JPS6361302B1 - - Google Patents
Info
- Publication number
- JPS6361302B1 JPS6361302B1 JP62504006A JP50400687A JPS6361302B1 JP S6361302 B1 JPS6361302 B1 JP S6361302B1 JP 62504006 A JP62504006 A JP 62504006A JP 50400687 A JP50400687 A JP 50400687A JP S6361302 B1 JPS6361302 B1 JP S6361302B1
- Authority
- JP
- Japan
- Prior art keywords
- glutathione
- compound
- glutamyl
- administered
- cysteine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 229960003180 glutathione Drugs 0.000 description 66
- 108010024636 Glutathione Proteins 0.000 description 65
- 150000001875 compounds Chemical class 0.000 description 56
- RITKHVBHSGLULN-WHFBIAKZSA-N L-gamma-glutamyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(O)=O RITKHVBHSGLULN-WHFBIAKZSA-N 0.000 description 24
- 230000000694 effects Effects 0.000 description 24
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- KJQFBVYMGADDTQ-CVSPRKDYSA-N L-buthionine-(S,R)-sulfoximine Chemical compound CCCCS(=N)(=O)CC[C@H](N)C(O)=O KJQFBVYMGADDTQ-CVSPRKDYSA-N 0.000 description 17
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- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 10
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- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 229940093609 tricaprylin Drugs 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62-504006A JPWO1988000182A1 (ja) | 1986-07-07 | 1987-07-07 | ｒ‐Ｌ‐グルタミル‐Ｌ‐システインエチルエステル及びそれを有効成分とする医薬 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15779886 | 1986-07-07 | ||
| JP61-157798 | 1986-07-07 | ||
| JP62-54229 | 1987-03-11 | ||
| JP5422987 | 1987-03-11 | ||
| JP62-504006A JPWO1988000182A1 (ja) | 1986-07-07 | 1987-07-07 | ｒ‐Ｌ‐グルタミル‐Ｌ‐システインエチルエステル及びそれを有効成分とする医薬 |
| PCT/JP1987/000475 WO1988000182A1 (fr) | 1986-07-07 | 1987-07-07 | ESTER D'ETHYLE DE gamma-L-GLUTAMYL-L-CYSTEINE ET MEDICAMENT LE CONTENANT EN TANT QU'INGREDIENT ACTIF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO1988000182A1 JPWO1988000182A1 (ja) | 1988-04-07 |
| JPS6361302B1 true JPS6361302B1 (enExample) | 1988-11-28 |
Family
ID=
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01161903U (enExample) * | 1988-04-28 | 1989-11-10 | ||
| JPH01306307A (ja) * | 1988-05-31 | 1989-12-11 | Hayakawa Rubber Co Ltd | タイヤ滑り止め具 |
| WO1992018120A1 (en) * | 1991-04-15 | 1992-10-29 | Teijin Limited | Preventive or remedy for ischemia, reperfusion-induced tissue disorder and arrhythmia as well as pulmonary disorder caused by activated oxygen free radical |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01161903U (enExample) * | 1988-04-28 | 1989-11-10 | ||
| JPH01306307A (ja) * | 1988-05-31 | 1989-12-11 | Hayakawa Rubber Co Ltd | タイヤ滑り止め具 |
| WO1992018120A1 (en) * | 1991-04-15 | 1992-10-29 | Teijin Limited | Preventive or remedy for ischemia, reperfusion-induced tissue disorder and arrhythmia as well as pulmonary disorder caused by activated oxygen free radical |
| SG82552A1 (en) * | 1991-04-15 | 2001-08-21 | Teijin Ltd | Preventive or therapeutic agent for ischemia- reperfussion tissue injury, arrhythmia and lung injury caused by active oxygens and free radicals |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1988000182A1 (fr) | 1988-01-14 |
| EP0276317A1 (en) | 1988-08-03 |
| DE3784905D1 (de) | 1993-04-22 |
| EP0276317B1 (en) | 1993-03-17 |
| DE3784905T2 (de) | 1993-08-05 |
| US4927808A (en) | 1990-05-22 |
| EP0276317A4 (en) | 1989-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |