JPWO2018235104A5 - - Google Patents
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- Publication number
- JPWO2018235104A5 JPWO2018235104A5 JP2019571018A JP2019571018A JPWO2018235104A5 JP WO2018235104 A5 JPWO2018235104 A5 JP WO2018235104A5 JP 2019571018 A JP2019571018 A JP 2019571018A JP 2019571018 A JP2019571018 A JP 2019571018A JP WO2018235104 A5 JPWO2018235104 A5 JP WO2018235104A5
- Authority
- JP
- Japan
- Prior art keywords
- abuse
- cellulose
- pharmaceutical composition
- oral solid
- alkalizing agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 12
- 239000000194 fatty acid Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 230000003113 alkalizing Effects 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- -1 alcohol fatty acid ester Chemical class 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- 230000002459 sustained Effects 0.000 claims description 7
- VUKAUDKDFVSVFT-UHFFFAOYSA-N 2-[6-[4,5-bis(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dimethoxy-2-(methoxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol Chemical compound COC1C(OC)C(OC2C(C(O)C(OC)C(CO)O2)O)C(COC)OC1OC1C(COCC(C)O)OC(OC)C(OCC(C)O)C1OCC(C)O VUKAUDKDFVSVFT-UHFFFAOYSA-N 0.000 claims description 5
- 239000001856 Ethyl cellulose Substances 0.000 claims description 4
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 4
- 229920001249 ethyl cellulose Polymers 0.000 claims description 4
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 4
- 150000004665 fatty acids Chemical class 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 4
- 239000008158 vegetable oil Substances 0.000 claims description 4
- CWSZBVAUYPTXTG-UHFFFAOYSA-N 5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OCCO)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 CWSZBVAUYPTXTG-UHFFFAOYSA-N 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- 229920002301 Cellulose acetate Polymers 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 235000010981 methylcellulose Nutrition 0.000 claims description 3
- 125000005456 glyceride group Chemical group 0.000 claims description 2
- 229920005862 polyol Polymers 0.000 claims description 2
- 150000003077 polyols Chemical class 0.000 claims description 2
- 239000011541 reaction mixture Substances 0.000 claims description 2
- 235000003702 sterols Nutrition 0.000 claims description 2
- 150000003432 sterols Chemical class 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000007787 solid Substances 0.000 claims 9
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims 4
- 230000002378 acidificating Effects 0.000 claims 3
- 230000001419 dependent Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drugs Drugs 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M NaHCO3 Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- 239000000395 magnesium oxide Substances 0.000 claims 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- BVDRUCCQKHGCRX-UHFFFAOYSA-N 2,3-dihydroxypropyl formate Chemical compound OCC(O)COC=O BVDRUCCQKHGCRX-UHFFFAOYSA-N 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N 2-methyl-2-propenoic acid methyl ester Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- XAPRFLSJBSXESP-UHFFFAOYSA-N Oxycinchophen Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=C(O)C=1C1=CC=CC=C1 XAPRFLSJBSXESP-UHFFFAOYSA-N 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 239000001187 sodium carbonate Substances 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 230000002209 hydrophobic Effects 0.000 description 3
- 150000003626 triacylglycerols Chemical class 0.000 description 3
- WCOXQTXVACYMLM-UHFFFAOYSA-N 2,3-bis(12-hydroxyoctadecanoyloxy)propyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC(O)CCCCCC)COC(=O)CCCCCCCCCCC(O)CCCCCC WCOXQTXVACYMLM-UHFFFAOYSA-N 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 239000010514 hydrogenated cottonseed oil Substances 0.000 description 1
- 239000008173 hydrogenated soybean oil Substances 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 239000008184 oral solid dosage form Substances 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201621044051 | 2017-06-23 | ||
| IN201621044051 | 2017-06-23 | ||
| PCT/IN2018/050410 WO2018235104A2 (fr) | 2017-06-23 | 2018-06-22 | Forme pharmaceutique solide orale dissuasive d'abus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020524697A JP2020524697A (ja) | 2020-08-20 |
| JPWO2018235104A5 true JPWO2018235104A5 (fr) | 2022-02-16 |
| JP7125436B2 JP7125436B2 (ja) | 2022-08-24 |
Family
ID=64736917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019571018A Active JP7125436B2 (ja) | 2017-06-23 | 2018-06-22 | 乱用抑止経口固体投与形態 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11439600B2 (fr) |
| EP (1) | EP3641734A4 (fr) |
| JP (1) | JP7125436B2 (fr) |
| CN (1) | CN110869007B (fr) |
| AU (1) | AU2018288071A1 (fr) |
| CA (1) | CA3067945A1 (fr) |
| WO (1) | WO2018235104A2 (fr) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8765178B2 (en) * | 2006-07-19 | 2014-07-01 | Watson Laboratories, Inc. | Controlled release formulations and associated methods |
| WO2008067037A2 (fr) * | 2006-10-05 | 2008-06-05 | Santarus, Inc. | Nouvelles formulations pour une libération immédiate d'inhibiteurs de pompe à protons et procédés d'utilisation de ces formulations |
| GB0808537D0 (en) | 2008-05-12 | 2008-06-18 | Archimedes Dev Ltd | Compositions |
| TW201022253A (en) * | 2008-11-14 | 2010-06-16 | Portola Pharm Inc | Solid composition for controlled release of ionizable active agents with poor aqueous solubility at low pH and methods of use thereof |
| CA2827273A1 (fr) | 2011-02-17 | 2012-08-23 | QRxPharma Ltd. | Technologie pour prevenir l'abus de formes pharmaceutiques solides |
| WO2014085599A1 (fr) | 2012-11-30 | 2014-06-05 | Acura Pharmaceuticals, Inc. | Libération autorégulée de principe pharmaceutique actif |
| WO2014145195A1 (fr) | 2013-03-15 | 2014-09-18 | Cerovene, Inc. | Compositions pharmaceutiques comprenant un composant dépendant du ph et un agent d'augmentation du ph |
| US20150118300A1 (en) | 2013-10-31 | 2015-04-30 | Cima Labs Inc. | Immediate Release Abuse-Deterrent Granulated Dosage Forms |
| US9616029B2 (en) | 2014-03-26 | 2017-04-11 | Sun Pharma Advanced Research Company Ltd. | Abuse deterrent immediate release coated reservoir solid dosage form |
| EP3169316A4 (fr) * | 2014-07-15 | 2018-01-24 | Isa Odidi | Compositions et procédés pour réduire une surdose |
| JP6696994B2 (ja) | 2014-12-08 | 2020-05-20 | クレシオ・バイオサイエンシズ・リミテッド | 即放性乱用抑止性顆粒剤形 |
| WO2016120892A1 (fr) * | 2015-01-29 | 2016-08-04 | Sun Pharma Advanced Research Company Ltd. | Forme pharmaceutique solide à libération contrôlée à dissuasion d'abus |
| EP3319605A4 (fr) | 2015-07-10 | 2019-01-23 | Sun Pharma Advanced Research Company Ltd | Forme galénique solide d'hydrocodone à libération immédiate résistant à la prise abusive de plusieurs pilules |
| US20170157052A1 (en) * | 2015-12-08 | 2017-06-08 | Cima Labs Inc. | Immediate release dosage forms that deter abuse by oral ingestion of multiple dosage units |
-
2018
- 2018-06-22 JP JP2019571018A patent/JP7125436B2/ja active Active
- 2018-06-22 EP EP18820399.6A patent/EP3641734A4/fr not_active Withdrawn
- 2018-06-22 WO PCT/IN2018/050410 patent/WO2018235104A2/fr active Application Filing
- 2018-06-22 US US16/625,271 patent/US11439600B2/en active Active
- 2018-06-22 AU AU2018288071A patent/AU2018288071A1/en active Pending
- 2018-06-22 CN CN201880042133.1A patent/CN110869007B/zh active Active
- 2018-06-22 CA CA3067945A patent/CA3067945A1/fr active Pending
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