JPS63159303A - Skin cosmetic - Google Patents

Abstract

PURPOSE:To obtain a skin cosmetic having improved effects on chapped skin and on keratin, accelerating effects on turnover of keratin layer, inhibitory effects on skin aging such as skin beautifying effects, by blending a skin cosmetic with calcium hopantenate. CONSTITUTION:A skin cosmetic containing 0.1-1.5wt% compound shown by the formula I (R1 is CH2OH; R2 is NHCH2CH2CH2COO). The compound shown by the formula promotes blood circulation of skin, accelerates skin function, restores or improve characteristic function of skin, keeps skin in a healthy state and shows excellent effects especially in application to aged skin. The form of the cosmetic used is lotion, milky lotion, cream, pack, etc.

Description

Detailed Description of the Invention (Technical Field) The present invention provides skin anti-aging effects (improving rough skin, improving keratin, accelerating the turnover of the stratum corneum, beautifying skin, etc.) by incorporating calcium hopanthenate. ) concerning excellent skin cosmetics.

(Prior Art) Aging skin is rough skin that is dry and lacks smoothness, exhibits peeling of corneocytes, has a high collagen/elastin ratio in connective tissue, and has many wrinkles.

Furthermore, in aging skin, the turnover of the stratum corneum is slow due to a decline in cell metabolism, and therefore, it is said that the turnover becomes faster when an anti-aging effect is imparted to the skin, and various skin cell activating ingredients are being studied.

In addition, the present inventor proposed a cosmetic composition containing γ-aminobutyric acid and its derivatives, as described in Japanese Patent Publication No. 5B-26726, but in practical use, it has not been found that the &tl tissue function of the skin can be restored. Alternatively, it has been difficult to obtain skin cosmetics that have been improved to the extent that they can restore the functions originally possessed by the skin and exhibit remarkable anti-aging effects on the skin.

(Disclosure of the Invention) Therefore, as a result of intensive research in view of the above circumstances, the present inventor found that calcium hopanthenate has an even more excellent skin function enhancing effect than the above-mentioned T-aminobutyric acid and its derivatives. History has shown that skin cosmetics containing calcium hopanthenate accelerate the turnover of aging skin, exhibiting remarkable effects on improving rough skin and keratin, as well as providing moisture (moist feeling) and flexibility to the skin ( smooth),
The present invention was completed by confirming that it also has a beautifying effect that imparts elasticity (tension) and elasticity to the skin.

(Object of the Invention) That is, the object of the present invention is to provide a skin cosmetic with excellent skin aging prevention effects (improving rough skin, improving keratin, accelerating the turnover of the stratum corneum, beautifying skin, etc.). There is a particular thing.

(Structure of the Invention) The present invention is a skin cosmetic containing calcium hopanthenate.

(Specific explanation of the composition) Calcium hopantenate used in the present invention is a known substance, and its pharmacological effect is to promote the uptake of glucose into the brain and its metabolism, and it is effective against aftereffects of encephalitis, cerebral palsy, etc. It is known to be effective in treating accompanying hyperactivity, decreased attention, and language disorders, and to have few side effects.

The chemical characteristics of calcium hopantenate are as follows.

(1) Structure (R3 in the above structural formula is HOCH, R2 is NHC
Hz CHt CHz Represents COO group. ) (2) Chemical name Calcium D-(+)-4-(2,4-dihydroxy-
3,3-dimethyl butyroamide) butyrate hemihydrate Calcium D-(+) -4-(2,
4-dihydroxy-3,3-dimethylb
utyrate hemihydrat(3) -1
1Q name: Calcium fobantenate (Calcium
hopantenate) (4) Molecular formula: C2°H,,
CaNO3”/!H!0 (5) Molecular weight: 513.60 (6) Melting point: 155-165°C Calcium hopantenate to be added to the skin cosmetic of the present invention is prepared by adding 400+ g of sodium metal to 40 ml of methanol and heating. to make a suspension solution, to which 1 t-aminobutyric acid was added.
．． Add 2g and dissolve 0 then vantolactone 1.3
After stirring for 2 hours, the solvent was distilled off, water was added to the precipitated white crystals, and insoluble matter was removed by centrifugation.
Water was evaporated and, after drying, white crystalline calcium hopantenate was obtained.

Calcium hopantenate obtained by the above synthesis method was used in various tests of the present invention.

The calcium hopantenate incorporated into the skin cosmetics of the present invention promotes blood circulation in the skin, enhances skin functions, restores or improves the skin's inherent functions, and maintains the skin in a healthy state. However, remarkable effects are observed especially when applied to aging skin.

The blending amount of calcium hopantenate is 0.05 to 2.0% by weight (based on the total weight of the skin cosmetic composition of the present invention).
(hereinafter abbreviated as wt%), preferably 0.
It is 1 to 1.5 wt%.

If the blending amount is less than 0.05 wt%, it is not sufficient to achieve the desired effect of the present invention (on the other hand, even if it exceeds 2.0 wt%, an improvement in the effect commensurate with the increase cannot be expected.

The skin cosmetics of the present invention can be applied to, for example, lotions, emulsions, creams, packs, and the like.

In addition to the above, pigments, fragrances, preservatives, surfactants, pigments, antioxidants, and the like may be appropriately incorporated into the skin cosmetic of the present invention within a range that achieves the object of the present invention.

(Examples) Hereinafter, the present invention will be described in detail based on Examples and Comparative Examples.

In addition, rough skin improvement effect test, keratin improvement effect test, stratum corneum turnover measurement test, sensory test (skin beautification effect test)
is as follows.

(1) Effect test on improving rough skin The effect of continuous application for 4 weeks was investigated on 20 middle-aged and elderly subjects who had rough skin on their lower legs. Approximately 1 g of the sample was applied to the test site of the left lower leg of the subject once a day, and the condition of the skin before and after the test was judged according to the following criteria. No sample was applied to the right lower leg, which served as a control.

Judgment criteria for skin dryness -: Normal ±: Slight dryness, no flaking +: Mild dryness, flaking ++; Moderate dryness, flaking +++: Significant dryness, flaking Comparing the judgment results of the test site and control site before and after the test, If the skin dryness has improved by two or more levels (e.g. +→-
1++→±) was considered valid, one level improvement was considered somewhat effective, and no change was considered invalid. Test results are valid;
It is shown by the number of subjects who were somewhat effective.

(2) Effect test on improving keratin (increasing anti-exfoliation properties of keratinocytes) Scotch tape (Tiban mending tape) was adhered to the subject's skin before and after the above-mentioned rough skin improvement effect test, and when the tape was peeled off. The condition of the keratinocytes attached to the skin was examined in detail using a scanning electron microscope, and the skin keratinocyte anti-exfoliation property was analyzed according to the following criteria to determine the keratin improving effect.

Judgment criteria for keratin improvement effect (increased anti-desquamation property of keratinocytes) Evaluation points: 1 No two scales observed 2: Small scales dotted 3: Small scales noticeable 4: Large scales noticeable Evaluation is evaluation of the test area after 4 weeks of continuous application If the difference between the score and the control site is 2 or more points, it is considered valid, if it is 1 point, it is considered somewhat effective, and if it is 0 points, it is invalid. Judgment results are shown by the number of subjects who found the test to be valid or slightly effective. .

(3) Test for measuring the turnover of the stratum corneum An ointment containing 5 g of the fluorescent dye Danzyl chloride in white petrolatum was prepared, and the ointment was applied to the skin of the forearms of 20 subjects for 24 hours. Osmotic binding of chloride. Thereafter, the test sample was applied to the same area twice a day (morning and evening), and the fluorescence of danzyl chloride was checked every day, and the number of days until the fluorescence disappeared was defined as the turnover of the stratum corneum of the skin.

The judgment results were shown as the average value of the number of days of the subjects. Note that the normal turnover of the stratum corneum of the skin is 14 to 16 days,
In aging skin, it lasts for about 18 days. On the other hand, if the anti-aging effect appears, the time will be shortened to around 12 days.

(4) Sensory test (skin beautification effect test) Female subjects (35-5
The effects were evaluated after 3 consecutive months of administering the sample to 20 children (5 years old) twice a day (morning and evening). The test results were shown by the number of people who answered that their skin was moisturized, smoothed, or taut for each item of skin wettability, smoothness, and elasticity.

Comparative Examples 1 to 5, Example 1.2 [Two-layer skin lotion] Each skin lotion was prepared by blending calcium hopanthenate into a two-layer skin lotion base as shown in Table 1, as shown in the composition below. A lotion was prepared and the tests described above were conducted.

(1) Composition (2)! jl Manufacturing method Calcium hopantenate, component (C), is mixed and dissolved in component (B) in advance, and after each component (A) and (B) is uniformly dissolved, the (A) component and (B) component are mixed and stirred. dispersed,
Then fill the container. When using, shake and disperse the contents uniformly.

(3) Characteristics The results of various tests conducted on each two-layer skin low silane are listed in the right column of Table 1.

Compared to the skin lotion containing no calcium fobantenate (Comparative 4M 1.2), the skin cosmetic of the present invention gave better results in various tests.

It was clear that calcium hopanthenate had a much better skin function 90 effect than T-aminobutyric acid.

Examples 6 to 9, Comparative Example 3.4 [Skin Cream] Similarly to Example 1, each skin cream was prepared with the following composition and various tests were conducted. The results are shown in the right column of Table 1. .

(1) Preparation method (2) Preparation method Calcium hopantenate (C) component is blended into (B) component, (^) After heating and melting each (B) component at 80°C, they are mixed. Each skin cream was prepared by cooling to 30°C while stirring.

(3) Characteristics As shown in Table 1, Example 6 is a skin cosmetic of the present invention.
It is clear that the skin creams No. 9 to 9 are superior in all properties compared to Comparative Example 3.4, and no abnormality was observed in the blending properties.

(Effects of the Invention) As described above, it is clear that the skin cosmetic of the present invention provides an excellent skin cosmetic that improves skin functions and exhibits a remarkable effect on preventing skin aging.

Claims (1)

[Claims] A skin cosmetic containing calcium hopantenate.