JPS6342636B2 - - Google Patents

Info

Publication number
JPS6342636B2
JPS6342636B2 JP55128271A JP12827180A JPS6342636B2 JP S6342636 B2 JPS6342636 B2 JP S6342636B2 JP 55128271 A JP55128271 A JP 55128271A JP 12827180 A JP12827180 A JP 12827180A JP S6342636 B2 JPS6342636 B2 JP S6342636B2
Authority
JP
Japan
Prior art keywords
enzyme
compound
arginine
ester
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP55128271A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5753445A (en
Inventor
Setsuo Fujii
Mamoru Sugimoto
Takashi Yaegashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torii Pharmaceutical Co Ltd
Original Assignee
Torii Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torii Pharmaceutical Co Ltd filed Critical Torii Pharmaceutical Co Ltd
Priority to JP55128271A priority Critical patent/JPS5753445A/ja
Priority to US06/300,415 priority patent/US4418012A/en
Priority to GB8127835A priority patent/GB2086911B/en
Priority to DE3136511A priority patent/DE3136511C2/de
Priority to FR8117405A priority patent/FR2490221A1/fr
Publication of JPS5753445A publication Critical patent/JPS5753445A/ja
Publication of JPS6342636B2 publication Critical patent/JPS6342636B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/30—Naphthol derivatives, e.g. alpha-naphthyl-esters, i.e. alpha-NE, beta-naphthyl-esters, i.e. beta-NE
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP55128271A 1980-09-16 1980-09-16 Peptide compound Granted JPS5753445A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP55128271A JPS5753445A (en) 1980-09-16 1980-09-16 Peptide compound
US06/300,415 US4418012A (en) 1980-09-16 1981-09-09 Leucylalany-arginine derivative
GB8127835A GB2086911B (en) 1980-09-16 1981-09-15 Leucylalanylarginine derivatives process for their preparation and their use in measuring enzyme activity
DE3136511A DE3136511C2 (de) 1980-09-16 1981-09-15 L-Leucyl-L-alanyl-L-argininderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
FR8117405A FR2490221A1 (fr) 1980-09-16 1981-09-15 Derive de la leucylalanylarginine, procede pour sa production et procede pour la mesure de l'activite d'enzymes utilisant celui-ci

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55128271A JPS5753445A (en) 1980-09-16 1980-09-16 Peptide compound

Publications (2)

Publication Number Publication Date
JPS5753445A JPS5753445A (en) 1982-03-30
JPS6342636B2 true JPS6342636B2 (enExample) 1988-08-24

Family

ID=14980703

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55128271A Granted JPS5753445A (en) 1980-09-16 1980-09-16 Peptide compound

Country Status (5)

Country Link
US (1) US4418012A (enExample)
JP (1) JPS5753445A (enExample)
DE (1) DE3136511C2 (enExample)
FR (1) FR2490221A1 (enExample)
GB (1) GB2086911B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2652581B1 (fr) * 1989-10-02 1991-12-13 Rhone Poulenc Chimie Procede de solubilisation de peptides et procede de synthese de peptides.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380258B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser
SE407058B (sv) * 1974-12-05 1979-03-12 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
US4137225A (en) * 1975-07-11 1979-01-30 Ab Kabi Novel chromogenic enzyme substrates
JPS5559149A (en) * 1978-10-30 1980-05-02 Torii Yakuhin Kk Aminoacid derivative
JPS5559150A (en) * 1978-10-30 1980-05-02 Torii Yakuhin Kk Aminoacid derivative
US4308202A (en) * 1979-10-25 1981-12-29 Torii & Co., Ltd. Prolylphenylalanylarginine derivatives, process for producing same and method for measuring activity of enzymes using same

Also Published As

Publication number Publication date
FR2490221B1 (enExample) 1983-11-10
US4418012A (en) 1983-11-29
DE3136511C2 (de) 1983-07-07
GB2086911B (en) 1983-12-21
DE3136511A1 (de) 1982-04-01
FR2490221A1 (fr) 1982-03-19
GB2086911A (en) 1982-05-19
JPS5753445A (en) 1982-03-30

Similar Documents

Publication Publication Date Title
US4147692A (en) Novel dipeptide derivatives, and method of measuring enzymatic activity
KR980010425A (ko) 뇨중 백혈구 및 단백질 분해 효소 검출을 위한 조성물 및 측정기구
JPS6342635B2 (enExample)
US4308202A (en) Prolylphenylalanylarginine derivatives, process for producing same and method for measuring activity of enzymes using same
JPS6126917B2 (enExample)
JPS6342636B2 (enExample)
JPS6126918B2 (enExample)
US4816562A (en) Novel substrate for plasma kallikrein and a method for measuring biological components using the same
JPS5827784B2 (ja) アミノ酸誘導体
US6503725B2 (en) Composition and device for detecting leukocytes in urine
JPS6121640B2 (enExample)
JP5016752B2 (ja) トリプシン基質及び診断具ならびにその使用方法
US4191809A (en) Method of measuring enzymatic activity using novel peptide derivatives
US4292404A (en) Method for determining the activity of the angiotensin-converting enzyme
US6528652B1 (en) Composition and device for detecting leukocytes in urine
JPS5850986B2 (ja) リジン誘導体
JPS6112898B2 (enExample)
JPS6342638B2 (enExample)
JPS6143360B2 (enExample)
JPS58177951A (ja) 発色性ペプチドおよびその製法
JPS593989B2 (ja) チロシン誘導体
CN120289321A (zh) 一种氨肽酶n荧光探针及其制备方法和应用
JPH0411537B2 (enExample)
JPH03246285A (ja) アゾレゾルシノールエステル誘導体および加水分解酵素基質
CA2359689A1 (en) Composition and device for detecting leukocytes in urine