JPWO2005042737A1 - 遺伝子導入された樹状細胞の製造方法 - Google Patents

遺伝子導入された樹状細胞の製造方法 Download PDF

Info

Publication number
JPWO2005042737A1
JPWO2005042737A1 JP2005515163A JP2005515163A JPWO2005042737A1 JP WO2005042737 A1 JPWO2005042737 A1 JP WO2005042737A1 JP 2005515163 A JP2005515163 A JP 2005515163A JP 2005515163 A JP2005515163 A JP 2005515163A JP WO2005042737 A1 JPWO2005042737 A1 JP WO2005042737A1
Authority
JP
Japan
Prior art keywords
cells
dendritic cells
gene
cell
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2005515163A
Other languages
English (en)
Japanese (ja)
Inventor
慎士 岡野
慎士 岡野
米満 吉和
吉和 米満
居石 克夫
克夫 居石
智子 柴田
智子 柴田
長谷川 護
護 長谷川
Original Assignee
株式会社ディナベック研究所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社ディナベック研究所 filed Critical 株式会社ディナベック研究所
Publication of JPWO2005042737A1 publication Critical patent/JPWO2005042737A1/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/19Dendritic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24Antigen-presenting cells [APC]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4244Enzymes
    • A61K40/4245Tyrosinase or tyrosinase related proteinases [TRP-1 or TRP-2]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4271Melanoma antigens
    • A61K40/4272Melan-A/MART
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/428Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • C12N5/12Fused cells, e.g. hybridomas
    • C12N5/16Animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57Skin; melanoma
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18811Sendai virus
    • C12N2760/18841Use of virus, viral particle or viral elements as a vector
    • C12N2760/18843Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2005515163A 2003-11-04 2004-10-29 遺伝子導入された樹状細胞の製造方法 Withdrawn JPWO2005042737A1 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2003374808 2003-11-04
JP2003374808 2003-11-04
JP2004187028 2004-06-24
JP2004187028 2004-06-24
PCT/JP2004/016089 WO2005042737A1 (ja) 2003-11-04 2004-10-29 遺伝子導入された樹状細胞の製造方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011214253A Division JP2012065652A (ja) 2003-11-04 2011-09-29 遺伝子導入された樹状細胞の製造方法

Publications (1)

Publication Number Publication Date
JPWO2005042737A1 true JPWO2005042737A1 (ja) 2007-05-10

Family

ID=34554806

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2005515163A Withdrawn JPWO2005042737A1 (ja) 2003-11-04 2004-10-29 遺伝子導入された樹状細胞の製造方法
JP2011214253A Pending JP2012065652A (ja) 2003-11-04 2011-09-29 遺伝子導入された樹状細胞の製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011214253A Pending JP2012065652A (ja) 2003-11-04 2011-09-29 遺伝子導入された樹状細胞の製造方法

Country Status (8)

