JPS6447718A - Diabetic remedy - Google Patents

Diabetic remedy

Info

Publication number
JPS6447718A
JPS6447718A JP62204905A JP20490587A JPS6447718A JP S6447718 A JPS6447718 A JP S6447718A JP 62204905 A JP62204905 A JP 62204905A JP 20490587 A JP20490587 A JP 20490587A JP S6447718 A JPS6447718 A JP S6447718A
Authority
JP
Japan
Prior art keywords
earthworm
dried powder
give
water
extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62204905A
Other languages
Japanese (ja)
Other versions
JPH0780778B2 (en
Inventor
Yoichi Ishii
Hisashi Mihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIMEI KK
Eimei Co Ltd
Original Assignee
EIMEI KK
Eimei Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EIMEI KK, Eimei Co Ltd filed Critical EIMEI KK
Priority to JP62204905A priority Critical patent/JPH0780778B2/en
Priority to KR1019880007132A priority patent/KR930002010B1/en
Priority to US07/228,672 priority patent/US5024844A/en
Priority to DE3827623A priority patent/DE3827623C2/en
Priority to GB8819523A priority patent/GB2208602B/en
Priority to CA000575021A priority patent/CA1322956C/en
Priority to CN88106168A priority patent/CN1031653A/en
Publication of JPS6447718A publication Critical patent/JPS6447718A/en
Priority to US07/641,519 priority patent/US5128148A/en
Publication of JPH0780778B2 publication Critical patent/JPH0780778B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PURPOSE:To obtain a diabetic remedy having excellent lowering activity against amount of blood sugar, comprising dried powder or an extract of earthworm as an active ingredient. CONSTITUTION:Castings in digestive tube of live earthworm are vomited, dirt attached to the earthworm is washed with water, removed or the above- mentioned operations are carried out in the reverse order. The earthworm is ground in a wet state to give a suspension, which is frozen at -10--60 deg.C. Then freezing and vacuum drying are carried out in a temperature range of -60-80 deg.C at <=10mmHg degree of vacuum for 10-100hr while stepwise raising temperature and the final process of the freezing and vacuum drying is done at 70-80 deg.C for 0.01-0.5mmHg for 5-10hr to give dried powder of earthworm. The suspension or the dried powder in the operation is extracted with an extractant selected from an aqueous solvent, a water-miscible solvent or a water- immiscible organic solvent and the extracting solvent is removed to give an extract. A diabetic remedy contains the dried powder or the extract obtained by the operation.
JP62204905A 1987-08-18 1987-08-18 Antidiabetic agent Expired - Lifetime JPH0780778B2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP62204905A JPH0780778B2 (en) 1987-08-18 1987-08-18 Antidiabetic agent
KR1019880007132A KR930002010B1 (en) 1987-08-18 1988-06-14 Antidiabetics
US07/228,672 US5024844A (en) 1987-08-18 1988-08-05 Process for the production of dried earthworm powder and antihyperlipemic, antidiabetic, antihypertensive and antihypotensive preparations containing dried earthworm powder as active ingredient
DE3827623A DE3827623C2 (en) 1987-08-18 1988-08-15 Process for the preparation of pharmaceutically usable dried earthworm powder and its use as an antihyperlipemic, anti-diabetic, antihypertensive and antihypotonic preparation
CA000575021A CA1322956C (en) 1987-08-18 1988-08-17 Process for the production of dried earthworm powder and antihyperlipemic, antidiabetic, antihypertensive and antihypotensive preparations containing dried earthworm powder as active ingredient
GB8819523A GB2208602B (en) 1987-08-18 1988-08-17 Process for the production of dried earthworm powder and antihyperlipemic,anti-diabetic,antihypertensive and antihypotensive preparations containing dried ear
CN88106168A CN1031653A (en) 1987-08-18 1988-08-18 Dry earthworm powder and contain the hyperlipidemia of dry earthworm powder as active component, anti-diabetic, the production method of the preparation of resisting hypertension and hypotension
US07/641,519 US5128148A (en) 1987-08-18 1991-01-15 Process for the production of dried earthworm powder and antihyperlipemic, antidiabetic, antihypertensive and antihypotensive preparations containing dried earthworm powder as active ingredient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62204905A JPH0780778B2 (en) 1987-08-18 1987-08-18 Antidiabetic agent

Publications (2)

Publication Number Publication Date
JPS6447718A true JPS6447718A (en) 1989-02-22
JPH0780778B2 JPH0780778B2 (en) 1995-08-30

Family

ID=16498329

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62204905A Expired - Lifetime JPH0780778B2 (en) 1987-08-18 1987-08-18 Antidiabetic agent

Country Status (2)

Country Link
JP (1) JPH0780778B2 (en)
KR (1) KR930002010B1 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008081476A (en) * 2006-09-29 2008-04-10 Ｗｅｌｌ Ｓｔｏｎｅ 有限会社 Method for producing dried powder of earthworm
EP2105139A1 (en) 2008-03-26 2009-09-30 Well Stone Co. Method of producing a dry earthworm powder
EP2316464A1 (en) 2009-10-13 2011-05-04 Well Stone Co. Method of producing a dry earthworm powder
US8137701B2 (en) 2008-03-21 2012-03-20 Well Stone Co. Method of producing a dry earthworm powder
WO2012073593A1 (en) 2011-04-11 2012-06-07 Ｗｅｌｌ Ｓｔｏｎｅ 有限会社 Manufacturing method for dried earthworm powder
WO2015152045A1 (en) * 2014-03-29 2015-10-08 国立大学法人新潟大学 Composition inhibiting fatty liver and nephromegaly caused by diabetes and method for producing same
JP5901092B1 (en) * 2015-08-26 2016-04-06 ワキ製薬株式会社 Method for producing human dipeptidyl peptidase IV inhibitor
JP6249581B1 (en) * 2017-06-12 2017-12-20 ワキ製薬株式会社 Method for producing carbohydrase inhibitor
WO2018173971A1 (en) 2017-03-21 2018-09-27 Ｗｅｌｌ Ｓｔｏｎｅ 有限会社 Production method of nasal drop composition, and nasal drop composition
WO2018173972A1 (en) 2017-03-21 2018-09-27 Ｗｅｌｌ Ｓｔｏｎｅ 有限会社 Method for producing therapeutic agent for skin lesions, and therapeutic agent for skin lesions

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100363197B1 (en) * 2000-07-11 2002-12-05 (주)이오바이오텍 the extracting method of earthworm's body fluids using water contained activated oxygen
KR100557892B1 (en) * 2002-03-29 2006-03-10 보은군 loess include earthworm powder and a method of processing thereof
KR101884939B1 (en) * 2016-10-24 2018-08-03 안동대학교 산학협력단 Composition containing Lumbricus rubellus extract reducing lipid accumulation as effective component

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008081476A (en) * 2006-09-29 2008-04-10 Ｗｅｌｌ Ｓｔｏｎｅ 有限会社 Method for producing dried powder of earthworm
US8137701B2 (en) 2008-03-21 2012-03-20 Well Stone Co. Method of producing a dry earthworm powder
EP2105139A1 (en) 2008-03-26 2009-09-30 Well Stone Co. Method of producing a dry earthworm powder
US8394417B2 (en) 2009-10-13 2013-03-12 Well Stone Co. Method of producing a dry earthworm powder
EP2316464A1 (en) 2009-10-13 2011-05-04 Well Stone Co. Method of producing a dry earthworm powder
US9511098B2 (en) 2011-04-11 2016-12-06 Well Stone Co. Method for producing dry earthworm powder
WO2012073593A1 (en) 2011-04-11 2012-06-07 Ｗｅｌｌ Ｓｔｏｎｅ 有限会社 Manufacturing method for dried earthworm powder
WO2015152045A1 (en) * 2014-03-29 2015-10-08 国立大学法人新潟大学 Composition inhibiting fatty liver and nephromegaly caused by diabetes and method for producing same
JP2015199707A (en) * 2014-03-29 2015-11-12 国立大学法人 新潟大学 Composition suppressing fatty liver and nephromegaly caused by diabetes, and manufacturing method of the same
JP5901092B1 (en) * 2015-08-26 2016-04-06 ワキ製薬株式会社 Method for producing human dipeptidyl peptidase IV inhibitor
WO2018173971A1 (en) 2017-03-21 2018-09-27 Ｗｅｌｌ Ｓｔｏｎｅ 有限会社 Production method of nasal drop composition, and nasal drop composition
WO2018173972A1 (en) 2017-03-21 2018-09-27 Ｗｅｌｌ Ｓｔｏｎｅ 有限会社 Method for producing therapeutic agent for skin lesions, and therapeutic agent for skin lesions
JP6249581B1 (en) * 2017-06-12 2017-12-20 ワキ製薬株式会社 Method for producing carbohydrase inhibitor

Also Published As

Publication number Publication date
JPH0780778B2 (en) 1995-08-30
KR890003395A (en) 1989-04-14
KR930002010B1 (en) 1993-03-20

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