JPS646283A - 2beta-substituted methylpenicillanic acid derivative, salt and ester thereof - Google Patents

2beta-substituted methylpenicillanic acid derivative, salt and ester thereof

Info

Publication number
JPS646283A
JPS646283A JP62160278A JP16027887A JPS646283A JP S646283 A JPS646283 A JP S646283A JP 62160278 A JP62160278 A JP 62160278A JP 16027887 A JP16027887 A JP 16027887A JP S646283 A JPS646283 A JP S646283A
Authority
JP
Japan
Prior art keywords
formula
2beta
ester
salt
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62160278A
Other languages
Japanese (ja)
Other versions
JP2599595B2 (en
Inventor
Shigeru Torii
Hideo Tanaka
Motoaki Tanaka
Shozo Yamada
Akira Nakai
Tomoyasu Ono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to JP62160278A priority Critical patent/JP2599595B2/en
Priority to US07/123,631 priority patent/US4891369A/en
Priority to DE8787310582T priority patent/DE3777987D1/en
Priority to EP87310582A priority patent/EP0273599B1/en
Priority to DE8787310583T priority patent/DE3778132D1/en
Priority to ES87310582T priority patent/ES2032299T3/en
Priority to EP87310583A priority patent/EP0272016B1/en
Priority to CA000553304A priority patent/CA1299566C/en
Priority to AU82018/87A priority patent/AU615884B2/en
Priority to FI875315A priority patent/FI89050C/en
Priority to CA000553305A priority patent/CA1294953C/en
Priority to AU82020/87A priority patent/AU614945B2/en
Priority to KR1019870013789A priority patent/KR920002846B1/en
Priority to KR1019870013788A priority patent/KR920008709B1/en
Publication of JPS646283A publication Critical patent/JPS646283A/en
Priority to US07/371,230 priority patent/US4933444A/en
Application granted granted Critical
Publication of JP2599595B2 publication Critical patent/JP2599595B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Abstract

NEW MATERIAL:A compound expressed by formula I (n is 0-2; formula II represents monocyclic or dicyclic heterocyclic group which has 2-4 N atoms. as hetero-atoms. and may have alkyl, alkoxycarbonyl, halogen atom. or nitro as a substituent group, except 1,2,3-triazolyl), salt and ester thereof. EXAMPLE:p-Nitrobenzyl 2alpha-methyl-2beta-(tetrazol-1-yl)methylpenam-3alpha-carboxylate. USE:A beta-lactamase inhibitor as an antibacterial agent for Gram-positive and Gram-negative bacteria. PREPARATION:A penam derivative expressed by formula III is reacted with a heterocyclic compound expressed by formula IV, as necessary, in the presence of a base.
JP62160278A 1986-12-03 1987-06-26 2β-substituted methylpenicillanic acid derivatives, salts and esters thereof Expired - Lifetime JP2599595B2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
JP62160278A JP2599595B2 (en) 1987-06-26 1987-06-26 2β-substituted methylpenicillanic acid derivatives, salts and esters thereof
US07/123,631 US4891369A (en) 1986-12-03 1987-11-23 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
EP87310582A EP0273599B1 (en) 1986-12-03 1987-12-01 Process for preparing 2beta-substituted-methyl-penicillin derivatives
DE8787310583T DE3778132D1 (en) 1986-12-03 1987-12-01 2-BETA-SUBSTITUTED METHYLPENICILLANIC ACID DERIVATIVES AND THEIR SALTS AND ESTERS.
ES87310582T ES2032299T3 (en) 1986-12-03 1987-12-01 PROCEDURE FOR OBTAINING 3-BETA-SUBSTITUTED METHYL-PENICILIN DERIVATIVES.
EP87310583A EP0272016B1 (en) 1986-12-03 1987-12-01 2beta-substituted-methylpenicillanic acid derivatives, and salts and esters thereof
DE8787310582T DE3777987D1 (en) 1986-12-03 1987-12-01 METHOD FOR PRODUCING 2-BETA SUBSTITUTED METHYLPENICILLIN DERIVATIVES.
AU82018/87A AU615884B2 (en) 1986-12-03 1987-12-02 Process for preparing 2beta-substituted-methylpenicillin derivatives
CA000553304A CA1299566C (en) 1986-12-03 1987-12-02 2.beta.-SUBSTITUTED-METHYL-PENICILLANIC ACID DERIVATIVES, AND SALTS AND ESTERS THEREOF
FI875315A FI89050C (en) 1986-12-03 1987-12-02 FOERFARANDE FOER FRAMSTAELLNING AV 2 -SUBSTITUERADE METYLPENICILLINDERIVAT
CA000553305A CA1294953C (en) 1986-12-03 1987-12-02 PROCESS FOR PREPARING 2.beta.-SUBSTITUTED-METHYLPENICILLIN DERIVATIVES
AU82020/87A AU614945B2 (en) 1986-12-03 1987-12-02 2beta-substituted-methylpenicillanic acid derivatives, and salts and esters thereof
KR1019870013789A KR920002846B1 (en) 1986-12-03 1987-12-03 Process for preparing 2(beta)-substituted methylpenicillin derivatives
KR1019870013788A KR920008709B1 (en) 1986-12-03 1987-12-03 2 beta-substituted-methylpenicillanic acid derivatives and salts and esters thereof
US07/371,230 US4933444A (en) 1986-12-03 1989-06-26 Process for preparing 2β-substituted-methylpenicillin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62160278A JP2599595B2 (en) 1987-06-26 1987-06-26 2β-substituted methylpenicillanic acid derivatives, salts and esters thereof

Publications (2)

Publication Number Publication Date
JPS646283A true JPS646283A (en) 1989-01-10
JP2599595B2 JP2599595B2 (en) 1997-04-09

Family

ID=15711535

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62160278A Expired - Lifetime JP2599595B2 (en) 1986-12-03 1987-06-26 2β-substituted methylpenicillanic acid derivatives, salts and esters thereof

Country Status (1)

Country Link
JP (1) JP2599595B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002053581A (en) * 2000-08-11 2002-02-19 Otsuka Chem Co Ltd Penicillin crystal and method for manufacturing the same
JP2002053582A (en) * 2000-08-11 2002-02-19 Otsuka Chem Co Ltd Penicillin crystal and method for manufacturing the same
JP2014504279A (en) * 2010-11-25 2014-02-20 アレクラ セラピューティクス ゲーエムベーハー Compounds and uses thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002053581A (en) * 2000-08-11 2002-02-19 Otsuka Chem Co Ltd Penicillin crystal and method for manufacturing the same
JP2002053582A (en) * 2000-08-11 2002-02-19 Otsuka Chem Co Ltd Penicillin crystal and method for manufacturing the same
JP2014504279A (en) * 2010-11-25 2014-02-20 アレクラ セラピューティクス ゲーエムベーハー Compounds and uses thereof

Also Published As

Publication number Publication date
JP2599595B2 (en) 1997-04-09

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