Country Link
US (1) US20070269414A1 (https=)
EP (1) EP1690937B1 (https=)
JP (2) JPWO2005042737A1 (https=)
KR (1) KR101279748B1 (https=)
CN (1) CN1902312B (https=)
AU (1) AU2004286144A1 (https=)
CA (1) CA2544786A1 (https=)
WO (1) WO2005042737A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0863202T3 (da) 1995-11-01 2010-09-27 Dnavec Research Inc Rekombinant Sendai-virus
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
JPWO2001072340A1 (ja) * 2000-03-30 2004-01-08 株式会社ディナベック研究所 センダイウイルスベクターを用いたaidsウイルスワクチン
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
CA2503317A1 (en) * 2002-10-24 2004-05-06 Dnavec Research Inc. Method of transferring gene into t cells
KR20060028432A (ko) * 2003-06-30 2006-03-29 가부시키가이샤 디나벡크 겐큐쇼 고변이영역이 개변된 유전자를 탑재하는 마이너스가닥 rna 바이러스 벡터
WO2005042737A1 (ja) * 2003-11-04 2005-05-12 Dnavec Research Inc. 遺伝子導入された樹状細胞の製造方法
AU2005205441A1 (en) * 2004-01-13 2005-07-28 Dnavec Research Inc. Gene therapy for tumor using minus-strand RNA virus vector encoding immunostimulating cytokine
US20080038234A1 (en) * 2004-03-23 2008-02-14 Shuji Hayashi Bone Marrow-Related Cells Associated With Tissue Maintenance And/Or Repair
WO2006001120A1 (ja) * 2004-06-24 2006-01-05 Dnavec Research Inc. マイナス鎖rnaウイルスを含む抗癌剤
WO2006134917A1 (ja) * 2005-06-14 2006-12-21 Dnavec Corporation 抗体の作製方法
CA2636600A1 (en) * 2006-01-17 2007-07-26 Dnavec Corporation Novel protein expression system
US20100203027A1 (en) * 2007-04-27 2010-08-12 Kyushu Univeristy National University Viral vector for gene therapy
EP2154243B1 (en) 2007-05-17 2016-01-13 ID Pharma Co., Ltd. Method for production of dendritic cell
EP2173374A2 (en) * 2007-07-24 2010-04-14 Stichting Katholieke Universiteit, Radboud University Nijmegen Medical Centre Compositions and methods for generating an immune response in a subject
JP2010537629A (ja) * 2007-08-30 2010-12-09 アカデミシュ ジーケンハウス ビイ デ ユニヴェアズィテート ファン アムステルダム 動脈形成に関与する経路及びその使用
JP5808915B2 (ja) * 2008-03-03 2015-11-10 ザ・ユニバーシティ・オブ・トレド 樹状細胞前駆体集団、それに由来する樹状細胞集団およびそれの使用
KR101527260B1 (ko) 2008-11-14 2015-06-08 디나벡크 가부시키가이샤 수상세포의 제조방법
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2020237315A1 (en) * 2019-05-31 2020-12-03 Telethon Kids Institute Immunogenic compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004616A2 (en) * 2001-07-05 2003-01-16 Phylogix, Inc. Dendritic cell isolation methods
WO2003022215A2 (en) * 2001-09-06 2003-03-20 Northwest Biotherapeutics, Inc. Compositions and methods for priming monocytic dendritic cells and t cells for th-1 response

