JPS6440470A - Production of 4,6-dialkoxy-2-alkylthiopyrimidines - Google Patents
Production of 4,6-dialkoxy-2-alkylthiopyrimidinesInfo
- Publication number
- JPS6440470A JPS6440470A JP19708887A JP19708887A JPS6440470A JP S6440470 A JPS6440470 A JP S6440470A JP 19708887 A JP19708887 A JP 19708887A JP 19708887 A JP19708887 A JP 19708887A JP S6440470 A JPS6440470 A JP S6440470A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- useful
- dihydroxypyrimidines
- reacting
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PURPOSE:To obtain the titled compound useful as a production intermediate for guanidine derivative, in high purity in one step, by using 4,6- dihydroxypyrimidines as raw material and reacting the material with a sulfonic acid derivative in the presence of a selected combination of a reaction solvent and a base. CONSTITUTION:The objective compound of formula IV (R<3>=R<2>) useful as a production intermediate for a guanidine derivative useful as a herbicide and plant growth regulator can be produced by reacting (A) 4,6-dihydroxypyrimidines of formula I (R<1> is H or alkyl) with (B) a sulfonic acid derivative of formula II (R<2> is alkyl) or formula III (Y is aryl, CH3 or CF3) such as dimethyl sulfate or methyl p-toluenesulfonate in the presence of (C) an alkali metal or alkaline- earth metal carbonate such as anhydrous K2CO3 as a base in (D) an aprotic polar solvent such as dimethyl-formamide when R<1> is H or an aprotic polar solvent such as ketones or acetone when R<1> is H in an essentially anhydrous state at 0-90 deg.C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62197088A JP2561480B2 (en) | 1987-08-06 | 1987-08-06 | Process for producing 4,6-dialkoxy-2-alkylthiopyrimidines |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62197088A JP2561480B2 (en) | 1987-08-06 | 1987-08-06 | Process for producing 4,6-dialkoxy-2-alkylthiopyrimidines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6440470A true JPS6440470A (en) | 1989-02-10 |
| JP2561480B2 JP2561480B2 (en) | 1996-12-11 |
Family
ID=16368524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62197088A Expired - Lifetime JP2561480B2 (en) | 1987-08-06 | 1987-08-06 | Process for producing 4,6-dialkoxy-2-alkylthiopyrimidines |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2561480B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5266697A (en) * | 1991-11-26 | 1993-11-30 | Lonza Ltd. | Process for the production of 2-substituted 4,6-dialkoxypyrimidines |
| US6693194B2 (en) | 2000-07-21 | 2004-02-17 | Syngenta Crop Protection, Inc. | Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine |
-
1987
- 1987-08-06 JP JP62197088A patent/JP2561480B2/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5266697A (en) * | 1991-11-26 | 1993-11-30 | Lonza Ltd. | Process for the production of 2-substituted 4,6-dialkoxypyrimidines |
| US6693194B2 (en) | 2000-07-21 | 2004-02-17 | Syngenta Crop Protection, Inc. | Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2561480B2 (en) | 1996-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |