JPS6479133A - Production of optically active (r)-2-hydroxy-4-phenyllactic acid - Google Patents

Production of optically active (r)-2-hydroxy-4-phenyllactic acid

Info

Publication number
JPS6479133A
JPS6479133A JP23699087A JP23699087A JPS6479133A JP S6479133 A JPS6479133 A JP S6479133A JP 23699087 A JP23699087 A JP 23699087A JP 23699087 A JP23699087 A JP 23699087A JP S6479133 A JPS6479133 A JP S6479133A
Authority
JP
Japan
Prior art keywords
acid
phenyl lactic
acetic acid
lactic acid
acetoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP23699087A
Other languages
Japanese (ja)
Other versions
JPH0822832B2 (en
Inventor
Satomi Takahashi
Kazuhiko Yamada
Masabumi Fukae
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Priority to JP23699087A priority Critical patent/JPH0822832B2/en
Publication of JPS6479133A publication Critical patent/JPS6479133A/en
Publication of JPH0822832B2 publication Critical patent/JPH0822832B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE:To economically obtain the titled compound useful as an anti- hypertensive in high yield, by reacting an acetic acid of (R)-2-amino-4-phenyl lactic acid readily available with nitrous acid in the presence of acetic acid alkali metal salt. CONSTITUTION:(R)-2-Amino-4-phenyl lactic acid is used as a raw material and an acetic acid solution thereof is reacted with nitrous acid (e.g., sodium nitrite or potassium nitrite) in the presence of acetic acid alkali metal salt to give (R)-2-acetoxy-4-phenyl lactic acid, which is then hydrolyzed with an acid to provide the aimed compound. The above-mentioned acid hydrolysis is carried out by heating crude (R)-2-acetoxy-4-phenyl lactic acid at 60-100 deg.C while vigorously stirring in a mineral acid from 0.5N to 2N. The heat hydrolysis may be also carried out after directly adding a mineral acid and water to an acetic acid reaction solution of (R)-2-acetoxy-4-phenyl lactic acid.
JP23699087A 1987-09-21 1987-09-21 Process for producing optically active (R) -2-hydroxy-4-phenylbutyric acid Expired - Fee Related JPH0822832B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP23699087A JPH0822832B2 (en) 1987-09-21 1987-09-21 Process for producing optically active (R) -2-hydroxy-4-phenylbutyric acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23699087A JPH0822832B2 (en) 1987-09-21 1987-09-21 Process for producing optically active (R) -2-hydroxy-4-phenylbutyric acid

Publications (2)

Publication Number Publication Date
JPS6479133A true JPS6479133A (en) 1989-03-24
JPH0822832B2 JPH0822832B2 (en) 1996-03-06

Family

ID=17008754

Family Applications (1)

Application Number Title Priority Date Filing Date
JP23699087A Expired - Fee Related JPH0822832B2 (en) 1987-09-21 1987-09-21 Process for producing optically active (R) -2-hydroxy-4-phenylbutyric acid

Country Status (1)

Country Link
JP (1) JPH0822832B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055074A1 (en) * 2000-01-25 2001-08-02 Kaneka Corporation Process for producing optically active carboxylic acid substituted in 2-position

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055074A1 (en) * 2000-01-25 2001-08-02 Kaneka Corporation Process for producing optically active carboxylic acid substituted in 2-position
US7094926B2 (en) 2000-01-25 2006-08-22 Kaneka Corporation Process for producing optically active carboxylic acid substituted in 2-position

Also Published As

Publication number Publication date
JPH0822832B2 (en) 1996-03-06

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Legal Events

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