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6147186A (ja) 1984-08-09 1986-03-07 Chemo Sero Therapeut Res Inst インフルエンザウイルスの精製方法
JPS6147185A (ja) 1984-08-09 1986-03-07 Chemo Sero Therapeut Res Inst 日本脳炎ウイルスの精製方法
JPS6147187A (ja) 1984-08-10 1986-03-07 Chemo Sero Therapeut Res Inst 狂犬病ウイルスの精製方法
JPH084508B2 (ja) 1987-09-16 1996-01-24 国立予防衛生研究所長 組み換えワクチニアウイルス
US5124148A (en) * 1988-04-27 1992-06-23 United Cancer Research Institute Method for treating viral diseases with attenuated virus
JPH01285498A (ja) 1988-05-11 1989-11-16 Mitsubishi Heavy Ind Ltd 宇宙用パネル展開装置
TW232710B (https=) 1991-09-13 1994-10-21 American Cyanamid Co
JPH05192160A (ja) 1992-01-20 1993-08-03 Banyu Pharmaceut Co Ltd C型肝炎ウイルスゲノムRNA、cDNA及びポリペプチド
WO1994008000A1 (en) 1992-10-06 1994-04-14 Akzo Nobel N.V. Pseudorabies virus vaccine
US6077519A (en) * 1993-01-29 2000-06-20 University Of Pittsburgh Methods for isolation and use of T cell epitopes eluted from viable cells in vaccines for treating cancer patients
EP2009119A1 (en) * 1993-04-30 2008-12-31 Wellstat Biologics Corporation Compositions for treating cancer using viruses
US5744144A (en) 1993-07-30 1998-04-28 University Of Pittsburgh University Patent Committee Policy And Procedures Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof
US5798100A (en) 1994-07-06 1998-08-25 Immunomedics, Inc. Multi-stage cascade boosting vaccine
US6300090B1 (en) * 1994-07-29 2001-10-09 The Rockefeller University Methods of use of viral vectors to deliver antigen to dendritic cells
DK0864645T3 (da) * 1995-10-31 2005-10-24 Dnavec Research Inc Negativstrenget RNA-virusvektor med autonom replikeringsaktivitet
DK0863202T3 (da) * 1995-11-01 2010-09-27 Dnavec Research Inc Rekombinant Sendai-virus
US6734014B1 (en) * 1996-02-08 2004-05-11 The United States Of America As Represented By The Department Of Health And Human Services Methods and compositions for transforming dendritic cells and activating T cells
EP0884383A4 (en) 1996-02-29 2001-12-05 Takara Shuzo Co METHOD FOR CLEANING AND REMOVING VIRUSES.
WO1998053048A1 (en) * 1997-05-21 1998-11-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods and compositions for making dendritic cells from expanded populations of monocytes and for activating t cells
KR100739938B1 (ko) 1999-05-18 2007-07-16 가부시키가이샤 디나벡크 겐큐쇼 엔벨로프 유전자 결손 파라믹소과 바이러스 벡터
US20030022376A1 (en) * 1999-05-18 2003-01-30 Kaio Kitazato Paramyxovirus-derived RNP
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
ATE399206T1 (de) 1999-05-18 2008-07-15 Dnavec Research Inc Ribonukleoproteinkomplex aus paramyxovirus
US7226786B2 (en) * 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
EP1067179A1 (en) 1999-07-09 2001-01-10 Pierre Fabre Medicament Method to select attenuated paramyxoviridae useful for vaccines and therapeutics
US20020123479A1 (en) * 1999-12-08 2002-09-05 Song Elizabeth S. Immunostimulation mediated by gene-modified dendritic cells
US6472208B1 (en) * 1999-12-13 2002-10-29 Héma-Québec Method of producing human IFN-α using sendai virus-infected hematopoietic stem cells
JPWO2001072340A1 (ja) * 2000-03-30 2004-01-08 株式会社ディナベック研究所 センダイウイルスベクターを用いたaidsウイルスワクチン
CA2322057A1 (en) * 2000-05-18 2001-11-18 Dnavec Research Inc. Paramyxovirus vectors used for transfer of foreign genes
AU2002305452A1 (en) * 2001-05-08 2002-11-18 Emory University Regulating immine responses using dendritic cells
JPWO2003025570A1 (ja) * 2001-09-18 2004-12-24 株式会社ディナベック研究所 粒子形成能が低下した(−)鎖rnaウィルスベクターの検査方法および製造方法
US20050048030A1 (en) * 2001-09-28 2005-03-03 Raymond Pickles Paramyxoviruses as gene transfer vectors to lung cells
JPWO2003029475A1 (ja) * 2001-09-28 2005-01-20 株式会社ディナベック研究所 エピトープ結合β2mをコードする哺乳動物細胞感染性ウイルスベクターおよびその利用
FR2838123B1 (fr) * 2002-04-04 2005-06-10 Sanofi Synthelabo Nouveaux derives d'indolozine-1,2,3 substituee, inhibiteurs selectifs du b-fgf
US20050191617A1 (en) * 2002-06-03 2005-09-01 Makoto Inoue Pramyxovirusl vectors encoding antibody and utilization thereof
AU2002951082A0 (en) * 2002-08-30 2002-09-12 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland Therapeutic cellular agents
CA2503317A1 (en) * 2002-10-24 2004-05-06 Dnavec Research Inc. Method of transferring gene into t cells
WO2004053095A2 (en) * 2002-12-10 2004-06-24 Merix Bioscience, Inc. In situ maturation of dendritic cells
WO2005042737A1 (ja) * 2003-11-04 2005-05-12 Dnavec Research Inc. 遺伝子導入された樹状細胞の製造方法
AU2005205441A1 (en) * 2004-01-13 2005-07-28 Dnavec Research Inc. Gene therapy for tumor using minus-strand RNA virus vector encoding immunostimulating cytokine
JP4999330B2 (ja) * 2004-01-22 2012-08-15 株式会社ディナベック研究所 サイトメガロウイルスエンハンサーおよびニワトリβ−アクチンプロモーターを含むハイブリッドプロモーターを利用したマイナス鎖RNAウイルスベクターの製造方法
CA2560046A1 (en) * 2004-03-16 2005-09-22 Dnavec Research Inc. Methods for suppressing tumor proliferation
US20080038234A1 (en) * 2004-03-23 2008-02-14 Shuji Hayashi Bone Marrow-Related Cells Associated With Tissue Maintenance And/Or Repair
WO2006001120A1 (ja) * 2004-06-24 2006-01-05 Dnavec Research Inc. マイナス鎖rnaウイルスを含む抗癌剤
AU2006237903A1 (en) * 2005-04-20 2006-10-26 Dna Vec Corporation Highly safe intranasally administrable gene vaccines for treating Alzheimer's disease
CA2654033A1 (en) * 2006-05-31 2007-12-06 Dnavec Corporation Therapeutic agent for alzheimer's disease
EP2154243B1 (en) * 2007-05-17 2016-01-13 ID Pharma Co., Ltd. Method for production of dendritic cell

