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Arakawa Chemical Industries Ltd
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Arakawa Chemical Industries Ltd
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Application filed by Arakawa Chemical Industries LtdfiledCriticalArakawa Chemical Industries Ltd
Priority to JP21870387ApriorityCriticalpatent/JPS6461473A/en
Publication of JPS6461473ApublicationCriticalpatent/JPS6461473A/en
PURPOSE:To readily obtain the titled substance having high optical purity in high yield, by reacting (R)-(+)-gamma-butylolactone-gamma-3-propionic acid ester with a metal hydride such as NaBH4, KBH4 or LiAlH[OC(CH3)3]3. CONSTITUTION:A compound expressed by formula I (R is 1-4C alkyl excluding tert.-butyl) is reduced with at least one kind of metal hydride selected from NaHB4, KHB4 and LiAlH[OC(CH3)3]3 and used at an amount of 5-10 equivalent based on 1 equivalent compound expressed by formula I in a solvent such as THF or methanol at 0-10 deg.C to provide the compound expressed by formula II. The compound expressed by formula II is useful as a raw material or precursor for physiologically active substance, perfume, etc.
JP21870387A1987-09-011987-09-01Production of (s)-(-)-gamma-butylolactone-gamma-3-propanol
PendingJPS6461473A
(en)