JPWO2012074037A1 - 豊胸促進剤 - Google Patents
豊胸促進剤 Download PDFInfo
- Publication number
- JPWO2012074037A1 JPWO2012074037A1 JP2012546924A JP2012546924A JPWO2012074037A1 JP WO2012074037 A1 JPWO2012074037 A1 JP WO2012074037A1 JP 2012546924 A JP2012546924 A JP 2012546924A JP 2012546924 A JP2012546924 A JP 2012546924A JP WO2012074037 A1 JPWO2012074037 A1 JP WO2012074037A1
- Authority
- JP
- Japan
- Prior art keywords
- calcium phosphate
- particles
- breast augmentation
- calcium
- fine particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000481 breast Anatomy 0.000 title claims abstract description 76
- 230000003416 augmentation Effects 0.000 title claims abstract description 66
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 108
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 108
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 106
- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 106
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 67
- 239000010419 fine particle Substances 0.000 claims abstract description 57
- 239000011164 primary particle Substances 0.000 claims description 80
- 239000002245 particle Substances 0.000 claims description 76
- 238000000034 method Methods 0.000 claims description 64
- 238000005245 sintering Methods 0.000 claims description 49
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 35
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 35
- 238000002156 mixing Methods 0.000 claims description 32
- 230000000694 effects Effects 0.000 abstract description 32
- 230000037319 collagen production Effects 0.000 abstract description 13
- 210000002950 fibroblast Anatomy 0.000 abstract description 6
- 239000011859 microparticle Substances 0.000 abstract description 6
- 229960001714 calcium phosphate Drugs 0.000 description 98
- -1 hydroxide ions Chemical class 0.000 description 63
- 150000001875 compounds Chemical class 0.000 description 36
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- 235000001014 amino acid Nutrition 0.000 description 13
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- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 10
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 9
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 8
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- 210000004207 dermis Anatomy 0.000 description 8
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- 235000021317 phosphate Nutrition 0.000 description 8
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 8
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 8
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- 125000003277 amino group Chemical group 0.000 description 6
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- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 6
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- 239000004480 active ingredient Substances 0.000 description 5
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 5
- 150000007942 carboxylates Chemical class 0.000 description 5
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- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 4
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 4
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- 239000000463 material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 150000002816 nickel compounds Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 125000006353 oxyethylene group Chemical group 0.000 description 1
- 229940075639 palmitoyl glycine Drugs 0.000 description 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- RAFRTSDUWORDLA-UHFFFAOYSA-N phenyl 3-chloropropanoate Chemical compound ClCCC(=O)OC1=CC=CC=C1 RAFRTSDUWORDLA-UHFFFAOYSA-N 0.000 description 1
- HOKBIQDJCNTWST-UHFFFAOYSA-N phosphanylidenezinc;zinc Chemical compound [Zn].[Zn]=P.[Zn]=P HOKBIQDJCNTWST-UHFFFAOYSA-N 0.000 description 1
- 229940085991 phosphate ion Drugs 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000172 poly(styrenesulfonic acid) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229940005642 polystyrene sulfonic acid Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 235000007686 potassium Nutrition 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- SATVIFGJTRRDQU-UHFFFAOYSA-N potassium hypochlorite Chemical compound [K+].Cl[O-] SATVIFGJTRRDQU-UHFFFAOYSA-N 0.000 description 1
- 235000010289 potassium nitrite Nutrition 0.000 description 1
- 239000004304 potassium nitrite Substances 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- YAZJAPBTUDGMKO-UHFFFAOYSA-L potassium selenate Chemical compound [K+].[K+].[O-][Se]([O-])(=O)=O YAZJAPBTUDGMKO-UHFFFAOYSA-L 0.000 description 1
- VISKNDGJUCDNMS-UHFFFAOYSA-M potassium;chlorite Chemical compound [K+].[O-]Cl=O VISKNDGJUCDNMS-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229940091258 selenium supplement Drugs 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000037393 skin firmness Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 description 1
- 229960002218 sodium chlorite Drugs 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 239000011655 sodium selenate Substances 0.000 description 1
- 235000018716 sodium selenate Nutrition 0.000 description 1
- 229960001881 sodium selenate Drugs 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- MWZFQMUXPSUDJQ-KVVVOXFISA-M sodium;[(z)-octadec-9-enyl] sulfate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCCOS([O-])(=O)=O MWZFQMUXPSUDJQ-KVVVOXFISA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229910001427 strontium ion Inorganic materials 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 108010021724 tonin Proteins 0.000 description 1
- 229910001428 transition metal ion Inorganic materials 0.000 description 1
- 229910000314 transition metal oxide Inorganic materials 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 229940102001 zinc bromide Drugs 0.000 description 1
- 239000011667 zinc carbonate Substances 0.000 description 1
- 235000004416 zinc carbonate Nutrition 0.000 description 1
- 229910000010 zinc carbonate Inorganic materials 0.000 description 1
- 229940043825 zinc carbonate Drugs 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 1
- 229940007718 zinc hydroxide Drugs 0.000 description 1
- 229910021511 zinc hydroxide Inorganic materials 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- 229940105296 zinc peroxide Drugs 0.000 description 1
- 229940048462 zinc phosphide Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- QPQOIFMSSWHRJQ-UHFFFAOYSA-L zinc;dichlorite Chemical compound [Zn+2].[O-]Cl=O.[O-]Cl=O QPQOIFMSSWHRJQ-UHFFFAOYSA-L 0.000 description 1
- OXCRJCXSFXJLFS-UHFFFAOYSA-N zinc;dihypochlorite Chemical compound [Zn+2].Cl[O-].Cl[O-] OXCRJCXSFXJLFS-UHFFFAOYSA-N 0.000 description 1
- HHIMNFJHTNVXBJ-UHFFFAOYSA-L zinc;dinitrite Chemical compound [Zn+2].[O-]N=O.[O-]N=O HHIMNFJHTNVXBJ-UHFFFAOYSA-L 0.000 description 1
- VIFYIFQGOLPNHA-UHFFFAOYSA-L zinc;dioxido-oxo-sulfanylidene-$l^{6}-sulfane Chemical compound [Zn+2].[O-]S([O-])(=O)=S VIFYIFQGOLPNHA-UHFFFAOYSA-L 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
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Abstract
Description
リン酸カルシウムを含有する一次粒子と融着防止剤とを混合する、混合工程と、
上記混合工程によって得られた混合粒子を焼結温度に曝す、焼結工程と、
を含む方法により製造された、前記発明(4)の豊胸促進剤である。
次に、本最良形態に係るリン酸カルシウム微粒子の製造方法について説明する。リン酸カルシウム微粒子は、湿式法や、乾式法、加水分解法、水熱法等の公知の製造方法によって、人工的に製造されたものであってもよく、また、骨、歯等から得られる天然由来のものであってもよい。また、粒径の大きなリン酸カルシウム粒子を製造して、周知の方法により粉砕したものであってもよい。
当該一次粒子生成工程は、リン酸カルシウム微粒子を生成することができる工程であれば特に限定されるものではなく、製造する高結晶性リン酸カルシウム微粒子の原料により適宜選択の上、採用すればよい。例えば、常温下において水酸化カルシウムスラリーにリン酸を滴下すれば、リン酸カルシウム(CaP)の粒子が沈殿する。
当該混合工程は、一次粒子と融着防止剤とを混合する工程である。上記一次粒子生成工程によって得られた一次粒子群の粒子間に、あらかじめ融着防止剤を介在させておくことで、その後の焼結工程における一次粒子同士の融着を防止することができるというものである。尚、当該混合工程によって得られた一次粒子と融着防止剤との混合物を「混合粒子」と呼ぶ。
当該焼結工程は、上記混合工程によって得られた混合粒子を焼結温度に曝して、当該混合粒子に含まれる一次粒子を高結晶性リン酸カルシウム微粒子(焼結体粒子)にする工程である。一次粒子の粒子間に融着防止剤が介在しているために、焼結工程における高温条件に曝された場合であっても一次粒子同士の融着を防止することができるというものである。
当該除去工程は、焼結工程によって得られた高結晶性リン酸カルシウム微粒子の粒子間に混在する融着防止剤を取り除く工程である。
上記、本最良形態に係るリン酸カルシウム粒子の製造方法によって製造されたリン酸カルシウム粒子は、融着防止剤の作用によって一次粒子同士の融着が防止されているために、その過半数が一次粒子の状態をキープしている。よって、当該高結晶性リン酸カルシウム粒子を溶媒中に懸濁した際には、高結晶性リン酸カルシウム粒子の過半数が単結晶からなる一次粒子又は前記単結晶からなる一次粒子がイオン的相互作用にて集合化した粒子塊(単結晶一次粒子)で分散することができる。
本最良形態に係る豊胸促進剤を胸部に塗布する豊胸促進方法は、特に限定されない。例えば、一日1〜3回(好適には2回)、一回250〜4000mg(好適には、500〜2000mg、更に好適には1000mg)(但し、この中にリン酸カルシウムが10〜300mg(好適には25〜200mg、より好適には50mg)含まれる)、胸部(特に上方胸部)に塗布する外皮用として用いることにより効能を発揮する。さらに、1週間〜1年といった長期間継続的に用いることにより、さらなる効能を発揮する。
(一次粒子生成工程)
連続オイル相としてドデカン〔CH3(CH2)10CH3〕、非イオン性界面活性剤として曇点31℃のペンタエチレングリコールドデシルエーテル〔CH3(CH2)10CH2O(CH2CH2O)4CH2CH2OH〕を用いた。室温において、上記非イオン性界面活性剤0.5gを含有している連続オイル相40mlを調製した。次に、上記で調製した連続オイル相に2.5mol/l水酸化カルシウム〔Ca(OH)2〕分散水溶液10mlを添加し、油中水滴型溶液(W/O溶液)を調製した。上記W/O溶液を攪拌しながら、そこに1.5mol/lリン酸二水素カリウム〔(KH2PO4)〕溶液を10ml添加した。そして、24時間、室温で撹拌しながら反応させた。次に、得られた反応物を遠心分離により分離洗浄することにより、ハイドロキシアパタイト(HAp)一次粒子群を取得した。
1.0gのポリアクリル酸ナトリウム(ALDRICH社製、重量平均分子量15,000g/mol)を含むpH12.0の水溶液100mlに、1.0gのハイドロキシアパタイト(HAp)一次粒子群を分散させることで、同粒子表面にポリアクリル酸ナトリウムを吸着させた。この水溶液のpHは株式会社 堀場製作所製pHメータD−24SEを用いて測定した。
上記混合粒子をルツボに入れ、焼結温度800℃にて1時間焼結を行なった。この際、ポリアクリル酸カルシウムは熱分解し、酸化カルシウム〔CaO〕となった。焼結工程終了後の酸化カルシウム〔CaO〕の残存率は25%以上であった。
融着防止剤の水への溶解性を上げるために、50mmol/l硝酸アンモニウム〔NH4NO3〕水溶液を調製した。次に、上記で調製した水溶液500mlに、上記工程にて得られた焼結体を懸濁し、遠心分離により分離洗浄し、さらに蒸留水に懸濁し、同様に遠心分離により分離洗浄を行なうことによって、融着防止剤及び硝酸アンモニウムを除去し、高結晶性ハイドロキシアパタイト(HAp)微粒子を回収した。これらの工程により得られたハイドロキシアパタイト微粒子の詳細な情報については、以下にまとめた。
形状:球状
平均粒径(電子顕微鏡より):28nm
変動係数:14%
一次粒子生成工程における反応温度を30℃としたこと以外では製造例1と同条件で一次粒子生成工程をのみ行い、その後の混合工程や焼結工程等のその後の工程を行わないで、製造例2の未焼成のハイドロキシアパタイト微粒子を得た。以下、当該ハイドロキシアパタイト微粒子の詳細な情報について記載する。
形状:粒子形状
平均粒径(電子顕微鏡より):42nm
変動係数:17%
正常ヒト線維芽細胞を試料含有0.5%FBS−DMEM培地にて24時間培養後、培地中のコラーゲン量をELISAにて定量した。当該実験はそれぞれの条件において6回反復して行なった(n=6)。陽性コントロール(P.C.)には、アルコルビン酸リン酸マグネシウム(VCPMg)を用いた。尚、用いた試料は、製造例1において製造した焼成のハイドロキシアパタイトと、製造例2において使用した未焼成したハイドロキシアパタイトである。結果を表1に示した。ここで、表1中の「mean」は、測定で得られたコラーゲン量の実測値(平均値)を示しており、「SD」とは、標準偏差を示しており、「p(t−test)」とは、「t−test」により得られたp値{一般的に0.05(厳密に議論する場合は、0.01)以下であれば、差がある値であることを示し、逆に、0.05より大きな値である場合、差がほとんどないことを示す。}を示している。
試験条件:被験者成人女性に試験内容、趣旨を説明したのち、前腕部にてパッチテストを行い異常が認められないことを確認した上で、本発明に係る豊胸促進剤の効果を調査した。
製造例1のハイドロキシアパタイト(焼成):5質量%
グリセリン:6質量%
ポリエチレングリコール:14質量%
水:75質量%
長期投与における効果を調査する目的で、2名の被験者A及びBに豊胸促進試験1で用いた豊胸促進剤を2ヶ月間朝晩の一日二回ずつ継続投与し(適用量:片方あたり約500mg、即ち、1回あたり約1g)、以下に示す設問に塗布後の感想を記入してもらった。設問に対する感想を、「変わらない」を0、上がった程度を+1〜+4の4段階、下がった程度を−1〜−4の4段階と、計9段階との評価とした。評価の詳細及び詳細を表2及び表3にそれぞれ示す。
2ヶ月継続した試験により、いずれの設問においても継続性、即効性共に使用前に比べ改善した意見のみであった。ハリについては、即効性、持続性共に同等のスコアであり、初期に獲得したハリが維持されることを示唆している。ボリュームについては、即効性に比べ継続性に関するスコアが高いことから試用期間の経過と共にボリュームアップの効果が獲得できていることを示唆している。いずれの被験者も弾力の改善(即効性、継続性ともに)に関する効果を認めている。
豊胸促進試験2を経た被験者A及びBについて、塗布前後におけるバスト状態の変化を検証するために、エコー断面写真の撮影を行った。図2及び図3に結果を示す。写真に向かって左側が適用前の画像で、(C)「白点間の距離」が胸部皮下組織の厚みである。対して、右側が2ヶ月(材適応並びに問診期間)後の画像で、(C)「白点間の距離」が胸部皮下組織の厚みである。いずれの被験者も胸部皮下組織が厚くなり効果が認められた。
Claims (6)
- リン酸カルシウム微粒子を含有することを特徴とする豊胸促進剤。
- 前記リン酸カルシウム微粒子がハイドロキシアパタイト微粒子である、請求項1記載の豊胸促進剤。
- 前記リン酸カルシウム微粒子の平均粒子径が、10〜1,000nmである、請求項1又は2記載の豊胸促進剤。
- 前記リン酸カルシウム微粒子が、焼結体である、請求項1〜3のいずれか一項記載の豊胸促進剤。
- 前記焼結体が、
リン酸カルシウムを含有する一次粒子と融着防止剤とを混合する、混合工程と、
上記混合工程によって得られた混合粒子を焼結温度に曝す、焼結工程と、
を含む方法により製造された、請求項4記載の豊胸促進剤。 - 外用である、請求項1〜5のいずれか一項記載の豊胸促進剤。
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EP3508225A4 (en) * | 2016-08-30 | 2020-05-06 | SofSera Corporation | NEW COMPOSITE MATERIAL OF CERAMIC PARTICLES |
US20190290807A1 (en) * | 2016-08-30 | 2019-09-26 | Sofsera Corporation | Ceramic particle carrying stent |
US20200000684A1 (en) * | 2016-08-30 | 2020-01-02 | Sofsera Corporation | Ceramic particle carrying medical tube and/or cuff |
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JPH0517111A (ja) | 1991-02-21 | 1993-01-26 | Ricoh Co Ltd | 水酸アパタイト超微粒子 |
JP2000302667A (ja) | 1999-04-23 | 2000-10-31 | Kobe Tennenbutsu Kagaku Kk | 豊胸促進剤 |
US7094282B2 (en) * | 2000-07-13 | 2006-08-22 | Calcitec, Inc. | Calcium phosphate cement, use and preparation thereof |
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JP4076203B2 (ja) | 2000-10-31 | 2008-04-16 | 独立行政法人科学技術振興機構 | ハイドロキシアパタイトナノ粒子およびその製造方法 |
JP2003320017A (ja) * | 2002-05-07 | 2003-11-11 | Ngk Spark Plug Co Ltd | リン酸カルシウム多孔体及びその製造方法 |
JP4353694B2 (ja) * | 2002-11-28 | 2009-10-28 | 独立行政法人産業技術総合研究所 | 亜鉛徐放性リン酸カルシウムを用いた硬化性骨補填剤及び皮膚欠損治療用剤 |
CN102815935B (zh) * | 2004-09-14 | 2014-12-31 | 独立行政法人科学技术振兴机构 | 陶瓷颗粒群及其用途 |
JP5261712B2 (ja) * | 2005-08-15 | 2013-08-14 | 国立大学法人京都大学 | リン酸カルシウム類微粒子を安定化させる方法、それを利用したリン酸カルシウム類微粒子の製造方法、およびその利用 |
FR2898807B1 (fr) * | 2006-03-23 | 2008-12-05 | Oreal | Composition comprenant de l'hydroxyapatite et un sel de calcium pour renforcer la fonction barriere de la peau et/ou des semi-muqueuses |
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