JPH01190614A - Skin cosmetic - Google Patents
Skin cosmeticInfo
- Publication number
- JPH01190614A JPH01190614A JP1169288A JP1169288A JPH01190614A JP H01190614 A JPH01190614 A JP H01190614A JP 1169288 A JP1169288 A JP 1169288A JP 1169288 A JP1169288 A JP 1169288A JP H01190614 A JPH01190614 A JP H01190614A
- Authority
- JP
- Japan
- Prior art keywords
- molecular weight
- hyaluronic acid
- skin
- water
- edetate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title abstract description 15
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 38
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 38
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 150000003839 salts Chemical class 0.000 claims abstract description 18
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 14
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229940009662 edetate Drugs 0.000 claims abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 8
- 239000004615 ingredient Substances 0.000 abstract description 7
- 230000001681 protective effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 31
- 239000000203 mixture Substances 0.000 description 23
- 230000001953 sensory effect Effects 0.000 description 14
- 238000012360 testing method Methods 0.000 description 14
- 230000000052 comparative effect Effects 0.000 description 13
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 11
- 229940014041 hyaluronate Drugs 0.000 description 11
- 239000000686 essence Substances 0.000 description 10
- 230000007423 decrease Effects 0.000 description 9
- 229920002385 Sodium hyaluronate Polymers 0.000 description 7
- 229940010747 sodium hyaluronate Drugs 0.000 description 7
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000003205 fragrance Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 4
- QZKRHPLGUJDVAR-UHFFFAOYSA-K EDTA trisodium salt Chemical compound [Na+].[Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O QZKRHPLGUJDVAR-UHFFFAOYSA-K 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 238000013112 stability test Methods 0.000 description 3
- 230000000087 stabilizing effect Effects 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 229960005066 trisodium edetate Drugs 0.000 description 3
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 2
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 2
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- 229940097043 glucuronic acid Drugs 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- 229950006780 n-acetylglucosamine Drugs 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- UXHQLGLGLZKHTC-CUNXSJBXSA-N 4-[(3s,3ar)-3-cyclopentyl-7-(4-hydroxypiperidine-1-carbonyl)-3,3a,4,5-tetrahydropyrazolo[3,4-f]quinolin-2-yl]-2-chlorobenzonitrile Chemical compound C1CC(O)CCN1C(=O)C1=CC=C(C=2[C@@H]([C@H](C3CCCC3)N(N=2)C=2C=C(Cl)C(C#N)=CC=2)CC2)C2=N1 UXHQLGLGLZKHTC-CUNXSJBXSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920002567 Chondroitin Polymers 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- SXPWTBGAZSPLHA-UHFFFAOYSA-M cetalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SXPWTBGAZSPLHA-UHFFFAOYSA-M 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- AYOOGWWGECJQPI-NSHDSACASA-N n-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(3-propan-2-yloxy-1h-pyrazol-5-yl)imidazo[4,5-b]pyridin-5-amine Chemical compound N1C(OC(C)C)=CC(N2C3=NC(N[C@@H](C)C=4N=CC(F)=CN=4)=CC=C3N=C2)=N1 AYOOGWWGECJQPI-NSHDSACASA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000008844 regulatory mechanism Effects 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 239000002884 skin cream Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- -1 vaseline Chemical compound 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は皮膚の保護並びに皮膚表面での水分保持に優れ
、経日粘度安定性の良い皮膚化粧料に関する。DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a skin cosmetic that is excellent in protecting the skin and retaining moisture on the skin surface, and has good viscosity stability over time.
（従来技術）
−ａに、皮膚角質層の水分が、１０〜１５％を含んだ状
態が健康な皮膚と言われている。老化や季節変動等によ
り、正常な角質水分調節機構が損われることから、皮膚
表面の水分保持が皮膚化粧料にとって重要な役割となっ
ている。(Prior Art) -A. Healthy skin is said to have a moisture content of 10 to 15% in the stratum corneum of the skin. Since the normal stratum corneum moisture regulation mechanism is impaired due to aging, seasonal changes, etc., moisture retention on the skin surface has become an important role for skin cosmetics.
従来より、グリセリン、プロピレングリコール、ソルビ
トール、ピロリドンカルボン酸ナトリウム等の保湿剤が
利用されているが、吸湿性に由来するペタツキ感が生じ
易く、更に、低湿度下の使用では外気湿度がないことに
より、皮膚中から保湿剤へと逆に水分がとり込まれ皮膚
を乾燥せしめる。Humectants such as glycerin, propylene glycol, sorbitol, and sodium pyrrolidone carboxylate have been used in the past, but they tend to cause a sticky feeling due to their hygroscopic properties, and furthermore, when used in low humidity conditions, there is no outside humidity. , moisture is absorbed from the skin into the moisturizer, drying out the skin.
