JPS6461426A - Artificial erythrocyte - Google Patents
Artificial erythrocyteInfo
- Publication number
- JPS6461426A JPS6461426A JP62215366A JP21536687A JPS6461426A JP S6461426 A JPS6461426 A JP S6461426A JP 62215366 A JP62215366 A JP 62215366A JP 21536687 A JP21536687 A JP 21536687A JP S6461426 A JPS6461426 A JP S6461426A
- Authority
- JP
- Japan
- Prior art keywords
- inositol hexaphosphate
- hemoglobin
- liposome
- membrane
- hemoglobin solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003633 blood substitute Substances 0.000 title abstract 3
- 102000001554 Hemoglobins Human genes 0.000 abstract 5
- 108010054147 Hemoglobins Proteins 0.000 abstract 5
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 abstract 5
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 abstract 5
- 229940068041 phytic acid Drugs 0.000 abstract 5
- 239000002502 liposome Substances 0.000 abstract 4
- 239000012528 membrane Substances 0.000 abstract 3
- 230000003281 allosteric effect Effects 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62215366A JPS6461426A (en) | 1987-08-31 | 1987-08-31 | Artificial erythrocyte |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62215366A JPS6461426A (en) | 1987-08-31 | 1987-08-31 | Artificial erythrocyte |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6461426A true JPS6461426A (en) | 1989-03-08 |
| JPH0466456B2 JPH0466456B2 (enrdf_load_stackoverflow) | 1992-10-23 |
Family
ID=16671102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62215366A Granted JPS6461426A (en) | 1987-08-31 | 1987-08-31 | Artificial erythrocyte |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6461426A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0615747A1 (en) * | 1993-03-18 | 1994-09-21 | Terumo Kabushiki Kaisha | Hemoglobin-encapsulating liposome and method for making the same |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010215517A (ja) * | 2009-03-13 | 2010-09-30 | Terumo Corp | 酸素親和性を中酸素親和性に制御したヘモグロビン含有リポソーム懸濁液 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5449314A (en) * | 1977-09-06 | 1979-04-18 | Studiengesellschaft Kohle Mbh | Improving of oxygen discharging property of erythrocyte |
| JPS5726621A (en) * | 1977-09-06 | 1982-02-12 | Studiengesellschaft Kohle Mbh | Blood containing non-injured erythropoesis having improved oxygen-release characteristica |
| JPS58183625A (ja) * | 1982-04-02 | 1983-10-26 | ザ・リ−ジエンツ・オブ・ザ・ユニバ−シテイ・オブ・カリフオルニア | 酸素運搬システム |
| JPS6137735A (ja) * | 1984-07-31 | 1986-02-22 | Terumo Corp | ヘモグロビン含有リポソ−ムおよびその製造方法 |
| JPS62178521A (ja) * | 1986-01-30 | 1987-08-05 | Terumo Corp | ヘモグロビン含有リポソ−ム |
-
1987
- 1987-08-31 JP JP62215366A patent/JPS6461426A/ja active Granted
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5449314A (en) * | 1977-09-06 | 1979-04-18 | Studiengesellschaft Kohle Mbh | Improving of oxygen discharging property of erythrocyte |
| JPS5726621A (en) * | 1977-09-06 | 1982-02-12 | Studiengesellschaft Kohle Mbh | Blood containing non-injured erythropoesis having improved oxygen-release characteristica |
| JPS58183625A (ja) * | 1982-04-02 | 1983-10-26 | ザ・リ−ジエンツ・オブ・ザ・ユニバ−シテイ・オブ・カリフオルニア | 酸素運搬システム |
| JPS6137735A (ja) * | 1984-07-31 | 1986-02-22 | Terumo Corp | ヘモグロビン含有リポソ−ムおよびその製造方法 |
| JPS62178521A (ja) * | 1986-01-30 | 1987-08-05 | Terumo Corp | ヘモグロビン含有リポソ−ム |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0615747A1 (en) * | 1993-03-18 | 1994-09-21 | Terumo Kabushiki Kaisha | Hemoglobin-encapsulating liposome and method for making the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0466456B2 (enrdf_load_stackoverflow) | 1992-10-23 |
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