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004616A2 (en) * 2001-07-05 2003-01-16 Phylogix, Inc. Dendritic cell isolation methods
WO2003022215A2 (en) * 2001-09-06 2003-03-20 Northwest Biotherapeutics, Inc. Compositions and methods for priming monocytic dendritic cells and t cells for th-1 response

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
JPN6010049262; J Immunother.(2002),Vol.25,No.6,p.445-454 *
JPN6011001446; 生化学(2003.08.25),Vol.75,No.8,p.737 *
JPN6014016073; J.Infect.dis. Vol.187,No.7, 200304, pp.1126-1136
JPN6014016074; J.Immunol. Vol.163, 1999, pp.1409-1419
JPN7010002694; J Interferon Cytokine Res.(2002),Vol.22,p.653-659 *
JPN7010002695; Gene Ther.(2003 Feb),Vol.10,No.3,p.272-277 *
JPN7010002696; Gene Ther.(2000),Vol.7,No.3,p.249-254 *
JPN7010002697; J Immunol Methods.(2002),Vol.271,No.1-2,p.153-165 *
JPN7010002698; Gene Ther.(2003 Aug),Vol.10,No.16,p.1381-1391 *

Also Published As

Publication number Publication date
EP1690937A1 (en) 2006-08-16
CA2544786A1 (en) 2005-05-12
CN1902312A (zh) 2007-01-24
US20070269414A1 (en) 2007-11-22
HK1103418A1 (en) 2007-12-21
WO2005042737A1 (ja) 2005-05-12
AU2004286144A2 (en) 2005-05-12
EP1690937B1 (en) 2012-10-17
JP2012065652A (ja) 2012-04-05
CN1902312B (zh) 2011-02-23
EP1690937A4 (en) 2007-01-03
AU2004286144A1 (en) 2005-05-12
KR101279748B1 (ko) 2013-07-04
KR20060125783A (ko) 2006-12-06

Similar Documents

Publication Publication Date Title
JP2012065652A (ja) 遺伝子導入された樹状細胞の製造方法
JP5296983B2 (ja) Rnaウイルスが導入された樹状細胞を含む抗癌剤
EP1561819A1 (en) Method of transferring gene into t cells
US7521043B2 (en) Gene therapy for tumors using minus-strand RNA viral vectors encoding immunostimulatory cytokines
US20100203027A1 (en) Viral vector for gene therapy
HK1089208A (en) Method of constructing transgenic dendritic cell
HK1103418B (en) Method for producing gene transferred dendritic cells
HK1078108A (en) Method of transferring gene into t cells
HK1106793A (en) Anticancer agent containing minus-strand rna virus
HK1088036A (en) Methods of transducing genes into t cells
HK1094874A (en) Gene therapy for tumor using minus-strand rna viral vectors encoding immunostimulatory cytokines

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071026

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071108

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100825

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101022

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101022

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110117

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110317

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110706

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110929

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20111012

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20111209

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20140203

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20140613