JPS63255212A - Skin cosmetic - Google Patents
Skin cosmeticInfo
- Publication number
- JPS63255212A JPS63255212A JP62090322A JP9032287A JPS63255212A JP S63255212 A JPS63255212 A JP S63255212A JP 62090322 A JP62090322 A JP 62090322A JP 9032287 A JP9032287 A JP 9032287A JP S63255212 A JPS63255212 A JP S63255212A
- Authority
- JP
- Japan
- Prior art keywords
- saponin
- skin
- ceramide
- cosmetic
- storage stability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 20
- 229930182490 saponin Natural products 0.000 claims abstract description 24
- 150000007949 saponins Chemical class 0.000 claims abstract description 24
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims abstract description 22
- 229940106189 ceramide Drugs 0.000 claims abstract description 15
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 9
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 9
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 9
- 150000002305 glucosylceramides Chemical class 0.000 claims abstract description 9
- DDOVBCWVTOHGCU-QMXMISKISA-N n-[(e,2s,3r)-3-hydroxy-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxynonadec-4-en-2-yl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O DDOVBCWVTOHGCU-QMXMISKISA-N 0.000 claims abstract description 9
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000000419 plant extract Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 5
- 239000006071 cream Substances 0.000 abstract description 3
- 239000006210 lotion Substances 0.000 abstract description 3
- 235000013311 vegetables Nutrition 0.000 abstract 2
- 241000202722 Bupleurum falcatum Species 0.000 abstract 1
- 244000061944 Helianthus giganteus Species 0.000 abstract 1
- 239000002453 shampoo Substances 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 20
- 235000017709 saponins Nutrition 0.000 description 18
- 239000003921 oil Substances 0.000 description 11
- 239000012071 phase Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 150000001783 ceramides Chemical class 0.000 description 6
- 239000000843 powder Substances 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000002845 discoloration Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000002884 skin cream Substances 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 229940099259 vaseline Drugs 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N beta-monoglyceryl stearate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 229940033329 phytosphingosine Drugs 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 1
- 241001464798 Anguis Species 0.000 description 1
- 241000258957 Asteroidea Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 244000307700 Fragaria vesca Species 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 241000208690 Hamamelis Species 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- 241000545744 Hirudinea Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 244000241838 Lycium barbarum Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 235000015468 Lycium chinense Nutrition 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- YDNKGFDKKRUKPY-TURZORIXSA-N N-hexadecanoylsphingosine Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)\C=C\CCCCCCCCCCCCC YDNKGFDKKRUKPY-TURZORIXSA-N 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 244000309715 mini pig Species 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- NWMIYTWHUDFRPL-UHFFFAOYSA-N sapogenin Natural products COC(=O)C1(CO)C(O)CCC2(C)C1CCC3(C)C2CC=C4C5C(C)(O)C(C)CCC5(CCC34C)C(=O)O NWMIYTWHUDFRPL-UHFFFAOYSA-N 0.000 description 1
- 229940048730 senega Drugs 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
（技術分野）
本発明はセラミド類とサポニン等を含有してなる保存安
定性に優れた皮膚化粧料に関する。DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to a skin cosmetic containing ceramides, saponin, etc. and having excellent storage stability.
（従来技術）
老化皮膚とは、乾燥して滑らかさのない荒れた肌で、角
質細胞の剥維現象が認められ、角質層のターンオーバー
速度も遅くなる。(Prior Art) Aging skin is dry, rough skin that lacks smoothness, exhibits a phenomenon of keratin cell ablation, and a slow turnover rate of the stratum corneum.
このよっな皮膚老化の防止効果を期待して、従来から血
行促進剤等が検討されているが単に血行促進させるだけ
では皮膚の老化防止効果は発現するものではなかった。In the hope of preventing such skin aging, blood circulation promoters and the like have been studied, but simply promoting blood circulation has not been enough to produce skin aging prevention effects.
セラミド等はエモリエント効果に優れ（特開昭６１−２
６０００８号公報）皮膚が本来備えている水分保持機能
を九進し、皮膚を紬常な状態に保持する（特開昭６１−
２７１２０５号公報）ので優れた皮膚老化防止剤である
が、本発明者のその後の検討でセラミド等は長期に保存
した場合には次第に変色を起こすことが判明した。特に
化粧品や医薬品などの基剤中に配合した場合には、その
傾向が強い。Ceramides etc. have excellent emollient effects (Japanese Patent Application Laid-Open No. 61-2
No. 60008) The skin's inherent moisture retention function is enhanced to maintain the skin in its normal state (Japanese Unexamined Patent Application Publication No. 1986-61)
271205) and is therefore an excellent skin anti-aging agent, however, subsequent studies by the present inventors revealed that ceramides and the like gradually discolor when stored for a long period of time. This tendency is particularly strong when it is incorporated into the base of cosmetics, pharmaceuticals, and the like.
（発明の開示）
そこで、本発明者は、上記の事情に鑑み鋭意研究した結
果、セラミド類とサポニン又はサポニンを含有する植物
抽出物を含有した皮膚化粧料は、保存安定性に優れてい
る事を見出し本発明を完成した。(Disclosure of the Invention) Therefore, as a result of intensive research in view of the above circumstances, the present inventor has found that a skin cosmetic containing ceramides and saponin or a plant extract containing saponin has excellent storage stability. They found this and completed the present invention.
（発明の目的）
本発明の目的は、保存安定性、老化防止効果、皮膚安全
性に優れた皮膚化粧料を提供するにある。(Objective of the Invention) An object of the present invention is to provide a skin cosmetic with excellent storage stability, anti-aging effect, and skin safety.
（発明の構成）
本発明はセラミド、グルコシルセラミド、ガラクトシル
セラミドからなる群から選択された少なくとも一種と、
サポニン及びサポニンを含有する植物抽出物より選ばれ
た少なくとも一種とを含有していること、を特徴とする
皮膚化粧料に関する。(Structure of the Invention) The present invention provides at least one selected from the group consisting of ceramide, glucosylceramide, and galactosylceramide;
The present invention relates to a skin cosmetic containing at least one selected from saponin and a plant extract containing saponin.
（構成の具体的な説明）
本発明に用いるセラミド、グルコシルセラミド、ガラク
トシルセラミドは、人、豚、牛、馬、羊などの哺乳動物
の表皮に微量存在する化合物であって（バイオケミスト
リー、アンド、フィジオロジー、オブ、ザ、スキン、第
８６８頁〜第８８１頁、Ｂｉｏｃｈｅｍｉｓｔｒｙａｎ
ｄ Ｐｈｙｓｉｏｌｏｇｙ ｏｆ ｔｈｅ ５ｋｉｎ
、０ｘｆｏｒｄＵｎｉｖｅｒｓｉｔｙ Ｐｒｅｓｓ ｅ
Ｉｎｃ、１９８８ Ｎｅｗ Ｙｏｒｋ 、ジャーナル
、オブ、リピッド、リサーチ第２４巻１９８８等を参照
）、これらの動物表皮より通常の抽出方法にて得ること
が可能である。本発明においては、特開昭６１−２７１
２０５号公報や生化学実験書（脂質の生化学、生化学実
験講座、第８巻、２０〜２１頁、１９７４年、日本生化
学金繰、東京化学同人）に記載されている製造方法によ
り得られるセラミド、グルコシルセラミド、ガラクトシ
ルセラミドを用いることができる。ここでセラミドは、
Ｎ−アシルスフィンゴシン、Ｎ−（α−ヒドキシアシル
）−フィトスフィンゴシン、Ｎ−アシルフィトスフィン
ゴシンなどの混合物である。また、グルコシルセラミド
は主にＮ−アシルグルコシルスフィンゴシン、Ｎ−（α
−ヒドキシアシル）−グルコシルフィトスフィンゴシン
、Ｎ−（α−ヒドキシアシル）−グルコシルスフィンゴ
シン、Ｎ−アシルグルコシルフィトスフィン１−（８”
Ｑ−アシル）グルコシルなどの混合物である。ガラクト
シルセラミドは主にＮ−アシルガラクトシルスフィンゴ
シン、Ｎ−（α−ヒドキシアシル）−ガラクトシルフィ
トスフィンゴシン、Ｎ−（α−ヒドキシアシル）−ガラ
クトシルスフィンゴシンなどの混合物である。(Specific explanation of composition) Ceramide, glucosylceramide, and galactosylceramide used in the present invention are compounds that exist in trace amounts in the epidermis of mammals such as humans, pigs, cows, horses, and sheep (biochemistry, and Physiology, of the Skin, pp. 868-881, Biochemistryan
d Physiology of the 5kin
, Oxford University Press
Inc., 1988 New York, Journal of Lipid Research Vol. 24, 1988), and can be obtained from the epidermis of these animals by a conventional extraction method. In the present invention, JP-A-61-271
Obtained by the production method described in Publication No. 205 and the Biochemistry Experiment Book (Biochemistry of Lipids, Biochemistry Experiment Course, Vol. 8, pp. 20-21, 1974, Nippon Seikagaku Kanji, Tokyo Kagaku Dojin). Ceramide, glucosylceramide, and galactosylceramide can be used. Here, ceramide is
It is a mixture of N-acylsphingosine, N-(α-hydroxyacyl)-phytosphingosine, N-acyl phytosphingosine, and the like. In addition, glucosylceramide is mainly N-acylglucosylsphingosine, N-(α
-Hydoxyacyl)-glucosylphytosphingosine, N-(α-hydroxyacyl)-glucosylsphingosine, N-acylglucosylphytosphingosphine 1-(8”
It is a mixture of Q-acyl)glucosyl and the like. Galactosylceramide is mainly a mixture of N-acylgalactosylsphingosine, N-(α-hydroxyacyl)-galactosylphytosphingosine, N-(α-hydroxyacyl)-galactosylsphingosine, and the like.
本発明に用いるサポニン及びサポニンを含有する植物抽
出物は公知の物質である。The saponin and saponin-containing plant extract used in the present invention are known substances.
本発明におけるサポニンは、ステロール或いはトリテル
ペンという無極性グループ（サポゲニン）、！［（ヘン
ドース、ヘキソース、ウロン酸）が結合した化合物であ
ると定義される。The saponin in the present invention is a nonpolar group called sterol or triterpene (sapogenin). [Defined as a compound in which (hendose, hexose, uronic acid) is combined.
その存在は、ある種のヒトデを例外として一般に広く植
物界に見られ、かつ−穏の植物中にも多種顕のサポニン
が存在する２本発明ではその構造は特に限定されるもの
ではないが、製法も公知である（例、７７ ルｖ シフ
Ｖｏｌ １５、Ｎｏ、１０ ８９７〜８９９（１９７
９）等）麦門冬、天門冬、商陸、セネガ、遠志、人参、
特開昭５６−１６０９８１号公報に記載されている大豆
、特開昭５６−１２７８１６号公報に記載されている、
アマチャズル、箸の各種サポニンが使用される。Its existence is generally widely seen in the plant kingdom, with the exception of certain starfish, and there are many types of saponins even in common plants.2 Although the present invention does not particularly limit its structure, The manufacturing method is also known (e.g., 77 Lev Schiff Vol 15, No. 10 897-899 (197
9) etc.) Mugimonfuyu, Tenmonfuyu, Shangluku, Senega, Toshi, Ninjin,
The soybean described in JP-A-56-160981, the soybean described in JP-A-56-127816,
Amachazur, various saponins of chopsticks are used.
次に、本発明で使用できるサポニンを含有する植物抽出
物は例えば特開昭６１−１７８９０８号公報に記載され
ている、ヒマワリ（Ｈｅｔｉａｎｔｈｕｓｉｎｎｕｕｓ
Ｌ、 ）の種子、ミシマサイコ（ＢｕｐＪｅｕｒｕｍ
ｆａｌｃａｔｕｎ Ｌ、 ）の根、チュ（８ａｎｇｕｉ
ｓｏｒｂａ ｏｆｆｉｃ−ｉｎａＪｉｓ Ｌ、 ）の
根基から得られる抽出物、特開昭５２−１２５５１０号
公報に記載されているムクロジの果皮の抽出物、特公昭
４２−１０９２８号公報に記載されているミシマサイコ
の根等から得られる粗サポニン、特公昭５８−４０９２
８号公報に記載されている薊、クコ、シコン、川→、水
蛭から得られる抽出物、特開昭５７−１０６６０７号公
報に記載されている七ネガ、ハマメリス、オオヘビイチ
ゴ、抽出物等が使用できる。Next, the saponin-containing plant extract that can be used in the present invention is, for example, sunflower (Hetianthusinnuus) described in JP-A-61-178908.
L, ) seeds, BupJeurum
falcatun L, ) root, Chu (8 angui
extract obtained from the root group of sorba offic-inaJis L, ), extract of the pericarp of Sapindium sapinata described in JP-A No. 125510/1983, root of Sapindium sapiens described in JP-A No. 42-10928. Crude saponin obtained from etc., Special Publication No. 58-4092
Extracts obtained from iris, wolfberry, citrus, kawa →, and water leech, which are described in Publication No. 8, and extracts from Shichinaga, Hamamelis, and Strawberry, which are described in JP-A-57-106607, are used. can.
本発明における前記セラミド、グルコシルセラミド、ガ
ラクトシルセラミドからなる群から選択された少なくと
も一種の配合量は皮膚化粧料の総量を基準として０．０
６〜５．０重ｉ％（以下ｗｔチと略記する）である。In the present invention, the blending amount of at least one selected from the group consisting of ceramide, glucosylceramide, and galactosylceramide is 0.0% based on the total amount of the skin cosmetic.
It is 6 to 5.0 weight i% (hereinafter abbreviated as wt).
又、前記サポニン又はサポニンを含有する植物抽出物よ
り選ばれた少なくとも一種の配合量は皮膚化粧料の総量
を基準として０６０１〜ｇ、 Ｏｗ ｔ ｆｙ’（サポ
ニン含量として）である。Further, the blending amount of at least one selected from the saponin or the saponin-containing plant extract is 0.601 to 0.60 g Ow t fy' (as saponin content) based on the total amount of the skin cosmetic.
本発明の皮膚化粧料は、水溶液系、可溶化系、乳化系、
粉末分散系、水−油２膚系、水−油一粉末８１１系など
の広い範囲の剤型に適用でき、用途も化粧水、乳液、ク
リーム、パックなどの基礎化粧料、口紅、ファンデージ
肩ンなどのメーキャツ化粧料などの化粧料のほか、医薬
品、医薬部外品など多岐にわたる。The skin cosmetics of the present invention are aqueous solution type, solubilized type, emulsion type,
It can be applied to a wide range of formulations such as powder dispersion, water-oil two-skin type, water-oil one-powder 811 system, and can be used in basic cosmetics such as lotions, emulsions, creams, and packs, lipstick, and foundation makeup. In addition to cosmetics such as cosmetics, such as cosmetics, there is a wide range of products, including pharmaceuticals and quasi-drugs.
本発明の皮膚化粧料には必要に応じて、本発明の効果を
損なわない範囲で、保湿剤、増粘剤、油分、防腐剤、乳
化剤、酸化防止剤、金属イオン封鎖剤、紫外線吸収剤、
粉末、薬剤、色剤、香料などを配合できる。The skin cosmetics of the present invention may contain moisturizing agents, thickeners, oils, preservatives, emulsifiers, antioxidants, sequestrants, ultraviolet absorbers, etc., as necessary, to the extent that the effects of the present invention are not impaired.
Powders, drugs, colorants, fragrances, etc. can be added.
（実施例） 以下、皿々の実施例及び比較例にて詳説する。(Example) Hereinafter, detailed explanation will be given using various examples and comparative examples.
記載されている保存安定性試験実用特性試験は次の方法
で測定した。The storage stability test and practical property test described were measured by the following method.
