JPS6340168B2 - - Google Patents
Info
- Publication number
- JPS6340168B2 JPS6340168B2 JP54151668A JP15166879A JPS6340168B2 JP S6340168 B2 JPS6340168 B2 JP S6340168B2 JP 54151668 A JP54151668 A JP 54151668A JP 15166879 A JP15166879 A JP 15166879A JP S6340168 B2 JPS6340168 B2 JP S6340168B2
- Authority
- JP
- Japan
- Prior art keywords
- cyanocobalamin
- taurine
- solution
- aqueous solution
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 36
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 22
- 229960002104 cyanocobalamin Drugs 0.000 claims description 18
- 235000000639 cyanocobalamin Nutrition 0.000 claims description 18
- 239000011666 cyanocobalamin Substances 0.000 claims description 18
- 229960003080 taurine Drugs 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 4
- 230000000087 stabilizing effect Effects 0.000 claims description 4
- 230000006641 stabilisation Effects 0.000 claims 2
- 238000011105 stabilization Methods 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 4
- 235000013923 monosodium glutamate Nutrition 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- 239000004471 Glycine Substances 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229940073490 sodium glutamate Drugs 0.000 description 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 229960000686 benzalkonium chloride Drugs 0.000 description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 2
- 239000004327 boric acid Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229960002449 glycine Drugs 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 208000031845 Pernicious anaemia Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 208000003464 asthenopia Diseases 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- ASARMUCNOOHMLO-WLORSUFZSA-L cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2s)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O ASARMUCNOOHMLO-WLORSUFZSA-L 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000004223 monosodium glutamate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15166879A JPS5675438A (en) | 1979-11-22 | 1979-11-22 | Method for stabilizing aqueous solution of cyanocobalamin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15166879A JPS5675438A (en) | 1979-11-22 | 1979-11-22 | Method for stabilizing aqueous solution of cyanocobalamin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5675438A JPS5675438A (en) | 1981-06-22 |
| JPS6340168B2 true JPS6340168B2 (enrdf_load_html_response) | 1988-08-10 |
Family
ID=15523618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15166879A Granted JPS5675438A (en) | 1979-11-22 | 1979-11-22 | Method for stabilizing aqueous solution of cyanocobalamin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5675438A (enrdf_load_html_response) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT376879B (de) * | 1982-10-27 | 1985-01-10 | Gerot Pharmazeutika | Verfahren zur herstellung einer injektionsloesung |
| WO1996038149A1 (fr) * | 1995-05-30 | 1996-12-05 | Taisho Pharmaceutical Co., Ltd. | Gouttes oculaires |
| JP2005075735A (ja) * | 2003-08-28 | 2005-03-24 | Rohto Pharmaceut Co Ltd | オキシメタゾリン含有組成物 |
| JP5977919B2 (ja) * | 2010-03-31 | 2016-08-24 | 小林製薬株式会社 | 医薬用組成物 |
| JP2015098490A (ja) * | 2015-02-25 | 2015-05-28 | 小林製薬株式会社 | 医薬用組成物 |
| JP7270465B2 (ja) * | 2019-05-31 | 2023-05-10 | 小林製薬株式会社 | ビタミンｂ１２類の光安定化方法 |
-
1979
- 1979-11-22 JP JP15166879A patent/JPS5675438A/ja active Granted
Non-Patent Citations (1)
| Title |
|---|
| DRUG MAGAZINE=S53 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5675438A (en) | 1981-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US2795529A (en) | Stabilized hyaluronidase solution containing calcium chloride | |
| US5356620A (en) | Pharmaceutical compositions containing N-(3,4-dimethoxycinnamoyl) anthranilic acid | |
| Stein et al. | The effect of topically administered carbonic anhydrase inhibitors on aqueous humor dynamics in rabbits | |
| CA1052270A (en) | Oxytetracycline solution for parenteral peroral and local administration and processes for the production thereof | |
| JP6094388B2 (ja) | ペメトレキセドを含む注射用組成物 | |
| CA2717605A1 (en) | Low viscosity, highly flocculated triamcinolone acetonide suspensions for intravitreal injection | |
| KR20080041621A (ko) | 잔탄 검 및 테르페노이드를 포함하는 점안제 | |
| JPH08291065A (ja) | 有機アミンを配合したプラノプロフェン点眼液 | |
| JPS6340168B2 (enrdf_load_html_response) | ||
| JP7599838B2 (ja) | エピナスチン又はその塩を含有する水性医薬組成物 | |
| TWI406675B (zh) | Pharmaceutical composition | |
| JP2010527363A (ja) | ヒアルロン酸又はその薬学的に許容される塩を含む保存組成物及び関連する方法 | |
| CN105919931B (zh) | 一种稳定的盐酸法舒地尔注射液及其制备方法 | |
| JP3146218B2 (ja) | 点眼剤 | |
| JPH0637388B2 (ja) | 水性液剤 | |
| JPH0780760B2 (ja) | 安定化されたフエニレフリン系液剤 | |
| US2719812A (en) | Stabilized aqueous solutions of streptomycin | |
| JP2011207874A (ja) | ソフトコンタクトレンズ用眼科組成物 | |
| KR20230092814A (ko) | 브린졸라미드 및 티몰롤을 함유하는 투명 복합점안제 | |
| WO2013147000A1 (ja) | ２－アミノ－３－（４－ブロモベンゾイル）フェニル酢酸含有水性組成物 | |
| US3526698A (en) | Stabilization of levo-3-(3,4-dihydroxyphenyl)-2-methylalanine with sodium bisulfite and sorbitol | |
| JPH0647536B2 (ja) | トコフエロ−ル類含有液剤 | |
| JP4806956B2 (ja) | 点眼用液剤 | |
| JPH02164829A (ja) | ヒアルロン酸点眼液 | |
| JPS62149614A (ja) | 点眼用製剤 |