JPS6346726B2 - - Google Patents
Info
- Publication number
- JPS6346726B2 JPS6346726B2 JP55024344A JP2434480A JPS6346726B2 JP S6346726 B2 JPS6346726 B2 JP S6346726B2 JP 55024344 A JP55024344 A JP 55024344A JP 2434480 A JP2434480 A JP 2434480A JP S6346726 B2 JPS6346726 B2 JP S6346726B2
- Authority
- JP
- Japan
- Prior art keywords
- ibuprofen
- granules
- content
- angle
- repose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008187 granular material Substances 0.000 claims description 72
- 239000000203 mixture Substances 0.000 claims description 31
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 30
- 229960001680 ibuprofen Drugs 0.000 claims description 29
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 24
- 239000002775 capsule Substances 0.000 claims description 22
- 239000007884 disintegrant Substances 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 15
- 238000001816 cooling Methods 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 7
- 238000002844 melting Methods 0.000 claims description 6
- 230000008018 melting Effects 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229940126701 oral medication Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 description 27
- 238000009472 formulation Methods 0.000 description 20
- 238000000034 method Methods 0.000 description 20
- 239000002245 particle Substances 0.000 description 10
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 7
- 239000008116 calcium stearate Substances 0.000 description 7
- 235000013539 calcium stearate Nutrition 0.000 description 7
- 241000282472 Canis lupus familiaris Species 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 238000007907 direct compression Methods 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 239000007902 hard capsule Substances 0.000 description 4
- 239000001341 hydroxy propyl starch Substances 0.000 description 4
- 235000013828 hydroxypropyl starch Nutrition 0.000 description 4
- 239000011088 parchment paper Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 229910002012 Aerosil® Inorganic materials 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- 238000007908 dry granulation Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 238000010298 pulverizing process Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000005550 wet granulation Methods 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- 229940125716 antipyretic agent Drugs 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 208000015220 Febrile disease Diseases 0.000 description 1
- 206010065390 Inflammatory pain Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000002269 analeptic agent Substances 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000012812 general test Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000012768 molten material Substances 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000012254 powdered material Substances 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 238000010583 slow cooling Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
Landscapes
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2434480A JPS56120616A (en) | 1980-02-27 | 1980-02-27 | Ibuprofen-containing granule, its preparation, and internal medicine comprising it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2434480A JPS56120616A (en) | 1980-02-27 | 1980-02-27 | Ibuprofen-containing granule, its preparation, and internal medicine comprising it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56120616A JPS56120616A (en) | 1981-09-22 |
| JPS6346726B2 true JPS6346726B2 (de) | 1988-09-19 |
Family
ID=12135561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2434480A Granted JPS56120616A (en) | 1980-02-27 | 1980-02-27 | Ibuprofen-containing granule, its preparation, and internal medicine comprising it |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56120616A (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5240712A (en) * | 1987-07-17 | 1993-08-31 | The Boots Company Plc | Therapeutic agents |
| GB8716975D0 (en) * | 1987-07-17 | 1987-08-26 | Boots Co Plc | Therapeutic agents |
| DE3833448A1 (de) * | 1988-10-01 | 1990-04-12 | Hoechst Ag | Verfahren zur gewinnung von ibuprofen fuer die direkttablettierung |
| DE3833446A1 (de) * | 1988-10-01 | 1990-04-05 | Hoechst Ag | Verfahren zur herstellung von arzneimittelwirkstoff-partikeln mit verbesserten fliess-, lager- und formulierungseigenschaften sowie arzneimittel, die diese arzneimittelwirkstoff-partikeln enthalten |
| ES2263510T3 (es) | 1999-12-09 | 2006-12-16 | Reckitt Benckiser Healthcare (Uk) Limited | Preparacion en comprimidos que comprende un antiinflamatorio no esteroideo (aine). |
| WO2007069874A1 (en) * | 2005-12-16 | 2007-06-21 | Hanmi Pharm. Co., Ltd. | Solid dispersion comprising an active ingredient having a low melting point and tablet for oral administration comprising same |
| WO2013143688A1 (en) | 2012-03-26 | 2013-10-03 | Glatt Ag | Taste-masked ibuprofen granules |
| CN105816434B (zh) * | 2016-04-19 | 2019-09-17 | 山东新华制药股份有限公司 | 布洛芬颗粒及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52111533A (en) * | 1976-03-12 | 1977-09-19 | Kanebo Ltd | Preparation of fine powder of ibuprophene |
-
1980
- 1980-02-27 JP JP2434480A patent/JPS56120616A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52111533A (en) * | 1976-03-12 | 1977-09-19 | Kanebo Ltd | Preparation of fine powder of ibuprophene |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS56120616A (en) | 1981-09-22 |
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