又、実施例に使用したセラミド、グルコシルセラミド、
ガラクトシルセラミドはミニブタから得られたもの適用
した。In addition, ceramide, glucosylceramide,
Galactosylceramide obtained from mini pigs was applied.
（１）保存安定性試験
試料を４５°Ｃ恒温室に８カ月間保存し、色及び匂いの
変化について評価した。(1) Storage stability test Samples were stored in a constant temperature room at 45°C for 8 months, and changes in color and odor were evaluated.
（色）
変色全くなし ◎やや変色
○
かなり変色 △
著しい変色 ×
（匂い）
変臭全くなし つやや変臭
○
かなり変臭 △
著しい変臭 ×
（２）実用特性試験
試料を２０名の被検者が使用して、「保湿性」「刺激」
について評価した。試験結果はそれぞれ「肌がしっとり
した」「刺激がある」と回答した人数で示した。(Color) No discoloration at all ◎Slight discoloration
○ Significant discoloration △ Significant discoloration × (Odor) No odor at all Shiny or odor
○ Significant odor △ Significant odor × (2) Practical property test samples were used by 20 subjects and were found to be ``moisturizing'' and ``irritating.''
was evaluated. The test results are shown by the number of people who answered that their skin felt moist and irritated.
実施例１〜１０ 比較例１〜４
（スキンクリーム）
（１）処 方
人 、油 相 配合量（ｗ
ｔ％）セタノール ４．０
ワセリン ７．０
スクワラン ２１．０
ステアリン酸モノグリセライド ２．０エチ
ルパラベン ０．２第−表に示す成分
第−表に示す配合ルＢ、水 相
プロピレングリコール ５．０精
製 水 全紙を１００とする残量（２
）製法
人に属する油相部の成分とＢに属する水相部の成分とを
それぞれ別々に加熱溶解し、油相部を水相部に混合して
乳化し、室温まで冷却してスキンクリームを得た。Examples 1 to 10 Comparative Examples 1 to 4 (Skin cream) (1) Prescriber, oil phase blending amount (w
t%) Setanol 4.0 Vaseline 7.0 Squalane 21.0 Stearic acid monoglyceride 2.0 Ethylparaben 0.2 Ingredients shown in Table 1
Blend B shown in Table 1, aqueous phase propylene glycol 5.0%
Remaining amount (2
) The components of the oil phase belonging to the manufacturing company and the components of the aqueous phase belonging to B are heated and dissolved separately, the oil phase is mixed with the water phase to emulsify, and the skin cream is cooled to room temperature. Obtained.
（３）特 性
その特性を第１表に示す。第１表から明らかなように、
セラミド類とサポニン等を配合した実施例１〜１０のス
キンクリームはそれぞれ単独配合の比較例１〜４に較べ
て保存安定性、実用特性の両面に優れたものであった。(3) Characteristics The characteristics are shown in Table 1. As is clear from Table 1,
The skin creams of Examples 1 to 10 in which ceramides, saponin, etc. were blended had better storage stability and practical properties than Comparative Examples 1 to 4 in which ceramides and saponin were blended alone.
更に、従来酸化防止剤として知られている、ジブチルヒ
ドロキシトルエ゛ンを安定化剤として配合した比較例５
のスキンクリームは保存安定性には優れるが、皮膚刺激
のあるものであった。Furthermore, Comparative Example 5 contains dibutylhydroxytoluene, which is conventionally known as an antioxidant, as a stabilizer.
The skin cream had excellent storage stability, but was irritating to the skin.
、−・
（以５、下牟２白）
ど、］−７・
実施例１１（スキンミルク）
（１）処 方
Ａ、油 相 配合ム（ｗｔ
斧）ステアリン酸 ２．５
セタノール １．６
ワ セ リ ン
５．０減動パラフイン １０
．０プロピルパラベン ０．１セ
ラ ミ ド
１．０ムクロジ果皮抽出物
０．０５Ｂ、水 相
グ リ セ リ ン
１０．０精 製 水 ６７．
８５（２７！法
実施例１に準じる
（３）特 性
その特性を第２表に示す。第２表から明らかな如く、本
発明のスキンミルクは保存安定性、実用特性に優れたも
のであった。, -. (hereinafter referred to as 5, Shimomu 2 white) Do,] -7. Example 11 (skin milk) (1) Formulation A, oil phase blend (wt
Ax) Stearic acid 2.5 Setanol 1.6 Vaseline
5.0 Reduction paraffin 10
．． 0 propylparaben 0.1 se
La Mido
1.0 Sapindica peel extract
0.05B, water phase glycerin
10.0 Purified water 67.
85 (27! According to Method Example 1) (3) Properties The properties are shown in Table 2. As is clear from Table 2, the skin milk of the present invention has excellent storage stability and practical properties. Ta.
実施例１２（ファンデージ冒ン）
（１）処 方
ム、油 相 配合量（ｗ
ｔチ）セタノール ８．６
脱臭ラノリン ４．０
ホホ″油 ・・５．０
ワ セ リ ン
２．０スクワラン ６．０
ステアリン酸モノグリセライド ２．５ミシマ
サイコの根粒サポニン ０．０５Ｂ、水 相
グリセリン ８．０
調合粉末 １２．０
精 製 水 ５８．４５（２
）製法
Ａをζ属する油相部の成分を加熱溶解する。これとは別
に、調合粉末を除くＢに属する水相部の成分を加熱溶解
し、これに調合粉末を分散する。油相部を水相部中に混
合して乳化し、室温まで冷却してファンデーシロンクリ
ームを得た。Example 12 (foundage exposure) (1) Formula, oil phase blending amount (w
t) Setanol 8.6 Deodorized lanolin 4.0 Jojo oil...5.0 Vaseline
2.0 Squalane 6.0 Stearic acid monoglyceride 2.5 Mishimasaiko root nodule saponin 0.05B, water Phase glycerin 8.0 Mixed powder 12.0 Purified water 58.45 (2
) Heat and dissolve the components of the oil phase that belong to Production Method A. Separately, the components of the aqueous phase belonging to B, excluding the blended powder, are heated and dissolved, and the blended powder is dispersed therein. The oil phase was mixed into the water phase, emulsified, and cooled to room temperature to obtain a foundation cream.
（３）特 性
その特性を第２表に示す。第２表から明らかな如く、本
発明のファンデージ理ンの保存安定性、実用特性は優れ
たものであった。(3) Characteristics The characteristics are shown in Table 2. As is clear from Table 2, the storage stability and practical properties of the foundationage resin of the present invention were excellent.
第２表
（発明の効果）
以上記載の如く、本発明の皮膚化粧料は保存安定性、実
用特性に優れ、皮膚刺激の無いものであることは明らか
である。Table 2 (Effects of the Invention) As described above, it is clear that the skin cosmetic of the present invention has excellent storage stability and practical properties, and is free from skin irritation.
Claims (1)
からなる群から選択された少なくとも一種と、サポニン
及びサポニンを含有する植物抽出物より選ばれた少なく
とも一種とを含有していることを特徴とする皮膚化粧料
。A skin cosmetic comprising at least one selected from the group consisting of ceramide, glucosylceramide, and galactosylceramide, and at least one selected from saponin and a plant extract containing saponin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62090322A JP2572730B2 (en) | 1987-04-13 | 1987-04-13 | Skin cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62090322A JP2572730B2 (en) | 1987-04-13 | 1987-04-13 | Skin cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63255212A true JPS63255212A (en) | 1988-10-21 |
| JP2572730B2 JP2572730B2 (en) | 1997-01-16 |
Family
ID=13995288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62090322A Expired - Lifetime JP2572730B2 (en) | 1987-04-13 | 1987-04-13 | Skin cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2572730B2 (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0366604A (en) * | 1989-08-04 | 1991-03-22 | Kanebo Ltd | Dermal cosmetic |
| FR2657256A1 (en) * | 1990-01-24 | 1991-07-26 | Bonne Claude | NEW COSMETIC PREPARATIONS CONTAINING AN EXTRACT OF SUNFLOWER MEAL (HELIANTHUS ANNUUS). |
| FR2675045A1 (en) * | 1991-04-10 | 1992-10-16 | Carita Sa | Cosmetic composition having an antidehydrating effect which is usable in lipsticks |
| FR2690343A1 (en) * | 1992-04-28 | 1993-10-29 | Inocosm Laboratoires | Compsn. with anti-radical and anti-lipo-peroxidising effect contg. polar lipid - for use in cosmetics, dietetics, food industry and pharmacology |
| EP0662319A1 (en) * | 1994-01-10 | 1995-07-12 | L'oreal | Cosmetic and/or dermatologic composition for the treatment of aging containing ceramides, and its use |
| KR100249459B1 (en) * | 1997-11-12 | 2000-04-01 | 성재갑 | High moisturizing & transfer resistant lipstick composition |
| KR100358590B1 (en) * | 2000-07-10 | 2002-10-25 | 로제화장품 주식회사 | Cosmetic composition including bupleurum and/or plunus abstracts |
| KR20030047260A (en) * | 2001-12-10 | 2003-06-18 | 주식회사 엘지생활건강 | High moisturizing complex and lipstick composition containing the same |
| KR20040040031A (en) * | 2002-11-06 | 2004-05-12 | 주식회사 엘지생활건강 | Lip make up composition |
| JP2009079044A (en) * | 2007-09-04 | 2009-04-16 | Rohto Pharmaceut Co Ltd | Ceramide compound-containing composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61210009A (en) * | 1985-03-14 | 1986-09-18 | Shiseido Co Ltd | External preparation for skin |
| JPS61271205A (en) * | 1985-05-24 | 1986-12-01 | Kanebo Ltd | Skin cosmetic |
-
1987
- 1987-04-13 JP JP62090322A patent/JP2572730B2/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61210009A (en) * | 1985-03-14 | 1986-09-18 | Shiseido Co Ltd | External preparation for skin |
| JPS61271205A (en) * | 1985-05-24 | 1986-12-01 | Kanebo Ltd | Skin cosmetic |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0366604A (en) * | 1989-08-04 | 1991-03-22 | Kanebo Ltd | Dermal cosmetic |
| FR2657256A1 (en) * | 1990-01-24 | 1991-07-26 | Bonne Claude | NEW COSMETIC PREPARATIONS CONTAINING AN EXTRACT OF SUNFLOWER MEAL (HELIANTHUS ANNUUS). |
| FR2675045A1 (en) * | 1991-04-10 | 1992-10-16 | Carita Sa | Cosmetic composition having an antidehydrating effect which is usable in lipsticks |
| FR2690343A1 (en) * | 1992-04-28 | 1993-10-29 | Inocosm Laboratoires | Compsn. with anti-radical and anti-lipo-peroxidising effect contg. polar lipid - for use in cosmetics, dietetics, food industry and pharmacology |
| EP0662319A1 (en) * | 1994-01-10 | 1995-07-12 | L'oreal | Cosmetic and/or dermatologic composition for the treatment of aging containing ceramides, and its use |
| FR2714829A1 (en) * | 1994-01-10 | 1995-07-13 | Oreal | Cosmetic and / or dermatological composition for the treatment of aging containing ceramides, its use. |
| KR100249459B1 (en) * | 1997-11-12 | 2000-04-01 | 성재갑 | High moisturizing & transfer resistant lipstick composition |
| KR100358590B1 (en) * | 2000-07-10 | 2002-10-25 | 로제화장품 주식회사 | Cosmetic composition including bupleurum and/or plunus abstracts |
| KR20030047260A (en) * | 2001-12-10 | 2003-06-18 | 주식회사 엘지생활건강 | High moisturizing complex and lipstick composition containing the same |
| KR20040040031A (en) * | 2002-11-06 | 2004-05-12 | 주식회사 엘지생활건강 | Lip make up composition |
| JP2009079044A (en) * | 2007-09-04 | 2009-04-16 | Rohto Pharmaceut Co Ltd | Ceramide compound-containing composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2572730B2 (en) | 1997-01-16 |
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