JPS6463378A - Separation of single stranded tpa and double standard tpa - Google Patents

Separation of single stranded tpa and double standard tpa

Info

Publication number
JPS6463378A
JPS6463378A JP62194332A JP19433287A JPS6463378A JP S6463378 A JPS6463378 A JP S6463378A JP 62194332 A JP62194332 A JP 62194332A JP 19433287 A JP19433287 A JP 19433287A JP S6463378 A JPS6463378 A JP S6463378A
Authority
JP
Japan
Prior art keywords
tpa
single stranded
stranded tpa
carrier
elute
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62194332A
Other languages
English (en)
Other versions
JPH0556951B2 (ja
Inventor
Mitsuyoshi Morii
Masaharu Ooka
Toshihiko Suzuki
Katsuyuki Suzuki
Nobuhiro Kawashima
Noriko Morii
Kunizo Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP62194332A priority Critical patent/JPS6463378A/ja
Publication of JPS6463378A publication Critical patent/JPS6463378A/ja
Publication of JPH0556951B2 publication Critical patent/JPH0556951B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
JP62194332A 1986-08-11 1987-08-05 Separation of single stranded tpa and double standard tpa Granted JPS6463378A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62194332A JPS6463378A (en) 1986-08-11 1987-08-05 Separation of single stranded tpa and double standard tpa

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18685086 1986-08-11
JP11597687 1987-05-14
JP62194332A JPS6463378A (en) 1986-08-11 1987-08-05 Separation of single stranded tpa and double standard tpa

Publications (2)

Publication Number Publication Date
JPS6463378A true JPS6463378A (en) 1989-03-09
JPH0556951B2 JPH0556951B2 (ja) 1993-08-20

Family

ID=26454387

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62194332A Granted JPS6463378A (en) 1986-08-11 1987-08-05 Separation of single stranded tpa and double standard tpa

Country Status (9)

Country Link
US (1) US4978620A (ja)
EP (1) EP0276328B1 (ja)
JP (1) JPS6463378A (ja)
AU (1) AU594186B2 (ja)
DE (1) DE3784688D1 (ja)
DK (1) DK196288D0 (ja)
FI (1) FI881653A (ja)
NO (1) NO881454L (ja)
WO (1) WO1988001294A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991008303A1 (en) * 1989-11-28 1991-06-13 Teijin Limited Antibody against human double-stranded tissue plasminogen activator

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001355A (en) * 1982-12-14 1999-12-14 Dowdle; Eugene Bernard Davey Pro-tPA for the treatment of thrombosis, embolism and related conditions
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat
US5731186A (en) * 1996-02-05 1998-03-24 Schering Aktiengesellschaft Method for the production of rDSPA α1
JP2002267642A (ja) * 2001-03-13 2002-09-18 Tosoh Corp アルカリ土類金属イオン測定用イオンクロマトグラフィー溶離液およびそれを用いたアルカリ土類金属イオン分析方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
EP0112122B1 (en) * 1982-12-14 1991-08-28 South African Inventions Development Corporation Plasminogen activator
DD229151A5 (de) * 1983-11-21 1985-10-30 Ciba Geigy Ag Verfahren zur herstellung von gewebeplasminogenaktivatoren
JPS60168601A (ja) * 1984-02-14 1985-09-02 田之内　寅雄 外周駆動ロ−ラを備えたベニヤレ−スに於ける駆動力伝達装置
JPS6229975A (ja) * 1985-08-01 1987-02-07 Mitsui Toatsu Chem Inc 粗ｔＰＡの精製法
EP0238551A4 (en) * 1985-09-06 1988-02-01 Codon METHODS OF RECOVERING A TISSUE PLASMINOGEN ACTIVATOR.
ATE107664T1 (de) * 1985-10-04 1994-07-15 South African Inventions Reagens und verfahren.
JP3036282B2 (ja) * 1993-02-08 2000-04-24 トヨタ自動車株式会社 ヒータ付き酸素濃度センサ

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991008303A1 (en) * 1989-11-28 1991-06-13 Teijin Limited Antibody against human double-stranded tissue plasminogen activator

Also Published As

Publication number Publication date
NO881454D0 (no) 1988-04-05
EP0276328A1 (en) 1988-08-03
DK196288A (da) 1988-04-11
WO1988001294A1 (en) 1988-02-25
AU594186B2 (en) 1990-03-01
EP0276328B1 (en) 1993-03-10
EP0276328A4 (en) 1990-04-10
AU7756587A (en) 1988-03-08
DE3784688D1 (de) 1993-04-15
NO881454L (no) 1988-04-05
FI881653A0 (fi) 1988-04-08
DK196288D0 (da) 1988-04-11
US4978620A (en) 1990-12-18
JPH0556951B2 (ja) 1993-08-20
FI881653A (fi) 1988-04-08

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees