JPS61260008A - Cosmetic composition - Google Patents

Abstract

PURPOSE:A cosmetic composition for the skin and the hair having improved moisture retention and emollient effect, obtained by blending a cosmetic composition with a ceramide as an organism extract. CONSTITUTION:A cosmetic composition containing 0.001-10.0wt% ceramide [e.g., N-(omega-acyloxy)acylsphingosine, N-acylsphingosine or N-acylphytosphingo sine], one main component constituting a lipid membrane of a corneal layer of epidermis. Ceramide has high safety to the skin, improved moisture retention and emollient effect and the above-mentioned cosmetic can be used in the form of cream, milky lotion, pack, foundation, bath oil, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to cosmetic compositions. More specifically, the present invention relates to a cosmetic composition containing a biological extract with excellent moisturizing and emollient effects.

BACKGROUND OF THE INVENTION Cosmetic compositions that place emphasis on moisturizing properties have traditionally been formulated with various moisturizing agents. A cosmetic composition containing such a humectant imparts good wettability or flexibility to the skin and hair, and has desirable properties as a cosmetic composition.

＾匪(2) Base! Therefore, the present inventors have conducted various studies on ingredients that can be added to cosmetic compositions to provide excellent moisturizing properties, and have found that cosmetic compositions containing ceramides have excellent moisturizing properties and emollient effects. This discovery led to the completion of the present invention.

That is, the present invention is a cosmetic composition characterized by containing ceramide.

When applied to the skin, the cosmetic composition of the present invention not only absorbs moisture into the epidermis through the action of ceramides, increasing the moisturizing effect, but also prevents transpiration water loss from the epidermis, leaving the skin moist and supple. The ceramides blended in the detailed description of the invention are seven types of compounds that have a common structural unit of sphingolipids extracted from living bodies, and have a structure in which a fatty acid is bonded with an acid amide to the amino group of sphingosine. It is.

(1) N-(ω-acyloxy)acylsphingosine (2) N-acylsphingosine.

(3) N-acylphytosphingosine (4) N-(α
-Hydroxy)acylsphingosine (consisting of sphingosine having 18 and 20 carbon atoms and α-oxyacid having 24 to 2B carbon atoms) (5) N-(α-hydroxy)acylsphingosine (sphingosine having 17 and 18 carbon atoms, (consisting of α-oxypalmitic acid) (6a) N-[ω-(α-hydroxy)acyloxy]
Acylsphingosine (6b) N-(α-hydroxy)-acylphytosphingosine These ceramides are known lipids derived from naturally occurring epidermal cells, and are one of the components that increase in the epidermis as the epidermal cells keratinize. In particular, it is said to be one of the main components constituting the lipid membrane of stratum corneum cells. The present invention was achieved based on the discovery that ceramide, which is a biological extract, is highly safe for the skin and has excellent moisturizing and emollient effects.

The cosmetic composition of the present invention preferably contains 0.001 to 10.0% by weight of the ceramide based on the total weight of the composition.

The cosmetic composition of the present invention can be in a conventional form such as a cream, a milky lotion, a lotion, a pack, a foundation, a bath oil, etc., and each can be manufactured according to a conventional method.

In addition, the cosmetic composition of the present invention may contain oil, surfactants, pigments, fragrances, preservatives, humectants, ultraviolet absorbers, pigments, and antioxidants within the range that does not impair the effects of the present invention. agent,
Combine with other drugs.

Kanshiki Sacrifice Next, the present invention will be explained in more detail with reference to Examples.

Note that the present invention is not limited to this.

All percentages hereinafter refer to percentages by weight.

Example 1 (Cream) Component A Amount (%) Microcrystalline wax 8.0 Solid paraffin
2.0 Deodorizing beeswax
3,0 white petrolatum
5.0 Reduced lanolin 4.0 Squalane 25.0 Hexadecyl adipate 1000 Lipophilic glycerin monooleate 3.0 Polyoxyethylene sorbitan monooleate (20 E, 0 1.5 Dibutyl hydroxytoluene 0.1 Butyl paraoxybenzoate 0.1 ceramide
0.01 minutes”=
1 meeting IQσ1.3-butylene glycol
5.0 Methyl paraoxybenzoate 0.1
Purified water Adjusted to 100% Ingredients Ingredients Amount Qσ Fragrance 0.2 Component A and Component B were heated and dissolved separately at 80°C, and Component B was added to Component A while stirring, and homogenized for 10 minutes. It became. The resulting mixture was stirred while cooling and heated to 45°C.
Component C was further added thereto, and the mixture was cooled and stirred to 30°C to obtain a cream.

Next, regarding the usability and safety of the obtained cream,
A comparison was made with a control cream produced in exactly the same manner except that no ceramide was added. The results are shown in Table 1.

(a) Usability and skin condition testing method: The cream of Example 1 and the control cream were evaluated for feel when used by a specialized panel. moreover,
The skin condition after the use test after two months of continuous use was also tested in the same manner.

(b) Safety test using animals (1) Skin secondary irritation test Test method: The backs of animals that have been preliminarily raised for one week are shaved using clippers and a shaver. After finishing the test, make sure that the blood congestion caused by the shaver has disappeared, and sample 0.05g + 12 (or 0.05g).
A bandage for batch testing (Torii Pharmaceutical Co., Ltd.) coated with 1 m12) was applied to the shaved area for 24 hours. After removing the bandage, wipe the sample and test for 1 hour, 24 hours and 48 hours.
After a period of time, judgment is made based on the following criteria.

(2) Cumulative skin irritation test Test method - Using clippers on the back of animals that have been pre-housed for one week and shave with a shaver. After completing the test, confirm that the blood congestion caused by the shaver has disappeared, and sample 0.050g 181 times (5 times/
week). Judgment is carried out daily before application. The evaluation criteria are as follows: (No abnormality with no change in stimulation intensity) − 1 to ± Mild erythema ± to + Moderate erythema 10 to ++ Severe erythema and acanthosis ++ ++ to 10++ Edema ++++ ++ 10~Shido++ Formation of epithelium +++++ (3) Eye mucosal irritation test The Draize method was used.

Table 1 Feelings of use Moist Normal Fairly supple 〃 Skin condition No problems After 2 months of continuous use without any problems) Safety skin primary No abnormalities No abnormalities Cumulative 〃
〃 Ocular mucosa 〃 〃 Example 2 (emulsion) Component A Amount (%) Microcrystalline wax 1.0 Beeswax 1.2 Lanolin
2.0 liquid paraffin
15.0 Squalane 15.0 Sorbitan sesquioleate 3.0 Polyoxyethylene sorbitan monooleate (20°E, O,) 1.5 Aluminum stearate 0.3 Dibutylhydroxytoluene 0.1 Butyl paraoxene benzoate 0.1 Ceramide 0.1 Component B
Blend amount (%) Glycerin
6゜0 Methyl roseoxybenzoate 0.1 Purified water
Adjusted to 100% Ingredient C blending amount (%) Fragrance 0.1 The above components A and B were each heated and dissolved separately at 80° C., and component B was added to component A with stirring, followed by homogenization for 10 minutes. The resulting mixture was stirred while cooling, and component C was added at 45°C, and the mixture was cooled and stirred at 30°C to obtain a milky lotion. The obtained emulsion was moist and supple on the skin and did not cause any skin irritation.

Example 3 (lotion) Ingredient A Amount (%) Purified water
Glycerin adjusted to 100%
8.0 PCA soda 0.5 Methyl paraoxybenzoate 0.1 Coloring matter Warm up an appropriate amount Uen 95% ethanol 10.0 Fragrance
0.1 Escarol 507 0.01 Ceramide
o, oot polyoxyethylene hydrogenated castor oil (40, E, O) 0.1 above acid content A
, B were each stirred separately at room temperature until completely dissolved. Next, component B is added to component A and stirred until homogeneous to obtain a lotion. The obtained lotion was moist and supple on the skin and did not cause any skin irritation.

Example 4 (pack) Ingredient A Amount (%) Polyvinyl alcohol 15.0 Sodium carboxymethylcellulose 5.0 Glycerin
5.0 95% ethanol 8.0 Fragrance
0.1 Polyoxyethylene hydrogenated castor oil (40, E, O) 0.2 Ceramide
! , 0 component B
Mixture mk (%) Methyl paraoxybenzoate 0
．． 1 Purified water Adjusted to 100% Component A and the acid component were stirred separately, heated to 60°C and dissolved, and Component B was added to Component A to homogenize. Thereafter, the mixture is cooled and stirred to 30° C. to obtain a pack. The resulting pack was moist and supple on the skin and did not cause any skin irritation.

Example 5 (Foundation) Component A Amount (%) Stearic acid 2.2 Propylene glycol monostearate 2.0 Cetostearyl alcohol 0.3 Lanolin alcohol
1.5 Liquid paraffin
4.0 Isopropyl myristate
6.0 Butyl paraoxybenzoate 0. l Ceramide 1O10 ingredient B
Combination I! (%) Sodium carboxymethyl cellulose 0.2 Bentonite 0.4 1.3-Butylene glycol 5.0 Triethanolamine
0.9 Methyl paraoxybenzoate
0.1 Purified water 100
Acid content adjusted to % C blending amount (%) Talc 4.0 Titanium oxide 8.0 Yellow iron oxide
1.5 black iron oxide
0.4 Red Garla
0.7 Component D Compounding amount (%)
) Fragrance 0.2 Prepare the above component C in advance (after blending, pulverize it through a pulverizer. On the other hand, heat component A and component B to 75°C, respectively, and then add component A to component B while stirring.) ,
Homogenize for an additional approximately 10 minutes. Component C is then added and homogenized for an additional approximately 10 minutes. Then stir while cooling.
The ingredients are added at 45°C, and the mixture is further cooled and stirred to 30°C to obtain a foundation. The obtained foundation was moist and supple on the skin and did not cause any skin irritation.

Example 6 (bath oil) Component A Blending amount (%) Hexadecyl alcohol 30.0 Polyethylene glycol 400 20.0 Polyoxyethylene (40
Mol) Hydrogenated castor oil 7.095% ethanol 35.0 Fragrance
0.1 Pigment Appropriate amount Escarol 507 0.01 Ceramide O6l Component A is thoroughly stirred and dissolved at room temperature to obtain a bath oil. The obtained bath oil was moist and supple on the skin and did not cause any skin irritation.

Claims (1)

[Claims] (1) A cosmetic composition characterized by containing ceramide.