同じ目的でヒアルロン酸コンドロイチン四ＧＡ Ｍ、コ
ンドロイチン６硫酸あるいはそれらの塩類の一種又は二
種以上と可溶性コラーゲンの一種又は二種以上とを含有
することを特徴とする皮膚化粧料が捷案されている（特
許公報昭６０−１９７２５号）、このものは、それなり
に効果を示すが、経口で、ヒアルロン酸の劣化による粘
度低下が問題となっていた。For the same purpose, skin cosmetics have been developed which are characterized by containing one or more types of hyaluronic acid chondroitin 4GAM, chondroitin 6 sulfate, or their salts, and one or more types of soluble collagen. (Patent Publication No. 19725/1983), this product shows some effects, but when taken orally, a decrease in viscosity due to deterioration of hyaluronic acid has been a problem.
ヒアルロン酸及びその塩には、分子量数万〜数百万もの
が現在市場にある０分子量ｌＯ万以下のヒアルロン酸及
びその塩は、水に分散させても、粘度があがらずヒアル
ロン酸独特の滑らかな悪触を得がたい。Hyaluronic acid and its salts with molecular weights ranging from tens of thousands to millions are currently on the market.Hyaluronic acid and its salts with a molecular weight of 0,000 or less do not increase in viscosity even when dispersed in water, and have the unique smoothness of hyaluronic acid. It's hard to get any bad influence.
分子ｆｆ１２０万〜８０万のヒアルロン酸及びその塩は
、高濃度配合することで適度な粘度のものが得られるが
、使用時べたつき感があり官能特性上好ましくなく、更
に、経日により劣化し粘度低下をきたす。分子量１００
万以上のヒアルロン酸及びその塩は、水に少量配合する
だけで適度な粘度の組成物が得られ、官能特性において
も好ましいものが得られる。しかしながら、経口によっ
て粘度低下をきたす。Hyaluronic acid and its salts with a molecular ff of 1.2 million to 800,000 can be blended at a high concentration to provide a suitable viscosity, but they have a sticky feel when used, which is undesirable in terms of sensory properties.Furthermore, they deteriorate over time and their viscosity decreases. cause a decline. Molecular weight 100
By adding a small amount of hyaluronic acid and its salts to water, a composition with an appropriate viscosity can be obtained, and a composition with favorable sensory properties can be obtained. However, oral administration causes a decrease in viscosity.
ヒアルロン酸の劣化に伴なう粘度低下を解消するために
、ヒアルロン酸及び又はその塩と水溶性増粘剤の一種又
は、二種以上を配合することを特徴とする皮膚化粧料が
提供されている（特開昭５７−１８５２０８号公報）が
粘度安定化効果が十分でなく、更に、水溶性増粘剤を配
合することで、ヒアルロン酸本来の優れた感触が損われ
、べたつき感、ぬるつき感等が強く官能特性上好ましい
ものではない。In order to eliminate the decrease in viscosity caused by the deterioration of hyaluronic acid, a skin cosmetic is provided, which is characterized in that it contains hyaluronic acid and/or a salt thereof and one or more water-soluble thickeners. (Japanese Unexamined Patent Publication No. 57-185208) does not have a sufficient viscosity stabilizing effect, and furthermore, by incorporating a water-soluble thickener, the original excellent feel of hyaluronic acid is impaired, resulting in a sticky and slimy feeling. It has a strong feeling and is not preferable in terms of sensory characteristics.
（発明の開示）
本発明者らは、かかる事情に鑑み上記難点を解消すべく
鋭意研究した結果、後記特定の高分子量ヒアルロン酸、
低分子量ヒアルロン酸、多価アルコール、エデト酸塩、
及び水を配合してなる皮膚化粧料が、ヒアルロン酸本来
の特性である肌なじみ、滑らかな感触を損なわず経口に
よる粘度低下を防止し、皮膚の保護並びに皮膚表面の水
分保持効果により、皮膚を滑らかにし、適度な張りと潤
いを与えることを見出し、本発明を完成するに至った。(Disclosure of the Invention) In view of the above circumstances, the present inventors have conducted intensive research to solve the above-mentioned difficulties, and as a result, the following specific high molecular weight hyaluronic acid,
Low molecular weight hyaluronic acid, polyhydric alcohol, edetate,
A skin cosmetic containing hyaluronic acid and water prevents a decrease in viscosity due to oral administration without sacrificing the inherent properties of hyaluronic acid, such as blending into the skin and smooth feel, and has the effect of protecting the skin and retaining moisture on the skin surface. They found that it smoothes the skin and provides appropriate tension and moisture, leading to the completion of the present invention.
（発明の目的）
本発明の目的は、肌なじみが良く、皮膚の保護並びに皮
膚表面の水分保持効果に優れ、経口により粘度低下をき
たさない皮膚化粧料を提供することにある。(Objective of the Invention) An object of the present invention is to provide a skin cosmetic that blends well into the skin, has excellent skin protection and moisture retention effects on the skin surface, and does not cause a decrease in viscosity when administered orally.
（発明の構成）
即ち、本発明は分子Ｍ１００万以上の高分子量ヒアルロ
ン酸及び／又はその塩と分子量１０万以下の低分子量ヒ
アルロン酸及び／又はその塩と多価アルコールとエデト
酸塩及び水を含有してなる皮膚化粧料である。(Structure of the Invention) That is, the present invention comprises a high molecular weight hyaluronic acid with a molecular weight of 1 million or more and/or a salt thereof, a low molecular weight hyaluronic acid with a molecular weight of 100,000 or less and/or a salt thereof, a polyhydric alcohol, an edetate salt, and water. It is a skin cosmetic containing.
（構成の具体的な説明）
本発明に用いられる分子量１００万以上の高分子量ヒア
ルロン酸（以下高分子ヒアルロン酸と略記する）は、天
然物、微生物の培養により抽出されたものでも合成品で
もよく、その抽出法、精製処理方ｍ等製造法にかかわら
ずグルクロン酸とＮ−アセチルグルコサミンの等モルを
１単位とする多糖類であり、その分子量が１００万以上
であればさしつかえない、更に、ヒアルロン酸の塩とし
ては、ナトリウム、カリウム、塩基性アミノ酸等との塩
が用いられる。高分子量ヒアルロン酸及びその塩の各々
単独または、両者の配合量は、最終組成物の総量を基準
として０．０５〜２．０重量％（以下ｗｔ％と略記する
）の範囲内であり、好ましくは０．１−１．Ｏｗ ｔ％
の範囲内である。(Specific explanation of the structure) The high molecular weight hyaluronic acid with a molecular weight of 1 million or more (hereinafter abbreviated as high molecular weight hyaluronic acid) used in the present invention may be a natural product, one extracted by culturing microorganisms, or a synthetic product. It is a polysaccharide that has equimolar moles of glucuronic acid and N-acetylglucosamine as one unit, regardless of its extraction method, purification method, etc., and it is acceptable as long as its molecular weight is 1 million or more. As acid salts, salts with sodium, potassium, basic amino acids, etc. are used. The blending amount of high molecular weight hyaluronic acid and its salts alone or both is within the range of 0.05 to 2.0% by weight (hereinafter abbreviated as wt%) based on the total amount of the final composition, and is preferably is 0.1-1. Owt%
is within the range of
これより配合量が多いと、ペタツキ感があり官能特性上
好ましくない。又、逆に少ないと、皮膚保護作用並びに
皮膚上での水分保持効果が十分期待できない。If the blending amount is larger than this, it gives a sticky feeling and is unfavorable in terms of sensory characteristics. On the other hand, if the amount is too low, sufficient skin protection and moisture retention effects cannot be expected on the skin.
ここで上記ヒアルロン酸の分子量の測定は、掻限粘度法
が適用される。後記の低分子ヒアルロン酸についても同
様である。Here, the limiting viscosity method is applied to measure the molecular weight of the hyaluronic acid. The same applies to low-molecular-weight hyaluronic acid described later.
本発明に用いられる分子量１０万以下の低分子量ヒアル
ロン酸（以下低分子ヒアルロン酸と略記する）は、前記
高分子ヒアルロン酸と同様にその製造方法、精製方法に
かかわらずグルクロン酸とＮ−アセチルグルコサミンと
の等モルを一単位とする多糖類であり、その分子量がｌ
Ｏ万以下であれば良い、更に、この低分子ヒアルロン酸
の塩としては、低分子ヒアルロン酸とナトリウム、カリ
ウム、塩基性アミノ酸等との塩が用いられる。The low-molecular-weight hyaluronic acid with a molecular weight of 100,000 or less (hereinafter abbreviated as low-molecular-weight hyaluronic acid) used in the present invention is composed of glucuronic acid and N-acetylglucosamine, regardless of its production method or purification method, as with the above-mentioned polymeric hyaluronic acid. It is a polysaccharide whose unit is equimole of , and its molecular weight is 1
It is sufficient if it is less than 0,000,000.Furthermore, as the salt of this low molecular weight hyaluronic acid, a salt of low molecular weight hyaluronic acid and a sodium, potassium, basic amino acid, etc. is used.
低分子ヒアルロン酸及びその塩の各々単独または両者の
配合量は、最終組成物の総量を基準として、ｏ、 ｏ
ｏ ｓ〜ｌ、 Ｑ ｗ Ｌ％の範囲内、好ましくは’０
．０１〜Ｑ、 ５ ｗ Ｌ％の範囲内である。これより
配合量が多くても、酸含量に見合った粘度低下抑制効果
は見られない、逆にこれより少ないと粘度低下抑制効果
が期待出来ない。The amount of low-molecular-weight hyaluronic acid and its salt, alone or both, is o, o, based on the total amount of the final composition.
o s ~ l, Q w L%, preferably '0
．． It is within the range of 01 to Q, 5 wL%. Even if the amount is greater than this, the effect of suppressing viscosity reduction commensurate with the acid content cannot be observed, and conversely, if the amount is less than this, no effect of suppressing viscosity reduction can be expected.
本発明に用いられる多価アルコールは通常化粧品に配合
されるものであり、例えば、グリセリン。The polyhydric alcohol used in the present invention is one that is usually added to cosmetics, such as glycerin.
プロピレングリコール、ジプロピレングリコール。Propylene glycol, dipropylene glycol.
１．３−ブチレングリコール、ポリエチレングリコール
、ソルビトールなどが挙げられる。Examples include 1.3-butylene glycol, polyethylene glycol, and sorbitol.
多価アルコールの配合量は、最終組成物の総量を基準と
して、１．０〜３Ｑｗｔ％の範囲内で、好ましくは、５
．０〜２０ｗｔ％の範囲内である。これより配合量が多
いと、外気の湿度が低い場合、皮膚より水分を吸収する
可能性があり、更に塗布時にペタツキ感がある。これよ
り配合量が少ないと、粘度安定化効果が期待できない。The amount of polyhydric alcohol blended is within the range of 1.0 to 3 Qwt%, preferably 5 Qwt% based on the total amount of the final composition.
．． It is within the range of 0 to 20 wt%. If the amount is higher than this, if the humidity of the outside air is low, there is a possibility that water will be absorbed from the skin, and there will be a feeling of stickiness when applied. If the amount is less than this, no viscosity stabilizing effect can be expected.
本発明に用いられるエデト酸塩としては、エデト＃２ナ
トリウム、エデト酸３ナトリウム、エデト酸４ナトリウ
ムがあり、このうちの一種又は二種以上が適用される。The edetate salts used in the present invention include sodium edetate #2, trisodium edetate, and tetrasodium edetate, and one or more of these may be used.
エデト酸塩の配合量は、最終組成物の総量を基準として
０．００１〜Ｑ、５ ｗ ｔ％の範囲内であり、好まし
くは、０．００１〜Ｑ、’ｌ ｗ ｔ％の範囲内である
。これより多くなると、最終組成物の粘度低下をきたし
、逆に少ないと粘度安定化効果が期待できない。The amount of edetate salt is within the range of 0.001 to Q, 5 wt%, preferably within the range of 0.001 to Q'l wt%, based on the total amount of the final composition. be. If the amount is more than this, the viscosity of the final composition will decrease, and if it is less than this, no viscosity stabilizing effect can be expected.
本発明に用いられる水は、通常用いられる精製水であっ
て、イオン交換樹脂で処理した脱イオン精製水または蒸
留水が適用される。The water used in the present invention is commonly used purified water, such as deionized purified water treated with an ion exchange resin or distilled water.
本発明の皮膚化粧料は、水に高分子ヒアルロン酸、低分
子ヒアルロン酸１多価アルコール、エデト酸塩を均一に
混合溶解して得られる。The skin cosmetic of the present invention is obtained by uniformly mixing and dissolving high molecular weight hyaluronic acid, low molecular weight hyaluronic acid monopolyhydric alcohol, and edetate salt in water.
本発明は、スキンローション、エツセンス、スキンミル
ク、スキンクリーム等の皮Ｊｌ化粧料に適用可能である
。The present invention is applicable to skin cosmetics such as skin lotions, essences, skin milks, and skin creams.
また、本発明の目的を達成する範囲内で香料。Also, fragrances within the scope of achieving the purpose of the present invention.
着色剤、防腐剤、界面活性剤、油性成分などを適宜配合
することができる。Coloring agents, preservatives, surfactants, oily components, etc. can be added as appropriate.
（実施例）
以下実施例及び°比較例の記載にて本発明の詳細な説明
する。(Example) The present invention will be described in detail below with reference to Examples and Comparative Examples.
実施例に示した％とは重量％を、部とは重１部を意味す
る。In the Examples, % means % by weight, and part means 1 part by weight.
尚、実施例に記載する、経口安定性試験、官能特性試験
の各方法は下記の如くである。The methods for the oral stability test and sensory property test described in the Examples are as follows.
ｆｌ＋ 経口安定性試験
試作直後及び４５℃、１ケ月保存した後の試料の粘度を
測定し、その比を求め下記の如くその比の相違により経
口安定性の評価とした。fl+ Oral stability test The viscosity of the sample was measured immediately after prototype production and after being stored at 45°C for one month, and the ratio was determined, and the oral stability was evaluated based on the difference in the ratio as shown below.
試料を２０名の女性被験者が１週間朝夕２回通常方法で
使用し、（イ）べたつき感（＋１）肌なじみ（ハ）粘度
（＝）塗布後のしっとり感（ネ）皮膚刺激等の試験項目
に関して試験した。試験結果は、各項に対して（イ）べ
たつき怒が少ない（０）肌なじみが良い（ハ）丁度良い
粘度である （ニ）しっとり感がある （ネ）刺激があ
ると各々回答した被験者の人数で示した。The samples were used by 20 female subjects twice in the morning and evening for one week in the usual manner, and test items such as (a) stickiness (+1) skin familiarity (c) viscosity (=) moist feeling after application (n) skin irritation were evaluated. was tested. The test results show that for each item, the test subjects answered that (a) there is little stickiness and irritation, (0) it blends well into the skin, (c) it has just the right viscosity, (d) it has a moist feeling, and (n) it is irritating. Shown in number.
実施例１、比較例１〜７
〔エツセンス〕
第１表上段の組成の如く本発明のエツセンス及び比較用
のエツセンスを調製し、前記諸試験を実施した。その結
果を第１表下段に示した。Example 1, Comparative Examples 1 to 7 [Essence] Essence of the present invention and essence for comparison were prepared as shown in the compositions shown in the upper row of Table 1, and the various tests described above were conducted. The results are shown in the lower part of Table 1.
水に組成中１〜５の成分を加えて攪拌し、均一に混和す
る。Add ingredients 1 to 5 in the composition to water and stir to mix uniformly.
第１表下段に示した如く本発明の高分子ヒアルロン酸塩
、低分子ヒアルロン酸塩、多価アルコール、エデト酸塩
を各々好ましい量で配合してなる実施例１は、経口安定
性に優れ、また、官能特性諸試験の総てに優れていた。As shown in the lower part of Table 1, Example 1, which contains the polymer hyaluronate, low-molecular hyaluronate, polyhydric alcohol, and edetate of the present invention in preferred amounts, has excellent oral stability, In addition, it was excellent in all sensory characteristics tests.
高分子ヒアルロン酸塩、多価アルコール及び水を配合し
てなる比較例−１は、官能特性諸試験１こおいてば便れ
ていたが、経日安定性に著しく劣っていた。Comparative Example 1, in which a polymeric hyaluronate, a polyhydric alcohol, and water were blended, performed well in sensory characteristics test 1, but was significantly inferior in stability over time.
分子量５０万のヒアルロン酸ナトリウム、多価アルコー
ル、水を配合してなる比較例−２は、経口安定性が著く
悪く、更に、官能特性試験においてべたつき感が強く、
粘度、しっとり感も十分ではなかった。Comparative Example 2, which is a mixture of sodium hyaluronate with a molecular weight of 500,000, a polyhydric alcohol, and water, had extremely poor oral stability and also had a strong sticky feeling in the sensory characteristics test.
The viscosity and moist feeling were also insufficient.
低分子ヒアルロン酸塩、多価アルコール、水からなる比
較例−３は、経口安定性が悪く、更に官能性試験におい
て粘度、しっとり感の項目で著しく劣った。Comparative Example 3 consisting of a low-molecular hyaluronate, a polyhydric alcohol, and water had poor oral stability and was also significantly inferior in terms of viscosity and moist feeling in the sensory test.
高分子ヒアルロン酸塩、多価アルコール、エデト酸塩、
水からなる比較例−４は、比較例−１に比べると経口安
定性は、改善されたが実施例−１に比べると劣っていた
。Polymeric hyaluronate, polyhydric alcohol, edetate,
Comparative Example-4, which consisted of water, had improved oral stability compared to Comparative Example-1, but was inferior to Example-1.
高分子ヒアルロン酸塩、多価アルコール、低分子ヒアル
ロン酸塩及び水を配合してなる比較′例−５は、まずま
ずの経口安定性を見せたが、実施例−１と比較すると十
分とはいえない。Comparative Example-5, which is a combination of polymeric hyaluronate, polyhydric alcohol, low-molecular-weight hyaluronate, and water, showed fair oral stability, but compared to Example-1, it was not satisfactory. do not have.
分子量５０万のヒアルロン酸ナトリウム、低分子ヒアル
ロン酸塩、多価アルコール、エデト酸塩及び水を配合し
てなる比較例−６は、経日安定性試験において、実施例
−１より劣り、官能特性試験のべたつき感、粘度、しっ
とり感の項目で劣っていた。Comparative Example-6, which is a mixture of sodium hyaluronate with a molecular weight of 500,000, a low-molecular-weight hyaluronate, a polyhydric alcohol, an edetate salt, and water, was inferior to Example-1 in the aging stability test, and had poor sensory characteristics. It was inferior in the items of stickiness, viscosity, and moistness in the test.
ジプロピレングリコールを除いた比較例−７は経口安定
性、官能特性のしっとり惑等の項目で劣っていた。Comparative Example 7, which did not contain dipropylene glycol, was inferior in terms of oral stability and sensory characteristics such as moistness.
実施例２〜５
〔エツセンス〕
第１表上段の組成の如くエツセンスを調製し、前記諸試
験を実施した。その結果を第２表下段に示した。Examples 2 to 5 [Essence] Essence was prepared according to the composition shown in the upper row of Table 1, and the various tests described above were conducted. The results are shown in the lower part of Table 2.
水に組成中の１〜４の成分を加えて攪拌し、均一に混和
する。Add ingredients 1 to 4 in the composition to water and stir to mix uniformly.
第２表の下段に示した如く、本発明の高分子ヒアルロン
酸塩、低分子ヒアルロン酸塩、エデト酸塩及び水を各々
好ましい量で配合してなる実施例２〜５は、いずれも経
口安定性に優れ、また、官能特性諸試験においても優れ
ており、本発明の効比較例−１２
〔エツセンス〕
第３表の組成の如くエンセンスを調製し、前記諸試験を
実施した。その結果を第３表に示した。As shown in the lower part of Table 2, Examples 2 to 5, in which the high molecular weight hyaluronate, low molecular weight hyaluronate, edetate, and water of the present invention are blended in preferred amounts, are all orally stable. Comparative Example 12 of Efficacy of the Present Invention [Essence] Essence was prepared according to the composition shown in Table 3, and the various tests described above were conducted. The results are shown in Table 3.
〔調製方法〕 比較例−１２ 水ヒアルロン酸カリウム（分子量１００万）。 [Preparation method] Comparative example-12 Water potassium hyaluronate (molecular weight 1 million).
エデト酸二すトリウム、ｌ、３−ブチレングリコール、
カルボキシメチルセルロースを加えて均一に混合溶解す
る。Distrium edetate, l,3-butylene glycol,
Add carboxymethylcellulose and mix and dissolve uniformly.
第３表に示した結果を見て明らかな如く、ヒアルロン酸
と水溶性増粘剤を組み合せた比較例−１２は、経口安定
性が十分でなく、更に、使用時べたつき感が強かった。As is clear from the results shown in Table 3, Comparative Example 12, in which hyaluronic acid and a water-soluble thickener were combined, did not have sufficient oral stability and also had a strong sticky feeling when used.
実施例−６
〔エツセンス〕
下記の組成の如く本発明のエツセンスを調製し、前記諸
試験を実施した。Example 6 [Essence] The essence of the present invention was prepared as having the composition shown below, and the various tests described above were conducted.
〔組成〕 （％）ヒアルロン
酸（分子量１５０万）０．２ヒアルロン酸ナトリウム
（分子量５万）０．０１
グリセリン ８．０エデト酸四ナト
リウム ０．０１エチルアルコール
７．０パラオキシ安息香酸メチル ０，
０５香料 ０．０ＩＰＯ
Ｅ硬化ヒマシ油
（３０Ｅ、Ｏ，＞ ０．０５
水酸化カリウム ０．０２水
８ ４．
６ ５〔調製方法〕
＋１１ エチルアルコールにＰＯＥ硬化ヒマシ油、香
料、パラオキシ安息香酸メチルを加えて攪拌し、均一に
混合溶解する。[Composition] (%) Hyaluronic acid (molecular weight 1.5 million) 0.2 Sodium hyaluronate (molecular weight 50,000) 0.01 Glycerin 8.0 Tetrasodium edetate 0.01 Ethyl alcohol
7.0 Methyl paraoxybenzoate 0,
05 Fragrance 0.0IPO
E-hydrogenated castor oil (30E, O, > 0.05 Potassium hydroxide 0.02 Water
8 4.
6 5 [Preparation method] +11 Add POE hydrogenated castor oil, fragrance, and methyl p-oxybenzoate to ethyl alcohol and stir to mix and dissolve uniformly.
（２） 水にヒアルロン酸（分子量１５０万）、水酸
化カリウム、ヒアルロン酸ナトリウム（分子量５万）、
グリセリン、エデト酸四ナトリウムを加えて攪拌し、均
一に混合溶解する。(2) Hyaluronic acid (molecular weight 1.5 million), potassium hydroxide, sodium hyaluronate (molecular weight 50,000) in water,
Add glycerin and tetrasodium edetate and stir to uniformly mix and dissolve.
（３１ｆｌ＋に（２）を加えて撹拌し、均一に混合する
。(Add (2) to 31fl+ and stir to mix uniformly.
経日によって粘度低下をきたすことなく、更に、肌なじ
み、しっとり感、のびが良く使用時べたつき感がな（、
官能特性に優れていた。The viscosity does not decrease over time, and it blends well into the skin, feels moisturizing, spreads well, and does not feel sticky when used.
It had excellent sensory properties.
実施例−７
〔乳液〕
下記の組成の如く本発明の乳液を調製し、前記諸試験を
実施した。Example 7 [Emulsion] A milky lotion of the present invention was prepared with the composition shown below, and the various tests described above were conducted.
〔組成〕 （％）１．３−ブ
チレングリコール ８．０グリセリン
２．０スクワラン ５．
０ワセリン １．０セタノー
ル １．０ＰＯＥソルビタンモノ
オレエート
（２０Ｅ、Ｏ，） １．５
ヒアルロン酸ナトリウム
（分子量１００万）０．５
（分子量ｌＯ万）０．０２
エデト酸三ナトリウム ０．０１パラオキシ
安息香酸メチル ０．１香料
０．１グリセリンモノオレエート１．５
水
７ ９． ２ ７〔調製方法〕
（１１スクアラン、ワセリン、セタノール、ＰＯＥソル
ビクンモノオレエート （２０Ｅ、Ｏ，）、 グリセ
リンモノオレエートを約 ７０℃に加温し、均一に混合
溶解する。[Composition] (%) 1.3-butylene glycol 8.0 Glycerin
2.0 Squalane 5.
0 Vaseline 1.0 Cetol 1.0 POE sorbitan monooleate (20E, O,) 1.5 Sodium hyaluronate (molecular weight 1,000,000) 0.5 (molecular weight 10,000) 0.02 Trisodium edetate 0.01 Paraoxybenzoin Methyl acid 0.1 fragrance
0.1 glycerin monooleate 1.5 water
7 9. 2 7 [Preparation method] (11) Squalane, vaseline, cetanol, POE sorbicun monooleate (20E, O,), and glycerin monooleate are heated to about 70°C and mixed and dissolved uniformly.
（２） 水に１．３−ブチレングリコール、グリセリ
ン、ヒアルロン酸ナトリウム（分子量１００万）。(2) 1.3-butylene glycol, glycerin, and sodium hyaluronate (molecular weight: 1 million) in water.
ヒアルロン酸ナトリウム（分子！１０万）、エデト酸三
ナトリウム、バラオキシ安息香酸メチル。Sodium hyaluronate (molecules! 100,000), trisodium edetate, methyl hydroxybenzoate.
香料を加え、約７０℃に加温し均一に混合溶解する。Add fragrance and heat to approximately 70°C to mix and dissolve uniformly.
＋３１ ｉｌ＋に（２）を加えて攪拌、乳化し、室温
まで冷却し、本発明の乳液を得た。(2) was added to +31 il+, stirred, emulsified, and cooled to room temperature to obtain a milky lotion of the present invention.
経口安定性及び各種官能特性のいずれにも優れていた。 It was excellent in both oral stability and various sensory properties.
（発明の効果）
以上の記載の如く、本発明は、経日安定性に優れ、また
、官能特性においても優れた有用なる皮膚化粧料を提供
する事は、明らかである。(Effects of the Invention) As described above, it is clear that the present invention provides a useful skin cosmetic that has excellent stability over time and excellent sensory properties.
Claims (1)
／又はその塩と分子量１０万以下の低分子量ヒアルロン
酸及び／又はその塩と多価アルコールとエデト酸塩及び
水とを含有してなる皮膚化粧料。(1) Skin makeup containing high molecular weight hyaluronic acid and/or its salt with a molecular weight of 1 million or more, low molecular weight hyaluronic acid and/or its salt with a molecular weight of 100,000 or less, polyhydric alcohol, edetate, and water. fee.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63011692A JP2666210B2 (en) | 1988-01-21 | 1988-01-21 | Skin cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63011692A JP2666210B2 (en) | 1988-01-21 | 1988-01-21 | Skin cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01190614A true JPH01190614A (en) | 1989-07-31 |
| JP2666210B2 JP2666210B2 (en) | 1997-10-22 |
Family
ID=11785083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63011692A Expired - Fee Related JP2666210B2 (en) | 1988-01-21 | 1988-01-21 | Skin cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2666210B2 (en) |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994009795A1 (en) * | 1992-10-23 | 1994-05-11 | Allergan, Inc. | Bimodal molecular weight hyaluronate formulations and methods for using same |
| EP0718312A3 (en) * | 1994-12-22 | 1997-01-15 | Hercules Inc | Crosslinked acidic polysaccharides and their uses |
| EP1407759A1 (en) * | 2002-10-11 | 2004-04-14 | Giuseppe Petrigni | A cosmetic composition in colloidal form comprising hyaluronic acids and chitosan |
| JP2005047876A (en) * | 2003-07-31 | 2005-02-24 | P & P F:Kk | Liquid composition |
| JP2007077101A (en) * | 2005-09-15 | 2007-03-29 | Rohto Pharmaceut Co Ltd | External preparation for skin |
| WO2008003321A2 (en) * | 2006-07-07 | 2008-01-10 | Novozymes Biopolymer A/S | Compositions with several hyaluronic acid fractions for cosmetic use |
| FR2911066A1 (en) * | 2007-01-08 | 2008-07-11 | Oreal | Aqueous cosmetic care or make-up composition, e.g. skin care gel, contains hyaluronic acid as moisturizing agent and homopolymer of sulfonic acid monomer as stabilizer |
| WO2009066102A1 (en) * | 2007-11-19 | 2009-05-28 | Burdica Biomed Limited | Vaginal lubricant comprising hyaluronic acid |
| FR2924606A1 (en) * | 2007-12-10 | 2009-06-12 | Jean Noel Thorel | Composition, useful as a moisturizer and for treating dry skin or xerosis, comprises at least one hyaluronic acid in a free form and in a vectorized form |
| JP2011037849A (en) * | 2009-08-14 | 2011-02-24 | Holy Stone Healthcare Co Ltd | Hyaluronic acid mixture used for treating and preventing peptic ulcer and duodenal ulcer |
| JP2011057607A (en) * | 2009-09-09 | 2011-03-24 | Toshitsu Kagaku Kenkyusho:Kk | Composition containing hyaluronic acid and hyaluronic acid oligo-saccharide |
| JP2012012390A (en) * | 2010-06-04 | 2012-01-19 | Rohto Pharmaceutical Co Ltd | Hyaluronic acid-containing emulsified composition |
| CN104739705A (en) * | 2013-12-30 | 2015-07-01 | 谢铁强 | Four-molecular weights hyaluronic acid stock solution and preparation method thereof |
| JP2016098222A (en) * | 2014-11-26 | 2016-05-30 | 小林製薬株式会社 | External composition |
| JP2016098223A (en) * | 2014-11-26 | 2016-05-30 | 小林製薬株式会社 | External composition |
| JP2017186276A (en) * | 2016-04-06 | 2017-10-12 | キユーピー株式会社 | Anti-pollution agent and skin external composition for anti-pollution |
| CN111557863A (en) * | 2020-05-14 | 2020-08-21 | 华熙生物科技股份有限公司 | Application of composition containing hyaluronic acid and polyalcohol in improving skin permeability of water-soluble vitamin |
| CN114031667A (en) * | 2021-11-29 | 2022-02-11 | 杭州广科安德生物科技有限公司 | Protein stabilizer and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57212108A (en) * | 1981-06-17 | 1982-12-27 | Balazs Endre A | Hyaluronate composition and cosmetic blend containing same |
-
1988
- 1988-01-21 JP JP63011692A patent/JP2666210B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57212108A (en) * | 1981-06-17 | 1982-12-27 | Balazs Endre A | Hyaluronate composition and cosmetic blend containing same |
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994009795A1 (en) * | 1992-10-23 | 1994-05-11 | Allergan, Inc. | Bimodal molecular weight hyaluronate formulations and methods for using same |
| EP0718312A3 (en) * | 1994-12-22 | 1997-01-15 | Hercules Inc | Crosslinked acidic polysaccharides and their uses |
| US5690961A (en) * | 1994-12-22 | 1997-11-25 | Hercules Incorporated | Acidic polysaccharides crosslinked with polycarboxylic acids and their uses |
| EP1407759A1 (en) * | 2002-10-11 | 2004-04-14 | Giuseppe Petrigni | A cosmetic composition in colloidal form comprising hyaluronic acids and chitosan |
| JP2005047876A (en) * | 2003-07-31 | 2005-02-24 | P & P F:Kk | Liquid composition |
| JP2007077101A (en) * | 2005-09-15 | 2007-03-29 | Rohto Pharmaceut Co Ltd | External preparation for skin |
| WO2008003321A2 (en) * | 2006-07-07 | 2008-01-10 | Novozymes Biopolymer A/S | Compositions with several hyaluronic acid fractions for cosmetic use |
| WO2008003321A3 (en) * | 2006-07-07 | 2008-03-13 | Novozymes Biopolymer As | Compositions with several hyaluronic acid fractions for cosmetic use |
| FR2911066A1 (en) * | 2007-01-08 | 2008-07-11 | Oreal | Aqueous cosmetic care or make-up composition, e.g. skin care gel, contains hyaluronic acid as moisturizing agent and homopolymer of sulfonic acid monomer as stabilizer |
| WO2009066102A1 (en) * | 2007-11-19 | 2009-05-28 | Burdica Biomed Limited | Vaginal lubricant comprising hyaluronic acid |
| US20100284937A1 (en) * | 2007-11-19 | 2010-11-11 | Xiaobin Zhao | Vaginal lubricant comprising hyaluronic acid |
| US9044387B2 (en) | 2007-11-19 | 2015-06-02 | British Biocell International Limited | Vaginal lubricant comprising hyaluronic acid |
| EP3838277A1 (en) * | 2007-11-19 | 2021-06-23 | BBI Healthcare Limited | Vaginal lubricant comprising hyaluronic acid |
| FR2924606A1 (en) * | 2007-12-10 | 2009-06-12 | Jean Noel Thorel | Composition, useful as a moisturizer and for treating dry skin or xerosis, comprises at least one hyaluronic acid in a free form and in a vectorized form |
| JP2011037849A (en) * | 2009-08-14 | 2011-02-24 | Holy Stone Healthcare Co Ltd | Hyaluronic acid mixture used for treating and preventing peptic ulcer and duodenal ulcer |
| JP2011057607A (en) * | 2009-09-09 | 2011-03-24 | Toshitsu Kagaku Kenkyusho:Kk | Composition containing hyaluronic acid and hyaluronic acid oligo-saccharide |
| JP2012012390A (en) * | 2010-06-04 | 2012-01-19 | Rohto Pharmaceutical Co Ltd | Hyaluronic acid-containing emulsified composition |
| JP2016033146A (en) * | 2010-06-04 | 2016-03-10 | ロート製薬株式会社 | Hyaluronic acid-containing emulsion composition |
| JP2017149780A (en) * | 2010-06-04 | 2017-08-31 | ロート製薬株式会社 | Hyaluronic acid-containing emulsion composition |
| CN104739705A (en) * | 2013-12-30 | 2015-07-01 | 谢铁强 | Four-molecular weights hyaluronic acid stock solution and preparation method thereof |
| JP2016098222A (en) * | 2014-11-26 | 2016-05-30 | 小林製薬株式会社 | External composition |
| JP2016098223A (en) * | 2014-11-26 | 2016-05-30 | 小林製薬株式会社 | External composition |
| JP2017186276A (en) * | 2016-04-06 | 2017-10-12 | キユーピー株式会社 | Anti-pollution agent and skin external composition for anti-pollution |
| CN111557863A (en) * | 2020-05-14 | 2020-08-21 | 华熙生物科技股份有限公司 | Application of composition containing hyaluronic acid and polyalcohol in improving skin permeability of water-soluble vitamin |
| CN111557863B (en) * | 2020-05-14 | 2023-04-18 | 华熙生物科技股份有限公司 | Application of composition containing hyaluronic acid and polyalcohol in improving skin permeability of water-soluble vitamin |
| CN114031667A (en) * | 2021-11-29 | 2022-02-11 | 杭州广科安德生物科技有限公司 | Protein stabilizer and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| JP2666210B2 (en) | 1997-10-22 |
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