaccines
WO2005047483A2 (en) 2003-11-12 2005-05-26 Medical Research Council Renta: an hiv immunogen and uses thereof
WO2006010106A2 (en) * 2004-07-09 2006-01-26 The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services Dna-based vaccination of retroviral-infected individuals undergoing treatment
GB0417494D0 (en) 2004-08-05 2004-09-08 Glaxosmithkline Biolog Sa Vaccine
EP2319860A3 (en) 2004-08-27 2011-06-15 The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services Recombinant MVA viruses expressing clade A/G, clade B, and clade C modified HIV env, gag and pol genes
US20060095241A1 (en) 2004-10-29 2006-05-04 Microsoft Corporation Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails
US8000900B2 (en) 2004-09-21 2011-08-16 Microsoft Corporation Association-based predictions of pathogen characteristics
US8478535B2 (en) 2004-10-29 2013-07-02 Microsoft Corporation Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails
US20060160070A1 (en) 2004-10-29 2006-07-20 Microsoft Corporation Association-based epitome design
CA2853335A1 (en) 2005-02-24 2006-11-23 Medical Research Council Hivcon: an hiv immunogen and uses thereof
SG163572A1 (en) * 2005-07-11 2010-08-30 Globeimmune Inc Compositions and methods for eliciting an immune response to escape mutants of targeted therapies
BRPI0504117A (en) 2005-09-05 2007-05-22 Fundacao De Amparo A Pesquisa epitopes, combination of epitopes, uses of epitopes or their combination, composition, uses of composition, anti-HIV-1 prophylactic vaccines, therapeutic vaccines, method for identifying epitopes and methods for treatment or prevention.
KR20080106467A (en) 2006-03-10 2008-12-05 펩트셀 리미티드 Peptides, Compositions and Methods of Using HIV Modulators or Supplementary Proteins
GB0608368D0 (en) 2006-04-28 2006-06-07 Isis Innovation Process for making Oligopeptides
WO2007136763A2 (en) 2006-05-19 2007-11-29 Sanofi Pasteur, Inc. Immunological composition
EP2062023B2 (en) 2006-08-25 2016-11-09 The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services Intergenic sites between conserved genes in the genome of modified vaccinia ankara (mva) vaccinia virus
WO2008117813A1 (en) 2007-03-28 2008-10-02 Hiroshima University Chicken embryonic stem cell and method for evaluation thereof
JP5345135B2 (en) * 2007-04-26 2013-11-20 メルク・シャープ・アンド・ドーム・コーポレーション Synthetic expression vectors for insect cells
WO2009009743A2 (en) * 2007-07-12 2009-01-15 Institute For Advance Study Sequence optimization for expression of a foreign gene
AU2008348260A1 (en) 2008-01-16 2009-07-23 Opal Therapeutics Pty Ltd Immunomodulating compositions and uses therefor
RU2539765C2 (en) * 2008-07-16 2015-01-27 Бейлор Рисёч Инститьют HIV VACCINE BASED ON MAXIMISED Gag AND Nef TARGETING ON DENDRITE CELLS
US8709775B2 (en) 2008-08-29 2014-04-29 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
EP2161279A1 (en) 2008-08-29 2010-03-10 Centre National de la Recherche Scientifique Synthetic peptides corresponding to overlapping neutralizing determinants in the CBD1 epitope induce broadly neutralizing antibodies
US10369204B2 (en) 2008-10-02 2019-08-06 Dako Denmark A/S Molecular vaccines for infectious disease
HRP20181776T1 (en) 2008-11-18 2019-02-08 Beth Israel Deaconess Medical Center, Inc. Antiviral vaccines with improved cellular immunogenicity
WO2011035082A1 (en) 2009-09-17 2011-03-24 Sanofi Pasteur, Inc. Immunological compositions for hiv
SG178909A1 (en) 2009-10-08 2012-04-27 Bavarian Nordic As Generation of a broad t-cell response in humans against hiv
DK2488649T3 (en) 2009-10-16 2019-06-17 Us Health RECOMBINANT MODIFIED VACCINIA ANKARA (MVA) VACCINIA VIRUS CONTAINING RESTRUCTURED INSERTION PLACES
US20130195904A1 (en) 2010-01-04 2013-08-01 National University Of Singapore Human immunodeficiency virus (hiv-1) highly conserved and low variant sequences as targets for vaccine and diagnostic applications
CA2817418A1 (en) 2010-11-10 2012-05-18 Laboratorios Del Dr. Esteve, S.A. Highly immunogenic hiv p24 sequences
EP2620446A1 (en) 2012-01-27 2013-07-31 Laboratorios Del Dr. Esteve, S.A. Immunogens for HIV vaccination
JP2022535337A (en) 2019-05-22 2022-08-08 ギリアード サイエンシーズ， インコーポレイテッド Combining TLR7 Modulating Compounds with HIV Vaccines
AU2020279988A1 (en) 2019-05-22 2021-12-23 Aelix Therapeutics, S.L. Dosage regimens for vaccines
AU2020384323A1 (en) 2019-11-14 2022-06-02 Aelix Therapeutics, S.L. Dosage regimens for vaccines

Also Published As

Publication number Publication date
AU2013213564B2 (en) 2018-03-29
EP2807185A2 (en) 2014-12-03
ZA201405204B (en) 2015-10-28
EP2620446A1 (en) 2013-07-31
AU2013213564A1 (en) 2014-09-04
NZ628756A (en) 2016-12-23
BR112014018396B1 (en) 2023-03-21
KR20190085552A (en) 2019-07-18
NZ723229A (en) 2019-03-29
MX2014009091A (en) 2014-11-10
IL268629B (en) 2021-06-30
IL268629A (en) 2019-10-31
JP6749357B2 (en) 2020-09-02
US20180170971A1 (en) 2018-06-21
IL233771B (en) 2019-08-29
US10815278B2 (en) 2020-10-27
RU2018104969A (en) 2019-02-22
CN104080800B (en) 2019-08-27
KR20140122735A (en) 2014-10-20
WO2013110818A2 (en) 2013-08-01
US11325946B2 (en) 2022-05-10
CA2862172A1 (en) 2013-08-01
BR112014018396A2 (en) 2017-06-20
EP4163290A1 (en) 2023-04-12
KR102140778B1 (en) 2020-08-06
CN110372798A (en) 2019-10-25
CN104080800A (en) 2014-10-01
RU2014135053A (en) 2016-03-27
RU2721274C2 (en) 2020-05-18
US20190055289A1 (en) 2019-02-21
US20150050310A1 (en) 2015-02-19
KR102108149B1 (en) 2020-05-12
US9988425B2 (en) 2018-06-05
MX2018010483A (en) 2020-09-02
MX358711B (en) 2018-08-31
JP6306514B2 (en) 2018-04-04
US20210246172A1 (en) 2021-08-12
ES2932407T3 (en) 2023-01-18
WO2013110818A3 (en) 2013-11-07
BR112014018396A8 (en) 2017-07-11
JP2015509707A (en) 2015-04-02
RU2018104969A3 (en) 2019-02-22
NZ734689A (en) 2022-09-30
JP2018102314A (en) 2018-07-05
AU2018203264B2 (en) 2019-07-11
EP2807185B1 (en) 2022-09-14
CA2862172C (en) 2023-07-18
HK1204632A1 (en) 2015-11-27
AU2018203264A1 (en) 2018-05-31
US11919926B2 (en) 2024-03-05
IL233771A0 (en) 2014-09-30
RU2648791C2 (en) 2018-04-02

Similar Documents

Publication Publication Date Title
IN2014DN06164A (en)
SG10201900948PA (en) Modified nucleotide linkers
MX2020006117A (en) Targeted integration of nucleic acids.
IN2014CN04586A (en)
EP3741848A3 (en) Protease variants and polynucleotides encoding same
GB0917002D0 (en) Improved shigella blebs
EP4477734A3 (en) Protease variants and polynucleotides encoding same
EP3741849A3 (en) Protease variants and polynucleotides encoding same
HK1206636A1 (en) Modified polynucleotides for the production of oncology-related proteins and peptides
GB201009222D0 (en) Improved cancer therapy based on tumour associated antigens derived from cyclin D1
MX356647B (en) Polypeptides having phospholipase c activity and polynucleotides encoding same.
MX2015000312A (en) Polypeptides having lipase activity and polynucleotides encoding same.
MX351565B (en) COLLAGEN 7 and RELATED METHODS.
MY184037A (en) Antibodies to bradykinin b1 receptor ligands
MX2021013104A (en) Lipase variants and polynucleotides encoding same.
PH12016500500A1 (en) A viral vaccine and methods of manufacture thereof
IL235891A0 (en) Peptides derived from viral proteins for use as immunogens and dosage reactants
MX2015013447A (en) Polypeptides having phospholipase a activity and polynucleotides encoding same.
MA37749B1 (en) Vaccines against bluetongue and African horse sickness virus
GB201017519D0 (en) Vaccines
MX2016012840A (en) Improved modular antigen transportation molecules and uses therof.
WO2013168176A3 (en) Process for preparation of fosaprepitant and salt thereof
MX350713B (en) Subtilisin variants and polynucleotides encoding same.
MX2015014198A (en) Antibodies targeting m-csf.
SG10201506857QA (en) Method of synthesizing peptides, proteins and bioconjugates